| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Lu, Xiaoyan Tao, Hongyu Dai, Sunan Gao, Hongmei Zho. Peripheral and cerebral inflammation induced by repeated anesthesia and surgery do not cause impairment of learning and memory in middle‑aged mice. Acta neurobiologiae experimentalis. vol 83. issue 1. 2023-04-20. PMID:37078813. |
up‑regulation of iba1 and gfap, respectively, indicated activation of microglia and astrocytes in the hippocampus. |
2023-04-20 |
2023-08-14 |
mouse |
| Rengasamy Balakrishnan, Ju-Young Park, Duk-Yeon Cho, Jae-Yong Ahn, Dong-Sun Yoo, Sang-Ho Seol, Sung-Hwa Yoon, Dong-Kug Cho. AD-1 Small Molecule Improves Learning and Memory Function in Scopolamine-Induced Amnesic Mice Model through Regulation of CREB/BDNF and NF-κB/MAPK Signaling Pathway. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978896. |
western blot analysis showed that ad-1 small molecule reduced activated microglia and astrocytes via the attenuation of iba-1 and gfap protein expression. |
2023-03-29 |
2023-08-14 |
mouse |
| Barbara Fülöp, Ágnes Hunyady, Noémi Bencze, Viktória Kormos, Nikolett Szentes, Ádám Dénes, Nikolett Lénárt, Éva Borbély, Zsuzsanna Helye. IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982563. |
mechanonociception, cold tolerance, behavioral alterations, relative thymus/adrenal gland weights, microglia ionized calcium-binding adaptor molecule 1 (iba1) and astrocyte glial fibrillary acidic protein (gfap) integrated density, number and morphological transformation in pain-related brain regions were determined. |
2023-03-29 |
2023-08-14 |
mouse |
| Tailoi Chan-Ling, Ping Hu, Sergio Li Calzi, Jeff Warner, Nasir Uddin, Mariana DuPont, Martha Neuringer, Paul Kievit, Lauren Renner, Jonathan Stoddard, Renee Ryals, Michael E Boulton, Trevor McGill, Maria B Gran. Glial, neuronal, vascular, RPE and inflammatory cell damage in a new Western diet-induced primate model of diabetic retinopathy. The American journal of pathology. 2023-03-25. PMID:36965774. |
post-mortem changes included: decreased cluster of differentiation marker 31 (cd31) blood vessel density (p < 0.05); increased acellular capillaries (p < 0.05); increased density of ionized calcium binding adaptor molecule (iba-1) expressing amoeboid microglia/macrophage ; loss of regular distribution in stratum and spacing typical of ramified microglia; increased immunoreactivity of aquaporin (aqp) 4 and glial fibrillary acidic protein (gfap) (p<0.05). |
2023-03-25 |
2023-08-14 |
Not clear |
| Irais E Valenzuela-Arzeta, Luis O Soto-Rojas, Yazmin M Flores-Martinez, Karen M Delgado-Minjares, Bismark Gatica-Garcia, Juan U Mascotte-Cruz, Porfirio Nava, Omar Emiliano Aparicio-Trejo, David Reyes-Corona, Irma A Martínez-Dávila, M E Gutierrez-Castillo, Armando J Espadas-Alvarez, Carlos E Orozco-Barrios, Daniel Martinez-Fon. LPS Triggers Acute Neuroinflammation and Parkinsonism Involving NLRP3 Inflammasome Pathway and Mitochondrial CI Dysfunction in the Rat. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902058. |
neuroinflammatory variables were assessed from 48 h to 30 days after the injury by immunostaining for activated microglia (iba-1 +), neurotoxic a1 astrocytes (c3 + and gfap +), and active caspase-1. |
2023-03-11 |
2023-08-14 |
rat |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Dalin Wang, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834838. |
this rat in vivo study determined whether ep injury results in spinal dorsal horn sensitization (substance p, subp), microglia (iba1) and astrocytes (gfap), and evaluated their relationship with pain-related behaviors, ivd degeneration, and spinal macrophages (cd68). |
2023-02-25 |
2023-08-14 |
rat |
| Xiaona Zhao, Xinxin Li, Huiling Guo, Panmei Liu, Minyu Ma, Yanping Wan. Resolvin D1 Attenuates Mechanical Allodynia after Burn Injury: Involvement of Spinal Glia, p38 MAPK, and BDNF/TrkB signaling. Molecular pain. 2023-02-11. PMID:36765459. |
pain behavior and the expression levels of spinal dorsal horn iba-1 (microglia marker), gfap (astrocyte marker), p-p38 mitogen-activated protein kinase (mapk), brain-derived neurotrophic factor (bdnf), and tropomyosin-related kinase b (trkb) were detected by behavioral and immunocytochemical assays. |
2023-02-11 |
2023-08-14 |
rat |
| Shuai Ouyang, Xianbin Wang, Yan Chen, Luoyi Deng, Xianglian Yang, Shouxing Hu, Shuang W. Swimming training combined with fecal microbial transplantation protects motor functions in rats with spinal cord injury by improving the intestinal system. Neuroscience letters. 2023-02-09. PMID:36758789. |
in addition, combined interventions significantly suppressed inflammatory factor levels (p<0.05) in the colon and spinal cords and significantly protected forefoot motor neurons (neun) in the spinal cord injury area, inhibiting astrocyte activation and reducing the expressions of the signature glial fibrillary acidic protein (gfap) and markers of microglia (iba-1) at the lesion site(p<0.05). |
2023-02-09 |
2023-08-14 |
rat |
| Yu-Ting Wang, Kai Lu, Dan-Dan Yao, Shu-Xia Zhang, Gang Che. Anti-inflammatory and analgesic effect of Forsythiaside B on complete Freund's adjuvant-induced inflammatory pain in mice. Biochemical and biophysical research communications. vol 645. 2023-01-21. PMID:36680937. |
furthermore, the fb application ameliorated the activation of ionized calcium-binding adaptor molecule 1 (iba-1) and glial fibrillary acidic protein (gfap), the microglia and astrocytes markers respectively. |
2023-01-21 |
2023-08-14 |
mouse |
| Brown J, Zaben M, Ormonde C, Sharouf F, Spencer R, Bhatt H, Siebzehnrubl Fa, Gray W. A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance. Biochemical pharmacology. 2023-01-12. PMID:36632958. |
high-density 3d cultures contain tumor and host cells, including microglia, and retain key histopathological characteristics of their parent tumors, including proliferative activity, expression of the marker gfap, and presence of giant cells. |
2023-01-12 |
2023-08-14 |
human |
| Rafael Teixeira Ribeiro, Andrey Vinícios Soares Carvalho, Rafael Palavro, Luz Elena Durán-Carabali, Ângela Beatris Zemniaçak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajne. L-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress. Neurotoxicity research. 2022-12-29. PMID:36580261. |
we also determined immunohistochemical landmarks of neuronal viability (neun), astrogliosis (s100b and gfap), microglia activation (iba1), and myelination (mbp and cnpase) in the cerebral cortex and striatum following l-2-hg administration. |
2022-12-29 |
2023-08-14 |
rat |
| Rachel Gilfarb, Zoe Tapp, Elise Lemanski, John Velasquez, Sydney Cornelius, Olga N Kokiko-Cochran, Benedetta Leune. Multiparity differentially affects specific aspects of the acute neuroinflammatory response to traumatic brain injury in female mice. Neuroscience. 2022-12-19. PMID:36535576. |
increased cortical iba1, gfap, and cd68 immunolabeling was observed following tbi independent of parity and microglia morphology did not differ between tbi groups. |
2022-12-19 |
2023-08-14 |
mouse |
| Courtney B Subramaniam, Hannah R Wardill, Maya R Davies, Vivien Heng, Marc A Gladman, Joanne M Bowe. 5-Fluorouracil Induces an Acute Reduction in Neurogenesis and Persistent Neuroinflammation in a Mouse Model of the Neuropsychological Complications of Chemotherapy. Molecular neurobiology. 2022-11-30. PMID:36449255. |
the density of microglia and astrocytes were assessed using immunofluorescence staining of iba1 and gfap respectively. |
2022-11-30 |
2023-08-14 |
mouse |
| Laura Micheli, Elena Lucarini, Stefania Nobili, Gianluca Bartolucci, Andrea Pallecchi, Alessandra Toti, Valentina Ferrara, Clara Ciampi, Carla Ghelardini, Lorenzo Di Cesare Mannell. Ultramicronized N-palmitoylethanolamine contributes to morphine efficacy against neuropathic pain: implication of mast cells and glia. Current neuropharmacology. 2022-11-29. PMID:36443965. |
the activation of spinal microglia and astrocytes, commonly occurring both on opioid treatment and neuropathic pain, was investigated through gfap and iba-1 immunofluorescence. |
2022-11-29 |
2023-08-14 |
rat |
| Yujiao Li, Xiaolu He, Jieyu Zhang, Qing Zhou, Xuejiao Liu, Guohua Zho. Medicarpin Improves Depressive-Like Behaviors in a Chronic Unpredictable Mild Stress-Induced Mouse Model of Depression by Upregulating Liver X Receptor β Expression in the Amygdala. Neurotoxicity research. 2022-11-29. PMID:36445678. |
moreover, medicarpin treatment reduced m1 polarization and enhanced m2 polarization of amygdala microglia in cums-induced mice, as well as increased gfap level in the amygdala. |
2022-11-29 |
2023-08-14 |
mouse |
| I O Ishola, A K Oloyo, T G Olubodun-Obadun, O D Godswill, S A Omilabu, O O Adeyem. Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation. Metabolic brain disease. 2022-11-19. PMID:36401682. |
mptp-induced expression of microglia (iba-1), astrocytes (glia fibrillary acidic protein; gfap) as well as degeneration of dopamine neurons (tyrosine hydroxylase positive neurons) in the substantia nigra (sn) were reversed by dsc. |
2022-11-19 |
2023-08-14 |
mouse |
| Richard L Jayaraj, Sheikh Azimullah, Khatija A Parekh, Shreesh K Ojha, Rami Beira. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an Heliyon. vol 8. issue 11. 2022-11-17. PMID:36387498. |
further, citronellol prevented rotenone induced microglia (iba-1 staining) and astrocyte (gfap staining) activation. |
2022-11-17 |
2023-08-14 |
rat |
| Edward Pajarillo, Ivan Nyarko-Danquah, Alexis Digman, Cynthia Vied, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Le. Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation. Glia. 2022-10-27. PMID:36300569. |
astrocytic yy1 deletion significantly increased the expression of gfap as astrocytic activation and iba1 as microglial activation, indicating astrocytic yy1 deletion activated microglia as well. |
2022-10-27 |
2023-08-14 |
mouse |
| Sai Sandhya Narra, Philippe Rondeau, Danielle Fernezelian, Laura Gence, Batoul Ghaddar, Emmanuel Bourdon, Christian Lefebvre d'Hellencourt, Sepand Rastegar, Nicolas Diote. Distribution of microglia/immune cells in the brain of adult zebrafish in homeostatic and regenerative conditions: Focus on oxidative stress during brain repair. The Journal of comparative neurology. 2022-10-25. PMID:36282721. |
taking advantage of tg(fli:gfp) and tg(gfap::gfp) enabling the detection of endothelial cells and neural stem cells (nscs), we highlighted the association of elongated microglia/immune cells with blood vessels and rounded/amoeboid microglia with nscs. |
2022-10-25 |
2023-08-14 |
zebrafish |
| Yasuhiko Sato, Shoko Saito, Makiko Nakayama, Sunao Sugita, Akihiko Kudo, Hiroshi Kein. Genetic Ablation of Nrf2 Exacerbates Neuroinflammation in Ocular Autoimmunity. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233013. |
gfap positive cells (astrocytes) and iba-1 positive cells (microglia cells) in the retina were more numerous in nrf2 ko mice compared to wt mice. |
2022-10-14 |
2023-08-14 |
mouse |