| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E W Taylor, S P Duckles, D L Nelso. Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site. The Journal of pharmacology and experimental therapeutics. vol 236. issue 1. 1986-02-20. PMID:2934545. |
logs of these ka values did not correlate with log ki values for the inhibition of binding of the 5-ht2 ligand [3h] ketanserin (r = 0.2253, p greater than .05) or log ic50 values for inhibition of [3h]5-ht binding (r = 0.5732, p greater than 0.05), which labels both 5-ht1a and 5-ht1b sites. |
1986-02-20 |
2023-08-11 |
Not clear |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
meta chlorophenylpiperazine (cpp) and meta trifluoromethylphenylpiperazine (tfmpp), selective ligands for the 5ht1b receptor and ly165163, a selective ligand for the 5ht1a receptor, have been evaluated for their agonist and antagonist activity at serotonin receptors in the rat stomach fundus. |
1986-02-18 |
2023-08-11 |
rat |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
the affinity for serotonin receptors in the rat fundus was similar for all three phenylpiperazines in spite of the reported selectivity of mcpp and tfmpp for 5ht1b and of ly165163 for 5ht1a receptors. |
1986-02-18 |
2023-08-11 |
rat |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
furthermore, the affinity of these agents for serotonin receptors in the rat stomach fundus did not agree with their reported affinity for either 5ht1a or 5ht1b binding sites in rat cortical membranes. |
1986-02-18 |
2023-08-11 |
rat |
| M L Cohen, L A Wittenaue. Further evidence that the serotonin receptor in the rat stomach fundus is not 5HT1A or 5HT1B. Life sciences. vol 38. issue 1. 1986-02-18. PMID:3941588. |
thus, the similarity in affinities of these phenylpiperazine derivatives for serotonin receptors mediating contraction in the rat fundus along with their different affinities for 5ht1a and 5ht1b binding sites argues against the possibility that the serotonin receptor in the rat fundus is of the 5ht1a or 5ht1b subtype of serotonin receptor. |
1986-02-18 |
2023-08-11 |
rat |
| R W Ransom, K B Asarch, J C Shi. [3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain. Journal of neurochemistry. vol 46. issue 1. 1986-01-21. PMID:2933490. |
1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (papp) inhibits [3h]5-hydroxytryptamine (5-ht, serotonin) binding to 5-ht1a and 5-ht1b sites in rat brain with apparent equilibrium dissociation constants (kd) of 2.9 and 328 nm, respectively. |
1986-01-21 |
2023-08-11 |
rat |
| R W Ransom, K B Asarch, J C Shi. [3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain. Journal of neurochemistry. vol 46. issue 1. 1986-01-21. PMID:2933490. |
spiperone and 8-hydroxy-2-(di-n-propylamino)tetralin, two compounds that discriminate [3h]5-ht binding to 5-ht1a and 5-ht1b sites, inhibited [3h]papp binding in accordance with their much higher affinities for the 5-ht1a receptor subtype. |
1986-01-21 |
2023-08-11 |
rat |
| P J Monroe, D J Smit. Demonstration of an autoreceptor modulating the release of [3H]5-hydroxytryptamine from a synaptosomal-rich spinal cord tissue preparation. Journal of neurochemistry. vol 45. issue 6. 1985-12-16. PMID:3877146. |
furthermore quipazine, in concentrations that preferentially interact with the 5-ht1b subtype, antagonized the actions of exogenous 5-ht on k+-stimulated release. |
1985-12-16 |
2023-08-11 |
Not clear |
| S J Peroutk. Selective labeling of 5-HT1A and 5-HT1B binding sites in bovine brain. Brain research. vol 344. issue 1. 1985-11-12. PMID:4041865. |
drug interactions with serotonin(1a) 5-ht1a and serotonin(1b) (5-ht1b) binding sites were analyzed in bovine brain membranes. |
1985-11-12 |
2023-08-11 |
cattle |
| S J Peroutk. Selective labeling of 5-HT1A and 5-HT1B binding sites in bovine brain. Brain research. vol 344. issue 1. 1985-11-12. PMID:4041865. |
5-ht1b binding sites were labeled by [3h]5-ht in bovine striatal membranes where less than 15% of specific binding sites are sensitive to nanomolar concentrations of 8-oh-dpat. |
1985-11-12 |
2023-08-11 |
cattle |
| D N Middlemis. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. The Journal of pharmacy and pharmacology. vol 37. issue 6. 1985-09-16. PMID:2862270. |
moreover, since ru 24969 potently displaced ligand binding to the 5-ht1 and 5-ht1b recognition sites but was only weakly active at the 5-ht2 receptor, the results lend support to the claim for a pharmacological resemblance between the 5-ht autoreceptor and the 5-ht1 recognition site and in particular the low affinity 5-ht1b subtype. |
1985-09-16 |
2023-08-11 |
rat |
| G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 84. issue 3. 1985-06-20. PMID:2580582. |
radioligand binding techniques have demonstrated the existence of 5-hydroxytryptamine (5-ht) binding subtypes: 5-ht2, 5-ht1a and 5-ht1b. |
1985-06-20 |
2023-08-11 |
mouse |
| M B Emerit, H Gozlan, M D Hall, M Hamon, A Marque. Irreversible blockade of central 5-HT binding sites by 8-methoxy-2'-chloro-PAT. Biochemical pharmacology. vol 34. issue 6. 1985-04-17. PMID:3156602. |
although 8-methoxy-2'-chloro-pat bound irreversibly to different classes of 5-ht binding sites (5-ht1a, 5-ht1b, presynaptic sites), it can be considered a selective alkylating agent, since it exerted no action on 3h-spiperone binding to 5-ht2 sites, 3h-muscimol binding to gaba sites, or 3h-flunitrazepam binding to benzodiazepine sites. |
1985-04-17 |
2023-08-11 |
rat |
| A Pazos, R Cortés, J M Palacio. Quantitative receptor autoradiography: application to the characterization of multiple receptor subtypes. Journal of receptor research. vol 4. issue 1-6. 1985-04-04. PMID:6241253. |
in vitro autoradiographic techniques combined with computer assisted microdensitometry were used to analyze the characteristics and distribution of multiple recognition sites for the neurotransmitters acetylcholine (m1 and m2) and serotonin (5-ht1a and 5-ht1b). |
1985-04-04 |
2023-08-12 |
Not clear |
| D N Middlemis. Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol. European journal of pharmacology. vol 101. issue 3-4. 1984-10-10. PMID:6468503. |
(-)-propranolol displaced 5-ht1 and 5-ht1b receptor binding (pic50 6.76 and 6.31 respectively) and antagonized the inhibitory effect of 5-ht on continuous k+ (25 mm) evoked release of [3h]5-ht from superfused rat frontal cortex slices (apparent pa2 6.67). |
1984-10-10 |
2023-08-12 |
rat |
| D N Middlemis. Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol. European journal of pharmacology. vol 101. issue 3-4. 1984-10-10. PMID:6468503. |
the results support the claim that the 5-ht autoreceptor has a pharmacological resemblance to the 5-ht1 recognition site and in particular to the low affinity 5-ht1b subtype of this site. |
1984-10-10 |
2023-08-12 |
rat |