| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shabda Kulsange, Monika Sharma, Babasaheb Sonawane, Meera R Jaiswal, Mahesh Kulkarni, B Santhakumar. SWATH-MS reveals that Bisphenol A and its analogs regulate pathways leading to disruption in Insulin signaling and fatty acid metabolism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-04-23. PMID:38653447. |
insulin signaling demonstrated that bisphenols reduced phosphorylation of ir and akt2, glut4 translocation, and glucose uptake. |
2024-04-23 |
2024-04-26 |
Not clear |
| Brandon M Roberts, Alyssa V Geddis, Ronald W Mathen. Differential activation of AKT isoforms by growth factors in human myotubes. Physiological reports. vol 11. issue 20. 2023-10-25. PMID:37879895. |
in response to insulin, there was a significant treatment effect on phosphorylation of akt1 and akt2, but not akt3 (p < 0.01). |
2023-10-25 |
2023-11-08 |
human |
| Brandon M Roberts, Alyssa V Geddis, Ronald W Mathen. Differential activation of AKT isoforms by growth factors in human myotubes. Physiological reports. vol 11. issue 20. 2023-10-25. PMID:37879895. |
for insulin stimulation, akt1 was significantly higher than akt2 at 5 min and 60 min posttreatment (p < 0.05 both) and significantly different than akt3 at all timepoints (p < 0.05). |
2023-10-25 |
2023-11-08 |
human |
| M E Elangeeb, Imadeldin Elfaki, M A Elkhalifa, Khalid M Adam, A O Alameen, Ahmed Kamaleldin Elfadl, Ibrahim Altedlawi Albalawi, Kholoud S Almasoudi, Reema Almotairi, Basim S O Alsaedi, Marwan H Alhelali, Mohammad Muzaffar Mir, Dnyanesh Amle, Rashid Mi. In Silico Investigation of AKT2 Gene and Protein Abnormalities Reveals Potential Association with Insulin Resistance and Type 2 Diabetes. Current issues in molecular biology. vol 45. issue 9. 2023-09-27. PMID:37754255. |
in silico investigation of akt2 gene and protein abnormalities reveals potential association with insulin resistance and type 2 diabetes. |
2023-09-27 |
2023-10-07 |
Not clear |
| Lu Cai, Yi Tan, Sara Watson, Kupper Wintergers. Diabetic cardiomyopathy - Zinc preventive and therapeutic potentials by its anti-oxidative stress and sensitizing insulin signaling pathways. Toxicology and applied pharmacology. 2023-09-22. PMID:37739320. |
to support the role of zinc homeostasis in insulin signaling pathways, treatment of diabetic mice with zinc showed the preservation of phosphorylation levels of insulin-mediated glucose metabolism-related akt2 and gsk-3β and even rescued cardiac pathogenesis induced by global deletion of akt2 gene in a mt-dependent manner. |
2023-09-22 |
2023-10-07 |
mouse |
| Nika Rajabian, Debanik Choudhury, Izuagie Ikhapoh, Shilpashree Saha, Aishwarya S Kalyankar, Pihu Mehrotra, Aref Shahini, Kendall Breed, Stelios T Andreadi. Reversine ameliorates hallmarks of cellular senescence in human skeletal myoblasts via reactivation of autophagy. Aging cell. 2023-01-10. PMID:36625257. |
reversine reactivated autophagy and insulin signaling pathway via upregulation of adenosine monophosphate-activated protein kinase (ampk) and akt2, restoring insulin sensitivity and glucose uptake in senescent cells. |
2023-01-10 |
2023-08-14 |
human |
| Selina Mäkinen, Neeta Datta, Savithri Rangarajan, Yen Nguyen, Vesa Olkkonen, Aino Latva-Rasku, Pirjo Nuutila, Markku Laakso, Heikki A Koistine. Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes. Journal of molecular endocrinology. 2022-11-21. PMID:36409629. |
finnish-specific akt2 gene variant leads to impaired insulin signalling in myotubes. |
2022-11-21 |
2023-08-14 |
human |
| Okechukwu Patrick Nwabueze, Mridula Sharma, Abbirami Balachandran, Anand Gaurav, Anis Najwa Abdul Rani, Jeleń Małgorzata, Morak-Młodawska Beata, Charlie A Lavilla, Merell P Billacur. Comparative Studies of Palmatine with Metformin and Glimepiride on the Modulation of Insulin Dependent Signaling Pathway In Vitro, In Vivo & Ex Vivo. Pharmaceuticals (Basel, Switzerland). vol 15. issue 11. 2022-11-10. PMID:36355489. |
(5) conclusions: palmatine appears to have rejuvenated the impaired insulin signaling pathway through upregulation of the gene expression of irs-1, pi3k, akt2, and glut4 and downregulation of pkc-expression, according to in vitro, in vivo, and ex vivo studies. |
2022-11-10 |
2023-08-14 |
rat |
| Chuanmin Bai, Yujun Wang, Zhi Niu, Yaxin Guan, Jingshan Huang, Xin Nian, Fan Zuo, Juan Zhao, Tsutomu Kazumi, Bin W. Exenatide improves hepatocyte insulin resistance induced by different regional adipose tissue. Frontiers in endocrinology. vol 13. 2022-10-17. PMID:36246878. |
in addition, hepg2 cells in each co-culture group with and without insulin were collected, and the expression of key proteins irs2, p-irs2(s731), pi3k-p85, akt2, and p-akt2(s473) was detected by western blotting (wb). |
2022-10-17 |
2023-08-14 |
human |
| Yasuyo Urasaki, Thuc T L. Cinnamaldehyde and Curcumin Prime Akt2 for Insulin-Stimulated Activation. Nutrients. vol 14. issue 16. 2022-08-26. PMID:36014807. |
in this study, the effects of cinnamaldehyde and curcumin on akt2, a serine/threonine protein kinase central to the insulin signaling pathway, were examined in preadipocytes. |
2022-08-26 |
2023-08-14 |
Not clear |
| Hussam R Alkaissi, Zachary Mostel, Samy I McFarlan. Duplication of AKT2 Gene in Ovarian Cancer: A Potentially Novel Mechanism for Tumor-Induced Hypoglycemia. Cureus. vol 14. issue 6. 2022-07-13. PMID:35822150. |
in this report, we propose a potentially novel mechanism underlying nicth involving stimulation of the insulin signaling pathway in a 58-year-old woman with a rare ovarian tumor of müllerian origin that carries a duplication of the akt2 gene. |
2022-07-13 |
2023-08-14 |
Not clear |
| Hussam R Alkaissi, Zachary Mostel, Samy I McFarlan. Duplication of AKT2 Gene in Ovarian Cancer: A Potentially Novel Mechanism for Tumor-Induced Hypoglycemia. Cureus. vol 14. issue 6. 2022-07-13. PMID:35822150. |
akt2 is a molecular mediator of insulin signaling. |
2022-07-13 |
2023-08-14 |
Not clear |
| Maria Fernanda Ochoa Molina, Helena Poggi, Valeria De Toro, Carolina Mendoza, Khalid Hussai. Facial Dysmorphic Features in a Patient With Nonketotic Hypoglycemia and a Pathogenic Variant in the AACE clinical case reports. vol 8. issue 3. 2022-05-23. PMID:35602880. |
facial dysmorphic features in a patient with nonketotic hypoglycemia and a pathogenic variant in the akt2 is a serine/threonine kinase that plays a key role in regulating insulin signaling. |
2022-05-23 |
2023-08-13 |
Not clear |
| Song-Hua Hu, Xia-Di He, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang, Wen-Xing Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin, Jean J Zhao, Ming-Liang Ye, Jian-Yuan Zhao, Wei Xu, Shi-Min Zha. Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake. Cell reports. vol 38. issue 11. 2022-03-16. PMID:35294873. |
dha/epa deplete cytosolic pdk1 and akt2 and induce insulin resistance. |
2022-03-16 |
2023-08-13 |
mouse |
| Naoko Yokota-Nakagi, Sayo Omoto, Shoko Tazumi, Mizuho Kawakami, Akira Takamata, Keiko Morimot. Estradiol replacement improves high-fat diet-induced insulin resistance in ovariectomized rats. Physiological reports. vol 10. issue 5. 2022-03-03. PMID:35238495. |
therefore, we examined whether chronic estrogen replacement restores hfd-induced impairment in insulin sensitivity by its effects concomitant with alterations in the akt isoform 2 (akt2) and akt substrate of 160 kda (as160) phosphorylation in muscles of ovx rats. |
2022-03-03 |
2023-08-13 |
rat |
| Naoko Yokota-Nakagi, Sayo Omoto, Shoko Tazumi, Mizuho Kawakami, Akira Takamata, Keiko Morimot. Estradiol replacement improves high-fat diet-induced insulin resistance in ovariectomized rats. Physiological reports. vol 10. issue 5. 2022-03-03. PMID:35238495. |
in vivo insulin stimulation increased akt2 phosphorylation in the muscles of ncd-fed rats in both groups. |
2022-03-03 |
2023-08-13 |
rat |
| Naoko Yokota-Nakagi, Sayo Omoto, Shoko Tazumi, Mizuho Kawakami, Akira Takamata, Keiko Morimot. Estradiol replacement improves high-fat diet-induced insulin resistance in ovariectomized rats. Physiological reports. vol 10. issue 5. 2022-03-03. PMID:35238495. |
our data suggest that e2 replacement improves hfd-induced insulin resistance, and this effect is accompanied by the alterations in the akt2 and as160 phosphorylation in insulin-stimulated muscles of ovx rats. |
2022-03-03 |
2023-08-13 |
rat |
| Wataru Ogawa, Eiichi Araki, Yasushi Ishigaki, Yushi Hirota, Hiroshi Maegawa, Toshimasa Yamauchi, Tohru Yorifuji, Hideki Katagir. New classification and diagnostic criteria for insulin resistance syndrome. Endocrine journal. 2022-02-03. PMID:35110500. |
genetic insulin resistance syndrome includes type a insulin resistance as well as donohue and rabson-mendenhall syndromes, all of which are caused by abnormalities of the insulin receptor gene; conditions such as short syndrome caused by abnormalities of pik3r1, which encodes a regulatory subunit of phosphatidylinositol 3-kinase; conditions caused by abnormalities of akt2, tbc1d4, or prkce; and conditions in which a causative gene has not yet been identified. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ashley L Gehrand, Jonathan Phillips, Kyle D Welhouse, Hana Siddiqui, Matthew Schulgit, Jeff Hoffman, Hazel Hunt, Hershel Raf. Glucocorticoid Receptor Antagonist Alters Corticosterone and Receptor-sensitive mRNAs in the Hypoxic Neonatal Rat. Endocrinology. vol 163. issue 1. 2021-12-14. PMID:34791109. |
cort113176 pretreatment decreased baseline insulin receptor-sensitive gene mrnas akt2, irs1, pik3r1, and srebp1c at pd2. |
2021-12-14 |
2023-08-15 |
human |
| Medha Sharma, Chinmoy Sankar De. Role of Akt isoforms in neuronal insulin signaling and resistance. Cellular and molecular life sciences : CMLS. vol 78. issue 23. 2021-11-30. PMID:34724097. |
thus, isoforms play parallel with predominant role by akt2, and compensatory yet novel role by akt1 and akt3 to regulate neuronal insulin signaling, glucose uptake, and insulin-resistance. |
2021-11-30 |
2023-08-13 |
mouse |