| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Vergé, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan, M Hamo. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:2947981. |
these results are discussed in relation to the possible identity of 5-ht1a and/or 5-ht1b sites with the presynaptic 5-ht autoreceptors controlling nerve impulse flow and neurotransmitter release in serotoninergic neurons. |
1987-02-10 |
2023-08-11 |
rat |
| G Maura, M Raiter. Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. European journal of pharmacology. vol 129. issue 3. 1987-01-22. PMID:3780847. |
it can be concluded that hippocampal cholinergic terminals are endowed with inhibitory 5-ht receptors which appear to belong to the 5-ht1b subtype. |
1987-01-22 |
2023-08-11 |
rat |
| M G Palfreyman, A K Mir, M Kubina, D N Middlemiss, M Richards, M D Tricklebank, J R Fozar. Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase. European journal of pharmacology. vol 130. issue 1-2. 1987-01-06. PMID:3780861. |
the lack of effect of chronic mao treatment on the 5-ht autoreceptor measured in cortical slices corresponded to a lack of effect on the 5-ht1b binding site except that chronic administration of pargyline produced a small but significant decrease in 5-ht autoreceptor sensitivity. |
1987-01-06 |
2023-08-11 |
rat |
| H O Kalkman, G Engel, D Hoye. Inhibition of 5-carboxamidotryptamine-induced relaxation of guinea-pig ileum correlates with [125I]LSD binding. European journal of pharmacology. vol 129. issue 1-2. 1986-12-11. PMID:3770071. |
the results suggest that the 5-ht receptor-mediating relaxation in the guinea-pig ileum can be labelled with [125i]lsd and that this receptor does not belong to the 5-ht2, 5-ht1a, 5-ht1b or 5-ht1c receptor subtypes. |
1986-12-11 |
2023-08-11 |
Not clear |
| G Bonanno, G Maura, M Raiter. Pharmacological characterization of release-regulating serotonin autoreceptors in rat cerebellum. European journal of pharmacology. vol 126. issue 3. 1986-11-12. PMID:2944750. |
in conclusion, autoreceptors are present on 5-ht nerve endings in rat cerebellum and appear to belong to the 5-ht1b subtype. |
1986-11-12 |
2023-08-11 |
rat |
| R A Glenno. Discriminative stimulus properties of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH DPAT). Pharmacology, biochemistry, and behavior. vol 25. issue 1. 1986-10-16. PMID:2944129. |
the results of this study demonstrate that the serotonin agonist 8-oh dpat serves as a discriminative stimulus in rats and that it produces stimulus effects that are probably not 5-ht1b or 5-ht2-mediated. |
1986-10-16 |
2023-08-11 |
rat |
| R W Ransom, K B Asarch, J C Shi. Photoaffinity labeling of the 5-hydroxytryptamine 1A receptor in rat hippocampus. Journal of neurochemistry. vol 47. issue 4. 1986-10-15. PMID:3746296. |
1-[2-(4-azidophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (p-azido-papp) inhibits [3h]5-hydroxytryptamine [( 3h]5-ht) binding to 5-ht1a and 5-ht1b sites in rat brain with equilibrium dissociation constants (kd) of 0.9 nm and 230 nm, respectively. |
1986-10-15 |
2023-08-11 |
rat |
| S J Peroutk. Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex. Journal of neurochemistry. vol 47. issue 2. 1986-09-17. PMID:2942638. |
this subpopulation of total [3h]5-ht binding is designated 5-ht1b. |
1986-09-17 |
2023-08-11 |
rat |
| S D Mendelson, B B Gorzalk. 5-HT1A receptors: differential involvement in female and male sexual behavior in the rat. Physiology & behavior. vol 37. issue 2. 1986-09-17. PMID:2942955. |
furthermore, it is proposed that 5-ht1a receptors mediate inhibitory effects, whereas 5-ht1b receptors mediate presynaptic, facilitatory effects of serotonin. |
1986-09-17 |
2023-08-11 |
rat |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
[3h]5-ht was used to label both 5-ht1a and 5-ht1b receptor subtypes. |
1986-08-19 |
2023-08-11 |
human |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
in contrast to 5-ht1a receptors, it was not possible to identify 5-ht receptors having the pharmacological properties of 5-ht1b sites in the human brain, using either [3h]5-ht or [125i]cyp as ligands. |
1986-08-19 |
2023-08-11 |
human |
| D Hoyer, A Pazos, A Probst, J M Palacio. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain research. vol 376. issue 1. 1986-08-19. PMID:3719375. |
the absence of identifiable 5-ht1b receptors in human brain preparations, a fact previously found in pig brain tissue, is discussed in terms of the existence of species differences in brain serotonin receptors. |
1986-08-19 |
2023-08-11 |
human |
| M L Cohen, W E Colber. Relationship between receptors mediating serotonin (5-HT) contractions in the canine basilar artery to 5-HT1, 5-HT2 and rat stomach fundus 5-HT receptors. The Journal of pharmacology and experimental therapeutics. vol 237. issue 3. 1986-07-16. PMID:3712277. |
similarity of the contractile effects of 5-ht in the rat stomach fundus and in the basilar artery coupled to the previous observations that receptors mediating 5-ht-induced contractions in the fundus were not 5-ht1, 5-ht1a, 5-ht1b or 5-ht2 led us to consider the possibility that 5-ht receptors in the canine basilar artery may resemble those in the rat stomach fundus. |
1986-07-16 |
2023-08-11 |
rat |
| P A Blurton, M D Woo. Identification of multiple binding sites for [3H]5-hydroxytryptamine in the rat CNS. Journal of neurochemistry. vol 46. issue 5. 1986-05-19. PMID:3958711. |
these results suggest the presence of three binding sites for [3h]5-ht, one blocked by low concentrations of spiperone (5-ht1a), one blocked by low concentrations of mianserin (5-ht1c), and one blocked only by high concentrations of both mianserin and spiperone (5-ht1b). |
1986-05-19 |
2023-08-11 |
rat |
| J T Clark, S J Peroutka, R D Ciaranello, E R Smith, J M Davidso. Central effects of RDS-127: sexual behavior after intracerebroventricular administration and in vitro receptor binding studies. Behavioural brain research. vol 18. issue 3. 1986-04-24. PMID:2936365. |
rds-127 was essentially ineffective at 5-ht1b sites labeled by [3h]5-ht in rat striatum (ki = 13 000 +/- 4 000 nm). |
1986-04-24 |
2023-08-11 |
rat |
| G Engel, M Göthert, D Hoyer, E Schlicker, K Hillenbran. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:2936965. |
identity of inhibitory presynaptic 5-hydroxytryptamine (5-ht) autoreceptors in the rat brain cortex with 5-ht1b binding sites. |
1986-04-22 |
2023-08-11 |
rat |
| K G Charlton, R A Bond, D E Clark. An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney. Apparent distinction from the 5-HT1A, 5-HT1B and 5-HT1C subtypes. Naunyn-Schmiedeberg's archives of pharmacology. vol 332. issue 1. 1986-04-22. PMID:3951568. |
it is concluded that the receptor to 5-ht conforms to general criteria defining 5-ht1-like receptors but at the present time the receptor site cannot be fitted to the designated 5-ht1a, 5-ht1b or 5-ht1c subtypes. |
1986-04-22 |
2023-08-11 |
rat |
| M Hibert, D N Middlemis. Stereoselective blockade at the 5-HT autoreceptor and inhibition of radioligand binding to central 5-HT recognition sites by the optical isomers of methiothepin. Neuropharmacology. vol 25. issue 1. 1986-04-11. PMID:2936974. |
it is concluded that the chiral association of methiothepin with the 5-ht autoreceptor provides further evidence for a pharmacological similarity between this receptor and the 5-ht1b subtype of the 5-ht1 recognition site. |
1986-04-11 |
2023-08-11 |
rat |
| D Hoyer, G Engel, H O Kalkma. Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935410. |
[125i]cyp bound in rat but not in pig cortex to the 5-ht1b site which shows high affinity for (-)21-009 (4[3-ter-butyl-amino-2-hydroxy-propoxy]indol-2-carbonic acid isopropyl ester), (+/-)icyp (3-i-cyanopindolol), 5-ht, ru 24969 (5-methoxy-3-[1,2,3,6-tetrahydropyridon-4-yl]1h-indole) and low affinity for 8-oh-dpat, mesulergine and pirenperone. |
1986-03-05 |
2023-08-11 |
rat |
| D Hoyer, G Engel, H O Kalkma. Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. European journal of pharmacology. vol 118. issue 1-2. 1986-03-05. PMID:2935410. |
finally, the beta-adrenoceptor antagonist (-)21-009 which has different affinities for 5-ht1a, 5-ht1b and 5-ht1c recognition sites, yielded triphasic competition curves for [3h]5-ht binding in rat cortex membranes providing evidence that [3h]5-ht labels three distinct 5-ht1 sites in these membranes. |
1986-03-05 |
2023-08-11 |
rat |