| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle D Lee, Elizabeth M Somerville, Guy A Kennett, Colin T Dourish, Peter G Clifto. Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology. vol 176. issue 1. 2005-03-29. PMID:15138762. |
the possible role of compensatory changes in 5-ht2c receptors in the reduced hypophagic action of d-fenfluramine in 5-ht1b knockout (ko) mice was assessed by comparing their response to d-fenfluramine and the 5-ht2c receptor agonist mcpp. |
2005-03-29 |
2023-08-12 |
mouse |
| Brian D Schlag, Zhuangwei Lou, Myles Fennell, John Dunlo. Ligand dependency of 5-hydroxytryptamine 2C receptor internalization. The Journal of pharmacology and experimental therapeutics. vol 310. issue 3. 2004-11-01. PMID:15113845. |
in this study, we have examined the effects of 5-ht2c receptor agonists serotonin, ro 60-0175 [(s)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine], and way-161503 [(4ar)-8,9-dichloro-2,3,4,4a-tetrahydro-1h-pyrazino[1,2-a]quinoxalin-5(6h)-one]; partial agonists mcpp [1-(m-chlorophenyl)piperazine] and doi [(+)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane]; inverse agonists sb-206553 [n-3-pyridinyl-3,5-dihydro-5-methylbenzo(1,2-b:4,5-b')dipyrrole-1(2h)carboxamide] and mianserin; and neutral antagonists sb-242084 [6-chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline] and 5-methoxygramine on the internalization of a c-terminal green fluorescent protein (gfp)-tagged 5-ht2c receptor (vsv isoform) expressed in transiently transfected human embryonic kidney cells. |
2004-11-01 |
2023-08-12 |
human |
| Kenny J Simansky, Kuldip D Dave, Beth R Inemer, Danielle M Nicklous, J Michael Padron, Vincent J Aloyo, Anthony G Roman. A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits. Physiology & behavior. vol 82. issue 1. 2004-10-25. PMID:15234597. |
in radioligand binding to rabbit cortex, mcpp displayed 15-fold higher affinity for 5-ht2c than for 5-ht1b receptors. |
2004-10-25 |
2023-08-12 |
rabbit |
| Kenny J Simansky, Kuldip D Dave, Beth R Inemer, Danielle M Nicklous, J Michael Padron, Vincent J Aloyo, Anthony G Roman. A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits. Physiology & behavior. vol 82. issue 1. 2004-10-25. PMID:15234597. |
the serotonin antagonist mesulergine (7000-fold selective for 5-ht2c) reversed the hypophagic action of mcpp, but the 5-ht1b/1d antagonist gr127,935 did not. |
2004-10-25 |
2023-08-12 |
rabbit |
| Kenny J Simansky, Kuldip D Dave, Beth R Inemer, Danielle M Nicklous, J Michael Padron, Vincent J Aloyo, Anthony G Roman. A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits. Physiology & behavior. vol 82. issue 1. 2004-10-25. PMID:15234597. |
we conclude that mcpp stimulates 5-ht2c receptors to reduce food intake in rabbits. |
2004-10-25 |
2023-08-12 |
rabbit |
| G L Dalton, M D Lee, G A Kennett, C T Dourish, P G Clifto. mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology. vol 46. issue 5. 2004-06-15. PMID:14996544. |
the serotonin receptor agonist mcpp induces hyperlocomotion in 5-ht2c receptor knockout (ko) mice or in the presence of a 5-ht2c receptor antagonist. |
2004-06-15 |
2023-08-12 |
mouse |
| G L Dalton, M D Lee, G A Kennett, C T Dourish, P G Clifto. mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology. vol 46. issue 5. 2004-06-15. PMID:14996544. |
as previously reported, mcpp (3 mg/kg) induced hyperactivity in 5-ht2c ko mice. |
2004-06-15 |
2023-08-12 |
mouse |
| Paul S Frankel, Kathryn A Cunningha. m-Chlorophenylpiperazine (mCPP) modulates the discriminative stimulus effects of cocaine through actions at the 5-HT2C receptor. Behavioral neuroscience. vol 118. issue 1. 2004-04-13. PMID:14979792. |
m-chlorophenylpiperazine (mcpp) modulates the discriminative stimulus effects of cocaine through actions at the 5-ht2c receptor. |
2004-04-13 |
2023-08-12 |
Not clear |
| D Badauê-Passos, R R Ventura, L F S Silva, E L Olivares, L C Rei. Effect of brain serotoninergic stimulation on sodium appetite of euthyroid and hypothyroid rats. Experimental physiology. vol 88. issue 2. 2003-10-23. PMID:12621530. |
the 5ht2c receptor agonist mcpp (5.0 mg x kg(-1), i.p.) |
2003-10-23 |
2023-08-12 |
rat |
| Michael B Gatc. Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety. Life sciences. vol 73. issue 11. 2003-07-31. PMID:12850497. |
because functional assays indicate that mcpp is significantly more potent at 5-ht2c receptors, it may serve as a tool to investigate the contribution of 5-ht2c receptors to anxiety. |
2003-07-31 |
2023-08-12 |
Not clear |
| Michael B Gatc. Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety. Life sciences. vol 73. issue 11. 2003-07-31. PMID:12850497. |
although the discriminative stimulus effects of mcpp do not seem to be a useful screen for general anxiolytics, they do seem to be useful for characterization of the contribution of 5-ht1b and 5-ht2c receptors to the mediation of anxiety-like behaviors. |
2003-07-31 |
2023-08-12 |
Not clear |
| Nicholas Jones, Mark S Duxon, Sheila M Kin. 5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze. Psychopharmacology. vol 164. issue 2. 2003-01-29. PMID:12404085. |
numerous studies indicate that the anxiogenic effects of mcpp may be mediated by its action at the 5-ht2c receptor. |
2003-01-29 |
2023-08-12 |
rat |
| Nicholas Jones, Mark S Duxon, Sheila M Kin. 5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze. Psychopharmacology. vol 164. issue 2. 2003-01-29. PMID:12404085. |
this study aimed to examine the involvement of the 5-ht2c receptor in the unconditioned fear responses observed in the ueepm (after an acute dose of mcpp) by pre-treatment with the selective 5-ht2c receptor antagonist sb-242084. |
2003-01-29 |
2023-08-12 |
rat |
| L E Rueter, L H Tecott, P Blie. In vivo electrophysiological examination of 5-HT2 responses in 5-HT2C receptor mutant mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 5. 2000-08-16. PMID:10832601. |
the present study used 5-ht2c receptor mutant mice and their wild-type littermates to characterize the 5-ht2 receptor using the 5-ht2 agonists (+/-)-2-dimethoxy-4-iodoamphetamine hydrochloride (doi) and 1-(3-chlorophenyl)piperazine (mcpp) applied locally in the orbitofrontal cortex (ofc) and head of the caudate nucleus. |
2000-08-16 |
2023-08-12 |
mouse |
| L E Rueter, L H Tecott, P Blie. In vivo electrophysiological examination of 5-HT2 responses in 5-HT2C receptor mutant mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 5. 2000-08-16. PMID:10832601. |
mcpp, when applied locally, inhibits ofc firing activity by acting on both 5-ht2a and 5-ht2c receptors. |
2000-08-16 |
2023-08-12 |
mouse |
| b' T Koskinen, S Ruotsalainen, T Puumala, R Lappalainen, E Koivisto, P T M\\xc3\\xa4nnist\\xc3\\xb6, J Sirvi\\xc3\\xb. Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698013.' |
in contrast to doi, mcpp, [1-(3-phenyl)piperazine; 0.05 and 0.15 mg/kg], a 5-ht2c agonist, had no effect on choice accuracy or premature responding, but it reduced behavioral activity and/or arousal as indicated by the decreased number of trials completed and increased the probability of omissions. |
2000-05-16 |
2023-08-12 |
rat |
| I Misane, S O Ogre. Multiple 5-HT receptors in passive avoidance: comparative studies of p-chloroamphetamine and 8-OH-DPAT. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 2. 2000-02-14. PMID:10649830. |
however, the ability of the 5-ht2c receptor antagonist ro 60-0491 to block the inhibitory effects of mcpp indicated an important regulatory role of the 5-ht2c receptor in pa. |
2000-02-14 |
2023-08-12 |
rat |
| R H Porter, K R Benwell, H Lamb, C S Malcolm, N H Allen, D F Revell, D R Adams, M J Sheardow. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. British journal of pharmacology. vol 128. issue 1. 1999-11-22. PMID:10498829. |
piperazines such as m-chlorophenylpiperazine (mcpp), org-12962, mk-212 and also org-37684 exhibited a rank order of potency of 5-ht2c>5-ht2b>5-ht2a. |
1999-11-22 |
2023-08-12 |
human |
| R H Porter, K R Benwell, H Lamb, C S Malcolm, N H Allen, D F Revell, D R Adams, M J Sheardow. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. British journal of pharmacology. vol 128. issue 1. 1999-11-22. PMID:10498829. |
for example, mcpp had a relative efficacy of 65% at 5-ht2c receptors but <25% at either 5-ht2a or 5-ht2b receptors. |
1999-11-22 |
2023-08-12 |
human |
| M Zhelyazkova-Savova, M G Giovannini, G Pepe. Systemic chlorophenylpiperazine increases acetylcholine release from rat hippocampus-implication of 5-HT2C receptors. Pharmacological research. vol 40. issue 2. 1999-10-08. PMID:10433876. |
the results of the present work suggest that (i) the effect of mcpp on ach release could be attributed to stimulation of 5-ht2c receptors located outside the hippocampus and (ii) isoteoline antagonizes this mcpp-induced effect irrespective of its own enhancing action on ach release. |
1999-10-08 |
2023-08-12 |
rat |