| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian-Lan Jiang, Yu-Ping Peng, Yi-Hua Qiu, Jian-Jun Wan. Adrenoreceptor-coupled signal-transduction mechanisms mediating lymphocyte apoptosis induced by endogenous catecholamines. Journal of neuroimmunology. vol 213. issue 1-2. 2009-09-08. PMID:19559489. |
our previous work has shown that lymphocytes synthesize catecholamines (cas) and the endogenous cas accelerate apoptosis of concanavalin a (con a)-activated lymphocyte. |
2009-09-08 |
2023-08-12 |
Not clear |
| Yang Sun, Yu Qin, Fang-Yuan Gong, Xue-Feng Wu, Zi-Chun Hua, Ting Chen, Qiang X. Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice. Biochemical pharmacology. vol 77. issue 11. 2009-07-07. PMID:19428326. |
in the present study, we found that fraxinellone, a small natural compound isolated from the root bark of dictamnus dasycarpus, selectively facilitated apoptosis of concanavalin a (con a)-activated cd4(+) t cells rather than those non-activated, by disrupting the mitochondrial transmembrane potential, decreasing the ratio of bcl-2/bax, and increasing cytochrome c release from the mitochondria to the cytosol. |
2009-07-07 |
2023-08-12 |
mouse |
| A A Adams, C C Breathnach, M P Katepalli, K Kohler, D W Horoho. Advanced age in horses affects divisional history of T cells and inflammatory cytokine production. Mechanisms of ageing and development. vol 129. issue 11. 2009-03-05. PMID:18926847. |
we examined whether decreased t cell proliferation induced by con a is caused by increased apoptosis. |
2009-03-05 |
2023-08-12 |
Not clear |
| Magdalena Leiva, Alfonso Ruiz-Bravo, Encarnación Moreno, Maria Jiménez-Valer. Telithromycin inhibits the production of proinflammatory mediators and the activation of NF-kappaB in in vitro-stimulated murine cells. FEMS immunology and medical microbiology. vol 53. issue 3. 2008-10-03. PMID:18557935. |
proliferation and apoptosis (colorimetric assay), and cytokine production (enzyme immunoassay) of spleen cells in response to lipopolysaccharide and concanavalin a (con a), and nitric oxide (no) (colorimetric assay) and cytokine production by lipopolysaccharide-stimulated raw 264.7 cells were determined. |
2008-10-03 |
2023-08-12 |
mouse |
| Magdalena Leiva, Alfonso Ruiz-Bravo, Encarnación Moreno, Maria Jiménez-Valer. Telithromycin inhibits the production of proinflammatory mediators and the activation of NF-kappaB in in vitro-stimulated murine cells. FEMS immunology and medical microbiology. vol 53. issue 3. 2008-10-03. PMID:18557935. |
telithromycin moderately enhanced lymphocyte proliferation in response to lipopolysaccharide and con a, and enhanced apoptosis induced by camptothecin in mitogen-stimulated splenocytes. |
2008-10-03 |
2023-08-12 |
mouse |
| Fangyuan Gong, Yan Shen, Chaofeng Zhang, Jianliang Xu, Xuefeng Wu, Zichun Hua, Qiang X. Dregea volubilis ameliorates concanavalin A-induced liver injury by facilitating apoptosis of activated T cells. Experimental biology and medicine (Maywood, N.J.). vol 233. issue 9. 2008-09-30. PMID:18535162. |
activation of t cells is a critical event in the pathogenesis of concanavalin a (con a)-induced liver injury, and facilitating apoptosis of activated t cells may provide a strategy for the treatment. |
2008-09-30 |
2023-08-12 |
mouse |
| Fangyuan Gong, Yan Shen, Chaofeng Zhang, Jianliang Xu, Xuefeng Wu, Zichun Hua, Qiang X. Dregea volubilis ameliorates concanavalin A-induced liver injury by facilitating apoptosis of activated T cells. Experimental biology and medicine (Maywood, N.J.). vol 233. issue 9. 2008-09-30. PMID:18535162. |
here, we found that the ethanol extract from the stem parts of dregea volubilis (dve) inhibited cell proliferation and induced apoptosis, which was selective for con a-activated, rather than nonactivated, lymph node cells. |
2008-09-30 |
2023-08-12 |
mouse |
| Jian-Lan Jiang, Yu-Ping Peng, Yi-Hua Qiu, Jian-Jun Wan. Effect of endogenous catecholamines on apoptosis of Con A-activated lymphocytes of rats. Journal of neuroimmunology. vol 192. issue 1-2. 2008-03-14. PMID:17920695. |
effect of endogenous catecholamines on apoptosis of con a-activated lymphocytes of rats. |
2008-03-14 |
2023-08-12 |
rat |
| A R M Ruhul Amin, Rajib K Paul, Vijay S Thakur, Munna L Agarwa. A novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin, Concanavalin A. Cancer research. vol 67. issue 12. 2007-09-25. PMID:17575126. |
con a treatment leads to induction of p73 and several others that are important mediators of apoptosis and act downstream, such as p21, bax, foxo1a, and bim. |
2007-09-25 |
2023-08-12 |
human |
| Murat Bas, Henning Bier, Kerstin Schirlau, Ulrike Friebe-Hoffmann, Kathrin Scheckenbach, Vera Balz, Theresa L Whiteside, Thomas K Hoffman. Gamma-delta T-cells in patients with squamous cell carcinoma of the head and neck. Oral oncology. vol 42. issue 7. 2007-06-21. PMID:16527515. |
peripheral blood of 33 scchn patients and 33 age-matched controls (con) was evaluated for the frequency of gamma/delta-t-cells among cd3+ t-cells and their onset of apoptosis (annexin v binding) by multicolor flow cytometry. |
2007-06-21 |
2023-08-12 |
Not clear |
| Murat Bas, Henning Bier, Kerstin Schirlau, Ulrike Friebe-Hoffmann, Kathrin Scheckenbach, Vera Balz, Theresa L Whiteside, Thomas K Hoffman. Gamma-delta T-cells in patients with squamous cell carcinoma of the head and neck. Oral oncology. vol 42. issue 7. 2007-06-21. PMID:16527515. |
however, this increase was not paralleled with a difference in the onset of apoptosis if compared to con. |
2007-06-21 |
2023-08-12 |
Not clear |
| Byeong Suk Chae, Tae Yong Shi. Immunoregulatory abnormalities of T cells and hyperreactivity of B cells in the in vitro immune response in pristane-induced lupus mice. Archives of pharmacal research. vol 30. issue 2. 2007-03-29. PMID:17366741. |
in addition, splenic t cells and cd4+ t cells in thymocytes from pristane-induced lupus mice were more resistant than nonautoimmune normal cells to con a-induced apoptosis. |
2007-03-29 |
2023-08-12 |
mouse |
| b' G Leposavi\\xc4\\x87, N Arsenovi\\xc4\\x87-Ranin, K Radojevi\\xc4\\x87, D Kosec, V Pesi\\xc4\\x87, B Vidi\\xc4\\x87-Dankovi\\xc4\\x87, B Ple\\xc4\\x87as-Solarovi\\xc4\\x87, I Pilipovi\\xc4\\x8. Characterization of thymocyte phenotypic alterations induced by long-lasting beta-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis. Molecular and cellular biochemistry. vol 285. issue 1-2. 2006-08-31. PMID:16477376.' |
in addition, the sensitivity of thymocytes to induction of apoptosis and concanavalin a (con a) signaling was estimated. |
2006-08-31 |
2023-08-12 |
rat |
| b' G Leposavi\\xc4\\x87, N Arsenovi\\xc4\\x87-Ranin, K Radojevi\\xc4\\x87, D Kosec, V Pesi\\xc4\\x87, B Vidi\\xc4\\x87-Dankovi\\xc4\\x87, B Ple\\xc4\\x87as-Solarovi\\xc4\\x87, I Pilipovi\\xc4\\x8. Characterization of thymocyte phenotypic alterations induced by long-lasting beta-adrenoceptor blockade in vivo and its effects on thymocyte proliferation and apoptosis. Molecular and cellular biochemistry. vol 285. issue 1-2. 2006-08-31. PMID:16477376.' |
the thymocytes from p-treated (pt) rats exhibited an increased sensitivity to induction of apoptosis, as well as to con a stimulation. |
2006-08-31 |
2023-08-12 |
rat |
| Bofeng Li, Rui Sun, Haiming Wei, Bin Gao, Zhigang Tia. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology (Baltimore, Md.). vol 43. issue 6. 2006-07-13. PMID:16729307. |
in this study, pretreatment with il-15 prevented mice from con a-induced mortality, elevation of serum transaminase, liver necrosis, and hepatocyte apoptosis. |
2006-07-13 |
2023-08-12 |
mouse |
| Ye Zhang, Robert A Kirken, Lucrezia Furian, Slawa Janczewska, Xiumei Qu, Wayne W Hancock, Mouer Wang, Neelam Tejpal, Ronald Kerman, Barry D Kahan, Stanislaw M Stepkowsk. Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 1. 2006-02-16. PMID:16365403. |
in vitro, stat5a/b-/- t cells did not proliferate in response to con a or alloantigens but entered apoptosis within 48 h (95%). |
2006-02-16 |
2023-08-12 |
mouse |
| Hongna Pan, Feng Hong, Svetlana Radaeva, Bin Ga. Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cellular & molecular immunology. vol 1. issue 1. 2006-01-27. PMID:16212920. |
overexpression of il-22 by hydrodynamic gene delivery significantly protects against liver injury, necrosis, and apoptosis induced by administration of con a, carbon tetrachloride (ccl4), or the fas agonist jo-2 mab. |
2006-01-27 |
2023-08-12 |
mouse |
| Raja Fayad, Joseph A Sennello, Soo-Hyun Kim, Maria Pini, Charles A Dinarello, Giamila Fantuzz. Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids. European journal of immunology. vol 35. issue 8. 2005-10-04. PMID:16047339. |
compared to liver damage, the kinetics of con a-induced thymic atrophy is slower and more prolonged; the nadir in thymocyte number is reached 4 days after con a injection, whereas peak transaminase levels are observed at 12-24 h. marked alterations in the ratio of cd4+ and cd8+cells in the thymus and spleen and significantly increased rates of thymocyte and splenocyte apoptosis are observed. |
2005-10-04 |
2023-08-12 |
mouse |
| Raja Fayad, Joseph A Sennello, Soo-Hyun Kim, Maria Pini, Charles A Dinarello, Giamila Fantuzz. Induction of thymocyte apoptosis by systemic administration of concanavalin A in mice: role of TNF-alpha, IFN-gamma and glucocorticoids. European journal of immunology. vol 35. issue 8. 2005-10-04. PMID:16047339. |
neutralization of the cytokines tnf-alpha or ifn-gamma, which protects mice from con a-induced hepatitis, prevents thymic atrophy as well as alterations in cd4+ and cd8+ cell numbers and apoptosis rates. |
2005-10-04 |
2023-08-12 |
mouse |
| Sachiyo Hatada, Toshie Ohta, Yoshiko Shiratsuchi, Masayo Hatano, Yoshiro Kobayash. A novel accessory role of neutrophils in concanavalin A-induced hepatitis. Cellular immunology. vol 233. issue 1. 2005-09-12. PMID:15893298. |
concanavalin a (con a)-induced hepatitis has been investigated as a model of t cell-mediated liver injury, in which ifn-gamma plays an essential role by inducing apoptosis of liver cells. |
2005-09-12 |
2023-08-12 |
mouse |