| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H O Kalkma. Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal. International journal of clinical pharmacology research. vol 17. issue 2-3. 1998-01-07. PMID:9403358. |
administration of a bolus dose of mcpp, a 5-ht2c receptor agonist, to rats provokes endocrine and behavioural effects that are reminiscent of some of the symptoms of human depression. |
1998-01-07 |
2023-08-12 |
human |
| H O Kalkma. Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal. International journal of clinical pharmacology research. vol 17. issue 2-3. 1998-01-07. PMID:9403358. |
in humans, a bolus dose of mcpp can cause alcohol craving (in abstinent alcoholics) and migraine (in susceptible persons), suggesting that there is a 5-ht2c receptor hyperresponsiveness in these conditions also. |
1998-01-07 |
2023-08-12 |
human |
| M Maes, H Westenberg, E Vandoolaeghe, P Demedts, A Wauters, H Neels, H Y Meltze. Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine. Journal of clinical psychopharmacology. vol 17. issue 5. 1997-11-21. PMID:9315986. |
it is suggested that desensitization of 5-ht2c receptor function by mcpp as well as fluoxetine may contribute to the antidepressant effects of this combination. |
1997-11-21 |
2023-08-12 |
Not clear |
| K A Grant, G Colombo, G J Gatt. Characterization of the ethanol-like discriminative stimulus effects of 5-HT receptor agonists as a function of ethanol training dose. Psychopharmacology. vol 133. issue 2. 1997-11-20. PMID:9342779. |
the present studies extend this initial finding to four additional 5-ht agonists with different selectivity for 5-ht1a, 5-ht1b, or 5-ht2c receptors: cgs 12066b (7-trifluoromethyl-4(4-methyl-1-piperazinyl)-pyrrolo[1,2a]quinoxaline maleate), mcpp [1-(3-chlorophenyl)piperazine dihcl], ru 24969 [5-methoxy-3(1,2,3,4-tetrahydro-4-pyridinyl]-1h-indole succinate and 8-oh dpat [(+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hbr]. |
1997-11-20 |
2023-08-12 |
rat |
| M el Mansari, P Blie. In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225283. |
5-ht and the preferential 5-ht2a receptor agonist doi and the preferential 5-ht2c receptor agonist mcpp, suppressed the quisqualate (quis)-induced activation of neurons in both structures. |
1997-09-15 |
2023-08-12 |
Not clear |
| D L Willins, H Y Meltze. Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262333. |
the serotonin (5-ht)(2a/2c) agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi), the 5-ht2c agonist 6-chloro-2-[1-piperazinyl]-pyrazine and the 5-ht2a partial agonist m-chloro-phenylpiperazine (mcpp) were injected bilaterally into the medial prefrontal cortex of male rats. |
1997-09-11 |
2023-08-12 |
rat |
| M J Millan, J L Peglion, G Lavielle, S Perrin-Monneyro. 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists. European journal of pharmacology. vol 325. issue 1. 1997-08-11. PMID:9151932. |
the mixed 5-ht2a/5-ht2b/5-ht2c receptor agonist, m-(chlorophenyl)piperazine (mcpp), elicited penile erections in rats, an action mimicked by the selective 5-ht2c receptor agonist, ro 60-0175 (s)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine), whereas the preferential 5-ht2b receptor agonist, bw 723c86 (1-[5-(thienylmethoxy)-1h-3-indoyl] propan-2-amine) was ineffective. |
1997-08-11 |
2023-08-12 |
rat |
| P J Cowen, E M Clifford, A E Walsh, C Williams, C G Fairbur. Moderate dieting causes 5-HT2C receptor supersensitivity. Psychological medicine. vol 26. issue 6. 1997-04-08. PMID:8931161. |
we studied the effect of moderate dieting in healthy women on the prolactin response to the serotonin (5-ht) receptor agonist, m-chlorophenylpiperazine (mcpp), a measure of the sensitivity of post-synaptic 5-ht2c receptors. |
1997-04-08 |
2023-08-12 |
Not clear |
| D R Thomas, T L Gager, V Holland, A M Brown, M D Woo. m-Chlorophenylpiperazine (mCPP) is an antagonist at the cloned human 5-HT2B receptor. Neuroreport. vol 7. issue 9. 1997-03-06. PMID:8856697. |
we therefore investigated the activity of mcpp at cloned human 5-ht2b and 5-ht2c receptors. |
1997-03-06 |
2023-08-12 |
human |
| D R Thomas, T L Gager, V Holland, A M Brown, M D Woo. m-Chlorophenylpiperazine (mCPP) is an antagonist at the cloned human 5-HT2B receptor. Neuroreport. vol 7. issue 9. 1997-03-06. PMID:8856697. |
mcpp was a partial agonist at the human 5-ht2c receptor but antagonized the human 5-ht2b receptor. |
1997-03-06 |
2023-08-12 |
human |
| D R Thomas, T L Gager, V Holland, A M Brown, M D Woo. m-Chlorophenylpiperazine (mCPP) is an antagonist at the cloned human 5-HT2B receptor. Neuroreport. vol 7. issue 9. 1997-03-06. PMID:8856697. |
therefore, while supporting the proposal that at least some of the clinical effects of mcpp are likely to be mediated via stimulation of the 5-ht2c receptor, this study also suggests that any 5-ht2b receptor-mediated effects are more likely to result from receptor blockade than from receptor activation. |
1997-03-06 |
2023-08-12 |
human |
| J Benjamin, B D Greenberg, D L Murph. Daily administration of m-chlorophenylpiperazine to healthy human volunteers rapidly attenuates many of its behavioral, hormonal, cardiovascular and temperature effects. Psychopharmacology. vol 127. issue 2. 1997-01-07. PMID:8888380. |
the serotonergic agent meta-chlorophenylpiperazine (m-cpp) increases temperature and plasma acth and other hormones and decreases social interaction, locomotor activity and food intake in rats, most likely via stimulation of 5-ht2c receptors. |
1997-01-07 |
2023-08-12 |
human |
| Y Sugimoto, J Yamada, T Yoshikawa, K Horisak. Effects of the 5-HT2C/2B receptor agonist 1-(3-chlorophenyl) piperazine on plasma glucose levels of rats. European journal of pharmacology. vol 307. issue 1. 1996-12-10. PMID:8831107. |
our results suggest that hyperglycemia elicited by mcpp is mediated by 5-ht2c and/or 2b receptors, and in turn adrenomedullary catecholamine release, whereas that elicited by doi involves 5-ht2a receptors. |
1996-12-10 |
2023-08-12 |
rat |
| D L Murphy, C Aulakh, P Mazzola-Pomietto, N C Brigg. Neuroendocrine responses to serotonergic agonists as indices of the functional status of central serotonin neurotransmission in humans: a preliminary comparative analysis of neuroendocrine endpoints versus other endpoint measures. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788504. |
the question of whether changes in neuroendocrine responsivity to the 5-ht2c partial agonist, meta-chlorophenylpiperazine (m-cpp), are accompanied by similar changes in other endpoints (temperature, behavior) is addressed in this brief review of published studies. |
1996-12-04 |
2023-08-12 |
human |
| J Akiyoshi, K Isogawa, K Yamada, H Nagayama, I Fuji. Effects of antidepressants on intracellular Ca2+ mobilization in CHO cells transfected with the human 5-HT2C receptors. Biological psychiatry. vol 39. issue 12. 1996-11-18. PMID:8780834. |
exposure to 5-ht, a 5-ht receptor agonist, mcpp [1-(3-chlorophenyl)piperazine dihydrochloride], a 5-ht2c agonist, and doi [1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane], a 5-ht2c and 5-ht2 agonist, resulted in increased intracellular ca2+ levels. |
1996-11-18 |
2023-08-12 |
human |
| K C Fone, K Shalders, Z D Fox, R Arthur, C A Marsde. Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation. Psychopharmacology. vol 123. issue 4. 1996-11-15. PMID:8867874. |
to investigate whether isolation rearing alters 5-hydroxytryptamine2c (5-ht2c) receptors, the effect of the serotonin agonist m-chlorophenylpiperazine (mcpp) was examined on elevated plus-maze behaviour, plasma corticosterone and brain 5-ht2c receptor protein levels in rats. |
1996-11-15 |
2023-08-12 |
rat |
| K C Fone, K Shalders, Z D Fox, R Arthur, C A Marsde. Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation. Psychopharmacology. vol 123. issue 4. 1996-11-15. PMID:8867874. |
hippocampal 5-ht2c receptor protein-like immunoreactive levels were significantly lower following mcpp than saline only in rats reared in isolation. |
1996-11-15 |
2023-08-12 |
rat |
| F G Graeff, F S Guimarães, T G De Andrade, J F Deaki. Role of 5-HT in stress, anxiety, and depression. Pharmacology, biochemistry, and behavior. vol 54. issue 1. 1996-10-23. PMID:8728550. |
in healthy volunteers, d-fenfluramine and the 5-ht agonist mcpp (mainly 5-ht2c) increased, while the antagonists ritanserin (5-ht2a/2c) and sr 46349b (5-ht2a) decreased skin conductance responses to an aversively conditioned stimulus (tone). |
1996-10-23 |
2023-08-12 |
human |
| D Fiorella, S Helsley, R A Rabin, J C Winte. 5-HT2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 122. issue 3. 1996-09-26. PMID:8748393. |
the present study was designed to investigate the hypothesis that agonist interactions at 5-ht2c receptors mediate the discriminative stimulus properties of m-chlorophenylpiperazine (mcpp). |
1996-09-26 |
2023-08-12 |
Not clear |
| D Fiorella, S Helsley, R A Rabin, J C Winte. 5-HT2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 122. issue 3. 1996-09-26. PMID:8748393. |
mk-212 (fractional efficacy = 1.1) and (-)dom (0.77) were full agonists, while mcpp (0.72), lsd (0.27), quipazine (0.24), and tfmpp (0.22) were partial agonists with respect to the stimulation of pi hydrolysis at the 5-ht2c receptor. |
1996-09-26 |
2023-08-12 |
Not clear |