| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dionisio A Amodeo, Sophie Peterson, Alma Pahua, Rebekah Posadas, Armando Hernandez, Emily Hefner, David Qi, Jesus Veg. 5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory. Behavioural brain research. vol 349. 2018-11-26. PMID:29715539. |
serotonin 6 (5-ht6) receptors are primarily expressed in the central nervous system and to an even further extent brain regions responsible for learning and memory. |
2018-11-26 |
2023-08-13 |
mouse |
| Ramakrishna Nirogi, Koteshwara Mudigonda, Gopinadh Bhyrapuneni, Nageswara Rao Muddana, Vinod Kumar Goyal, Santosh Kumar Pandey, Raghava Choudary Palacharl. Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, SUVN-502, in Healthy Young Adults and Elderly Subjects. Clinical drug investigation. vol 38. issue 5. 2018-08-13. PMID:29380267. |
safety, tolerability and pharmacokinetics of the serotonin 5-ht6 receptor antagonist, suvn-502, in healthy young adults and elderly subjects. |
2018-08-13 |
2023-08-13 |
human |
| Lili Hu, Bingjie Wang, Yan Zhan. Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function. Alzheimer's research & therapy. vol 9. issue 1. 2018-05-17. PMID:28931427. |
serotonin 5-ht6 receptors affect cognition in a mouse model of alzheimer's disease by regulating cilia function. |
2018-05-17 |
2023-08-13 |
mouse |
| Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workma. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of disease. vol 105. 2018-04-18. PMID:28511918. |
the serotonin system may represent an important target for prevention and treatment of mci, particularly the post-synaptic receptors (5-ht4 and 5-ht6), which may not be as severely affected as presynaptic aspects of the serotonin system, as indicated by the observation of lower serotonin transporters in mci relative to healthy controls. |
2018-04-18 |
2023-08-13 |
human |
| Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine De Tauzia, Pawel Zajdel, Hélène Bénédetti, Philippe Marin, Séverine Morisset-Lope. Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 43. 2018-02-07. PMID:27791021. |
physical interaction between neurofibromin and serotonin 5-ht6 receptor promotes receptor constitutive activity. |
2018-02-07 |
2023-08-13 |
Not clear |
| Nancy C Baker, Denis Fourches, Alexander Tropsh. Drug Side Effect Profiles as Molecular Descriptors for Predictive Modeling of Target Bioactivity. Molecular informatics. vol 34. issue 2-3. 2018-01-16. PMID:27490038. |
serotonin 5-ht6 binding and dopamine antagonism were investigated in separate studies. |
2018-01-16 |
2023-08-13 |
Not clear |
| Alfredo Menese. Neural activity, memory, and dementias: serotonergic markers. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27926574. |
in addition, at least, 5-ht1a, 5-ht4, 5-ht6, and 5-ht7 receptors as well as serotonin transporter seem to be useful neural markers and therapeutic targets. |
2018-01-11 |
2023-08-13 |
Not clear |
| Katarzyna Grychowska, Grzegorz Satała, Tomasz Kos, Anna Partyka, Evelina Colacino, Severine Chaumont-Dubel, Xavier Bantreil, Anna Wesołowska, Maciej Pawłowski, Jean Martinez, Philippe Marin, Gilles Subra, Andrzej J Bojarski, Frédéric Lamaty, Piotr Popik, Paweł Zajde. Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease. ACS chemical neuroscience. vol 7. issue 7. 2017-10-19. PMID:27100049. |
modulators of the serotonin 5-ht6 receptor (5-ht6r) offer a promising strategy for the treatment of the cognitive deficits that are associated with dementia and alzheimer's disease. |
2017-10-19 |
2023-08-13 |
Not clear |
| Alexandre V Ivachtchenko, Yan A Ivanenkov, Mark S Veselov, I M Oku. AVN-322 is a Safe Orally Bio-Available Potent and Highly Selective Antagonist of 5-HT6R with Demonstrated Ability to Improve Impaired Memory in Animal Models. Current Alzheimer research. vol 14. issue 3. 2017-10-16. PMID:27829340. |
in recent years, 5-hydroxytryptamine subtype 6 receptor (5-ht6 receptor, 5- ht6r) has emerged as a promising therapeutic target for the treatment of neuropathological disorders, including alzheimer's disease (ad) and schizophrenia. |
2017-10-16 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
physiological effects of 5-ht are mediated by about 15 serotoninergic receptors grouped into seven broad families (5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht5, 5-ht6, 5-ht7 receptor families). |
2017-09-20 |
2023-08-13 |
Not clear |
| Patrick Aldrin-Kirk, Andreas Heuer, Gang Wang, Bengt Mattsson, Martin Lundblad, Malin Parmar, Tomas Björklun. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor. Neuron. vol 90. issue 5. 2017-06-28. PMID:27161524. |
dreadd modulation of transplanted da neurons reveals a novel parkinsonian dyskinesia mechanism mediated by the serotonin 5-ht6 receptor. |
2017-06-28 |
2023-08-13 |
Not clear |
| Patrick Aldrin-Kirk, Andreas Heuer, Gang Wang, Bengt Mattsson, Martin Lundblad, Malin Parmar, Tomas Björklun. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor. Neuron. vol 90. issue 5. 2017-06-28. PMID:27161524. |
we show that exclusive activation of a camp-linked (gs-coupled) dreadd or serotonin 5-ht6 receptor, located on the grafted da neurons, is sufficient to induce gids. |
2017-06-28 |
2023-08-13 |
Not clear |
| Ju-Ryun Na, Dool-Ri Oh, SeulHee Han, Yu-Jin Kim, EunJin Choi, Donghyuck Bae, Dong Hwan Oh, Yoo-Hyun Lee, Sunoh Kim, Woojin Ju. Antistress Effects of Rosa rugosa Thunb. on Total Sleep Deprivation-Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT6 Receptor Antagonist. Journal of medicinal food. vol 19. issue 9. 2017-05-05. PMID:27331439. |
this study aimed to screen and identify the physiological antistress effects of an extract of r. rugosa (ro) on sleep deprivation-induced anxiety-like behavior and cognitive tests (in vivo) and tested for hippocampal cort and monoamine levels (ex vivo), corticosterone (cort)-induced injury, n-methyl-d-aspartate (nmda) receptor, and serotonin 6 (5-hydroxytryptamine 6, 5-ht6) receptor activities (in vitro) in search of active principles and underlying mechanisms of action. |
2017-05-05 |
2023-08-13 |
rat |
| b' \\xc3\\x81d\\xc3\\xa1m A Kelemen, R\\xc3\\xb3bert Kiss, Gy\\xc3\\xb6rgy G Ferenczy, L\\xc3\\xa1szl\\xc3\\xb3 Kov\\xc3\\xa1cs, Be\\xc3\\xa1ta Flachner, Zsolt L\\xc5\\x91rincz, Gy\\xc3\\xb6rgy M Keser\\xc5\\xb. Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments. Journal of chemical information and modeling. vol 56. issue 2. 2016-10-31. PMID:26760056.' |
in prospective validation virtual fragment hits were tested on 5-ht6 serotonin receptors not involved in the development of fracs. |
2016-10-31 |
2023-08-13 |
Not clear |
| Nicholas V Cozzi, Paul F Dale. Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines. Bioorganic & medicinal chemistry letters. vol 26. issue 3. 2016-10-13. PMID:26739781. |
five of the dalt compounds had affinity in the 50-400 nm range for serotonin 5-ht1d, 5-ht6, and 5-ht7 receptors; again, it was the unsubstituted dalt that had the weakest affinity at all three subtypes. |
2016-10-13 |
2023-08-13 |
Not clear |
| Marek Śmieja, Dawid Warszyck. Average Information Content Maximization--A New Approach for Fingerprint Hybridization and Reduction. PloS one. vol 11. issue 1. 2016-08-16. PMID:26784447. |
this methodology, applied to the ligands of five cognate serotonin receptors (5-ht2a, 5-ht2b, 5-ht2c, 5-ht5a, 5-ht6), proved that 100 bits selected from four non-hashed fingerprints reflect almost all structural information required for a successful in silico discrimination test. |
2016-08-16 |
2023-08-13 |
Not clear |
| Ana M Gamo, Juan A González-Vera, Ainoa Rueda-Zubiaurre, Dulce Alonso, Henar Vázquez-Villa, Lidia Martín-Couce, Óscar Palomares, Juan A López, Mar Martín-Fontecha, Bellinda Benhamú, María L López-Rodríguez, Silvia Ortega-Gutiérre. Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors. Chemistry (Weinheim an der Bergstrasse, Germany). vol 22. issue 4. 2016-06-28. PMID:26560738. |
as proof of concept, this methodology has been applied to selected ligands of the therapeutically relevant serotonin 5-ht1a and 5-ht6 receptors, and we have identified and validated some of their off-targets. |
2016-06-28 |
2023-08-13 |
Not clear |
| Agnieszka Gunia-Krzyzak, Karolina Pytka, Karolina Słoczyńska, Anna M Waszkielewicz, Grzegorz Satała, Andrzej J Bojarski, Jacek Sapa, Barbara Filipek, Marek Cegła, Elzbieta Pekala, Henryk Maron. PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS. Acta poloniae pharmaceutica. vol 73. issue 2. 2016-06-20. PMID:27180427. |
to identify possible mechanism of action, we evaluated serotonin receptors (5-ht1a, 5-ht6 and 5-ht7) binding affinities of the compounds but none of them proved to bind to any of tested receptors. |
2016-06-20 |
2023-08-13 |
mouse |
| Julia T Brouard, Judith V Schweimer, Rachel Houlton, Katherine E Burnham, Philip Quérée, Trevor Shar. Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25837696. |
pharmacological evidence for 5-ht6 receptor modulation of 5-ht neuron firing in vivo. |
2016-04-19 |
2023-08-13 |
rat |
| Julia T Brouard, Judith V Schweimer, Rachel Houlton, Katherine E Burnham, Philip Quérée, Trevor Shar. Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25837696. |
accumulating evidence suggests that 5-ht6 receptors may be located and functional in the drn; therefore, 5-ht6 receptor ligands may have potential as novel modulators of 5-ht neurotransmission. |
2016-04-19 |
2023-08-13 |
rat |