| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saima Khaliq, Bilqees Irfan, Saida Haider, Darakhshan J Halee. m-CPP induced hypolocomotion does not interfere in the assessment of memory functions in rats. Pakistan journal of pharmaceutical sciences. vol 21. issue 2. 2008-06-04. PMID:18390444. |
the present study was designed to investigate the effect of different doses of 5-ht2c receptor agonist metachlorophenylpiperazine (mcpp) on locomotion and cognitive behavior in rats. |
2008-06-04 |
2023-08-12 |
rat |
| Vanessa Nunes-de-Souza, Ricardo Luiz Nunes-de-Souza, Robert John Rodgers, Azair Canto-de-Souz. 5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice. Behavioural brain research. vol 187. issue 1. 2008-03-11. PMID:17935799. |
as mcpp acts preferentially at 5-ht2b and 5-ht2c receptors, experiment 2 investigated its effects in animals pretreated with ketanserin, a preferential 5-ht2a/2c receptor antagonist. |
2008-03-11 |
2023-08-12 |
mouse |
| Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Yoshiki Yagi, Shuichi Kanazashi, Yasunari Kashihara, Koji Takeuchi, Isamu Yamaguch. Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice. Journal of pharmacological sciences. vol 105. issue 3. 2008-01-10. PMID:17965538. |
while the cerulein-induced hyperenzymemia was attenuated in mice pretreated with p-cpa, a 5-ht depletor, it was exaggerated by the preferential 5-ht2a agonist (doi), but not by the preferential 5-ht2b agonist (bw723c86) or the preferential 5-ht2c agonist (mcpp). |
2008-01-10 |
2023-08-12 |
mouse |
| Jason C G Halford, Joanne A Harrold, Emma J Boyland, Clare L Lawton, John E Blundel. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. vol 67. issue 1. 2007-03-21. PMID:17209663. |
additionally, sibutramine, dexfenfluramine, fluoxetine and the 5-ht2c receptor agonist chlorophenylpiperazine (mcpp) have all been shown to modify appetite in both lean and obese humans, resulting in reduced caloric intake. |
2007-03-21 |
2023-08-12 |
Not clear |
| Tina Kao, Jed S Shumsky, Stacy Jacob-Vadakot, B Timothy Himes, Marion Murray, Karen A Moxo. Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates. Brain research. vol 1112. issue 1. 2006-11-28. PMID:16914121. |
we therefore extended our previous work with the 5-ht2c receptor agonist 1-(m-chlorophenyl)-piperazine hydrochloride (mcpp), which enhances weight-supported stepping when administered to adult rats spinalized as neonates, to identify the optimal dose for improved weight-supported stepping with minimal side effects. |
2006-11-28 |
2023-08-12 |
rat |
| Tina Kao, Jed S Shumsky, Stacy Jacob-Vadakot, B Timothy Himes, Marion Murray, Karen A Moxo. Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates. Brain research. vol 1112. issue 1. 2006-11-28. PMID:16914121. |
in order to determine whether mcpp enhances weight-supported stepping after sci is through activation of the 5-ht2c receptor, we performed the following experiments. |
2006-11-28 |
2023-08-12 |
rat |
| Tina Kao, Jed S Shumsky, Stacy Jacob-Vadakot, B Timothy Himes, Marion Murray, Karen A Moxo. Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates. Brain research. vol 1112. issue 1. 2006-11-28. PMID:16914121. |
since mcpp does not have the behavioral toxicity associated with non-selective 5-ht2 receptor agonists, targeting the 5-ht2c receptor may have clinical relevance for the treatment of sci. |
2006-11-28 |
2023-08-12 |
rat |
| Miki Yamauchi, Takako Miyara, Tetsuya Matsushima, Taiichiro Imanish. Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors. Brain research. vol 1067. issue 1. 2006-05-02. PMID:16360124. |
the effect of these ssris on the response to mcpp is thought to be caused by the desensitization of 5-ht2c receptor function. |
2006-05-02 |
2023-08-12 |
rat |
| P L Cedraz-Mercez, A C Almeida, R H Costa-e-Sousa, D Badauê-Passos Júnior, L R Castilhos, E L Olivares, A Marinho Júnior, M A Medeiros, L C Rei. Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves). Brazilian journal of biology = Revista brasleira de biologia. vol 65. issue 4. 2006-04-28. PMID:16532182. |
administration of serotonin releaser, fenfluramine (fen) and 5-ht2c agonists, mcpp and mk212, 1.0 and 3.3 mg/kg induced significant inhibition of food intake in previously fasted fowls (0.71 +/- 0.18 g and 0.47 +/- 0.2 g; 0.49 +/- 0.22 g and 0.48 +/- 0.29 g; 0.82 +/- 0.13 g and 0.71 +/- 0.16 g, respectively). |
2006-04-28 |
2023-08-12 |
Not clear |
| P L Cedraz-Mercez, A C Almeida, R H Costa-e-Sousa, D Badauê-Passos Júnior, L R Castilhos, E L Olivares, A Marinho Júnior, M A Medeiros, L C Rei. Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves). Brazilian journal of biology = Revista brasleira de biologia. vol 65. issue 4. 2006-04-28. PMID:16532182. |
both serotonin releaser and 5-ht2c agonists, in a 3.3 mg/kg dose, induced hypophagy (fen, 0.78 +/- 0.08 g; mcpp, 0.89 +/- 0.07 g; mk212, 1.25 +/- 0.17 g vs. controls, 2.05 +/- 0.12 g, 120 min after food was presented, p < 0.0001 to p < 0.01). |
2006-04-28 |
2023-08-12 |
Not clear |
| Katsunori Nonogaki, Kana Ohashi-Nozue, Yoshitomo Ok. A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice. Biochemical and biophysical research communications. vol 341. issue 3. 2006-04-20. PMID:16430857. |
5-ht2c receptors and 5-ht1b receptors have been shown to mediate anorexic effects of 5-ht drugs such as d-fenfluramine, which stimulates 5-ht release and inhibits 5-ht reuptake, and m-chlorophenylpiperazine (mcpp), a 5-ht2c receptor agonist. |
2006-04-20 |
2023-08-12 |
mouse |
| Matthieu J Guitton, Rémy Pujol, Jean-Luc Pue. m-Chlorophenylpiperazine exacerbates perception of salicylate-induced tinnitus in rats. The European journal of neuroscience. vol 22. issue 10. 2006-01-17. PMID:16307611. |
the serotonin receptor 5-ht2c agonist m-chlorophenylpiperazine (mcpp) has been widely used to induce anxiety-like states in animals and anxiety in humans. |
2006-01-17 |
2023-08-12 |
rat |
| Katsuya Morita, Masahiro Hamamoto, Shigeaki Arai, Shigeo Kitayama, Masahiro Irifune, Michio Kawahara, Kenji Kihira, Toshihiro Doh. Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities. Brain research. vol 1057. issue 1-2. 2006-01-04. PMID:16125150. |
administration of ssri, zimelidine, citalopram and fluoxetine, 5-ht(2a,2c) receptor agonist, r(-)-doi and the 5-ht2c receptor agonists, mcpp, and mk212 resulted in a marked increase in incidence of convulsions and a reduction in the threshold of lidocaine-induced convulsions, while the 5-ht2b receptor agonist, bw723c86, had little influence. |
2006-01-04 |
2023-08-12 |
mouse |
| Hilda Silva Ferreira, Elenilda Oliveira, Thiallan Nery Faustino, Emilio de Castro E Silva, Josmara Bartolomei Fregonez. Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats. Brain research. vol 1040. issue 1-2. 2005-06-07. PMID:15804427. |
effect of the activation of central 5-ht2c receptors by the 5-ht2c agonist mcpp on blood pressure and heart rate in rats. |
2005-06-07 |
2023-08-12 |
rat |
| Hilda Silva Ferreira, Elenilda Oliveira, Thiallan Nery Faustino, Emilio de Castro E Silva, Josmara Bartolomei Fregonez. Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats. Brain research. vol 1040. issue 1-2. 2005-06-07. PMID:15804427. |
third ventricle injections of the 5-ht2c agonist mcpp elicited a significant increase in blood pressure in non-stressed animals. |
2005-06-07 |
2023-08-12 |
rat |
| Hilda Silva Ferreira, Elenilda Oliveira, Thiallan Nery Faustino, Emilio de Castro E Silva, Josmara Bartolomei Fregonez. Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats. Brain research. vol 1040. issue 1-2. 2005-06-07. PMID:15804427. |
these cardiovascular effects promoted by the central administration of mcpp were blocked by pretreatment with the 5-ht2c antagonist, sdz ser 082. |
2005-06-07 |
2023-08-12 |
rat |
| Hilda Silva Ferreira, Elenilda Oliveira, Thiallan Nery Faustino, Emilio de Castro E Silva, Josmara Bartolomei Fregonez. Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats. Brain research. vol 1040. issue 1-2. 2005-06-07. PMID:15804427. |
the pharmacological stimulation of central 5-ht2c receptors by mcpp did not change the hypertensive or tachycardic responses induced by restraint stress. |
2005-06-07 |
2023-08-12 |
rat |
| Katherine D Alex, Gregory J Yavanian, Hewlet G McFarlane, Charles P Pluto, Elizabeth A Pehe. Modulation of dopamine release by striatal 5-HT2C receptors. Synapse (New York, N.Y.). vol 55. issue 4. 2005-05-26. PMID:15668911. |
additionally, the effects of the 5-ht2c agonist mcpp on striatal da were measured. |
2005-05-26 |
2023-08-12 |
Not clear |
| Methvin Isaa. Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Current topics in medicinal chemistry. vol 5. issue 1. 2005-04-06. PMID:15638778. |
more specifically, the recent finding that the 5-ht2b/2c receptor agonist, 1-(m-chlorophenyl)-piperazine (mcpp) is anticonvulsant has kindled an interest into the investigation of the serotonergic 5-ht2c receptor subtype as a potential target for the treatment of epilepsy. |
2005-04-06 |
2023-08-12 |
Not clear |
| Michelle D Lee, Elizabeth M Somerville, Guy A Kennett, Colin T Dourish, Peter G Clifto. Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology. vol 176. issue 1. 2005-03-29. PMID:15138762. |
reduced hypophagic effects of d-fenfluramine and the 5-ht2c receptor agonist mcpp in 5-ht1b receptor knockout mice. |
2005-03-29 |
2023-08-12 |
mouse |