| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Claustre, J Benavides, B Scatto. Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:1848278. |
various 5-ht1a receptor agonists were found to inhibit carbachol (10 microm)-stimulated formation of total inositol phosphates in immature rat hippocampal slices with the following rank order of potency (ic50 values in nm): 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (11) greater than ipsapirone (20) greater than gepirone (120) greater than ru 24969 (140) greater than buspirone (560) greater than 1-(m-trifluoromethylphenyl)piperazine (1,500) greater than methysergide (5,644); selective 5-ht1b, 5-ht2, and 5-ht3 receptor agonists were inactive. |
1991-04-15 |
2023-08-11 |
rat |
| D A Jackson, S R Whit. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology. vol 29. issue 9. 1991-04-09. PMID:2149874. |
other 5-ht agonists, with relatively selective affinity for 5-ht1b, 5-ht1c and 5-ht2 receptors, increased the excitability of spinal motoneurons when applied iontophoretically or intravenously. |
1991-04-09 |
2023-08-11 |
rat |
| D A Jackson, S R Whit. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology. vol 29. issue 9. 1991-04-09. PMID:2149874. |
the iontophoretic results suggest that 5-ht1b, 5-ht1c and 5-ht2 receptors may all play a role in facilitation of the excitability of spinal motoneurons by locally applied 5-ht. |
1991-04-09 |
2023-08-11 |
rat |
| A Kłodzińska, E Chojnacka-Wójci. Anorexia induced by M-trifluoromethylphenylpiperazine (TFMPP) in rats. Polish journal of pharmacology and pharmacy. vol 42. issue 1. 1991-03-13. PMID:2281017. |
1-[3-(trifluoromethyl) phenyl] piperazine (tfmpp), a putative 5-ht1b, 5-ht1c and 5-ht2 agonist decreased dose-dependently food intake over 4 h in freely feeding rats. |
1991-03-13 |
2023-08-11 |
rat |
| A Kłodzińska, E Chojnacka-Wójci. Anorexia induced by M-trifluoromethylphenylpiperazine (TFMPP) in rats. Polish journal of pharmacology and pharmacy. vol 42. issue 1. 1991-03-13. PMID:2281017. |
the tfmpp-induced anorexia was blocked by mesulergine (a 5-ht1c and 5-ht2 antagonist), metergoline (a 5-ht1a, 5-ht1b, 5-ht1c and 5-ht2 antagonist), mianserin (a 5-ht1c and 5-ht2 antagonist) and attenuated by ketanserin and ritanserin (5-ht2 antagonists). |
1991-03-13 |
2023-08-11 |
rat |
| H Y Wang, E Friedma. Protein kinase C translocation in human blood platelets. Life sciences. vol 47. issue 16. 1991-01-16. PMID:2250559. |
serotonin (0.5-100 microm) and the specific 5-ht2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) (10-100 microm) but not the 5-ht1a or 5-ht1b agonists, (+/-) 8-hydroxy-dipropylamino-tetralin (8-oh-dpat) or 5-methoxy-3-3-(1,2,3,6-tetrahydro-4-pyridin) 1h-indole succinate (ru 24969) induced dose-dependent pkc translocations. |
1991-01-16 |
2023-08-11 |
human |
| R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry. vol 33. issue 10. 1990-11-20. PMID:2213830. |
whereas tryptamine derivatives generally display little selectivity for the various populations of 5-ht receptors, n1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (ki = 12 nm) and selectivity at 5-ht2 receptors relative to 5-ht1a (ki = 7100 nm), 5-ht1b (ki = 5000 nm), 5-ht1c (ki = 120 nm), and 5-ht1d (ki greater than 10,000 nm) receptors. |
1990-11-20 |
2023-08-11 |
Not clear |
| N A Frambes, C L Kirstein, C A Moody, L P Spea. 5-HT1A, 5-HT1B and 5-HT2 receptor agonists induce differential behavioral responses in preweanling rat pups. European journal of pharmacology. vol 182. issue 1. 1990-10-19. PMID:2144825. |
preweanling (postnatal day 17-18) sprague-dawley rat pups were tested in both the absence and presence of milk following administration of various doses of the 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) or ipsapirone, the 5-ht1b agonist 1-(3-chlorophenyl)piperazine (mcpp) or the 5-ht2 agonist 1-(2,5-dimethoxy-4-iodo-phenyl)-2-aminopropane (doi). |
1990-10-19 |
2023-08-11 |
rat |
| H Gozlan, G Daval, D Verge, U Spampinato, C M Fattaccini, M C Gallissot, S el Mestikawy, M Hamo. Aging associated changes in serotoninergic and dopaminergic pre- and postsynaptic neurochemical markers in the rat brain. Neurobiology of aging. vol 11. issue 4. 1990-09-10. PMID:2381503. |
of the three different classes of 5-ht receptors which were examined, 5-ht1b sites exhibited the largest age-dependent decrease in density, followed by 5-ht2 sites, while 5-ht1a sites remained practically unchanged during aging. |
1990-09-10 |
2023-08-11 |
rat |
| N S Buckholtz, D F Zhou, D X Freedman, W Z Potte. Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 2. 1990-05-07. PMID:1969270. |
daily administration of lsd [130 micrograms/kg (0.27 mumol/kg) intraperitoneally (ip)] for 5 days produced a decrease in serotonin2 (5-hydroxytryptamine2, 5-ht2) binding in cortex (measured 24 hours after the last drug administration) but did not affect binding to other receptor systems (5-ht1a, 5-ht1b, beta-adrenergic, alpha 1- or alpha 2-adrenergic, d2-dopaminergic) or to a recognition site for 5-ht uptake. |
1990-05-07 |
2023-08-11 |
rat |
| M Pawlik, P Kaulen, H G Baumgarten, H Rommelspache. Quantitative autoradiography of [3H]norharman [( 3H]beta-carboline) binding sites in the rat brain. Journal of chemical neuroanatomy. vol 3. issue 1. 1990-05-02. PMID:2156525. |
monoamine oxidase, benzodiazepine, tryptamine, 5-hydroxytryptamine receptors (5-ht1a, 5-ht1b, 5-ht1c, 5ht2], which suggests that a unique class of [3h]norharman binding sites exists in the rat brain. |
1990-05-02 |
2023-08-11 |
rat |
| A A Li, G J Marek, T H Hand, L S Seide. Antidepressant-like effects of trazodone on a behavioral screen are mediated by trazodone, not the metabolite m-chlorophenylpiperazine. European journal of pharmacology. vol 177. issue 3. 1990-04-26. PMID:2311675. |
m-chlorophenylpiperazine (m-cpp) is a 5-ht1b and 5-ht1c agonist, weak 5-ht2 antagonist, and trazodone metabolite. |
1990-04-26 |
2023-08-11 |
rat |
| K A King, J R Holtma. Characterization of the effects of activation of ventral medullary serotonin receptor subtypes on cardiovascular activity and respiratory motor outflow to the diaphragm and larynx. The Journal of pharmacology and experimental therapeutics. vol 252. issue 2. 1990-04-16. PMID:2138222. |
the purpose of the present study was to characterize the cardiorespiratory effects of activation of 5-ht1a, 5-ht1b and 5-ht2 receptor subtypes at the intermediate area of the ventral surface of the medulla. |
1990-04-16 |
2023-08-11 |
Not clear |
| C L Kirstein, J Traber, W H Gispen, L P Spea. ACTH-induced behaviors and their modulation by serotonergic agonists differ in neonatal and weanling rat pups. Psychopharmacology. vol 100. issue 2. 1990-03-27. PMID:2154832. |
four-day-old (p4) and 21-22-day-old (p21-22) rat pups received an intracisternal injection of either acth1-16nh2 or saline followed by a subcutaneous (sc) injection of saline, the serotonergic (5ht)1a agonists 8-oh-dpat or ipsapirone, the 5ht1b agonist tfmpp or the 5ht2 agonist doi. |
1990-03-27 |
2023-08-11 |
rat |
| M J Millan, K Bervoets, F C Colpaer. Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks. Neuroscience letters. vol 107. issue 1-3. 1990-03-14. PMID:2533334. |
agonists at other serotonin (5-ht) receptor types (5-ht1b, 5-ht1c, 5-ht2, 5-ht3) were inactive. |
1990-03-14 |
2023-08-11 |
rat |
| M Matsumoto, H Togashi, M Yoshioka, H Sait. [Serotonin and blood pressure regulation--antihypertensive mechanism of ketanserin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 94. issue 4. 1990-03-06. PMID:2575564. |
central and peripheral 5-ht receptors can be divided into three receptor subtypes: 5-ht1 (5-ht1a, 5-ht1b, 5-ht1c), 5-ht2 and 5-ht3 receptors. |
1990-03-06 |
2023-08-11 |
Not clear |
| D D Gillespie, D H Manier, F Sulse. Characterization of the inducible serotonin-sensitive dihydroalprenolol binding sites with low affinity for isoproterenol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 2. issue 4. 1990-02-28. PMID:2610822. |
neither the 5-ht1a agonist, 8-oh-dpat, nor mianserin, a 5-ht2 and 5-ht1c antagonist, altered the induced rl receptor population, whereas the selective 5-ht1b agonist cgs-12066b reduced the increase in the rl receptor population with a potency equal to that of 5-ht. |
1990-02-28 |
2023-08-11 |
Not clear |
| H Y Wang, E Friedma. Central 5-hydroxytryptamine receptor-linked protein kinase C translocation: a functional postsynaptic signal transduction system. Molecular pharmacology. vol 37. issue 1. 1990-02-23. PMID:2300046. |
serotonin (0.5-100 microm) and the specific 5-ht2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) (0.01-10 microm) but not the 5-ht1a or 5-ht1b agonists elicited time- and dose-related translocations in cortical slices. |
1990-02-23 |
2023-08-11 |
rat |
| A Jazayeri, W J Meyer, T A Ken. 5-HT1B and 5-HT2 serotonin binding sites in cultured Wistar-Kyoto rat aortic smooth muscle cells. European journal of pharmacology. vol 169. issue 1. 1990-02-06. PMID:2532143. |
5-ht1b and 5-ht2 serotonin binding sites in cultured wistar-kyoto rat aortic smooth muscle cells. |
1990-02-06 |
2023-08-11 |
rat |
| E Przegaliński, B Budziszewska, A Warchoł-Kania, E Błaszczyńsk. Stimulation of corticosterone secretion by the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. Pharmacology, biochemistry, and behavior. vol 33. issue 2. 1989-12-19. PMID:2530590. |
on the other hand, the 5-ht1b receptor antagonist 21009, the 5-ht2 receptor antagonists ketanserin and pirenperone, the 5-ht3 receptor antagonist ics 205-930, the alpha 2-adrenoceptor antagonists yohimbine and idazoxan, the beta-adrenoceptor blocker with no affinity to 5-ht1 receptors, atenolol, the dopaminergic antagonist pimozide, the histamine receptor blocker chloropyramine and the opiate receptor antagonist naloxone did not affect the hormonal response to 8-oh-dpat. |
1989-12-19 |
2023-08-11 |
rat |