| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manuel G Bruera, María M Benedetto, Mario E Guido, Alicia L Degano, María A Conti. Glial cell response to constant low light exposure in rat retina. Visual neuroscience. vol 39. 2022-09-27. PMID:36164752. |
retinal cells presented an increased expression of the macroglia marker gfap, as well as increased mrna levels of microglia markers iba1 and cd68 after 6 days. |
2022-09-27 |
2023-08-14 |
rat |
| Bao-Dong He, Chang-Mei Liu, Zhao-Qian Ten. A Mouse Model of Neurodegeneration Induced by Blade Penetrating Stab Wound to the Hippocampus. Biology. vol 11. issue 9. 2022-09-23. PMID:36138848. |
the immunofluorescence staining of neun, gfap, iba1, and tunel was conducted to analyze the changes in neurons, astrocytes, and microglia, as well as cell death. |
2022-09-23 |
2023-08-14 |
mouse |
| Alberto Llorente-Ovejero, Iker Bengoetxea de Tena, Jonatan Martínez-Gardeazabal, Marta Moreno-Rodríguez, Laura Lombardero, Iván Manuel, Rafael Rodríguez-Puerta. Cannabinoid Receptors and Glial Response Following a Basal Forebrain Cholinergic Lesion. ACS pharmacology & translational science. vol 5. issue 9. 2022-09-16. PMID:36110372. |
in this study, 7 days after the lesion, decreased astrocyte and increased microglia immunoreactivities (gfap and iba-1) were observed, indicating microglia-mediated neuroinflammation. |
2022-09-16 |
2023-08-14 |
rat |
| Rob D Dickerman, Julie Williamson, Ezek Mathew, Christopher M Butt, Clark W Bird, Lauren E Hood, Vivian Grimsha. Branched-Chain Amino Acids Are Neuroprotective Against Traumatic Brain Injury and Enhance Rate of Recovery: Prophylactic Role for Contact Sports and Emergent Use. Neurotrauma reports. vol 3. issue 1. 2022-09-05. PMID:36060454. |
on post-injury day 14, brains were harvested to assess levels of astrocytes and microglia with glial fibrillary acidic protein (gfap) and ionized calcium-binding adapter molecule 1 (iba-1) immunohistochemistry, respectively. |
2022-09-05 |
2023-08-14 |
mouse |
| Leonardo C Souza, Marcos K Andrade, Evellyn M Azevedo, Daniele C Ramos, Ellen L Bail, Maria A B F Vita. Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease. Neurotoxicity research. 2022-08-27. PMID:36029454. |
in the present study, we investigated the effects of andro in the icv-stz model relative to short-term spatial memory (object location test (olt) and y maze test), short-term recognition memory (object recognition test (ort)), locomotor activity (open field test (oft)), expression of amyloid precursor protein (app), and activation of astrocytes (glial fibrillary acidic protein (gfap) expression) and microglia (ionized calcium-binding adapter molecule-1 (iba-1) immunohistochemistry) in the prefrontal cortex (pfc) and hippocampus (hip). |
2022-08-27 |
2023-08-14 |
rat |
| E Gök, E Devec. Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride. Archives italiennes de biologie. vol 160. issue 1-2. 2022-08-01. PMID:35913387. |
an increase was found in ionized calcium binding adaptor molecule 1 (iba-1) expression in microglia cells and degenerative endothelial cells, and increased glial fibrillary acidic protein (gfap) expression was observed in astrocytes and degenerate neurons. |
2022-08-01 |
2023-08-14 |
rat |
| Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salu. The Antioxidant N-Acetyl-L-Cysteine Restores the Behavioral Deficits in a Neurodevelopmental Model of Schizophrenia Through a Mechanism That Involves Nitric Oxide. Frontiers in pharmacology. vol 13. 2022-07-29. PMID:35903343. |
analyses of markers involved in the inflammatory response, such as astrocytes (glial fibrillary acid protein, gfap) and microglia (binding adapter molecule 1, iba1), and parvalbumin (pv) positive gabaergic, were conducted in the prefrontal cortex [pfc, medial orbital cortex (mo) and prelimbic cortex (prl)] and dorsal and ventral hippocampus [ca1, ca2, ca3, and dentate gyrus (dg)] in rats under chronic treatment with nac. |
2022-07-29 |
2023-08-14 |
rat |
| Beatriz Martínez-Rojas, Esther Giraldo, Rubén Grillo-Risco, Marta R Hidalgo, Eric López-Mocholi, Ana Alastrue-Agudo, Francisco García-García, Victoria Moreno-Manzan. NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation. Cellular and molecular life sciences : CMLS. vol 79. issue 8. 2022-07-29. PMID:35904607. |
compared with transplanted animals, npcs + esi-05 treatment increases the scar area (as shown by gfap staining), polarizes microglia into an inflammatory phenotype, and increases the magnitude of the gap between neun + cells across the lesion. |
2022-07-29 |
2023-08-14 |
rat |
| Linshu Wang, Kiran Chaudhari, Ali Winters, Yuanhong Sun, Raymond Berry, Christina Tang, Shao-Hua Yang, Ran Li. Recurrent Transient Ischemic Attack Induces Neural Cytoskeleton Modification and Gliosis in an Experimental Model. Translational stroke research. 2022-07-22. PMID:35867329. |
neuronal cytoskeleton modification and neuroinflammation was found at 1, 3, and 7 days after recurrent tia, evidenced by the reduction of microtubule-associated protein 2 (map2), elevation of neurofilament-light chain (nfl), and increase of glial fibrillary acidic protein (gfap)-positive astrocytes and ionized calcium binding adaptor molecule 1 (iba1)-positive microglia at the tia-affected cerebral cortex and basal ganglion. |
2022-07-22 |
2023-08-14 |
rat |
| Ayaka Nakatani, Ryo Kunimatsu, Yuji Tsuka, Shuzo Sakata, Kayo Horie, Hidemi Gunji, Shota Ito, Isamu Kado, Nurul Aisyah Rizky Putranti, Ryuji Terayama, Kotaro Tanimot. Effects of high-frequency near infrared laser irradiation on experimental tooth movement-induced pain in rats. Lasers in medical science. 2022-06-13. PMID:35695995. |
high-frequency nir diode laser irradiation appears to have significant analgesic effects on etm-induced pain, which involve inhibiting neuronal activity, microglia, and astrocytes, and it inhibits c-fos, iba-1, and gfap expression, reducing etm-induced pain in rats. |
2022-06-13 |
2023-08-14 |
rat |
| Alana Gomes de Souza, Iardja Stéfane Lopes, Adriano José Maia Chaves Filho, Talita Matias Barbosa Cavalcante, João Victor Souza Oliveira, Michele Albuquerque Jales de Carvalho, Klistenes Alves de Lima, Paloma Marinho Jucá, Sabrina Silva Mendonça, Melina Mottin, Carolina Horta Andrade, Francisca Cléa Florenço de Sousa, Danielle S Macedo, Marta Maria de França Fontele. Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2022-06-06. PMID:35665831. |
microglia (iba1) and astrocyte (gfap) marker expressions were evaluated by immunofluorescence analyzes and the cytokines tnf-α and il-iβ by immunoenzymatic assay. |
2022-06-06 |
2023-08-14 |
mouse |
| Xusheng Zhang, Mengting Wang, Bingyan Feng, Qiuyu Zhang, Jia Tong, Mingyong Wang, Chengbiao Lu, Shiyong Pen. Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628400. |
the increased expression of gfap were seen at an earlier age of 4 months, and such an increase reached its peak at age of 6 months, indicating that astrocyte activation precedes microglia. |
2022-05-28 |
2023-08-13 |
mouse |
| Yang Liu, Qian Bai, V Wee Yong, Mengzhou Xu. EMMPRIN Promotes the Expression of MMP-9 and Exacerbates Neurological Dysfunction in a Mouse Model of Intracerebral Hemorrhage. Neurochemical research. 2022-05-24. PMID:35608790. |
emmprin expression was co-localized with gfap (astrocytes) and iba1 (microglia) at 3 d time point post-ich, but not in the control group mice. |
2022-05-24 |
2023-08-13 |
mouse |
| Parthasaradhi R Tanguturi, Subramaniam A Ananthan, Vibha Pathak, Phanindra K Venukadasula, Sixue Zhang, Omar Moukha Chafiq, Corinne E A Szafran, John M Streiche. SRI 22136, A Novel Delta Opioid Receptor (DOR) Antagonist for the Treatment of Alzheimer's Disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554003. |
also, in our brain histological analysis the compound exhibited greater efficacy in reduction of the ad pathology markers such as aβ signal, and secondary inflammation and activated glia detected by gfap (astrocytes) and cd11b (microglia) in app/ps ad model double-transgenic mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Sami I Alzarea, Muhammad Afzal, Metab Alharbi, Abdulrahman Alshammari, Ameeduzzafar Zafa. Renin inhibitor attenuates lipopolysaccharide-induced anhedonia and upregulation of neuroinflammatory markers in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556749. |
proinflammatory cytokines (tnf-α, il-1β, and il-6) and glial cells markers (cd11b for microglia and gfap for astrocytes) in the prefrontal cortex were determined via rt-pcr. |
2022-05-13 |
2023-08-13 |
mouse |
| Woo-Ju Song, Jeongtae Kim, Taekyun Shin, Myeong-Seon Jeong, Kil-Nam Kim, Jang-Hyuk Yun, Myung-Bok Wi. Esculetin and Fucoidan Attenuate Autophagy and Apoptosis Induced by Zinc Oxide Nanoparticles through Modulating Reactive Astrocyte and Proinflammatory Cytokines in the Rat Brain. Toxics. vol 10. issue 4. 2022-04-21. PMID:35448455. |
the number of reactive astrocytes measured by counting glial fibrillary acidic protein (gfap)-positive cells, but not microglia, increased following zno np treatment, and esculetin and fucoidan ameliorated the changes. |
2022-04-21 |
2023-08-13 |
rat |
| Milan R Stojiljkovic, Christian Schmeer, Otto W Witt. Pharmacological depletion of microglia leads to a dose-dependent reduction in inflammation and senescence in the aged murine brain. Neuroscience. 2022-02-26. PMID:35217122. |
in this study we pharmacologically depleted microglia using orally delivered low and high doses of the csf1r inhibitor plx5622 and assessed the expression levels of known inflammation markers (tnf-α, il1-β, il-6, il-10), glia markers (iba-1 and gfap) and specific senescence marker p16 |
2022-02-26 |
2023-08-13 |
Not clear |
| Giulia Vallarino, Annalisa Salis, Elena Lucarini, Federica Turrini, Guendalina Olivero, Alessandra Roggeri, Gianluca Damonte, Raffaella Boggia, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Anna Pittalug. Healthy Properties of a New Formulation of Pomegranate-Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis. Molecules (Basel, Switzerland). vol 27. issue 3. 2022-02-15. PMID:35164175. |
were comparable to those in the untreated eae animals, while microglia activation (measured as ionized calcium binding adaptor 1, iba1 staining) and astrocytosis (quantified as glial fibrillar acid protein, gfap immunopositivity) significantly recovered, particularly in the gray matter. |
2022-02-15 |
2023-08-13 |
mouse |
| Jian Kang, Yan Gu. Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Promote Neurological Function Recovery in a Rat Spinal Cord Injury Model. Neurochemical research. 2022-02-08. PMID:35132478. |
conversely, exosome treatment reduced the transcription levels of astrocytes marker gfap and microglia marker iba1, suggesting a reduced inflammatory state from sci injury. |
2022-02-08 |
2023-08-13 |
human |
| Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park, Myeong-Ok Kim, Phil-Ok Ko. Chlorogenic acid alleviates cerebral ischemia-induced neuroinflammation via attenuating nuclear factor kappa B activation. Neuroscience letters. 2022-02-02. PMID:35108588. |
furthermore, cerebral ischemia increased the expression of ionized calcium-binding adapter molecule-1 (iba-1) and glial fibrillary acidic protein (gfap), which are microglia and astrocyte activation markers, respectively. |
2022-02-02 |
2023-08-13 |
rat |