| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Fiorella, S Helsley, R A Rabin, J C Winte. 5-HT2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 122. issue 3. 1996-09-26. PMID:8748393. |
while compounds with agonist activity at the 5-ht2c receptor in vitro substitute for the mcpp stimulus in vivo, no clear relationship exists between in vitro intrinsic activity at the 5-ht2c receptor with respect to the stimulation of pi turnover and maximal substitution for the mcpp stimulus in vivo. |
1996-09-26 |
2023-08-12 |
Not clear |
| D Fiorella, S Helsley, R A Rabin, J C Winte. 5-HT2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 122. issue 3. 1996-09-26. PMID:8748393. |
the present data suggest that mcpp elicits a compound stimulus which is mediated by agonist interactions at the 5-ht2c receptor and possibly additional interactions with 5-ht2a, 5-ht3, and/or 5-ht1b receptors. |
1996-09-26 |
2023-08-12 |
Not clear |
| C T Douris. Multiple serotonin receptors: opportunities for new treatments for obesity? Obesity research. vol 3 Suppl 4. 1996-09-05. PMID:8697043. |
however, a number of issues remain unresolved, particularly regarding potential side-effects, as the 5-ht2c receptor agonist mcpp has been reported to induce anxiety and nausea in humans, actions that would clearly limit its therapeutic utility. |
1996-09-05 |
2023-08-12 |
Not clear |
| D Fiorella, R A Rabin, J C Winte. The interaction of clozapine with the meta-chlorophenylpiperazine (mCPP) discriminative stimulus. Life sciences. vol 58. issue 24. 1996-07-22. PMID:8649203. |
the psychotropic effects of the 5-ht2c agonist mcpp in human subjects are blocked by the atypical antipsychotic clozapine, but not by typical antipsychotics. |
1996-07-22 |
2023-08-12 |
human |
| H Y Meltzer, M Mae. Pindolol pretreatment blocks stimulation by meta-chlorophenylpiperazine of prolactin but not cortisol secretion in normal men. Psychiatry research. vol 58. issue 2. 1996-03-01. PMID:8570772. |
cortisol secretion stimulated by mcpp may occur following 5-ht2c receptor stimulation in the presence of 5-ht1a receptor blockade. |
1996-03-01 |
2023-08-12 |
Not clear |
| P M Callahan, K A Cunningha. Modulation of the discriminative stimulus properties of cocaine by 5-HT1B and 5-HT2C receptors. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562516. |
in substitution tests, the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat; 0.2-1.6 mg/kg), the 5-ht1a/b receptor agonists ru 24969 (0.25-2 mg/kg) and cgs 12066b (2-16 mg/kg), the 5-ht1b/2c receptor agonists m-chlorophenylpiperazine (mcpp; 0.25-2 mg/kg) and m-trifluoromethylphenylpiperazine (tfmpp; 0.125-2 mg/kg), the 5-ht2a/2c receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane ([+/-]-dob; 0.0625-0.5 mg/kg), the 5-ht2c receptor agonist mk 212 (0.25-1 mg/kg) and the nonselective 5-ht receptor agonist quipazine (1-8 mg/kg) engendered 30% to 70% cocaine-appropriate responding. |
1995-10-25 |
2023-08-12 |
rat |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
the affinity of these antagonists for 5-ht2a and 5-ht2c receptors was then correlated with maximal percent inhibition of the mcpp stimulus. |
1995-10-03 |
2023-08-12 |
Not clear |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
kd at the 5-ht2c receptor was inversely proportional (r = -0.75, p < 0.05), and kd at the 5-ht2a receptor directly proportional (r = +0.67, p < 0.05) to the maximal percent inhibition of the mcpp stimulus. |
1995-10-03 |
2023-08-12 |
Not clear |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
the 5-ht2c selectivity ratio [kd(5-ht2a)/kd(5-ht2c)] of the antagonists was directly proportional (r = +0.86, p < 0.01) to maximal percent inhibition of the mcpp stimulus. |
1995-10-03 |
2023-08-12 |
Not clear |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
a multiple regressions analysis indicated that 81% of the variance in the ability of a given antagonist to block the mcpp stimulus could be predicted on the basis of its affinity for 5-ht2a and 5-ht2c receptors. |
1995-10-03 |
2023-08-12 |
Not clear |
| D Fiorella, R A Rabin, J C Winte. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology. vol 119. issue 2. 1995-10-03. PMID:7659770. |
it is concluded that the stimulus effects of mcpp are mediated predominantly by a combination of agonist activity at 5-ht2c receptors and antagonist activity at 5-ht2a receptors. |
1995-10-03 |
2023-08-12 |
Not clear |
| A E Walsh, K A Smith, A D Oldman, C Williams, E M Goodall, P J Cowe. m-Chlorophenylpiperazine decreases food intake in a test meal. Psychopharmacology. vol 116. issue 1. 1995-03-23. PMID:7862925. |
the results suggest that activation of brain 5-ht2c receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mcpp in the present study could be a consequence of its adverse subjective side effects. |
1995-03-23 |
2023-08-12 |
human |
| T A Sipes, M A Geye. Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984282. |
the 5-ht2c agonist mcpp, [1-(m)-chlorophenyl-piperazine], was ineffective. |
1994-12-30 |
2023-08-12 |
rat |
| E L Gibson, A M Barnfield, G Curzo. Evidence that mCPP-induced anxiety in the plus-maze is mediated by postsynaptic 5-HT2C receptors but not by sympathomimetic effects. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984284. |
the effect of mcpp was more potently inhibited by 1-(1-naphthyl)piperazine than by ketanserin, indicative of its mediation via activation of 5-ht2c rather than 5-ht2a receptors. |
1994-12-30 |
2023-08-12 |
rat |
| E L Gibson, A M Barnfield, G Curzo. Evidence that mCPP-induced anxiety in the plus-maze is mediated by postsynaptic 5-HT2C receptors but not by sympathomimetic effects. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984284. |
these results indicate that mcpp induces anxiety in the rat in the elevated plus-maze primarily by stimulation of postsynaptic 5-ht2c receptors, and suggest that sympathomimetic effects of mcpp are not involved. |
1994-12-30 |
2023-08-12 |
rat |
| P M Callahan, K A Cunningha. Involvement of 5-HT2C receptors in mediating the discriminative stimulus properties of m-chlorophenylpiperazine (mCPP). European journal of pharmacology. vol 257. issue 1-2. 1994-10-10. PMID:8082704. |
involvement of 5-ht2c receptors in mediating the discriminative stimulus properties of m-chlorophenylpiperazine (mcpp). |
1994-10-10 |
2023-08-12 |
rat |
| P M Callahan, K A Cunningha. Involvement of 5-HT2C receptors in mediating the discriminative stimulus properties of m-chlorophenylpiperazine (mCPP). European journal of pharmacology. vol 257. issue 1-2. 1994-10-10. PMID:8082704. |
the present results suggest that the discriminative stimulus effects of mcpp in rats are mediated primarily by postsynaptic 5-ht2c receptors. |
1994-10-10 |
2023-08-12 |
rat |
| G A Kennett, M D Wood, A Glen, S Grewal, I Forbes, A Gadre, T P Blackbur. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. British journal of pharmacology. vol 111. issue 3. 1994-08-02. PMID:7912626. |
sb 200646a, n-(1-methyl-5-indolyl)-n'-(3-pyridyl) urea hydrochloride, the first reported selective 5-ht2c/2b over 5-ht2a receptor antagonist, (pk1 rat 5-ht2c receptor 6.9, pa2 rat 5-ht2b receptor 7.5, pk1 rat 5-ht2a receptor 5.2) dose-dependently blocked a putative rat model of 5-ht2c receptor activation; 1-(3-chlorophenyl)piperazine (mcpp, 5 mg kg-1, i.p. |
1994-08-02 |
2023-08-12 |
rat |
| G A Kennett, M D Wood, A Glen, S Grewal, I Forbes, A Gadre, T P Blackbur. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. British journal of pharmacology. vol 111. issue 3. 1994-08-02. PMID:7912626. |
sb 200646a also blocked another putative in vivo model of 5-ht2c receptor function; mcpp (5 mg kg-1, i.p. |
1994-08-02 |
2023-08-12 |
rat |
| S J Cooper, D J Barbe. Evidence for serotonergic involvement in saccharin preference in a two-choice test in rehydrating rats. Pharmacology, biochemistry, and behavior. vol 47. issue 3. 1994-07-11. PMID:8208772. |
several direct acting serotonergic receptor agonists (putatively agonists at the 5-ht2c receptor), mk212, mcpp, and tfmpp, respectively, blocked the saccharin taste preference normally exhibited in this test. |
1994-07-11 |
2023-08-12 |
rat |