| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Marinov, J Souce. Bovine seminal ribonuclease induces in vitro concentration dependent apoptosis in stimulated human lymphocytes and cells from human tumor cell lines. Neoplasma. vol 47. issue 5. 2001-01-11. PMID:11130246. |
in con a-stimulated human lymphocytes, bs rnase also induced apoptosis, eventhough not so pronounced as in human tumor cell lines. |
2001-01-11 |
2023-08-12 |
mouse |
| V Khare, S M Singh, A Sodh. Age-associated hematopoietic alterations in the spleen of tumor-bearing hosts. Natural immunity. vol 16. issue 5-6. 2000-11-13. PMID:11061590. |
splenocytes obtained from normal and tumor-bearing young, adult and old mice were checked for an in vitro blastogenic response to concanavalin a (con a), colony-forming ability and apoptosis. |
2000-11-13 |
2023-08-12 |
mouse |
| V Khare, S M Singh, A Sodh. Age-associated hematopoietic alterations in the spleen of tumor-bearing hosts. Natural immunity. vol 16. issue 5-6. 2000-11-13. PMID:11061590. |
there was an enhanced apoptosis of splenocytes and a concomitant inhibition of splenocyte blastogenesis and their responsiveness to the mitogenic stimulus of con a in aged mice. |
2000-11-13 |
2023-08-12 |
mouse |
| J Hughes, M Nangaku, C E Alpers, S J Shankland, W G Couser, R J Johnso. C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. American journal of physiology. Renal physiology. vol 278. issue 5. 2000-06-12. PMID:10807586. |
last, in con a gn, abrogation of gen apoptosis preserved endothelial integrity and renal function. |
2000-06-12 |
2023-08-12 |
rat |
| b' M Coli\\xc4\\x87, S Gasi\\xc4\\x87, D Vucevi\\xc4\\x87, L Pavici\\xc4\\x87, P Popovi\\xc4\\x87, D Jandri\\xc4\\x87, L Medi\\xc4\\x87-Mijacevi\\xc4\\x87, L Raki\\xc4\\x8. Modulatory effect of 7-thia-8-oxoguanosine on proliferation of rat thymocytes in vitro stimulated with concanavalin A. International journal of immunopharmacology. vol 22. issue 3. 2000-05-25. PMID:10685003.' |
the effect correlated with increased interleukin 2 (il-2) production, upregulation of the il-2 receptor alpha (il-2ralpha) expression and decreased apoptosis of thymocytes in comparison to the effect of con a alone. |
2000-05-25 |
2023-08-12 |
rat |
| H Fukumoto, T Tamura, Y Kamiya, J Usuda, T Suzuki, F Kanzawa, H J Kuh, Y Ohe, N Saijo, K Nishi. Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN-01. Investigational new drugs. vol 17. issue 4. 2000-04-28. PMID:10759401. |
con a-stimulated pbls were more sensitive to ucn-01-induced apoptosis than non-stimulated lymphocytes and ucn-01 increased the sfas-l released into culture medium from con a-stimulated pbls. |
2000-04-28 |
2023-08-12 |
human |
| E Sun, L Zhang, Y Zeng, Q Ge, M Zhao, W Ga. Apoptotic cells actively inhibit the expression of CD69 on Con A activated T lymphocytes. Scandinavian journal of immunology. vol 51. issue 3. 2000-04-04. PMID:10736091. |
the k562 or hl-60 human leukemia cell lines that had been induced apoptosis by fty720 or cycloheximide (chx) were added into the culture of mouse spleen cells stimulated with con a. |
2000-04-04 |
2023-08-12 |
mouse |
| T Azuma, N Watanabe, H Yagisawa, H Hirata, M Iwamura, Y Kobayash. Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant. Immunopharmacology. vol 46. issue 1. 2000-03-02. PMID:10665777. |
cprg enhanced the apoptosis of murine splenocytes and nylon fiber column-purified t cells cultured in the presence of con a, as shown by the decrease in cell size and/or dna fragmentation. |
2000-03-02 |
2023-08-12 |
Not clear |
| M Delgado, D Gane. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit antigen-induced apoptosis of mature T lymphocytes by inhibiting Fas ligand expression. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 3. 2000-02-24. PMID:10640731. |
vip and pacap reduce in a dose-dependent manner anti-cd3-induced apoptosis in con a/il-2-preactivated peripheral t cells and the murine t hybridomas 2b4.11 and a1.1. |
2000-02-24 |
2023-08-12 |
Not clear |
| T Harayama, E Ohuchi, T Aoki, H Sato, M Seiki, Y Okad. Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line. Japanese journal of cancer research : Gann. vol 90. issue 9. 1999-11-23. PMID:10551322. |
these results suggest that mt1-mmp release from con a-treated cells is due to shedding mediated by metalloproteinase(s) other than mmps, and is associated with apoptosis. |
1999-11-23 |
2023-08-12 |
human |
| E J Doolin, L F Strande, M K Chen, M S Kain, C W Hewit. The effect of leukocyte infiltration on apoptosis in an in vitro thermal injury bioartificial living skin equivalent model. The Journal of burn care & rehabilitation. vol 20. issue 5. 1999-10-28. PMID:10501324. |
tunel staining indicated the presence of apoptosis as follows: rej versus con (0.0015+/-0.0002 vs. 0.0003+/-0.0001, respectively, p<.001); brej versus bcon (0.0031+/-0.0006 vs. 0.0018+/-0.0004, respectively, p<.05); rej versus brej (0.0015+/-0.0002 vs. 0.0031+/-0.0006, respectively, p = .007). |
1999-10-28 |
2023-08-12 |
human |
| B Shankar, S Premachandran, S D Bharambe, P Sundaresan, K B Saini. Modification of immune response by low dose ionizing radiation: role of apoptosis. Immunology letters. vol 68. issue 2-3. 1999-09-16. PMID:10424426. |
reduction in expression of p53 was accompanied by reduced apoptosis, as measured by tunel assay, in the con a-stimulated spleen cells of irradiated c57bl/6 mice when compared with that in the sham-treated controls. |
1999-09-16 |
2023-08-12 |
mouse |
| C Martinez, M Delgado, C Abad, R P Gomariz, D Ganea, J Lecet. Regulation of VIP production and secretion by murine lymphocytes. Journal of neuroimmunology. vol 93. issue 1-2. 1999-07-01. PMID:10378876. |
in this study, we demonstrated for the first time, that agents that mediate important immune functions, such as proliferation and antigenic stimulation (con a, lps, and anti-tcr antibody), inflammation (lps, tnfalpha, il-6 and il-1beta) or apoptosis (dexamethasone) induce the production and release of vip to the lymphoid microenvironment. |
1999-07-01 |
2023-08-12 |
Not clear |
| S C Welburn, S Lillico, N B Murph. Programmed cell death in procyclic form Trypanosoma brucei rhodesiense --identification of differentially expressed genes during con A induced death. Memorias do Instituto Oswaldo Cruz. vol 94. issue 2. 1999-06-18. PMID:10224534. |
trypanosoma brucei rhodesiense can be induced to undergo apoptosis after stimulation with con a. |
1999-06-18 |
2023-08-12 |
Not clear |
| F Nagase, T Abo, K Hiramatsu, S Suzuki, J Du, I Nakashim. Induction of apoptosis and tyrosine phosphorylation of cellular proteins in T cells and non-T cells by stimulation with concanavalin A. Microbiology and immunology. vol 42. issue 8. 1998-12-30. PMID:9776398. |
this indicated that the mechanism of induction of apoptosis with con a is not necessarily tcr-dependent. |
1998-12-30 |
2023-08-12 |
mouse |
| F Nagase, T Abo, K Hiramatsu, S Suzuki, J Du, I Nakashim. Induction of apoptosis and tyrosine phosphorylation of cellular proteins in T cells and non-T cells by stimulation with concanavalin A. Microbiology and immunology. vol 42. issue 8. 1998-12-30. PMID:9776398. |
these results suggested that the con a-induced apoptosis of t cells and non-t cells involves different but possibly mutually related protein tyrosine phosphorylation-linked signals. |
1998-12-30 |
2023-08-12 |
mouse |
| K Bulloch, B S McEwen, J Nordberg, A Diwa, S Bair. Selective regulation of T-cell development and function by calcitonin gene-related peptide in thymus and spleen. An example of differential regional regulation of immunity by the neuroendocrine system. Annals of the New York Academy of Sciences. vol 840. 1998-07-09. PMID:9629282. |
the antagonist, cgrp(8-37), did not block apoptosis caused by con a or cgrp but rather enhanced it. |
1998-07-09 |
2023-08-12 |
Not clear |
| K Bulloch, B S McEwen, J Nordberg, A Diwa, S Bair. Selective regulation of T-cell development and function by calcitonin gene-related peptide in thymus and spleen. An example of differential regional regulation of immunity by the neuroendocrine system. Annals of the New York Academy of Sciences. vol 840. 1998-07-09. PMID:9629282. |
because proliferation of thymocytes and splenocytes induced by con a is blocked by this antagonist and splenocytes are refractory to cgrp induced apoptosis, cgrp appears to mediate at least two separate functions on subpopulations of thymocytes and t cells via two different cgrp receptors within the gland. |
1998-07-09 |
2023-08-12 |
Not clear |
| W G Li, A Zaheer, L Coppey, H J Oskarsso. Activation of JNK in the remote myocardium after large myocardial infarction in rats. Biochemical and biophysical research communications. vol 246. issue 3. 1998-07-02. PMID:9618295. |
furthermore, there was a twofold increase in myocyte apoptosis within the rm in inf vs. con. |
1998-07-02 |
2023-08-12 |
rat |
| X Su, J Cheng, W Liu, C Liu, Z Wang, P Yang, T Zhou, J D Mount. Autocrine and paracrine apoptosis are mediated by differential regulation of Fas ligand activity in two distinct Jurkat T cell populations. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 11. 1998-06-11. PMID:9605126. |
autocrine regulation of apoptosis was demonstrated by increased fasl activity after stimulation of gfp- cells with anti-cd3, phorbyl myristyl acetate plus ionomycin, or con a. paracrine regulation of apoptosis was suggested by the induction of apoptosis of gfp- cells after coculture with unstimulated gfp+ cells. |
1998-06-11 |
2023-08-12 |
human |