| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K E Heslop, G Curzo. Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology. vol 38. issue 6. 1999-08-25. PMID:10465692. |
head shakes on activating 5-ht2a receptors by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) and two effects of activating 5-ht2c receptors by 1-(3-chlorophenyl) piperazine (mcpp) were significantly increased (hypophagia, anxiety) and a third effect, hypolocomotion tended to increase but hypophagia on activating postsynaptic 5-ht1b receptors by cp-94, 253 was significantly attenuated. |
1999-08-25 |
2023-08-12 |
rat |
| S Helsley, R A Rabin, J C Winte. Further investigations of the serotonergic properties of the ibogaine-induced discriminative stimulus. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 2. 1999-08-17. PMID:10368872. |
significant ibogaine-appropriate responding was observed following treatment with the 5-ht2c agonists mk-212 (79.6%) and mcpp (76.4%). |
1999-08-17 |
2023-08-12 |
rat |
| P B Bergqvist, J Dong, P Blie. Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology. vol 143. issue 1. 1999-07-02. PMID:10227084. |
microiontophoretic application of the gabaa receptor antagonist bicuculline had no effect on the suppressant effect of neuronal activity in the ofc induced by microiontophoretic application of the preferential 5-ht2a and 5-ht2c receptor agonists (+)-1-(4-iodo-2, 5-dimethoxyphenyl)-2-aminopropane (doi) and m-chlorophenyl-piperazine (mcpp), respectively, but it antagonized the effect of gaba on the same neurons. |
1999-07-02 |
2023-08-12 |
rat |
| M Franklin, R D Craven, B Dowling, G Campling, J M Elliott, P J Cowe. Effect of a long-term low tryptophan diet on the prolactin responses to the 5-HT1A and 5-HT2C agonists, 8-OH-DPAT and mCPP in the male rat. Journal of psychopharmacology (Oxford, England). vol 13. issue 1. 1999-06-28. PMID:10221360. |
effect of a long-term low tryptophan diet on the prolactin responses to the 5-ht1a and 5-ht2c agonists, 8-oh-dpat and mcpp in the male rat. |
1999-06-28 |
2023-08-12 |
rat |
| M Franklin, R D Craven, B Dowling, G Campling, J M Elliott, P J Cowe. Effect of a long-term low tryptophan diet on the prolactin responses to the 5-HT1A and 5-HT2C agonists, 8-OH-DPAT and mCPP in the male rat. Journal of psychopharmacology (Oxford, England). vol 13. issue 1. 1999-06-28. PMID:10221360. |
this is associated with an enhanced prl response to mcpp probably resulting from a functional up-regulation of post-synaptic 5-ht2c receptors. |
1999-06-28 |
2023-08-12 |
rat |
| A Dekeyne, S Girardon, M J Milla. Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis. Neuropharmacology. vol 38. issue 3. 1999-06-15. PMID:10219979. |
the 5-ht2c receptor agonists, mcpp and mk 212, fully generalized to ro 60-0175 with ed50s of 0.8 and 0.4 mg/kg, s.c., respectively, whereas the preferential 5-ht2b agonist, bw 723c86 ( > 10.0 mg/kg, s.c.) and the 5-ht2a agonist, doi ( > 2.5 mg/kg, s.c.), were ineffective. |
1999-06-15 |
2023-08-12 |
rat |
| S Maurel, R Schreiber, J De Vr. Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in the generalization of 5-HT receptor agonists to the ethanol cue in the rat. Behavioural pharmacology. vol 9. issue 4. 1999-05-20. PMID:10065922. |
this suggests that 5-ht1b and 5-ht2c receptors are required for the generalization of mcpp to the etoh cue. |
1999-05-20 |
2023-08-12 |
rat |
| L Stern, J Zohar, R Cohen, Y Sasso. Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT1D agonist sumatriptan. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 8. issue 4. 1999-04-13. PMID:9928925. |
in pharmacological challenge tests, mcpp, a 5-ht agonist, with an affinity for 5ht2c as well as 5ht1a and 5ht1d receptors, was associated with a transient exacerbation of obsessive compulsive symptoms. |
1999-04-13 |
2023-08-12 |
Not clear |
| N Upton, T Stean, D Middlemiss, T Blackburn, G Kennet. Studies on the role of 5-HT2C and 5-HT2B receptors in regulating generalised seizure threshold in rodents. European journal of pharmacology. vol 359. issue 1. 1999-02-08. PMID:9831290. |
these results indicate that the observed anticonvulsant effects of mcpp are likely to be mediated by activation of 5-ht2c receptors. |
1999-02-08 |
2023-08-12 |
mouse |
| M Leone, A Attanasio, D Croci, A Ferraris, D D'Amico, L Grazzi, A Nespolo, G Busson. 5-HT1A receptor hypersensitivity in migraine is suggested by the m-chlorophenylpiperazine test. Neuroreport. vol 9. issue 11. 1998-11-18. PMID:9721941. |
migraine patients had a greater prl response to mcpp (p = 0.05) and greater anxiety (p < 0.01) than controls; cortisol response to mcpp did not differ suggesting that 5-ht2c receptors are normal in migraine. |
1998-11-18 |
2023-08-12 |
human |
| J Gommans, T H Hijzen, R A Maes, B Olivie. Discriminative stimulus properties of mCPP: evidence for a 5-HT2C receptor mode of action. Psychopharmacology. vol 137. issue 3. 1998-10-28. PMID:9683007. |
discriminative stimulus properties of mcpp: evidence for a 5-ht2c receptor mode of action. |
1998-10-28 |
2023-08-12 |
rat |
| J Gommans, T H Hijzen, R A Maes, B Olivie. Discriminative stimulus properties of mCPP: evidence for a 5-HT2C receptor mode of action. Psychopharmacology. vol 137. issue 3. 1998-10-28. PMID:9683007. |
previous drug discrimination studies with the serotonergic drug m-chlorophenylpiperazine (mcpp) showed conflicting results, with some authors concluding that the cue was mediated by 5-ht2c receptors, but others that it was definitively not. |
1998-10-28 |
2023-08-12 |
rat |
| J Gommans, T H Hijzen, R A Maes, B Olivie. Discriminative stimulus properties of mCPP: evidence for a 5-HT2C receptor mode of action. Psychopharmacology. vol 137. issue 3. 1998-10-28. PMID:9683007. |
these results show that the discriminative stimulus effects of mcpp are predominantly mediated by 5-ht2c receptors, and to some extent by 5-ht1b receptors. |
1998-10-28 |
2023-08-12 |
rat |
| M Zheliazkova-Savov. [The effect of isotheoline on mouse behavior under test conditions for detecting its anxiolytic activity]. Eksperimental'naia i klinicheskaia farmakologiia. vol 61. issue 3. 1998-09-22. PMID:9690069. |
bearing in mind that mcpp produces its anxiogenic effect via the 5-ht2c receptors, it is suggested that the mechanism of the anxiolytic action of isotheolin is realized through its interaction with the serotoninergic system at the level of 5-ht2c receptors. |
1998-09-22 |
2023-08-12 |
mouse |
| S D Gleason, H E Shanno. Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice. European journal of pharmacology. vol 341. issue 2-3. 1998-05-21. PMID:9543230. |
meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-ht1 as well as 5-ht2c receptors in mice. |
1998-05-21 |
2023-08-12 |
mouse |
| P O Mora, C F Netto, F G Graef. Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacology, biochemistry, and behavior. vol 58. issue 4. 1998-01-30. PMID:9408213. |
injection of the preferential 5-ht2c receptor agonists mcpp and tfmpp (0.1-0.8 mg/kg), 25 min before the experimental session enhanced inhibitory avoidance. |
1998-01-30 |
2023-08-12 |
rat |
| M Zhelyazkova-Savova, M G Giovannini, G Pepe. Increase of cortical acetylcholine release after systemic administration of chlorophenylpiperazine in the rat: an in vivo microdialysis study. Neuroscience letters. vol 236. issue 3. 1998-01-12. PMID:9406759. |
the changes in acetylcholine (ach) release from the cortex of freely moving rats after systemic administration of chlorophenylpiperazine (mcpp), a 5-ht2c agonist, were measured utilising microdialysis coupled to high performance liquid chromatography. |
1998-01-12 |
2023-08-12 |
rat |
| D J Quested, P A Sargent, P J Cowe. SSRI treatment decreases prolactin and hyperthermic responses to mCPP. Psychopharmacology. vol 133. issue 3. 1998-01-07. PMID:9361338. |
we studied the effect of 3 weeks treatment with the selective serotonin re-uptake inhibitor (ssri), paroxetine (30 mg daily), on the neuroendocrine and hyperthermic responses to the 5-ht2c receptor agonist, m-chlorophenylpiperazine (mcpp) (0.05 mg/kg i.v. |
1998-01-07 |
2023-08-12 |
human |
| P A Sargent, A L Sharpley, C Williams, E M Goodall, P J Cowe. 5-HT2C receptor activation decreases appetite and body weight in obese subjects. Psychopharmacology. vol 133. issue 3. 1998-01-07. PMID:9361339. |
we studied the effect of 2 weeks administration of the 5-ht2c receptor agonist, m-chlorophenylpiperazine (mcpp), on appetite and body weight in 18 moderately obese subjects in a double-blind, placebo-controlled trial, mcpp caused a small but significant (0.75 kg) reduction in body weight and in subjective ratings of hunger. |
1998-01-07 |
2023-08-12 |
human |
| P A Sargent, A L Sharpley, C Williams, E M Goodall, P J Cowe. 5-HT2C receptor activation decreases appetite and body weight in obese subjects. Psychopharmacology. vol 133. issue 3. 1998-01-07. PMID:9361339. |
our data suggest that during 2 weeks treatment in humans, mcpp may continue to activate brain 5-ht2c receptors, and that this effect is associated with decreases in appetite and body weight. |
1998-01-07 |
2023-08-12 |
human |