| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuyuki Takenaka, Mika Nakao, Sayaka Matsui, Takaya Sato. A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes. International journal of molecular sciences. vol 20. issue 21. 2020-03-30. PMID:31683681. |
a rac1-specific inhibitor almost completely suppressed glut4 translocation induced by insulin or a constitutively activated mutant of phosphoinositide 3-kinase or akt2. |
2020-03-30 |
2023-08-13 |
mouse |
| Wei Yu, Wenliang Zha, Hu Peng, Qiurong Wang, Shuning Zhang, Jun Re. Trehalose Protects against Insulin Resistance-Induced Tissue Injury and Excessive Autophagy in Skeletal Muscles and Kidney. Current pharmaceutical design. vol 25. issue 18. 2020-03-05. PMID:31538882. |
akt2 represents an important member of the akt family and plays an essential role in the maintenance of insulin signaling. |
2020-03-05 |
2023-08-13 |
Not clear |
| Mitra Kamran, Fatemeh Kharazmi, Kianoosh Malekzadeh, Ardeshir Talebi, Fatemah Khosravi, Nepton Soltan. Effect of Long-term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: the Role of Akt2 and IRS1 Gene Expressions. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30519800. |
effect of long-term administration of oral magnesium sulfate and insulin to reduce streptozotocin-induced hyperglycemia in rats: the role of akt2 and irs1 gene expressions. |
2020-02-04 |
2023-08-13 |
rat |
| Mitra Kamran, Fatemeh Kharazmi, Kianoosh Malekzadeh, Ardeshir Talebi, Fatemah Khosravi, Nepton Soltan. Effect of Long-term Administration of Oral Magnesium Sulfate and Insulin to Reduce Streptozotocin-Induced Hyperglycemia in Rats: the Role of Akt2 and IRS1 Gene Expressions. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30519800. |
the effects of long-term oral administration of magnesium sulfate and insulin on hyperglycemia were investigated using akt2 and irs1 gene expression methods in streptozotocin-induced diabetic rats. |
2020-02-04 |
2023-08-13 |
rat |
| Eleftheria Ieronymaki, Emmanouel M Theodorakis, Konstantina Lyroni, Eleni Vergadi, Eleni Lagoudaki, Ahmed Al-Qahtani, Marina Aznaourova, Elpida Neofotistou-Themeli, Aristides G Eliopoulos, Katerina Vaporidi, Christos Tsatsani. Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 6. 2020-01-10. PMID:30718296. |
in this study, we demonstrate that chronic exposure of macrophages to insulin either in culture or in vivo in diet-induced, glucose-intolerant mice rendered them resistant to insulin signals marked by failure to induce akt2 phosphorylation. |
2020-01-10 |
2023-08-13 |
mouse |
| Eleftheria Ieronymaki, Emmanouel M Theodorakis, Konstantina Lyroni, Eleni Vergadi, Eleni Lagoudaki, Ahmed Al-Qahtani, Marina Aznaourova, Elpida Neofotistou-Themeli, Aristides G Eliopoulos, Katerina Vaporidi, Christos Tsatsani. Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 6. 2020-01-10. PMID:30718296. |
similarly, macrophages lacking akt2 or igf1 receptor were also resistant to insulin signals. |
2020-01-10 |
2023-08-13 |
mouse |
| Liming Wang, Jae-Hyung Chang, Anne F Buckley, Robert F Spurne. Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice. Kidney international. vol 95. issue 2. 2020-01-02. PMID:30665571. |
while the mechanisms are not fully understood, insulin activates both akt2 and erk, which inhibits apoptosis signal regulated kinase 1 (ask1)-p38-induced apoptosis. |
2020-01-02 |
2023-08-13 |
mouse |
| M Kupreeva, A Diane, R Lehner, R Watts, M Ghosh, S Proctor, D Vin. Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model. American journal of physiology. Endocrinology and metabolism. vol 316. issue 1. 2019-11-21. PMID:30153063. |
metformin-flutamide treatment upregulated hepatic and intestinal insulin signaling, including insulin receptor, mapk1, and akt2. |
2019-11-21 |
2023-08-13 |
Not clear |
| Nobuyuki Takenaka, Natsumi Araki, Takaya Sato. Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle. PloS one. vol 14. issue 2. 2019-11-13. PMID:30735546. |
herein, we aimed to provide additional evidence that support a critical role for akt2 in insulin regulation of rac1 in mouse skeletal muscle. |
2019-11-13 |
2023-08-13 |
mouse |
| Nobuyuki Takenaka, Natsumi Araki, Takaya Sato. Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle. PloS one. vol 14. issue 2. 2019-11-13. PMID:30735546. |
knockdown of akt2 by rna interference abolished rac1 activation following intravenous administration of insulin or ectopic expression of a constitutively activated phosphoinositide 3-kinase mutant. |
2019-11-13 |
2023-08-13 |
mouse |
| Nobuyuki Takenaka, Natsumi Araki, Takaya Sato. Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle. PloS one. vol 14. issue 2. 2019-11-13. PMID:30735546. |
the activation of another small gtpase rala and glut4 translocation to the sarcolemma following insulin administration or ectopic expression of a constitutively activated form of phosphoinositide 3-kinase, but not rac1, were also diminished by downregulation of akt2 expression. |
2019-11-13 |
2023-08-13 |
mouse |
| Jun Ren, Zhaohui Pei, Xiyao Chen, Melissa J Berg, Khalid Matrougui, Qing-Hua Zhang, Yingmei Zhan. Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 1. 2019-08-12. PMID:30463689. |
this study was designed to examine the impact of inhibition of the cytochrome p450 2e1 (cyp2e1) enzyme on myocardial function and mitochondrial autophagy (mitophagy) in an akt2 knockout model of insulin resistance. |
2019-08-12 |
2023-08-13 |
Not clear |
| Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M A Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltune. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice. Neurobiology of aging. vol 75. 2019-07-11. PMID:30554086. |
intranasal insulin activates akt2 signaling pathway in the hippocampus of wild-type but not in app/ps1 alzheimer model mice. |
2019-07-11 |
2023-08-13 |
mouse |
| Youde Jiang, Li Liu, Jena J Steinl. miRNA15a regulates insulin signal transduction in the retinal vasculature. Cellular signalling. vol 44. 2019-06-26. PMID:29339083. |
mir15a knockout mice had reduced insulin receptor phosphorylation and akt2 levels, with increased insulin receptor substrate 1 (irs-1) phosphorylation on serine 307, a site known to inhibit insulin signaling. |
2019-06-26 |
2023-08-13 |
mouse |
| Javier T Gonzalez, Judith D Richardson, Enhad A Chowdhury, Francoise Koumanov, Geoffrey D Holman, Scott Cooper, Dylan Thompson, Kostas Tsintzas, James A Bett. Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults. The Journal of physiology. vol 596. issue 4. 2019-04-16. PMID:29193093. |
the content and activation status of key proteins involved in insulin signalling and glucose transport (glut4, akt1 and akt2) were unaffected by extended morning fasting. |
2019-04-16 |
2023-08-13 |
Not clear |
| A A K Salama, M Duque, L Wang, K Shahzad, M Olivera, J J Loo. Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat-stressed bovine mammary epithelial cells in vitro. Journal of dairy science. vol 102. issue 3. 2019-04-10. PMID:30639019. |
in addition, compared with the control, supply of met or arg upregulated genes related to transcription and translation (mapk1, mtor, srebf1, rps6kb1, jak2), insulin signaling (akt2, irs1), aa transport (slc1a5, slc7a1), and cell proliferation (mki67). |
2019-04-10 |
2023-08-13 |
cattle |
| Isabel Huang-Doran, Patsy Tomlinson, Felicity Payne, Alexandra Gast, Alison Sleigh, William Bottomley, Julie Harris, Allan Daly, Nuno Rocha, Simon Rudge, Jonathan Clark, Albert Kwok, Stefano Romeo, Emma McCann, Barbara Müksch, Mehul Dattani, Stefano Zucchini, Michael Wakelam, Lazaros C Foukas, David B Savage, Rinki Murphy, Stephen O'Rahilly, Inês Barroso, Robert K Sempl. Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. JCI insight. vol 1. issue 17. 2018-10-02. PMID:27766312. |
insulin resistance due to insulin receptor (insr) dysfunction is associated with none of these, but when due to dysfunction of the downstream kinase akt2 phenocopies obesity-related insulin resistance. |
2018-10-02 |
2023-08-13 |
Not clear |
| Minseo Kwon, Ji Eom, Donghwan Kim, Jinhwan Kim, Jose Heredia, Sang-Wook Kang, Youngsup Son. Skeletal Muscle Tissue Trib3 Links Obesity with Insulin Resistance by Autophagic Degradation of AKT2. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 48. issue 4. 2018-09-14. PMID:30071535. |
skeletal muscle tissue trib3 links obesity with insulin resistance by autophagic degradation of akt2. |
2018-09-14 |
2023-08-13 |
mouse |
| Xiaohua Zheng, Gregory D Carte. Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle. Scientific reports. vol 6. 2018-06-29. PMID:27966646. |
in adipocytes, akt2 versus akt1 has greater susceptibility for insulin-mediated redistribution from cytosolic to membrane localization, and insulin also causes subcellular redistribution of akt substrate of 160 kda (as160), an akt2 substrate and crucial mediator of insulin-stimulated glucose transport. |
2018-06-29 |
2023-08-13 |
rat |
| Xiaohua Zheng, Gregory D Carte. Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle. Scientific reports. vol 6. 2018-06-29. PMID:27966646. |
the major aim of this study was to determine insulin's effects on the subcellular localization and phosphorylation of akt1, akt2 and as160 in skeletal muscle. |
2018-06-29 |
2023-08-13 |
rat |