| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Felipe Correa-da-Silva, Jari B Berkhout, Pim Schouten, Margje Sinnema, Constance T R M Stumpel, Leopold M G Curfs, Charlotte Höybye, Ahmed Mahfouz, Onno C Meijer, Alberto M Pereira, Eric Fliers, Dick F Swaab, Andries Kalsbeek, Chun-Xia Y. Selective changes in vasopressin neurons and astrocytes in the suprachiasmatic nucleus of Prader-Willi syndrome subjects. Journal of neuroendocrinology. 2025-03-08. PMID:40055943. |
we profiled neural populations characterized by avp and vip, astroglia characterized by glial fibrillary acid protein (gfap), and microglia marked by ionized calcium-binding adapter molecule 1 (iba1) and nadph oxidase 2 (nox2). |
2025-03-08 |
2025-03-12 |
human |
| Zhiliang Li, Qi Xiong, Qin Li, Lanlan Tan. Parthenolide ameliorates diabetic retinopathy by suppressing microglia-induced Müller cell gliosis and inflammation via the NF-κB signalling. International immunopharmacology. vol 151. 2025-03-01. PMID:40022819. |
co-culture with microglia exacerbated hyperglycemia-induced gliosis in müller cells, indicated by increased gfap expression and reduced glast and kir4.1 levels. |
2025-03-01 |
2025-03-05 |
mouse |
| Huiqi Yuan, Yanan Xu, Hailun Jiang, Meizhu Jiang, Luofei Zhang, Shifeng Wei, Cao Li, Zhigang Zha. Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway. Molecular brain. vol 18. issue 1. 2025-02-05. PMID:39905541. |
transcriptional profiling combined with bioinformatics analysis revealed the upregulation of toll-like receptor signaling pathway related gene including tlr1/2, ccl3, ccl4, ccl5 and cd86 in asm ko mice, which was further confirmed by the detection of activated microglia and astrocytes through iba-1 and gfap immunohistochemical staining. |
2025-02-05 |
2025-02-07 |
mouse |
| E E Genrikhs, M O Shedenkova, D N Voronkov, N K Isaev, E V Stelmashoo. Activation of Microglia and Astroglia in Unilateral Focal Traumatic Brain Injury in Rats. Bulletin of experimental biology and medicine. vol 178. issue 2. 2025-01-13. PMID:39762704. |
quantitative assessment was performed by counting immunocytochemically stained microglia cells (iba1 marker) and activated astrocytes (gfap) at different distances from the lesion site. |
2025-01-13 |
2025-01-16 |
rat |
| Julietta A Sheng, Jonathan R Christenson, Luke A Schwerdtfeger, Stuart A Tobe. Maternal immune activation by toll-like receptor 7 agonist during mid-gestation increases susceptibility to blood-brain barrier leakage after puberty. Brain behavior and immunity integrative. vol 8. 2025-01-03. PMID:39749157. |
sections with fitc-labeled blood vessels through the pvn of offspring were immunolabeled for glial fibrillary acidic protein (gfap; astrocytic end feet) and iba-1 (microglia). |
2025-01-03 |
2025-01-05 |
mouse |
| Shuchao Liu, Ying Wang, Ye Zhang, Xiongjie Wang, Long Wan. Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Mitigates Neuroinflammation and Cognitive Impairment by Modulating Glial Activation in Sepsis-Associated Encephalopathy. Neurochemical research. vol 50. issue 1. 2024-11-29. PMID:39612058. |
the rhmanf treatment attenuated activation of microglia and astrocytes in the hippocampus and cortex, as evidenced by diminished iba-1 and gfap positive cells. |
2024-11-29 |
2024-12-01 |
mouse |
| Peter M Andrew, Jeremy A MacMahon, Pedro N Bernardino, Yi-Hua Tsai, Brad A Hobson, Valerie A Porter, Sydney L Huddleston, Audrey S Luo, Donald A Bruun, Naomi H Saito, Danielle J Harvey, Amy Brooks-Kayal, Abhijit J Chaudhari, Pamela J Lei. Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate. Journal of neuroinflammation. vol 21. issue 1. 2024-11-05. PMID:39497181. |
colocalization of iba-1, a marker for microglia, with inos or arg1 was used to identify pro- and anti-inflammatory microglia, respectively; colocalization of gfap, a marker for astrocytes, with c3 or s100a10, pro- and anti-inflammatory astrocytes, respectively. |
2024-11-05 |
2024-11-07 |
rat |
| Mateus Eduardo Herpich, Leonardo de Oliveira Guarnieri, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Morae. Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsy. Epilepsy & behavior : E&B. vol 161. 2024-10-28. PMID:39467457. |
animals were euthanized on day 26, and hippocampal slices were analyzed using fluoro-jade staining for cell death and immunofluorescence staining for iba-1 (microglia) and gfap (astrocyte) labeling. |
2024-10-28 |
2024-10-31 |
rat |
| Ruixin Zhang, Makiko Ohshima, David Brodin, Yu Wang, Antonin Morancé, Marianne Schultzberg, Gefei Chen, Jan Johansso. Intravenous chaperone treatment of late-stage Alzheimer´s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes. Translational psychiatry. vol 14. issue 1. 2024-10-25. PMID:39448576. |
sequencing of rna from cortical microglia cells showed that brichos treatment normalized the expression of identified plaque-induced genes in mice and humans, including clusterin and gfap. |
2024-10-25 |
2024-10-28 |
mouse |
| Gabriela C De Paula, Rui F Simões, Alba M Garcia-Serrano, João M N Duart. High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows Sex Specific Features in Mice. Neurochemical research. 2024-09-20. PMID:39302596. |
we determined the expression of pro- and anti-inflammatory cytokines, and of the inflammatory cell markers iba1, cd68, gfap and emr1 in the hypothalamus, and analyzed morphology of microglia (iba-1 |
2024-09-20 |
2024-09-22 |
mouse |
| Olawande Bamisi, Adesua Olukayode Oluwalabani, Tolulope Timothy Arogundade, Olayemi Joseph Olajid. Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium. Neurotoxicology and teratology. 2024-09-20. PMID:39303770. |
immunohistochemical labelling of gfap and iba-1 revealed increased expression of reactive astrocytes and microglia respectively, while the accompanying tnfα upregulation in both the hippocampus (dentate gyrus) and pfc causally linked intrauterine d. stramonium exposure with neuroinflammatory responses postnatally. |
2024-09-20 |
2024-09-23 |
rat |
| Ashwani Arya, Manish Dhall, Vineet Mittal, Deepak Kaushik, Priya Mudgal, Tarun Kumar, Manisha Pandey, Renu Kadian, Prerna Sharma, Nidhi Rani, Thakur Gurjeet Sing. Multiple Sclerosis: Pathogenesis Mechanism and Biomarkers. Central nervous system agents in medicinal chemistry. 2024-09-05. PMID:39234910. |
cortical inflammation, neurodegeneration, demyelination, axonal injury, axonal loss, oligodendrocytes, mitochondrial dysfunction, microglia activation, oxidative and nitrosative stress are the pathological hallmarks of the ms. cns neurofilaments, chitinase and chitinase 3-like proteins, soluble circulating form (scd163), chemokine ligand 13 (cxcl13), immunoglobulin m, microrna (mirna) and messenger ribonucleic acid (mrna), glial fibrillary acidic protein (gfap), serum osteopontin, 8-iso-prostaglandin f2α (8-iso-pgf2 α), apo-lipoprotein e and myelinreactive t cells are some of the therapeutically valuable biomarkers for such multifarious disorder. |
2024-09-05 |
2024-09-08 |
Not clear |
| Vittoria Borgonetti, Martina Morozzi, Nicoletta Galeott. Neuroinflammation evoked mechanisms for neuropathic itch in the spared nerve injury mouse model of neuropathic pain. Neuropharmacology. 2024-08-19. PMID:39159835. |
in coincidence with the peak of scratching behavior, sni mice showed a spinal overexpression of iba1 and gfap, microglia and astrocyte markers respectively. |
2024-08-19 |
2024-08-22 |
mouse |
| Jae Soo Kim, Mi-Hye Kim, Myeung Ju Kim, Hee Jung Ki. Licochalcone A attenuates NMDA-induced neurotoxicity. Animal cells and systems. vol 28. issue 1. 2024-08-14. PMID:39139398. |
the response of astrocyte and microglia was also evaluated by immunostaining for glial fibrillary acidic protein (gfap), ionized calcium-binding adaptor molecule 1 (iba-1) and tumor necrosis factor alpha (tnf-α). |
2024-08-14 |
2024-08-16 |
rat |
| Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. vol 35. issue 6. 2024-08-02. PMID:39094014. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-08-02 |
2024-08-06 |
mouse |
| Zsolt Gáll, Ágnes Csüdör, István-Gábor Sável, Krisztina Kelemen, Melinda Kolcsá. Cholecalciferol Supplementation Impacts Behavior and Hippocampal Neuroglial Reorganization in Vitamin D-Deficient Rats. Nutrients. vol 16. issue 14. 2024-07-27. PMID:39064769. |
an immunohistochemical analysis of the brain regions involved in learning and memory was performed by quantifying the neurons, astrocytes, and microglia labelled with anti-neuronal nuclei (neun), glial fibrillary acidic protein (gfap), and ionized calcium-binding adaptor molecule 1 (iba-1) antibodies, respectively. |
2024-07-27 |
2024-07-29 |
rat |
| Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. 2024-07-25. PMID:39051915. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-07-25 |
2024-07-28 |
mouse |
| Ryan K Shahidehpour, Peter T Nelson, Adam D Bachstette. A pathologic study of Perivascular pTDP-43 Lin bodies in LATE-NC. Acta neuropathologica communications. vol 12. issue 1. 2024-07-12. PMID:38997773. |
using multiplexed immunohistochemistry and digital pathology tools, we conducted pathological analyses to investigate the relationship between lin bodies and glial markers (gfap for astrocytes, iba1 for microglia) and ferritin. |
2024-07-12 |
2024-07-15 |
Not clear |
| D K Avrova, L V Bayunova, N F Avrova, I O Zakharov. The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury. Bulletin of experimental biology and medicine. 2024-06-21. PMID:38907060. |
the immunohistochemical reaction of specific antibodies to marker proteins of activated microglia (iba1) and astrocytes (gfap) in hippocampal slices revealed the neuroprotective effect of exogenous gangliosides which can be mostly explained by their ability to suppress neuroinflammation and gliosis. |
2024-06-21 |
2024-06-24 |
rat |
| Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (gfap)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. |
2024-05-25 |
2024-05-27 |
mouse |