| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Seuwen, I Magnaldo, J Pouysségu. Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. Nature. vol 335. issue 6187. 1988-10-12. PMID:3045568. |
serotonin stimulates dna synthesis in fibroblasts acting through 5-ht1b receptors coupled to a gi-protein. |
1988-10-12 |
2023-08-11 |
Not clear |
| K Seuwen, I Magnaldo, J Pouysségu. Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. Nature. vol 335. issue 6187. 1988-10-12. PMID:3045568. |
we show that the mitogenicity of 5-hydroxytryptamine can be uncoupled from phospholipase c activation that is mediated by 5-ht2 receptors, but correlates perfectly with inhibition of adenylate cyclase through 5-ht1b receptor. |
1988-10-12 |
2023-08-11 |
Not clear |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
5-hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-ht1 subtype different from 5-ht1a, 5-ht1b, and 5-ht1c. |
1988-09-15 |
2023-08-11 |
rat |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
5-ht binding sites of the 5-ht1 type are heterogeneous and appear to comprise several subtypes (5-ht1a, 5-ht1b and 5-ht1c); their physiological role is as yet unclear. |
1988-09-15 |
2023-08-11 |
rat |
| C Fayolle, M P Fillion, P Barone, P Oudar, J C Rousselle, G Fillio. 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Fundamental & clinical pharmacology. vol 2. issue 3. 1988-09-15. PMID:3402898. |
on the other hand, the high-affinity activation of the enzyme induced by 5-ht, 5-methoxytryptamine, bufotenin, lsd, and the activation induced by tfmpp were not inhibited by spiperone (1 microm), by propranolol (3 microm), or by mesulergine (0.1 microm), which selectively block 5-ht1a, 5-ht1b, and 5-ht1c sites. |
1988-09-15 |
2023-08-11 |
rat |
| C Waeber, M M Dietl, D Hoyer, A Probst, J M Palacio. Visualization of a novel serotonin recognition site (5-HT1D) in the human brain by autoradiography. Neuroscience letters. vol 88. issue 1. 1988-08-26. PMID:3399126. |
8-oh-dpat (8-hydroxy-2-[n,n-di-n-propyl-amino]tetralin) was used to block [3h]5-ht binding to 5-ht1a, the beta-blocker (-)-21 009 (4-[3-ter-butyl-amino-2-hydroxy-propoxy]indol-2-carbonic acid isopropyl ester) to 5-ht1b and the ergoline mesulergine to 5-ht1c recognition sites. |
1988-08-26 |
2023-08-11 |
human |
| D E Nichols, D H Lloyd, M P Johnson, A J Hoffma. Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. Journal of medicinal chemistry. vol 31. issue 7. 1988-08-05. PMID:3385733. |
synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-ht1b receptors. |
1988-08-05 |
2023-08-11 |
rat |
| D E Nichols, D H Lloyd, M P Johnson, A J Hoffma. Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. Journal of medicinal chemistry. vol 31. issue 7. 1988-08-05. PMID:3385733. |
to probe structure-activity relationships of serotonin receptors, affinities of the alpha-methyltryptamine enantiomers were then measured at the 5-ht2 antagonist receptor subtype, with displacement of [3h]ketanserin, and were estimated at the 5-ht1b receptor, with displacement of [3h]serotonin, respectively, in rat frontal cortex homogenates. |
1988-08-05 |
2023-08-11 |
rat |
| R E Solomon, G F Gebhar. Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats. The Journal of pharmacology and experimental therapeutics. vol 245. issue 3. 1988-07-29. PMID:2455040. |
the 5-ht1a agonist 8-hydroxy-n,n-dipropyl-2-aminotetralin and the 5ht1b agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole (ru-24969) also produced depressor effects but, in contrast to 5-ht, facilitated the tail-flick reflex, whereas the 5-ht2 agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, 6-chloro-2-(1-piperazinyl)-pyrazine (mk-212) and quipazine produced dose-dependent antinociception and had little or no effect on blood pressure. |
1988-07-29 |
2023-08-11 |
rat |
| P Wang, C S Aulakh, J L Hill, D L Murph. Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists. Psychopharmacology. vol 94. issue 4. 1988-07-14. PMID:2967518. |
the food intake suppressant effects of three serotonin agonists, m-cpp (a selective 5-ht1b agonist), 8-ohdpat (a selective 5-ht1a agonist) and fenfluramine (a 5-ht releasing agent) were compared in three different rat strains: wistar, sprague-dawley (sd) and fawn-hooded (fh) rats. |
1988-07-14 |
2023-08-11 |
rat |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
in human caudate and cortex membranes, [3h]serotonin ([3h]5-ht) labels 5-ht1a and 5-ht1c recognition sites which show nanomolar affinity for 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-ht1b binding could be identified. |
1988-06-02 |
2023-08-11 |
human |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
however, the majority of the sites labelled by [3h]5-ht (greater than or equal to 60% in cortex, 90% in caudate) are different from 5-ht1a, 5-ht1b and 5-ht1c sites. |
1988-06-02 |
2023-08-11 |
human |
| M R Pranzatell. The comparative pharmacology of the behavioral syndromes induced by TRH and by 5-HT in the rat. General pharmacology. vol 19. issue 2. 1988-05-12. PMID:2895033. |
a 5-ht1a agonist (8-oh-dpat) blocked wds, but like putative 5-ht1b (ru 24969) and 5-ht2 (doi) agonists and the 5-ht antagonists methysergide (non-selective), ritanserin (5-ht2 selective), and l-propranolol (5-ht1 selective), it did not block other antagonists behavioural effects of mk-771. |
1988-05-12 |
2023-08-11 |
rat |
| L Brown, J Amedro, G Williams, D Smit. A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor. European journal of pharmacology. vol 145. issue 2. 1988-05-06. PMID:2965026. |
the 5-ht receptor agonists serotonin (1-100 nm), lysergic acid diethylamide (10 nm-1 microm) and the 5-ht1b receptor agonists 1-(m-trifluoromethylphenyl)piperazine (100 nm-1 microm) and 1-(m-chlorophenyl) piperazine (100 nm-3 microm) concentration dependently decreased [3h]5-ht release, while 8-hydroxy-2-(di-n-propylamino)tetralin, a selective 5-ht1a receptor agonist, was inactive. |
1988-05-06 |
2023-08-11 |
rat |
| G Gross, G Hanft, N Kolass. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 6. 1988-05-03. PMID:2832770. |
in the present study, the affinities of these urapidil derivatives (5-acetyl, 5-formyl- and 5-methyl-urapidil) for 5-ht receptors were investigated using 3h-8-hydroxy-2-(di-n-propyl-amino)tetralin (3h-8-oh-dpat), 125i-iodocyanopindolol (125i-icyp) and 3h-ketanserin for labelling 5-ht1a, 5-ht1b and 5-ht2 binding sites, respectively. |
1988-05-03 |
2023-08-11 |
Not clear |
| R A Glennon, M E Pierson, J D McKenne. Stimulus generalization of 1-(3-trifluoromethylphenyl)piperazine (TFMPP) to propranolol, pindolol, and mesulergine. Pharmacology, biochemistry, and behavior. vol 29. issue 1. 1988-05-03. PMID:2895480. |
these results suggest that the tfmpp-stimulus may involve both a 5-ht1b and a 5-ht1c mechanism and further suggest that propranolol, pindolol, and mesulergine may be capable of acting as agonists at certain populations of serotonin receptors. |
1988-05-03 |
2023-08-11 |
rat |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
selective 5-ht1b agonists identify the 5-ht autoreceptor in lumbar spinal cord of rat. |
1988-04-22 |
2023-08-11 |
rat |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
the effect of selective 5-ht1a and 5-ht1b agonists on k+-evoked release of [3h]5-ht and the binding of [3h]5-ht were examined. |
1988-04-22 |
2023-08-11 |
rat |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
the 5-ht1b compounds, mcpp and quipazine were more potent than exogenous 5-ht at decreasing k+-evoked release of [3h]5-ht in slices of spinal cord. |
1988-04-22 |
2023-08-11 |
rat |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
the pec40 values of 5-ht agonists tested, determined from release assays, significantly correlated with the relative affinities (pkd's) of these compounds for the binding of [3h]5-ht to the 5-ht1b receptor subtype in the presence of 2 microm 8-ohdpat, as determined from radioligand binding studies (r = 0.98, p = 0.003). |
1988-04-22 |
2023-08-11 |
rat |