| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Wang, Wen Zhang, Chang-Hui Ge, Rong-Hua Yin, Yang Xiao, Yi-Qun Zhan, Miao Yu, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yan. Toll-like receptor 5 signaling restrains T-cell/natural killer T-cell activation and protects against concanavalin A-induced hepatic injury. Hepatology (Baltimore, Md.). vol 65. issue 6. 2017-09-01. PMID:28273362. |
we also report that administration of cblb502, an exogenous tlr5 agonist, substantially alleviated con a-mediated hepatitis in wild-type mice as shown by increased survival rates, reduced aminotransferase and proinflammatory cytokine production, impaired lymphocyte infiltration, and ameliorated hepatocyte necrosis and/or apoptosis. |
2017-09-01 |
2023-08-13 |
mouse |
| E E Connor, E H Wall, D M Bravo, C M Evock-Clover, T H Elsasser, R L Baldwin, M Santín, B T Vinyard, S Kahl, M P Walke. Reducing gut effects from Cryptosporidium parvum infection in dairy calves through prophylactic glucagon-like peptide 2 therapy or feeding of an artificial sweetener. Journal of dairy science. vol 100. issue 4. 2017-05-18. PMID:28131587. |
relative to con, calves in inf exhibited an increase in diarrhea severity, increased plasma serum amyloid a concentration on d 15 and 18, reduced intestinal villus height, increased villus apoptosis and crypt cell proliferation, and increased intestinal mrna expression of marveld2 and gpx2. |
2017-05-18 |
2023-08-13 |
Not clear |
| Yinglin Yuan, Xia Gong, Li Zhang, Rong Jiang, Junxia Yang, Bin Wang, Jingyuan Wa. Chlorogenic acid ameliorated concanavalin A-induced hepatitis by suppression of Toll-like receptor 4 signaling in mice. International immunopharmacology. vol 44. 2017-05-12. PMID:28088700. |
in the present study, we found that pretreatment with cga dose-dependently inhibited the elevation of plasma aminotransferases and alleviated hepatic pathological damage as well as hepatocyte apoptosis in con a-exposed mice. |
2017-05-12 |
2023-08-13 |
mouse |
| Kan Sun, Muru Xu, Kaichun Zhou, Huali Nie, Jing Quan, Limin Zh. Thermoresponsive diblock glycopolymer by RAFT polymerization for lectin recognition. Materials science & engineering. C, Materials for biological applications. vol 68. 2017-04-06. PMID:27524009. |
the diblock glycopolymer micelles have excellent biocompatibility with pig iliac endothelial cells, as measured using the mtt assay, but micelles loaded with con a could be used to induce apoptosis in human hepatoma smmc-7721 cells. |
2017-04-06 |
2023-08-13 |
human |
| Chao Liu, Yongping Cao, Xin Yang, Pengcheng Shan, Heng Li. Tauroursodeoxycholic acid suppresses endoplasmic reticulum stress in the chondrocytes of patients with osteoarthritis. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26238983. |
chondrocytes obtained from osteoarthritis patients at different stages were cultured in three conditions including: no treatment (con group), tunicamycin treatment to induce er stress (ers group) and tauroursodeoxycholic acid treatment after 4 h of tunicamycin (tda group); and cell proliferation, apoptosis, function and er stress level were assessed. |
2016-06-20 |
2023-08-13 |
Not clear |
| Ping Cheng, Kan Chen, Yujing Xia, Weiqi Dai, Fan Wang, Miao Shen, Chengfen Wang, Jing Yang, Rong Zhu, Huawei Zhang, Jingjing Li, Yuanyuan Zheng, Junshan Wang, Yan Zhang, Jie Lu, Yingqun Zhou, Chuanyong Gu. Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis. Drug design, development and therapy. vol 8. 2015-07-13. PMID:25246769. |
apoptosis and autophagy play important roles in concanavalin a (con a)-induced acute hepatitis. |
2015-07-13 |
2023-08-13 |
Not clear |
| W Wang, H Zhu, H Zhang, L Zhang, Q Ding, H Jian. Targeting HMGB1 inhibits bladder cancer cells bioactivity by lentivirus-mediated RNA interference. Neoplasma. vol 61. issue 6. 2015-06-01. PMID:25150308. |
the hmgb1 knockdown (kd) group displayed an increased proportion of cells in the g0/g1 phase and higher apoptosis rates of bc cells comparing with the control (con) group. |
2015-06-01 |
2023-08-13 |
mouse |
| Zhe Gao, Yuxiang Ma, Dan Zhao, Xiong Zhang, Hang Zhou, Hailiang Liu, Yang Zhou, Xuefeng Wu, Yan Shen, Yang Sun, Jianxin Li, Xudong Wu, Qiang X. Neochromine S5 improves contact hypersensitivity through a selective effect on activated T lymphocytes. Biochemical pharmacology. vol 92. issue 2. 2015-03-20. PMID:25218598. |
interestingly, neochromine s5 selectively inhibited proliferation and induced apoptosis in t lymphocytes activated by concanavalin a (con a) in a dose-dependent manner but not in naïve t lymphocytes, distinct from quercetin. |
2015-03-20 |
2023-08-13 |
mouse |
| Toshiaki Yamazak. Influence of hindlimb unweighting and intermittent weight bearing on dynamics of nuclei in rat soleus muscle. Journal of the Japanese Physical Therapy Association = Rigaku ryoho. vol 6. issue 1. 2015-03-20. PMID:25792927. |
this parameter in w10 and w40 were statistically not significantly different from con, suggesting that these weight bearing methods can prevent the loss of myonuclei by apoptosis. |
2015-03-20 |
2023-08-13 |
rat |
| Young Rae Ji, Hei Jung Kim, Dong Hun Yu, Ki Beom Bae, Seo Jin Park, Si Jun Park, Woo Young Jang, Min-Cheol Kang, Jain Jeong, Yong Hun Sung, Minjee Choi, Taejun Park, Taesun Park, Jong Won Yun, Hyun-Shik Lee, Sanggyu Lee, Myoung Ok Kim, Zae Young Ryo. Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25201726. |
in roquin tg mice, con a treatment caused greater increases in both the levels of liver injury enzymes and liver tissue apoptosis, as revealed by tunel and h&e staining, than wild type (wt) mice. |
2015-02-25 |
2023-08-13 |
mouse |
| Young Rae Ji, Hei Jung Kim, Dong Hun Yu, Ki Beom Bae, Seo Jin Park, Si Jun Park, Woo Young Jang, Min-Cheol Kang, Jain Jeong, Yong Hun Sung, Minjee Choi, Taejun Park, Taesun Park, Jong Won Yun, Hyun-Shik Lee, Sanggyu Lee, Myoung Ok Kim, Zae Young Ryo. Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25201726. |
furthermore, roquin regulates the immune response and apoptosis in con a induced hepatitis via stats, bax and bcl2. |
2015-02-25 |
2023-08-13 |
mouse |
| Yao Wang, Gao-Xiang Zhao, Li-Hui Xu, Kun-Peng Liu, Hao Pan, Jian He, Ji-Ye Cai, Dong-Yun Ouyang, Xian-Hui H. Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. PloS one. vol 9. issue 2. 2015-01-22. PMID:24587010. |
in addition, cuiib downregulated con a-induced stat3 phosphorylation and increased cell apoptosis. |
2015-01-22 |
2023-08-12 |
mouse |
| Hong Xie, Xia Liu, Chen Wang, Jiang Zhu, Chen Yang, Chunfeng Liu, Hong Liu, Xuemei W. The changes of technetium-99m-labeled annexin-V in delayed anesthetic preconditioning during myocardial ischemia/reperfusion. Molecular biology reports. vol 41. issue 1. 2014-08-26. PMID:24194194. |
radionuclide imaging indicated that apoptosis was reduced in sevo group (0.78 % ± 0.82) when compared with the con group (1.15 % ± 0.61), and the infarct size was also decreased in the sevo group (40 % ± 7). |
2014-08-26 |
2023-08-12 |
rat |
| Lu Fan, Lingna Hu, Baofang Yang, Xianying Fang, Zhe Gao, Wanshuai Li, Yang Sun, Yan Shen, Xuefeng Wu, Yongqian Shu, Yanhong Gu, Xudong Wu, Qiang X. Erlotinib promotes endoplasmic reticulum stress-mediated injury in the intestinal epithelium. Toxicology and applied pharmacology. vol 278. issue 1. 2014-07-18. PMID:24768708. |
erlotinib concentration- and time-dependently induced apoptosis and endoplasmic reticulum (er) stress in both iec-6 and human colon epithelial cells (ccd 841 con). |
2014-07-18 |
2023-08-13 |
mouse |
| Doaa I Mohamed, Ahmed A M Elmelegy, Lubna F A El-Aziz, Hala S Abdel Kawy, Abeer A Abd El-Samad, Omnyah A El-Kharash. Fenofibrate A peroxisome proliferator activated receptor-α agonist treatment ameliorates Concanavalin A-induced hepatitis in rats. European journal of pharmacology. vol 721. issue 1-3. 2014-07-15. PMID:24140572. |
histopathological examination revealed that treatment with ff significantly suppressed early inflammation, reduced α sma, and apoptosis of hepatocytes induced by con a, thereby preventing the progression of chronic liver injury and fibrosis. |
2014-07-15 |
2023-08-12 |
rat |
| Kun Lv, Yingying Zhang, Mengying Zhang, Min Zhong, Qifeng Su. Galectin-9 ameliorates Con A-induced hepatitis by inducing CD4(+)CD25(low/int) effector T-Cell apoptosis and increasing regulatory T cell number. PloS one. vol 7. issue 10. 2013-04-12. PMID:23118999. |
galectin-9 ameliorates con a-induced hepatitis by inducing cd4(+)cd25(low/int) effector t-cell apoptosis and increasing regulatory t cell number. |
2013-04-12 |
2023-08-12 |
mouse |
| Li-Li Feng, Xue-Feng Wu, Hai-Liang Liu, Wen-Jie Guo, Qiong Luo, Fei-Fei Tao, Hui-Ming Ge, Yan Shen, Ren-Xiang Tan, Qiang Xu, Yang Su. Vaticaffinol, a resveratrol tetramer, exerts more preferable immunosuppressive activity than its precursor in vitro and in vivo through multiple aspects against activated T lymphocytes. Toxicology and applied pharmacology. vol 267. issue 2. 2013-04-03. PMID:23276654. |
it also induced con a-activated t cells undergoing apoptosis through mitochondrial pathway. |
2013-04-03 |
2023-08-12 |
mouse |
| Wenjie Guo, Wen Liu, Shaocheng Hong, Hailiang Liu, Cheng Qian, Yan Shen, Xuefeng Wu, Yang Sun, Qiang X. Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by asiatic acid for preventing murine fulminant hepatitis. PloS one. vol 7. issue 9. 2013-03-05. PMID:23029367. |
mitochondria-dependent apoptosis of con a-activated t lymphocytes induced by asiatic acid for preventing murine fulminant hepatitis. |
2013-03-05 |
2023-08-12 |
mouse |
| Wenjie Guo, Wen Liu, Shaocheng Hong, Hailiang Liu, Cheng Qian, Yan Shen, Xuefeng Wu, Yang Sun, Qiang X. Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by asiatic acid for preventing murine fulminant hepatitis. PloS one. vol 7. issue 9. 2013-03-05. PMID:23029367. |
in the present study, we found that asiatic acid, a natural triterpenoid, selectively triggered apoptosis of concanavalin a (con a)-activated t cells in a mitochondria-dependent manner indicated by the disruption of the mitochondrial transmembrane potential, release of cytochrome c from mitochondria to cytosol, caspases activation, and cleavage of parp. |
2013-03-05 |
2023-08-12 |
mouse |
| Yuji Ogawa, Masato Yoneda, Wataru Tomeno, Kento Imajo, Yoshiyasu Shinohara, Koji Fujita, Wataru Shibata, Hiroyuki Kirikoshi, Satoru Saito, Koichiro Wada, Shin Maeda, Atsushi Nakajim. Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus. PPAR research. vol 2012. 2012-12-20. PMID:23251143. |
electrophoresis mobility shift assay (emsa) revealed that activation of translocation of nuclear factor- (nf-) κb, which is a suppressor of apoptosis, in the nucleus of the hepatocytes was suppressed in the pioglitazone-treated mice after con a injection. |
2012-12-20 |
2023-08-12 |
mouse |