| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marya Dushar, Jędrzej Nowaczyk, Beata Pyrżak, Hayane Akopyan, Robert Śmigiel, Anna Walczak, Małgorzata Rydzanicz, Rafał Płoski, Krzysztof Szczałub. Efficacy and safety of sirolimus therapy in familial hypoinsulinemic hypoglycemia caused by AKT2 mutation inherited from the mosaic father. European journal of medical genetics. vol 64. issue 12. 2021-11-22. PMID:34673243. |
activating mutation in the insulin signal-transducing kinase akt2 results in severe hypoinsulinemic hypoketotic hypoglycemia and a characteristic phenotype of possible overgrowth and, sometimes, acanthosis nigricans. |
2021-11-22 |
2023-08-13 |
Not clear |
| Suna Habahbeh, Amer Imraish, Malek Zihli. The crosstalk between adenosine A2B receptor and insulin signalling in rat skeletal muscle cells. Biologia futura. vol 71. issue 3. 2021-09-24. PMID:34554511. |
differentiated l6 cell rat muscle cells were treated with insulin, adenosine agonist neca, selective ar2b antagonist psb 603 and combinations between these reagents, the expression of akt2, gsk3α, and gsk3β were measured by qpcr hydrolysis probe technique. |
2021-09-24 |
2023-08-13 |
rat |
| Suna Habahbeh, Amer Imraish, Malek Zihli. The crosstalk between adenosine A2B receptor and insulin signalling in rat skeletal muscle cells. Biologia futura. vol 71. issue 3. 2021-09-24. PMID:34554511. |
insulin increases akt2, gsk3α and gsk3β mrna expression, while ar2b antagonist inhibits akt2 gsk3α and gsk3β mrna expression and combining ar2b antagonist with insulin diminish insulin action and decrease akt2 gsk3α and gsk3β mrna expression, which means a strong relationship between ar2b and insulin action. |
2021-09-24 |
2023-08-13 |
rat |
| Wen-Yu Hsiao, Su Myung Jung, Yuefeng Tang, John A Haley, Rui Li, Huawei Li, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Chien-Min Hung, Amelia K Luciano, Victoria DeMambro, Kathryn E Wellen, Clifford J Rosen, Lihua Julie Zhu, David A Guerti. The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development. Cell reports. vol 33. issue 1. 2021-09-15. PMID:33027655. |
mechanistically, mtorc2 promotes transcriptional upregulation of select lipid metabolism genes controlled by pparγ and chrebp, including genes that control lipid uptake, synthesis, and degradation pathways as well as akt2, which encodes a major mtorc2 substrate and insulin effector. |
2021-09-15 |
2023-08-13 |
Not clear |
| Hossein Rezazadeh, Mohammad Reza Sharifi, Mohmmadreza Sharifi, Nepton Soltan. Gamma-aminobutyric acid attenuates insulin resistance in type 2 diabetic patients and reduces the risk of insulin resistance in their offspring. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33667789. |
the role of gamma-aminobutyric acid (gaba) in attenuates insulin resistance (ir) in type 2 diabetic (t2d) patients and the reduction of the risk of ir in their offspring, and the function of glut4, irs1 and akt2 genes expression were investigated. |
2021-07-22 |
2023-08-13 |
rat |
| Nobuyuki Takenaka, Mika Nakao, Kiko Hasegawa, Man Piu Chan, Takaya Sato. The guanine nucleotide exchange factor FLJ00068 activates Rac1 in adipocyte insulin signaling. FEBS letters. vol 594. issue 24. 2021-06-03. PMID:32978791. |
here, we show that knockdown of the guanine nucleotide exchange factor flj00068 inhibits rac1 activation and glut4 translocation by insulin and a constitutively activated form of the protein kinase akt2. |
2021-06-03 |
2023-08-13 |
Not clear |
| Isabella Supardi Parida, Soo Takasu, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Toshiyuki Kimura, Takahiro Eitsuka, Kiyotaka Nakagaw. Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue. Food & function. vol 11. issue 5. 2021-03-23. PMID:32374310. |
to investigate how these physiological events could take place, we analyzed the expression of genes involved in lipid metabolism and insulin signaling in epididymal white adipose tissue and found that cbp had a regulatory effect on the expression of genes related to lipid metabolism (pparγ, srebf1c, acc, scd, hsl, lpl), adiponectin secretion (foxo1 and sirt1), and insulin signaling (irs1 and akt2). |
2021-03-23 |
2023-08-13 |
mouse |
| Miao Chen, Caoyu Ji, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis, Fangrong Yan, Junmei Y. AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle. Clinical science (London, England : 1979). vol 134. issue 17. 2021-03-23. PMID:32880392. |
moreover, akt2 ko mice exhibited impaired ampk signaling in response to insulin stimulation compared with wt mice. |
2021-03-23 |
2023-08-13 |
mouse |
| Lina He, Yang Li, Ni Zeng, Bangyan L Stile. Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2. The Biochemical journal. vol 477. issue 5. 2020-10-21. PMID:32096546. |
we found that, in the absence of insulin signal, akt2 is required for maintaining the basal level expression of phosphoenolpyruvate carboxyl kinase (pepck) and to a lesser extent g6pase, two key rate-limiting enzymes for gluconeogenesis that support glucose excursion due to pyruvate loading. |
2020-10-21 |
2023-08-13 |
Not clear |
| Lina He, Yang Li, Ni Zeng, Bangyan L Stile. Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2. The Biochemical journal. vol 477. issue 5. 2020-10-21. PMID:32096546. |
when insulin signal is absent, this activity appears to be inhibited by akt2 in manner that is independent of its phosphorylation by akt. |
2020-10-21 |
2023-08-13 |
Not clear |
| Lina He, Yang Li, Ni Zeng, Bangyan L Stile. Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2. The Biochemical journal. vol 477. issue 5. 2020-10-21. PMID:32096546. |
together, this action of akt2 on foxo1 and creb to maintain basal gluconeogenesis activity may provide fine-tuning for insulin and glucocorticoid/glucagon to regulate gluconeogenesis in a timely manner to meet metabolic needs. |
2020-10-21 |
2023-08-13 |
Not clear |
| Xinyu Chen, Majd M Ariss, Gopalakrishnan Ramakrishnan, Veronique Nogueira, Catherine Blaha, William Putzbach, Abul B M M K Islam, Maxim V Frolov, Nissim Ha. Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer. Molecular cell. vol 80. issue 1. 2020-10-14. PMID:32931746. |
elevated circulating insulin level induced by akt2 systemic deletion hyperactivates tumor akt, exacerbating erbb2-mediated tumorigenesis, curbed by pharmacological reduction of the elevated insulin. |
2020-10-14 |
2023-08-13 |
mouse |
| Juwen C DuBois, Alex K Ray, Ross C Gruber, Yongwei Zhang, Ranee Aflakpui, Fernando Macian-Juan, Bridget Shafit-Zagard. Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. Frontiers in immunology. vol 10. 2020-10-13. PMID:31404142. |
while the isoforms akt1 and akt2 are involved in apoptosis and insulin signaling, respectively, the role for akt3 remains uncertain. |
2020-10-13 |
2023-08-13 |
mouse |
| Xin-Yu Huang, Liang Zhang, Jian Sun, Neng-Gui Xu, Wei Y. Acupuncture Alters Expression of Insulin Signaling Related Molecules and Improves Insulin Resistance in OLETF Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2020-09-30. PMID:27738449. |
mrna expressions of several insulin signaling related molecules irs1, irs2, akt2, apkc |
2020-09-30 |
2023-08-13 |
rat |
| Roger Mariné-Casadó, Cristina Domenech-Coca, Josep M Del Bas, Cinta Bladé, Lluís Arola, Antoni Caimar. The Exposure to Different Photoperiods Strongly Modulates the Glucose and Lipid Metabolisms of Normoweight Fischer 344 Rats. Frontiers in physiology. vol 9. 2020-09-30. PMID:29725308. |
compared with l12 rats, l6 animals displayed a marked alteration of glucose homeostasis and fatty acid uptake and oxidation, which were evidenced by the following observations: (1) increased circulating levels of glucose and non-esterified fatty acids; (2) a sharp down-regulation of the phosphorylated akt2 levels, a downstream post-receptor target of insulin, in both the soleus and gastrocnemius muscles; (3) decreased expression in the soleus muscle of the glucose metabolism-related microrna-194 and lower mrna levels of the genes involved in glucose metabolism ( |
2020-09-30 |
2023-08-13 |
rat |
| Xing Xiao, Pei Qiu, Hui-Zhen Gong, Xue-Ming Chen, Yan Sun, An Hong, Yi M. PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity. Journal of cellular and molecular medicine. vol 23. issue 9. 2020-08-28. PMID:31270932. |
our previous study showed that fas apoptosis inhibitory molecule (faim) is a new mediator of akt2 signalling, increases the insulin signalling pathway and lipid metabolism. |
2020-08-28 |
2023-08-13 |
mouse |
| Dorte E Steenberg, Janne R Hingst, Jesper B Birk, Anette Thorup, Jonas M Kristensen, Kim A Sjøberg, Bente Kiens, Erik A Richter, Jørgen F P Wojtaszewsk. A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action. Diabetes. vol 69. issue 4. 2020-08-03. PMID:31974138. |
insulin signaling at the level of akt2 was impaired in the nonexercised muscle on the exercise day, suggesting that decreased insulin action in nonexercised muscle may reduce glut4 translocation in response to insulin. |
2020-08-03 |
2023-08-13 |
human |
| N Jaiswal, M G Gavin, W J Quinn, T S Luongo, R G Gelfer, J A Baur, P M Titchenel. The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Molecular metabolism. vol 28. 2020-06-22. PMID:31444134. |
mice and humans harboring systemic loss-of-function mutations in akt2, the most abundant akt isoform in metabolic tissues, are glucose intolerant and insulin resistant. |
2020-06-22 |
2023-08-13 |
mouse |
| Filip Roudnicky, Yanjun Lan, Max Friesen, Gregor Dernick, Jitao David Zhang, Andreas Staempfli, Natalie Bordag, Antje Wagner-Golbs, Klaus Christensen, Martin Ebeling, Martin Graf, Mark Burcin, Claas Aiko Meyer, Chad A Cowan, Christoph Patsc. Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype. International journal of molecular sciences. vol 20. issue 24. 2020-04-23. PMID:31835296. |
the kinase akt2 (pkb) is an important mediator of insulin signaling, for which loss-of-function knockout (ko) mutants lead to early onset diabetes mellitus, and dominant active mutations lead to early development of obesity and endothelial cell (ec) dysfunction. |
2020-04-23 |
2023-08-13 |
human |
| Nobuyuki Takenaka, Mika Nakao, Sayaka Matsui, Takaya Sato. A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes. International journal of molecular sciences. vol 20. issue 21. 2020-03-30. PMID:31683681. |
a crucial role for the small gtpase rac1 downstream of the protein kinase akt2 in insulin signaling that regulates glucose uptake in mouse adipocytes. |
2020-03-30 |
2023-08-13 |
mouse |