| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susannah E Murphy, Lucy C Wright, Michael Browning, Philip J Cowen, Catherine J Harme. A role for 5-HT Psychological medicine. vol 50. issue 16. 2021-09-06. PMID:31615585. |
a role for 5-ht 5-ht4 receptor stimulation has pro-cognitive and antidepressant-like effects in animal experimental studies; however, this pharmacological approach has not yet been tested in humans. |
2021-09-06 |
2023-08-13 |
human |
| Nadine Tod, Gabrielle Stalder, Hanna Rauch, Stefan Boehmdorfer, Anna Haw, Hanno Gerritsmann, Johanna Painer, Leith Meye. Investigation of cardiorespiratory effects of the selective 5-HT4 agonist BIMU-8 in etorphine-immobilised goats (Capra aegagrus hircus) in a randomized, blinded and controlled trial. The Veterinary record. vol 189. issue 1. 2021-09-01. PMID:33908044. |
we therefore aimed to determine whether the selective 5-hydroxytryptamine receptor 4 (5-ht4) agonist, bimu-8, reverses opioid-induced respiratory compromise in etorphine-immobilised goats. |
2021-09-01 |
2023-08-13 |
Not clear |
| Ji Taek Hon. Current Opinion on Prucalopride in Gastroparesis and Chronic Constipation Treatment: A Focus on Patient Selection and Safety. Therapeutics and clinical risk management. vol 17. 2021-06-19. PMID:34135588. |
prucalopride is a third-generation, highly selective 5-hydroxytryptamine 4 (5-ht4) receptor agonist. |
2021-06-19 |
2023-08-13 |
Not clear |
| Antoine-Guy Lopez, Céline Duparc, Alexandre Naccache, Mireille Castanet, Hervé Lefebvre, Estelle Louise. Role of Mast Cells in the Control of Aldosterone Secretion. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 52. issue 6. 2021-04-02. PMID:32215882. |
in human, mast cell degranulation stimulates aldosterone synthesis through the release of serotonin (5-ht) and activation of 5-ht4 receptors. |
2021-04-02 |
2023-08-13 |
mouse |
| Zainab Eydipour, Mohammad Nasehi, Salar Vaseghi, Seyed Hamid Jamaldini, Mohammad-Reza Zarrindas. The role of 5-HT4 serotonin receptors in the CA1 hippocampal region on memory acquisition impairment induced by total (TSD) and REM sleep deprivation (RSD). Physiology & behavior. vol 215. 2021-03-04. PMID:31863855. |
the role of 5-ht4 serotonin receptors in the ca1 hippocampal region on memory acquisition impairment induced by total (tsd) and rem sleep deprivation (rsd). |
2021-03-04 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Xiang Li, Alexander O Tarakanov, David Savelli, Manuel Narváez, Kirill Shumilov, Yuniesky Andrade-Talavera, Antonio Jimenez-Beristain, Bartosz Pomierny, Zaida Díaz-Cabiale, Riccardo Cuppini, Patrizia Ambrogini, Maria Lindskog, Kjell Fux. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. ACS omega. vol 2. issue 8. 2020-10-01. PMID:28920103. |
there are many 5-ht subtypes involved; some need to be blocked (e.g., 5-ht2a, 5-ht3, and 5-ht7), whereas others need to be activated (e.g., postjunctional 5-ht1a and 5-ht4). |
2020-10-01 |
2023-08-13 |
Not clear |
| Joel A. Sach, Lin Chan. Irritable Bowel Syndrome. Current treatment options in gastroenterology. vol 5. issue 4. 2020-09-30. PMID:12095474. |
some of the most promising emerging therapies in ibs revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-ht3 and 5-ht4 subtypes), which are involved in sensory and motor functions of the gut. |
2020-09-30 |
2023-08-12 |
Not clear |
| Vincenzo Stanghellini, Roberto De Giorgio, Giovanni Barbara, Rosanna Cogliandro, Cesare Tosetti, Fabrizio De Ponti, Roberto Corinaldes. Delayed Gastric Emptying in Functional Dyspepsia. Current treatment options in gastroenterology. vol 7. issue 4. 2020-09-29. PMID:15238200. |
drugs capable of prokinetic effects, such as antidopaminergics (eg, metoclopramide, domperidone, levosulpiride) and serotonin 5-ht4 receptor agonists (eg, tegaserod) can be potentially used in the treatment of dyspeptic patients. |
2020-09-29 |
2023-08-12 |
Not clear |
| Asim Tameez Ud Din, Ameer H Khan, Hamza Bajwa, Muhammad Haisum Maqsood, Mustafa N Mali. Clinical Efficacy and Safety Profile of Prucalopride in Chronic Idiopathic Constipation. Cureus. vol 11. issue 4. 2020-09-29. PMID:31218146. |
prucalopride is a prokinetic agent which works at the 5-hydroxytryptamine receptor 4 (5-ht4) as an agonist with greater receptor selectivity. |
2020-09-29 |
2023-08-13 |
Not clear |
| Christine J Park, Sarah J Armenia, Lucy Zhang, Robert A Cowle. The 5-HT4 Receptor Agonist Prucalopride Stimulates Mucosal Growth and Enhances Carbohydrate Absorption in the Ileum of the Mouse. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 23. issue 6. 2020-07-06. PMID:30109470. |
while an indirect mechanism was postulated to explain these effects, the presence of 5-ht4 receptors on enterocytes raises the possibility of a direct action of serotonin. |
2020-07-06 |
2023-08-13 |
mouse |
| J Ogden, D Ovbey, K Sail. Effects of preoperative cisapride on postoperative aspiration pneumonia in dogs with laryngeal paralysis. The Journal of small animal practice. vol 60. issue 3. 2020-07-01. PMID:30387153. |
retrospective evaluation of a preoperative prokinetic protocol using a constant-rate infusion of a serotonin 5-ht4 receptor agonist, cisapride, and its association with frequency of postoperative aspiration pneumonia in dogs undergoing unilateral arytenoid lateralisation as compared to a historical population at the same institution. |
2020-07-01 |
2023-08-13 |
Not clear |
| Julie Le Mestre, Céline Duparc, Yves Reznik, Fidéline Bonnet-Serrano, Philippe Touraine, Olivier Chabre, Jacques Young, Mari Suzuki, Mathilde Sibony, Françoise Gobet, Constantine A Stratakis, Gérald Raverot, Jérôme Bertherat, Hervé Lefebvre, Estelle Louise. Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. The Journal of clinical endocrinology and metabolism. vol 104. issue 11. 2020-06-01. PMID:31074783. |
in primary pigmented nodular adrenocortical disease cells, activation of the camp/protein kinase a (pka) pathway by prkar1a mutations triggers upregulation of the 5-ht synthesizing enzyme tryptophan hydroxylase (tph) and the 5-ht4, 5-ht6, and 5-ht7 receptors. |
2020-06-01 |
2023-08-13 |
human |
| Jiqiang Guo, Huaxia Ding, Zhuangwei Lv, Junna Jiao, Hui Wang, Yanhong J. Down-regulation effects of IFN-α on p11, 5-htr1b and 5-HTR4 protein levels were affected by NH Journal of biosciences. vol 44. issue 4. 2020-01-30. PMID:31502579. |
down-regulation effects of ifn-α on p11, 5-htr1b and 5-htr4 protein levels were affected by nh in previous studies, we found interferon-α (ifn-α) could reduce protein levels of p11, 5-hydroxytryptamine receptor 1b (5-ht1b) and 5-hydroxytryptamine receptor 4 (5-ht4), but does not influence their messenger rna levels in sh-sy5y cells. |
2020-01-30 |
2023-08-13 |
Not clear |
| Thomas A Marciniak, Victor Serebruan. Should We Use Tegaserod for Irritable Bowel Syndrome? American journal of therapeutics. vol 26. issue 3. 2019-11-15. PMID:30946048. |
tegaserod, a serotonin (5-ht4) agonist initially approved for constipation but withdrawn from use in 2007 because of concerns about cardiovascular adverse effects, was resubmitted to the food and drug administration (fda) in 2018 for use in a restricted population. |
2019-11-15 |
2023-08-13 |
Not clear |
| Kyeong Seop Kim, Mi Ae Kim, Young Chang Soh. Molecular characterization, expression analysis, and functional properties of multiple 5-hydroxytryptamine receptors in Pacific abalone (Haliotis discus hannai). General and comparative endocrinology. vol 276. 2019-05-17. PMID:30849410. |
a phylogenetic analysis indicated that the molluskan 5-ht receptors are largely classified into four major clades: 5-ht1/5/7, 5-ht2, 5-ht4, and 5-ht6. |
2019-05-17 |
2023-08-13 |
Not clear |
| Heike Rebholz, Eitan Friedman, Julia Castell. Alterations of Expression of the Serotonin 5-HT4 Receptor in Brain Disorders. International journal of molecular sciences. vol 19. issue 11. 2019-02-12. PMID:30428567. |
alterations of expression of the serotonin 5-ht4 receptor in brain disorders. |
2019-02-12 |
2023-08-13 |
Not clear |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
to determine what 5-ht receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle was evaluated in the presence of agonists selective for 5-ht1b (cp 93129), 5-ht1d (l-694, 247), 5-ht2a (tcb-2), 5-ht2b (bw 723c86), 5-ht4 (bimu-8), and 5-ht7 (lp 44) receptors. |
2018-10-09 |
2023-08-13 |
cattle |
| Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workma. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of disease. vol 105. 2018-04-18. PMID:28511918. |
the serotonin system may represent an important target for prevention and treatment of mci, particularly the post-synaptic receptors (5-ht4 and 5-ht6), which may not be as severely affected as presynaptic aspects of the serotonin system, as indicated by the observation of lower serotonin transporters in mci relative to healthy controls. |
2018-04-18 |
2023-08-13 |
human |
| J E Dalziel, W Young, P Bercik, N J Spencer, L J Ryan, K E Dunstan, C M Lloyd-West, P K Gopal, N W Haggarty, N C Ro. Tracking gastrointestinal transit of solids in aged rats as pharmacological models of chronic dysmotility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 28. issue 8. 2018-02-12. PMID:27028044. |
the 5-hydroxytryptamine type 4 (5-ht4 ) receptor agonist prucalopride was used to accelerate transit, and the opioid agonist loperamide was used to delay transit. |
2018-02-12 |
2023-08-13 |
rat |
| Alfredo Menese. Neural activity, memory, and dementias: serotonergic markers. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27926574. |
in addition, at least, 5-ht1a, 5-ht4, 5-ht6, and 5-ht7 receptors as well as serotonin transporter seem to be useful neural markers and therapeutic targets. |
2018-01-11 |
2023-08-13 |
Not clear |