| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maureen N Ajuebor, Alex I Aspinall, Feng Zhou, Tai Le, Yang Yang, Stefan J Urbanski, Stéphané Sidobre, Mitchell Kronenberg, Cory M Hogaboam, Mark G Swai. Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 12. 2005-08-31. PMID:15944310. |
in this study, we demonstrate that ccr5 deficiency promotes the development of acute flf in mice following con a administration by preventing activated hepatic cd1d-restricted nkt cells (but not conventional t cells) from dying from activation-induced apoptosis. |
2005-08-31 |
2023-08-12 |
mouse |
| Maureen N Ajuebor, Alex I Aspinall, Feng Zhou, Tai Le, Yang Yang, Stefan J Urbanski, Stéphané Sidobre, Mitchell Kronenberg, Cory M Hogaboam, Mark G Swai. Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 12. 2005-08-31. PMID:15944310. |
the resistance of ccr5-deficient nkt cells from activation-induced apoptosis following con a administration is not due to a defective fas-driven death pathway. |
2005-08-31 |
2023-08-12 |
mouse |
| Yoshitaka Hirose, Shinji Murosaki, Yoshihiro Yamamoto, Hideyuki Ikematsu, Kikuo Nomot. Nigerooligosaccharides augments mitogen-induced proliferation and suppresses activation-induced apoptosis of human peripheral blood mononuclear cells. Immunopharmacology and immunotoxicology. vol 26. issue 3. 2005-08-05. PMID:15518172. |
stimulation of pbmc with con a or ok-432 induced apoptosis, but nigerose suppressed such activation-induced cell death. |
2005-08-05 |
2023-08-12 |
human |
| A Wang, D M McKa. Immune modulation by a high molecular weight fraction from the rat tapeworm Hymenolepis diminuta. Parasitology. vol 130. issue Pt 5. 2005-07-28. PMID:15991500. |
co-treatment with the h. diminuta extract (100 microg protein/ml) virtually abolished con a-induced immune cell proliferation, which was not due to increased apoptosis. |
2005-07-28 |
2023-08-12 |
human |
| Anabela Cordeiro-da-Silva, Joana Tavares, Natália Araújo, Fátima Cerqueira, Ana Tomás, Paul Kong Thoo Lin, Ali Ouaiss. Immunological alterations induced by polyamine derivatives on murine splenocytes and human mononuclear cells. International immunopharmacology. vol 4. issue 4. 2005-06-10. PMID:15099532. |
furthermore, the ability for these polyamine derivatives to induce apoptosis on con a-stimulated splenocytes could be related to their antiproliferative activity. |
2005-06-10 |
2023-08-12 |
mouse |
| Bhavani Shankar, Krishna B Saini. Cell cycle regulators modulating con A mitogenesis and apoptosis in low-dose radiation-exposed mice. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 24. issue 1. 2005-03-28. PMID:15715507. |
cell cycle regulators modulating con a mitogenesis and apoptosis in low-dose radiation-exposed mice. |
2005-03-28 |
2023-08-12 |
mouse |
| Bhavani Shankar, Krishna B Saini. Cell cycle regulators modulating con A mitogenesis and apoptosis in low-dose radiation-exposed mice. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 24. issue 1. 2005-03-28. PMID:15715507. |
in 20 cgy-exposed c57bl/6 mice, the caspase activity and apoptosis were reduced in con a-stimulated spleen cells as compared to sham controls. |
2005-03-28 |
2023-08-12 |
mouse |
| D J Campbell, J M Rawlings, P R Heaton, D G Blount, D I Pritchard, J J Strain, B M Hanniga. Insulin-like growth factor-I (IGF-I) and its association with lymphocyte homeostasis in the ageing cat. Mechanisms of ageing and development. vol 125. issue 7. 2005-03-02. PMID:15246745. |
while rhlgf-i induced low-level thymidine incorporation in the lymphocytes isolated from the senior group, it did not enhance the proliferative response to t-cell mitogens, con a and pha in either group, nor did it rescue cells from oxidatively induced apoptosis. |
2005-03-02 |
2023-08-12 |
human |
| S Santosh Kumar, Bhavani Shankar, Krishna B Saini. Effect of chlorophyllin against oxidative stress in splenic lymphocytes in vitro and in vivo. Biochimica et biophysica acta. vol 1672. issue 2. 2004-06-07. PMID:15110092. |
the extent of radiation-induced apoptosis and suppression of concanavalin a (con a)-induced mitogenesis ex vivo corresponded with changes in ros levels in chl-administered mice. |
2004-06-07 |
2023-08-12 |
mouse |
| Jieyun Jiang, Chunxiang Zhou, Qiang X. Alleviating effects of si-ni-san, a traditional Chinese prescription, on experimental liver injury and its mechanisms. Biological & pharmaceutical bulletin. vol 26. issue 8. 2004-04-07. PMID:12913256. |
si-ni-san facilitated apoptosis in nonparenchymal cells from liver-injured mice, as well as in spleen cells activated by pcl in vivo or by con a in vitro. |
2004-04-07 |
2023-08-12 |
mouse |
| Sawako Kobayashi, Shuichi Seki, Norifumi Kawada, Hiroyasu Morikawa, Kazuki Nakatani, Naoki Uyama, Kazuo Ikeda, Yuji Nakajima, Tetsuo Arakawa, Kenji Kaned. Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells. Cell and tissue research. vol 311. issue 3. 2004-02-11. PMID:12658443. |
in order to demonstrate t-cell apoptosis in the hepatic fibrotic tissue, we induced t-cell infiltration in the fibrotic liver of the rat by injecting concanavalin a (con a), a t-cell mitogen. |
2004-02-11 |
2023-08-12 |
human |
| Sawako Kobayashi, Shuichi Seki, Norifumi Kawada, Hiroyasu Morikawa, Kazuki Nakatani, Naoki Uyama, Kazuo Ikeda, Yuji Nakajima, Tetsuo Arakawa, Kenji Kaned. Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells. Cell and tissue research. vol 311. issue 3. 2004-02-11. PMID:12658443. |
in vitro experiments demonstrated that lymphocyte apoptosis was more frequently induced in the co-culture of con a-activated splenic t cells/activated hscs compared to that induced in activated t cells/quiescent hscs or resting t cells/activated hscs. |
2004-02-11 |
2023-08-12 |
human |
| Ruchi Pandey, Ramesh Chander, K B Saini. A novel prodigiosin-like immunosuppressant from an alkalophilic Micrococcus sp. International immunopharmacology. vol 3. issue 2. 2003-10-14. PMID:12586597. |
at inhibitory concentration, mampdm induced apoptosis in con a stimulated cells. |
2003-10-14 |
2023-08-12 |
mouse |
| Juan José Lasarte, Pablo Sarobe, Patricia Boya, Noelia Casares, Laura Arribillaga, Ascensión López-Díaz de Cerio, Marta Gorraiz, Francisco Borrás-Cuesta, Jesús Priet. A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage. Hepatology (Baltimore, Md.). vol 37. issue 2. 2003-03-12. PMID:12540797. |
we show that radce1 markedly attenuates hepatocellular apoptosis and the increase in serum transaminase levels after concanavalin a (con a) challenge. |
2003-03-12 |
2023-08-12 |
mouse |
| M A Pahlavani, J F Mele, A Richardso. Effect of overexpression of human Cu/Zn-SOD on activation-induced lymphocyte proliferation and apoptosis. Free radical biology & medicine. vol 30. issue 11. 2002-07-30. PMID:11368930. |
activation-induced apoptosis was determined by incubating the t cells with anti-cd3 (primary stimulus) for 72 h, followed by restimulation with con a (secondary stimulus) for various times. |
2002-07-30 |
2023-08-12 |
mouse |
| Y Segawa, Y Itokazu, N Inoue, T Saito, K Suzuk. Possible changes in expression of chemotaxin LECT2 mRNA in mouse liver after concanavalin A-induced hepatic injury. Biological & pharmaceutical bulletin. vol 24. issue 4. 2001-08-23. PMID:11305608. |
serum glutamate pyruvate transaminase (s-gpt) activity and the percentage of liver dna fragmentation, an indicator of hepatic apoptosis, increased 8 h after intravenous administration of con a (13 mg/kg). |
2001-08-23 |
2023-08-12 |
mouse |
| Y Segawa, Y Itokazu, N Inoue, T Saito, K Suzuk. Possible changes in expression of chemotaxin LECT2 mRNA in mouse liver after concanavalin A-induced hepatic injury. Biological & pharmaceutical bulletin. vol 24. issue 4. 2001-08-23. PMID:11305608. |
z-val-ala-asp(ome)-ch2f (z-vad-fmk), a caspase inhibitor, was administered to mice to investigate whether lect2 was involved in apoptosis of liver cells after con a injection. |
2001-08-23 |
2023-08-12 |
mouse |
| D Chen, R J McKallip, A Zeytun, Y Do, C Lombard, J L Robertson, T W Mak, P S Nagarkatti, M Nagarkatt. CD44-deficient mice exhibit enhanced hepatitis after concanavalin A injection: evidence for involvement of CD44 in activation-induced cell death. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 10. 2001-08-09. PMID:11342603. |
administration of lower doses of con a (12 mg/kg body weight) into cd44 wt mice induced hepatitis as evident from increased plasma aspartate aminotransferase levels accompanied by active infiltration of mononuclear cells and neutrophils, and significant induction of apoptosis in the liver. |
2001-08-09 |
2023-08-12 |
mouse |
| b' V Cupi\\xc4\\x87, M Coli\\xc4\\x87, L Pavici\\xc4\\x87, D Vucevi\\xc4\\x87, V M Varagi\\xc4\\x8. Immunomodulatory effect of xylazine, an alpha(2) adrenergic agonist, on rat spleen cells in culture. Journal of neuroimmunology. vol 113. issue 1. 2001-02-08. PMID:11137573.' |
the inhibited proliferation of splenocytes to con a correlated with increased apoptosis of t cells. |
2001-02-08 |
2023-08-12 |
rat |
| b' V Cupi\\xc4\\x87, M Coli\\xc4\\x87, L Pavici\\xc4\\x87, D Vucevi\\xc4\\x87, V M Varagi\\xc4\\x8. Immunomodulatory effect of xylazine, an alpha(2) adrenergic agonist, on rat spleen cells in culture. Journal of neuroimmunology. vol 113. issue 1. 2001-02-08. PMID:11137573.' |
the apoptosis was not blocked by yohimbine or antibodies to fas and fas-l. n-nitro-l-arginine methyl ester (l-name), an inhibitor of nitric oxide (no) synthase, enhanced proliferation of splenocytes to con a, partly abrogated the inhibitory effect of xylazine in the proliferation assay, and, only at high concentration (1000 microm), partly suppressed apoptosis of lymphocytes. |
2001-02-08 |
2023-08-12 |
rat |