| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Trautwein, T Rakemann, N P Malek, J Plümpe, G Tiegs, M P Mann. Concanavalin A-induced liver injury triggers hepatocyte proliferation. The Journal of clinical investigation. vol 101. issue 9. 1998-06-08. PMID:9576761. |
this study demonstrates that after con a injection, tnf- and il-6- dependent signals trigger nuclear events regulating hepatocyte apoptosis and proliferation during liver injury. |
1998-06-08 |
2023-08-12 |
mouse |
| C Trautwein, T Rakemann, D A Brenner, K Streetz, L Licato, M P Manns, G Tieg. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology. vol 114. issue 5. 1998-05-22. PMID:9558294. |
concanavalin a (con a) induces tumor necrosis factor (tnf)-dependent hepatocyte apoptosis resembling immune-mediated fulminant hepatic failure in humans. |
1998-05-22 |
2023-08-12 |
mouse |
| T Dao, J W Huleatt, R Hingorani, I N Crisp. Specific resistance of T cells to CD95-induced apoptosis during S phase of the cell cycle. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 9. 1997-11-12. PMID:9379021. |
we have examined the susceptibility of mouse thymocytes and con a-activated mature t cells to cd95 (fas; apo-1)-induced apoptosis at different phases of the cell cycle. |
1997-11-12 |
2023-08-12 |
mouse |
| A Horigome, T Hirano, K Oka, H Takeuchi, E Sakurai, K Kozaki, N Matsuno, T Nagao, M Kozak. Glucocorticoids and cyclosporine induce apoptosis in mitogen-activated human peripheral mononuclear cells. Immunopharmacology. vol 37. issue 1. 1997-10-29. PMID:9285247. |
here we show that potent immunosuppressive gcs and csa induce apoptosis in concanavalin a (con a)-activated human pbmcs. |
1997-10-29 |
2023-08-12 |
human |
| G Tieg. Experimental hepatitis and role of cytokines. Acta gastro-enterologica Belgica. vol 60. issue 2. 1997-09-08. PMID:9260332. |
administration of the t cell mitogen concanavalin a (con a) to unsensitized mice also resulted in hepatic apoptosis and the ensuing necrosis. |
1997-09-08 |
2023-08-12 |
mouse |
| Y Tagawa, K Sekikawa, Y Iwakur. Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 3. 1997-08-14. PMID:9233639. |
since apoptosis of liver cells was rarely observed in con a-treated lpr/lpr mice, involvement of the fas-fas ligand system in this apoptotic process was suggested. |
1997-08-14 |
2023-08-12 |
mouse |
| Y Tagawa, K Sekikawa, Y Iwakur. Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 3. 1997-08-14. PMID:9233639. |
these observations suggest that ifn-gamma plays a central role in con a-hepatitis by activating fas-induced apoptosis of liver cells. |
1997-08-14 |
2023-08-12 |
mouse |
| D J Smith, M J McGuire, M J Tocci, D L Thiel. IL-1 beta convertase (ICE) does not play a requisite role in apoptosis induced in T lymphoblasts by Fas-dependent or Fas-independent CTL effector mechanisms. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 1. 1997-01-30. PMID:8977187. |
in addition, anti-fas abs induced apoptosis in thymocytes, con a-stimulated spleen t cells, lps-stimulated spleen b cells, and thymocytes from ice -/- mice. |
1997-01-30 |
2023-08-12 |
mouse |
| C C Solorzano, R Ksontini, J H Pruitt, P J Hess, P D Edwards, A Kaibara, A Abouhamze, T Auffenberg, R E Galardy, J N Vauthey, E M Copeland, C K Edwards, G Y Lauwers, M Clare-Salzler, S L MacKay, L L Moldawer, D D Lazaru. Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 1. 1997-01-30. PMID:8977217. |
in con a-induced hepatitis, gm-6001 actually exacerbates hepatocellular necrosis and apoptosis despite greater than 90% reduction in plasma tnf-alpha concentrations. |
1997-01-30 |
2023-08-12 |
mouse |
| C C Solorzano, R Ksontini, J H Pruitt, P J Hess, P D Edwards, A Kaibara, A Abouhamze, T Auffenberg, R E Galardy, J N Vauthey, E M Copeland, C K Edwards, G Y Lauwers, M Clare-Salzler, S L MacKay, L L Moldawer, D D Lazaru. Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 1. 1997-01-30. PMID:8977217. |
our studies suggest that cell-associated tnf-alpha plays a role in the hepatocellular necrosis and apoptosis that accompany d-galn/lps- or con a-induced hepatitis, and that matrix metalloproteinase inhibitors are ineffective in preventing this hepatic injury. |
1997-01-30 |
2023-08-12 |
mouse |
| S Z Liu, Y C Zhang, Y Mu, X Su, J X Li. Thymocyte apoptosis in response to low-dose radiation. Mutation research. vol 358. issue 2. 1996-12-30. PMID:8946023. |
when thymocytes were cultured 24 h after wbi with 75 mgy x-rays in complete rpmi 1640 medium, a reduction in apoptosis was observed in the course of incubation for 72 h, and the presence of con a in the medium accentuated this reduction in a dose- and time-dependent manner. |
1996-12-30 |
2023-08-12 |
mouse |
| K L Anderson, G Anderson, R H Michell, E J Jenkinson, J J Owe. Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 11. 1996-08-08. PMID:8666773. |
in contrast, con a stimulates ptdins(4,5)p2 hydrolysis, but does not induce thymocyte apoptosis. |
1996-08-08 |
2023-08-12 |
mouse |
| K L Anderson, G Anderson, R H Michell, E J Jenkinson, J J Owe. Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 11. 1996-08-08. PMID:8666773. |
anti-cd3, anti-fas, and con a all fail to change thymic camp levels, but beta-adrenergic stimulation causes a large increase in intracellular camp, and agents that elevate camp induce thymocyte apoptosis. |
1996-08-08 |
2023-08-12 |
mouse |
| A Ben-Amor, M C Leite-De-Moraes, F Lepault, E Schneider, F Machavoine, A Arnould, L Chatenoud, M D. In vitro T cell unresponsiveness following low-dose injection of anti-CD3 MoAb. Clinical and experimental immunology. vol 103. issue 3. 1996-05-28. PMID:8608651. |
the low proliferation was also not explained by apoptosis, following secondary challenge with con a. splenocytes from anti-cd3-injected mice were highly responsive to il-2, but generated little or no il-2, il-3, il-4 and interferon-gamma (ifn-gamma) when exposed to con a. |
1996-05-28 |
2023-08-12 |
mouse |
| O M Pitt. Con A cytotoxicity: a model for the study of key signaling steps leading to lymphocyte apoptosis in AIDS? Medical hypotheses. vol 45. issue 3. 1996-03-05. PMID:8569557. |
con a cytotoxicity: a model for the study of key signaling steps leading to lymphocyte apoptosis in aids? |
1996-03-05 |
2023-08-12 |
Not clear |
| G V Kulkarni, C A McCulloc. Concanavalin A induced apoptosis in fibroblasts: the role of cell surface carbohydrates in lectin mediated cytotoxicity. Journal of cellular physiology. vol 165. issue 1. 1995-10-31. PMID:7559793. |
we used con a to examine the role of cell surface carbohydrates in apoptosis. |
1995-10-31 |
2023-08-12 |
human |
| G V Kulkarni, C A McCulloc. Concanavalin A induced apoptosis in fibroblasts: the role of cell surface carbohydrates in lectin mediated cytotoxicity. Journal of cellular physiology. vol 165. issue 1. 1995-10-31. PMID:7559793. |
the sugar methyl-alpha-d-mannopyranoside (madm) competes for binding sites with con a but failed to induce apoptosis. |
1995-10-31 |
2023-08-12 |
human |