| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Murphy, F P Zemla. Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat. Neuropharmacology. vol 27. issue 1. 1988-04-22. PMID:3352865. |
thus, the 5-ht autoreceptor in spinal cord appears to bear a significant pharmacological similarity to the 5-ht1b binding site. |
1988-04-22 |
2023-08-11 |
rat |
| B A McMillen, J K Chamberlain, J P DaVanz. Effects of housing and muricidal behavior on serotonergic receptors and interactions with novel anxiolytic drugs. Journal of neural transmission. vol 71. issue 2. 1988-04-18. PMID:2894404. |
binding of [3h]-5-hydroxytryptamine (5ht) to 5ht1a receptors decreased in septum of both groups of isolated rats and binding to 5ht1b receptors decreased 50% in hippocampus of isolated and aggregated muricidal rats. |
1988-04-18 |
2023-08-11 |
mouse |
| S J Offord, G A Ordway, A Fraze. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. The Journal of pharmacology and experimental therapeutics. vol 244. issue 1. 1988-02-24. PMID:3335996. |
competition for [125i]icyp (100 pm) labeled binding sites by 15 serotonin agonists or antagonists was adequately described by a single site model, and the affinity of these drugs for the site labeled by [125i]icyp was similar to that determined previously when using indirect methods to label 5-ht1b receptors. |
1988-02-24 |
2023-08-11 |
rat |
| J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences. vol 42. issue 3. 1988-02-23. PMID:2961966. |
for example, 8-oh-dpat 5ht1a had an ic50 of 117 nm; tfmpp 5ht1b (2.3 microm0 and papp 1a + 5ht2 (9 microm); ipsapirone 5ht1a (21.1 microm) and buspirone 5ht1a (greater than 100 microm); ketanserin 5ht2 (greater than 100 microm); 5-ht uptake inhibitors: paroxetine (13 nm); chlorimipramine (73 nm) and fluoxetine (653 nm). |
1988-02-23 |
2023-08-11 |
human |
| M W Hamblin, K Ariani, P I Adriaenssens, R D Ciaranell. [3H]dihydroergotamine as a high-affinity, slowly dissociating radioligand for 5-HT1B binding sites in rat brain membranes: evidence for guanine nucleotide regulation of agonist affinity states. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2826763. |
competition by the agonists 5-ht and ru 24969 at 5-ht1b sites are often best described by two site fits. |
1988-02-02 |
2023-08-11 |
human |
| G J Molderings, K Fink, E Schlicker, M Göther. Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 3. 1988-01-11. PMID:3683595. |
ketanserin, a 5-ht2 receptor antagonist, and spiperone, which blocks 5-ht2 and 5-ht1a but not 5-ht1b or 5-ht1c receptors, failed to antagonize the effect of 5-ht. |
1988-01-11 |
2023-08-11 |
rat |
| C S Aulakh, R M Cohen, J L Hill, D L Murphy, J Zoha. Long-term imipramine treatment enhances locomotor and food intake suppressant effects of m-chlorophenylpiperazine in rats. British journal of pharmacology. vol 91. issue 4. 1987-12-14. PMID:3664076. |
rapidly developing 5-hydroxytryptamine uptake inhibition may be responsible for this change, or it may represent an earlier adaptive change in the 5-ht1b receptors mediating food intake compared to more complexly modulated motor responses. |
1987-12-14 |
2023-08-11 |
rat |
| T J Feuerstein, A Lupp, G Herttin. The serotonin (5-HT) autoreceptor in the hippocampus of the rabbit: role of 5-HT biophase concentration. Neuropharmacology. vol 26. issue 8. 1987-11-18. PMID:2958718. |
this value corresponds to the pkd of 5-ht at the 5-ht1b binding site. |
1987-11-18 |
2023-08-11 |
rat |
| T J Feuerstein, A Lupp, G Herttin. The serotonin (5-HT) autoreceptor in the hippocampus of the rabbit: role of 5-HT biophase concentration. Neuropharmacology. vol 26. issue 8. 1987-11-18. PMID:2958718. |
the 5-ht biophase concentration at the autoreceptor of 10(-8.220 +/- 0.132)m was markedly enhanced by 6-nitroquipazine (10(-6)m) to 10(-7.476 +/- 0.132)m. it is concluded that the 5-ht autoreceptor belongs to the 5-ht1b subtype of receptor; the corresponding 5-ht biophase concentration can be estimated quantitatively; 8-oh-dpat decreased the evoked release of 5-ht through both 5-ht autoreceptors and alpha 2-heteroreceptors and (+/-)-cyanopindolol acts as partial agonist at the 5-ht autoreceptor. |
1987-11-18 |
2023-08-11 |
rat |
| C Oberlander, Y Demassey, A Verdu, D Van de Velde, C Bardela. Tolerance to the serotonin 5-HT1 agonist RU 24969 and effects on dopaminergic behaviour. European journal of pharmacology. vol 139. issue 2. 1987-10-29. PMID:2443369. |
it is concluded that both the state of tolerance and the reversal of the action of ru 24969 that followed repeated treatment might be related to down-regulation of a subtype of the 5-ht1 receptor, possibly the 5-ht1b subtype, that would play a critical role in the expression of da-mediated behaviour, locomotor activity and 5-ht metabolism. |
1987-10-29 |
2023-08-11 |
rat |
| M Göthert, E Schlicker, K Fink, K Classe. Effects of RU 24969 on serotonin release in rat brain cortex: further support for the identity of serotonin autoreceptors with 5-HT1B sites. Archives internationales de pharmacodynamie et de therapie. vol 288. issue 1. 1987-10-27. PMID:3662697. |
effects of ru 24969 on serotonin release in rat brain cortex: further support for the identity of serotonin autoreceptors with 5-ht1b sites. |
1987-10-27 |
2023-08-11 |
rat |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
stereoselective blockade of central [3h]5-hydroxytryptamine binding to multiple sites (5-ht1a, 5-ht1b and 5-ht1c) by mianserin and propranolol. |
1987-10-26 |
2023-08-11 |
rat |
| B S Alexander, M D Woo. Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol. The Journal of pharmacy and pharmacology. vol 39. issue 8. 1987-10-26. PMID:2888864. |
the interaction of the enantiomers of mianserin and propranolol with the binding of [3h]5-hydroxytryptamine ([3h]5-ht) to the 5-ht1a, 5-ht1b and 5-ht1c sites, and with the binding of [3h]ketanserin to the 5-ht2 site, has been evaluated in rat brain membranes. |
1987-10-26 |
2023-08-11 |
rat |
| R F Neale, S L Fallon, W C Boyar, J W Wasley, L L Martin, G A Stone, B S Glaeser, C M Sinton, M William. Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. European journal of pharmacology. vol 136. issue 1. 1987-07-24. PMID:3496228. |
the compound had an ic50 value of 51 nm at the 5ht1b recognition site as determined using the binding of [3h]5ht in the presence of 1 microm spiperone. |
1987-07-24 |
2023-08-11 |
rat |
| H H Berendsen, C L Broekkam. Drug-induced penile erections in rats: indications of serotonin1B receptor mediation. European journal of pharmacology. vol 135. issue 3. 1987-07-17. PMID:3495447. |
penile erections were also induced by the 5ht uptake inhibitors zimelidine, fluoxetine, citalopram, org 6997, by the 5ht-releasing agent fenfluramine and by the putative 5-ht1b receptor agonist 1-(3'-chlorophenyl)-piperazine (mcpp). |
1987-07-17 |
2023-08-11 |
rat |
| K B Asarch, J C Shi. Solubilization of serotonin1a and serotonin1b binding sites from bovine brain. Journal of neurochemistry. vol 48. issue 5. 1987-05-20. PMID:2951498. |
the density of [3h]dpat binding sites relative to the [3h]5-ht sites in the solubilized cortical membranes (35%) corresponds well with the proportion of 5-ht1a sites in the crude membranes determined by spiperone displacement (33%), suggesting that both the 5-ht1a and 5-ht1b binding sites have been cosolubilized. |
1987-05-20 |
2023-08-11 |
cattle |
| G Maura, E Roccatagliata, M Raiter. Serotonin autoreceptor in rat hippocampus: pharmacological characterization as a subtype of the 5-HT1 receptor. Naunyn-Schmiedeberg's archives of pharmacology. vol 334. issue 4. 1987-04-20. PMID:3821924. |
in conclusion, 5-ht nerve terminals of rat hippocampus possess autoreceptors which appear to belong to the 5-ht1b subtype. |
1987-04-20 |
2023-08-11 |
rat |
| D G Spencer, J Trabe. The interoceptive discriminative stimuli induced by the novel putative anxiolytic TVX Q 7821: behavioral evidence for the specific involvement of serotonin 5-HT1A receptors. Psychopharmacology. vol 91. issue 1. 1987-04-06. PMID:2881318. |
in addition, non-selective 5-ht agonists and antagonists such as bufotenin, quipazine, and methysergide, as well as substances with high affinity for the 5-ht1b receptor (m-trifluoromethylphenylpiperazine, tfmpp; 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)-1h-indole succinate, ru 24969) did not substitute for tvx q 7821. |
1987-04-06 |
2023-08-11 |
rat |
| R D Todd, R D Ciaranell. Multiple high-affinity [3H]serotonin binding sites in human frontal cortex. Brain research. vol 400. issue 2. 1987-04-02. PMID:3815073. |
high-affinity [3h]serotonin (5-hydroxytryptamine, 5-ht) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-ht1a, 5-ht1b and 5-ht3) based on affinity for [3h]serotonin and spiperone. |
1987-04-02 |
2023-08-11 |
human |
| G M Goodwin, R J DeSouza, A J Wood, A R Gree. Lithium decreases 5-HT1A and 5-HT2 receptor and alpha 2-adrenoceptor mediated function in mice. Psychopharmacology. vol 90. issue 4. 1987-03-20. PMID:3027734. |
by contrast with this reduction of 5-hydroxytryptamine (5-ht) function mediated by the 5-ht1a and 5-ht2 receptor sub-types, repeated lithium administration had no effect on the motor response to a putative 5-ht1b receptor agonist 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1h indole (ru 24969, 3 mg/kg ip). |
1987-03-20 |
2023-08-11 |
mouse |