| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Mark P Pabona, Alexander F Burnett, Dustin M Brown, Charles M Quick, Frank A Simmen, Maria Theresa E Montales, Shi J Liu, Tyler Rose, Iad Alhallak, Eric R Siegel, Rosalia Cm Simme. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reproductive sciences (Thousand Oaks, Calif.). vol 27. issue 1. 2020-12-07. PMID:32046384. |
endometrial tumors obtained at surgery (met, n = 4; con, n = 4) were analyzed for proliferation (ki67), apoptosis (tunel), and nuclear expression of erα, pgr, pten, and klf9 proteins in tumor glandular epithelial (ge) and stromal (st) cells. |
2020-12-07 |
2023-08-13 |
human |
| Mengyi Shen, Ruoting Men, Xiaoli Fan, Tingting Wang, Chen Huang, Haoran Wang, Tinghong Ye, Xuefeng Luo, Li Yan. Total glucosides of paeony decreases apoptosis of hepatocytes and inhibits maturation of dendritic cells in autoimmune hepatitis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 124. 2020-11-12. PMID:32004939. |
in vitro, tgp pretreatment ameliorated the con a-induced mitochondrial membrane potential decline, reactive oxygen species increase, and apoptosis increase in hepatocytes. |
2020-11-12 |
2023-08-13 |
mouse |
| Dongjie Liu, Renbing Yuan, Fang Yang, Dehui Zhan. Effects of tanshinones mediated by forkhead box O3a transcription factor on the proliferation and apoptosis of lung cancer cells. Oncology letters. vol 17. issue 1. 2020-09-30. PMID:30655786. |
similarly, compared with con, flow cytometry results revealed that ts induce lc cell apoptosis in a dose-dependent manner (p<0.05). |
2020-09-30 |
2023-08-13 |
Not clear |
| Hui Zhang, Yang Bai, Min Gao, Junfeng Zhang, Guanjun Dong, Fenglian Yan, Qun Ma, Xingqin Fu, Qingqing Zhang, Chunxia Li, Hui Shi, Zhaochen Ning, Jun Dai, Zhihua Li, Jiankuo Ming, Qingjie Xue, Chuanping Si, Huabao Xion. Hepatoprotective effect of capsaicin against concanavalin A-induced hepatic injury via inhibiting oxidative stress and inflammation. American journal of translational research. vol 11. issue 5. 2020-09-29. PMID:31217872. |
our findings indicate that capsaicin pretreatment protects mice from con a-induced hepatic damage and is partially involved in inhibiting hepatocyte apoptosis, oxidative stress, and inflammatory mediators as well as regulating activation and recruitment of intrahepatic leukocytes. |
2020-09-29 |
2023-08-13 |
mouse |
| Peilu Jia, Shuli Ji, Hao Zhang, Yanan Chen, Tian Wan. Piceatannol Ameliorates Hepatic Oxidative Damage and Mitochondrial Dysfunction of Weaned Piglets Challenged with Diquat. Animals : an open access journal from MDPI. vol 10. issue 7. 2020-09-28. PMID:32708214. |
compared to the results of the con group, dq increased the percentage of apoptosis cells in the liver, also decreased the amount of reduced glutathione (gsh) and increased the concentration of malondialdehyde (mda). |
2020-09-28 |
2023-08-13 |
human |
| Qian Chen, Pu Wang, Qingmei Zhang, Meng Xia, Guizhong Zhang, Junxin Li, Enyun Shen, Youhai H Chen, Xiaochun Wa. Preclinical studies of a death receptor 5 fusion protein that ameliorates acute liver failure. Journal of molecular medicine (Berlin, Germany). vol 97. issue 9. 2020-06-17. PMID:31230087. |
sdr5-fc bound with high affinity to both human and monkey tumor necrosis factor-related apoptosis-inducing ligand (trail) effectively blocked trail-induced apoptosis in vitro and significantly ameliorated alf induced by concanavalin a (con a) in mice. |
2020-06-17 |
2023-08-13 |
mouse |
| Ze-Bing Huang, Yi-Xiang Zheng, Ning Li, Sheng-Lan Cai, Yan Huang, Juan Wang, Xing-Wang Hu, Yang Wang, Jie Wu, Xue-Gong Fa. Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice. Acta pharmacologica Sinica. vol 40. issue 11. 2020-04-13. PMID:30918343. |
we found that con a caused severe acute liver injury evidenced by significantly increased serum aminotransferase levels, massive hepatocyte apoptosis, and necrosis, as well as lymphocyte infiltration in liver tissues. |
2020-04-13 |
2023-08-13 |
mouse |
| Ze-Bing Huang, Yi-Xiang Zheng, Ning Li, Sheng-Lan Cai, Yan Huang, Juan Wang, Xing-Wang Hu, Yang Wang, Jie Wu, Xue-Gong Fa. Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice. Acta pharmacologica Sinica. vol 40. issue 11. 2020-04-13. PMID:30918343. |
treatment with gw significantly ameliorated con a-induced pathological injury in liver tissue, decreased serum aminotransferase levels, and decreased hepatocyte apoptosis. |
2020-04-13 |
2023-08-13 |
mouse |
| Ze-Bing Huang, Yi-Xiang Zheng, Ning Li, Sheng-Lan Cai, Yan Huang, Juan Wang, Xing-Wang Hu, Yang Wang, Jie Wu, Xue-Gong Fa. Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice. Acta pharmacologica Sinica. vol 40. issue 11. 2020-04-13. PMID:30918343. |
in the coculture of jurkat t cells with l02 liver cells, gw dose-dependently protected l02 cells from apoptosis induced by con a (5 μg/ml). |
2020-04-13 |
2023-08-13 |
mouse |
| Helen R. Chernykh, Maxim N. Norkin, Olga Yu. Leplina, Nataliya A. Khonina, Marina A. Tihonova, Alexander A. Ostani. Peripheral T Cell Apoptosis and Its Role in Generalized Bacterial Infections: A Minireview. Russian journal of immunology : RJI : official journal of Russian Society of Immunology. vol 6. issue 2. 2019-11-20. PMID:12687214. |
to characterize t cell death and its role in the pathogenesis of bacterial infections an anti-cd3-mab or con a-induced apoptosis in patients with severe and generalized forms of surgical infections have been investigated. |
2019-11-20 |
2023-08-12 |
Not clear |
| Kun Peng Song, Peng Shu, Ju Lei Ma, Bing Wang, Bo Che. [Ribosomal Protein S9 Expression in Multiple Myeloma and Its Effect on Cell Biological Function]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 41. issue 2. 2019-08-20. PMID:31060671. |
methods bone marrow mononuclear cells were harvested in 10 healthy volunteers(con group)and bone marrow cd138 +cells from 30 mm patients(cd138+group).quantitative polymerase chain reaction(qpcr)was performed to detect rps9 expression at mrna level.in three cases from con group and 11 cases from cd138+group,western blot was performed to detect rps9 at protein level.gse19784 dataset was employed to detect the relationships of rps9 expression with the overall survival rate,nuclear factor-κb(nf-κb),small ubiquitin-like modifier(sumo),and ubiquitin pathway.after the rps9 knock-down vector was constructed,flow cytometry was performed to detect the infection efficiency and qpcr and western blot to detect the knock-down efficiency.rpmi8226 was divided into con group and rps9-short hairpin rna(shrna)group,in which annexin v allophycocyanin/propidium iodide(pi)double staining was performed to detect the change of apoptosis,cck8 to detect the proliferation change,and pi staining to detect cell cycle change.after sentrin-specific protease 1(senp1)overexpression vector was constructed,western blot was performed to detect the phosphorylation of p65 and inhibitory subunit-κbα(iκbα)from nf-κb pathway in con,rps9-shrna,and rps9-shrna-senp1 cells;in addition,annexin v/pi double staining was also performed to detect the apoptosis in these three cells. |
2019-08-20 |
2023-08-13 |
human |
| Kun Peng Song, Peng Shu, Ju Lei Ma, Bing Wang, Bo Che. [Ribosomal Protein S9 Expression in Multiple Myeloma and Its Effect on Cell Biological Function]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 41. issue 2. 2019-08-20. PMID:31060671. |
results the relative expression of rps9 in con group and cd138+group was(1.00±0.12)and(5.45±0.71),respectively(t=4.291,p=0.0036).western blot showed rps9 expression was high in most myeloma cd138+cells.the high expression of rps9 was associated with both extramedullary invasion and overall survival in gse19784 dataset.after rpmi8226 was infected with con or rps9-shrna lentivirus for 48 hours,flow cytometry confirmed that the infection efficiencies were above 90% in both groups.qpcr and western blot confirmed that rps9 expression was inhibited at both mrna and protein levels.after rpmi8226 con and rps9-shrna infected with virus for 48 hours,the proportion of annexin v-positive cells in con and rps9-shrna cells was(3.47±0.37)% and(18.60±64.00)%(t=9.015,p=0.0008).the proliferation index significantly differed between con group and rps9-shrna group at 72 hours(t=6.846,p=0.0024).when con and rps9-shrna were infected with virus for 48 hours,the proportion of g2 phase cells was(29.28±3.42)% and(10.43±1.43)%,respectively(t=9.329,p=0.0007).the rps9 expression was positively correlated with senp1 in gse19784 dataset and negatively correlated with iκbα coding gene nfkbia.western blot further confirmed that rps9 knockdown inhibited the expression of senp1,inhibited the phosphorylation of nf-κb subunit p65 and inhibitor iκbα,and promoted the expression of iκbα.overexpression of senp1 not only impeded this effect but also reduced rps9-induced apoptosis. |
2019-08-20 |
2023-08-13 |
human |
| Chao Ji, Ju Lei Ma, Peng Sh. [Effect of Denticleless E3 Ubiquitin Protein Ligase on Proliferation and Colone Formation of Multiple Myeloma Cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 41. issue 2. 2019-08-20. PMID:31060674. |
methods mononuclear cells were extracted from 34 mm patients.mononuclear cells harvested from 14 healthy volunteers were used as controls.quantitative polymerase chain reaction was used to detect the change of dtl at mrna level.furthermore,12 mm patients and 2 controls were selected,in whom the change of dtl at protein level was detected by western blot.human mm cell line rpmi8226 was divided into control(con)group and dtl-short hairpin rna(dtl-shrna)group,which was infected with the con and dtl-shrna virus,respectively,for 48 hours.the infection efficiency was detected by using flow cytometry,the knock-down efficiencies at mrna and protein levels were detected by quantitative polymerase chain reaction and western blot,the change of cell counts in the next 0,24,48,72,96 hours were measured with cck8 assay.the con and dtl-shrna cells were cultured in semisolid medium.ten days later,inverted phase microscopy was used to measure the number of colones that contain more than 50 cells,annexin v/propidium iodide double staining to detect apoptosis,and propidium iodide staning to detect cell cycle.finally,western blot was empoyed to detect the phosphorylation of p65 and inhibitory subunit-κbα(iκbα)in nuclear factor-κb(nf-κb)pathway and electrophoretic mobility shift assay(emsa)to detect the nf-κb transcriptional ability. |
2019-08-20 |
2023-08-13 |
human |
| Ehsan Almasi, Marjan Gharagozloo, Nahid Eskandari, Afshin Almasi, Ali Mohammad Sabzghabae. Inhibition of Apoptosis and Proliferation in T Cells by Immunosuppressive Silymarine. Iranian journal of allergy, asthma, and immunology. vol 16. issue 2. 2019-07-01. PMID:28601050. |
the aim of this study was to compare effects of silymarin, rapamycin and fk506 on proliferation and apoptosis of human t cells stimulated with con a. |
2019-07-01 |
2023-08-13 |
human |
| Min Chen, Chang Chen, Xiaohui Yuan, Xiaoqi Chen, Feng Zheng, Liang Shao, Zongze Zhan. Angiotensin II aggravates lipopolysaccharide induced human pulmonary microvascular endothelial cells permeability in high glucose status. Endocrine journal. vol 65. issue 7. 2018-11-14. PMID:29709898. |
compared to the con group, the hg, lh and lha groups had significantly higher cellular permeability, cellular apoptosis and tnf-α levels, with more extensive cytoskeletal damage and lower f-actin levels. |
2018-11-14 |
2023-08-13 |
human |
| Jiajie Chen, Xu Sun, Tingting Xia, Qiqi Mao, Liang Zhon. Pretreatment with dihydroquercetin, a dietary flavonoid, protected against concanavalin A-induced immunological hepatic injury in mice and TNF-α/ActD-induced apoptosis in HepG2 cells. Food & function. vol 9. issue 4. 2018-09-25. PMID:29589006. |
our findings suggest that the immunosuppressive effects of dhq ameliorated con a-mediated immunological liver injury by reducing the expression of pro-inflammatory mediators and infiltration of cd4+ and cd8+ t cells in liver tissues, and dhq protected hepg2 cells against tnf-α/actd-induced apoptosis possibly via modulation of the caspase and nf-kb pathways. |
2018-09-25 |
2023-08-13 |
mouse |
| Wei-Wei Zhang, Feng Xu, Ding Wang, Jia Ye, Shao-Qing Ca. Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences. Chinese journal of natural medicines. vol 16. issue 3. 2018-08-24. PMID:29576055. |
the following actions of these 15 compounds were revealed: 1) ferulic acid, calycosin, formononetin, astrapterocarpan-3-o-β-d-glucoside, paeonol, calycosin-7-o-β-d-glucoside, astraisoflavan-7-o-β-d-glucoside, ligustrazine, and propyl gallate significantly suppressed concanavalin a (con a)-induced t lymphocyte proliferation; 2) propyl gallate, calycosin-7-o-β-d-glucoside, paeonol, and ferulic acid markedly inhibited lps-induced apoptosis in raw264.7 cells; 3) propyl gallate and formononetin significantly inhibited lps-induced no release; 4) hydroxysafflor yellow a and inosine protected pc12 cells against the injuries caused by glutamate; and 5) formononetin, astragaloside iv, astraisoflavan-7-o-β-d-glucoside, inosine, paeoniflorin, ononin, paeonol, propyl gallate, ligustrazine, and ferulic acid significantly suppressed the constriction of the thoracic aorta induced by kcl in rats. |
2018-08-24 |
2023-08-13 |
rat |
| Soyong Jang, Taddesse Yayeh, Yea-Hyun Leem, Eun-Mi Park, Yoshihisa Ito, Seikwan O. Concanavalin A Induces Cortical Neuron Apoptosis by Causing ROS Accumulation and Tyrosine Kinase Activation. Neurochemical research. vol 42. issue 12. 2018-08-02. PMID:29019035. |
taken together, con a-induced apoptosis in cortical neurons occurred as a sequel to con a binding to neuronal glycoproteins and intracellular ros accumulation. |
2018-08-02 |
2023-08-13 |
rat |
| Jiyoung Park, Hayeon Kim, In-Seung Lee, Kang-Hoon Kim, Yumi Kim, Yun-Cheol Na, Jang-Hoon Lee, Hyeung-Jin Jan. The therapeutic effects of Yongdamsagan-tang on autoimmune hepatitis models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-18. PMID:28763748. |
furthermore, pretreatment with yst protected hepatic damage and reduces histological injury by suppressing apoptosis mediator and inflammatory cytokines expression in concanavalin a (con a)-induced autoimmune hepatitis mice model. |
2018-05-18 |
2023-08-13 |
mouse |
| Zhiqiang Zhang, Jinyi Lang, Zhi Cao, Rong Li, Xingyong Wang, Weidong Wan. Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue. Oncotarget. vol 8. issue 5. 2018-02-26. PMID:27999194. |
stably transfected ht-29 colorectal cancer cells and ccd 841 con normal colorectal cells were irradiated to a dose of 6-gy, and cell proliferation and apoptosis were observed. |
2018-02-26 |
2023-08-13 |
mouse |