| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaohua Zheng, Gregory D Carte. Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle. Scientific reports. vol 6. 2018-06-29. PMID:27966646. |
the results revealed that: 1) insulin increased muscle membrane localization of akt2, but not akt1; 2) insulin increased akt2 phosphorylation in the cytosol and membrane fractions; 3) insulin increased as160 localization to the cytosol and membranes; and 4) insulin increased as160 phosphorylation in the cytosol, but not membranes. |
2018-06-29 |
2023-08-13 |
rat |
| Xiaohua Zheng, Gregory D Carte. Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle. Scientific reports. vol 6. 2018-06-29. PMID:27966646. |
these results demonstrate distinctive insulin effects on the subcellular redistribution of akt2 and its substrate as160 in skeletal muscle. |
2018-06-29 |
2023-08-13 |
rat |
| Dean L Kellogg, Karen M McCammon, Kathryn S Hinchee-Rodriguez, Martin L Adamo, Linda J Roma. Neuronal nitric oxide synthase mediates insulin- and oxidative stress-induced glucose uptake in skeletal muscle myotubes. Free radical biology & medicine. vol 110. 2018-04-12. PMID:28666850. |
we found that insulin stimulation of neuronal nitric oxide synthase (nnos) phosphorylation, no production, and glut4 translocation were all significantly reduced by inhibition of either nnos or akt2. |
2018-04-12 |
2023-08-13 |
Not clear |
| Dougall M Norris, Pengyi Yang, James R Krycer, Daniel J Fazakerley, David E James, James G Burchfiel. An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction. Journal of cell science. vol 130. issue 16. 2018-02-08. PMID:28663386. |
in 3t3-l1 adipocytes, stimulation with insulin resulted in recruitment of akt2 to the plasma membrane in a polarised fashion. |
2018-02-08 |
2023-08-13 |
Not clear |
| Dougall M Norris, Pengyi Yang, James R Krycer, Daniel J Fazakerley, David E James, James G Burchfiel. An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction. Journal of cell science. vol 130. issue 16. 2018-02-08. PMID:28663386. |
additionally, we observed oscillations in plasma membrane localised akt2 in the presence of insulin with a consistent periodicity of 2 min. |
2018-02-08 |
2023-08-13 |
Not clear |
| Qiurong Wang, Jun Re. mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacological research. vol 111. 2018-01-05. PMID:27363949. |
akt2, a critical member of the akt family, plays an essential role in insulin signaling. |
2018-01-05 |
2023-08-13 |
mouse |
| Qiurong Wang, Jun Re. mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacological research. vol 111. 2018-01-05. PMID:27363949. |
this study was designed to examine the effect of trehalose, an mtor-independent autophagy inducer, on myocardial function in an akt2 knockout-induced insulin resistance model. |
2018-01-05 |
2023-08-13 |
mouse |
| Q Ling, H Xie, J Li, J Liu, J Cao, F Yang, C Wang, Q Hu, X Xu, S Zhen. Donor Graft MicroRNAs: A Newly Identified Player in the Development of New-onset Diabetes After Liver Transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 17. issue 1. 2017-12-11. PMID:27458792. |
irs2, pik3r1, akt2, and gsk3b) were involved in glucose import and the insulin signaling pathway. |
2017-12-11 |
2023-08-13 |
human |
| Mei-Qin Zhuo, Ya-Xiong Pan, Kun Wu, Yi-Huan Xu, Li-Han Zhang, Zhi Lu. AKTs/PKBs: molecular characterization, tissue expression and transcriptional responses to insulin and/or wortmannin in yellow catfish Pelteobagrus fulvidraco. Fish physiology and biochemistry. vol 43. issue 3. 2017-11-07. PMID:28000079. |
intraperitoneal insulin injection and incubation increased the mrna expression of akt1 and akt2, but not that of akt3a and akt3b in the liver and hepatocytes of yellow catfish. |
2017-11-07 |
2023-08-13 |
Not clear |
| Mei-Qin Zhuo, Yan-Xiong Pan, Kun Wu, Yi-Huan Xu, Zhi Lu. Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco. General and comparative endocrinology. vol 247. 2017-10-09. PMID:28410969. |
in the in vivo study, insulin treatment significantly increased hepatic protein content at 3h, accompanied with reduced plasma total amino acid contents and liver alt activity, and with increased total rna content and the mrna levels of pi3kcb, pi3kc2a, akt2, mtorc1 and s6k1 in liver. |
2017-10-09 |
2023-08-13 |
Not clear |
| Mei-Qin Zhuo, Yan-Xiong Pan, Kun Wu, Yi-Huan Xu, Zhi Lu. Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco. General and comparative endocrinology. vol 247. 2017-10-09. PMID:28410969. |
at 6h and 12h, insulin injection showed no significant effect on liver protein content and plasma total amino acid, but reduced liver alt activity and increased liver total rna and the mrna levels of akt2, mtorc1 and s6k1 in liver at 6h. |
2017-10-09 |
2023-08-13 |
Not clear |
| Mei-Qin Zhuo, Yan-Xiong Pan, Kun Wu, Yi-Huan Xu, Zhi Lu. Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco. General and comparative endocrinology. vol 247. 2017-10-09. PMID:28410969. |
in the in vitro study, insulin incubation also tended to increase protein content of hepatocytes, accompanied with reduced cell medium total amino acid contents and hepatocytes alt activity, and increased total rna content and the mrna levels of pi3kcb, pi3kc2a, akt2, mtorc1 and s6k1 in hepatocytes. |
2017-10-09 |
2023-08-13 |
Not clear |
| Mei-Qin Zhuo, Yan-Xiong Pan, Kun Wu, Yi-Huan Xu, Zhi Lu. Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco. General and comparative endocrinology. vol 247. 2017-10-09. PMID:28410969. |
akt2 and s6k1 mrna levels at 6 and 12h, mrna levels of mtorc1, 4e-bp1 and eef2 at 3 and 6h, and eif-4e mrna levels at 3 and 12h, pi3kcb and pi3kc2a mrna levels were significantly lower in insulin+wortmannin group than those in single insulin group. |
2017-10-09 |
2023-08-13 |
Not clear |
| Agné Kulyté, Anna Ehrlund, Peter Arner, Ingrid Dahlma. Global transcriptome profiling identifies KLF15 and SLC25A10 as modifiers of adipocytes insulin sensitivity in obese women. PloS one. vol 12. issue 6. 2017-09-26. PMID:28570579. |
these genes are enriched in pathways related to glucose and amino acid metabolism, cellular respiration, and insulin signaling, and include genes such as slc2a4, akt2, as well as genes coding for enzymes in the mitochondria respiratory chain. |
2017-09-26 |
2023-08-13 |
Not clear |
| Marina Minic, Nuno Rocha, Julie Harris, Matthijs P Groeneveld, Sarah Leiter, Nicholas Wareham, Alison Sleigh, Pascale De Lonlay, Khalid Hussain, Stephen O'Rahilly, Robert K Sempl. Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia. The Journal of clinical endocrinology and metabolism. vol 102. issue 8. 2017-09-20. PMID:28541532. |
the activating p.glu17lys mutation in akt2, a kinase mediating many of insulin's metabolic actions, causes hypoinsulinemic hypoglycemia and left-sided hemihypertrophy. |
2017-09-20 |
2023-08-13 |
Not clear |
| Zhenjiang Liu, Lu Gan, Guannv Liu, Yizhe Chen, Tianjiao Wu, Fei Feng, Chao Su. Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice. Journal of lipid research. vol 57. issue 8. 2017-09-05. PMID:27317762. |
moreover, activation of akt2 signal by using insulin significantly blunted the inhibitory effect of res on adipose inflammation. |
2017-09-05 |
2023-08-13 |
mouse |
| Richard N Bergman, Malini S Iye. Indirect Regulation of Endogenous Glucose Production by Insulin: The Single Gateway Hypothesis Revisited. Diabetes. vol 66. issue 7. 2017-08-29. PMID:28637826. |
more recently, mice lacking hepatic foxo1 in addition to akt1 and akt2 (l-aktfoxo1tko), all required for insulin signaling, surprisingly showed normal glycemia. |
2017-08-29 |
2023-08-13 |
mouse |
| Samuel A Molina, Hannah K Moriarty, Daniel T Infield, Barry R Imhoff, Rachel J Vance, Agnes H Kim, Jason M Hansen, William R Hunt, Michael Koval, Nael A McCart. Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 5. 2017-07-31. PMID:28213469. |
insulin stimulation of akt1 and akt2 signaling in cf airway cells was diminished compared with that observed in airway cells expressing wild-type cftr. |
2017-07-31 |
2023-08-13 |
human |
| Nobuyuki Takenaka, Yuma Nihata, Takaya Sato. Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle. PloS one. vol 11. issue 5. 2017-07-05. PMID:27163697. |
several lines of evidence suggested that the protein kinase akt2 plays a key role in this insulin action. |
2017-07-05 |
2023-08-13 |
mouse |
| Nobuyuki Takenaka, Yuma Nihata, Takaya Sato. Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle. PloS one. vol 11. issue 5. 2017-07-05. PMID:27163697. |
small interfering rna knockdown of flj00068 markedly diminished glut4 translocation to the sarcolemma following insulin administration or ectopic expression of a constitutively activated mutant of either phosphoinositide 3-kinase or akt2. |
2017-07-05 |
2023-08-13 |
mouse |