| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park, Myeong-Ok Kim, Phil-Ok Ko. Chlorogenic acid alleviates cerebral ischemia-induced neuroinflammation via attenuating nuclear factor kappa B activation. Neuroscience letters. 2022-02-02. PMID:35108588. |
furthermore, cerebral ischemia increased the expression of ionized calcium-binding adapter molecule-1 (iba-1) and glial fibrillary acidic protein (gfap), which are microglia and astrocyte activation markers, respectively. |
2022-02-02 |
2023-08-13 |
rat |
| Elisa Chludzinski, Christina Puff, Jürgen Weber, Marion Hewicker-Trautwei. Case Report: Primary Diffuse Leptomeningeal Oligodendrogliomatosis in a Young Adult Cat. Frontiers in veterinary science. vol 8. 2022-01-03. PMID:34977226. |
few gfap positive and iba-1 positive cells were interpreted as reactive astrocytes and macrophages or microglia, respectively. |
2022-01-03 |
2023-08-13 |
cat |
| Xiaokun Han, Xuan Liu, Jiejie Zhuang, Xida Liang, Qian Luo, Pei Chen, Ye Wen, Xiao Wang, Juan Peng, Ying Yang, Xiangyin Sha, Jing Zhuan. A modified high-yield method for primary culture of rat retinal microglial cells. Experimental eye research. 2022-01-03. PMID:34979098. |
then, the isolation was performed by a shaking method and isolated cells were identified with microglia markers ionized calcium-binding adapter molecule 1 (iba1), transmembrane protein 119 (tmem119), cluster of differentiation 11b (cd11b), as well as astrocyte marker glial fibrillary acidic protein (gfap) by immunofluorescence staining. |
2022-01-03 |
2023-08-13 |
rat |
| Yu Tian, Xiangyu Chen, Yue Wang, Yong He, Chong Chen, Heming Yu, Zhi Chen, Yi Ren, Ke Cheng, Peng Xi. Neuroinflammatory transcriptional signatures in the entorhinal cortex based on lipopolysaccharide-induced depression model in mice. Biochemical and biophysical research communications. vol 590. 2022-01-02. PMID:34974298. |
the molecular verification showed activation of il-1r1/nf-κb/ccl5 signaling and upregulation of markers of astrocyte (gfap) and microglia (aif1 and cd86) in the ec. |
2022-01-02 |
2023-08-13 |
mouse |
| Yin Yuxiong, Xiang Xujin, Tang Yi, Chen Ya, Li Yujuan, Hu Shanshan, Wang Huiwe. Brain-specific TRAF7 deletion ameliorates traumatic brain injury by suppressing MEKK3-regulated glial inflammation and neuronal death. International immunopharmacology. vol 103. 2021-12-25. PMID:34953447. |
moreover, the aberrant activation of astrocyte and microglia in cortex and hippocampus of tbi mice was significantly restrained by traf7 conditional knockout in brain, as indicated by the increased expression of gfap and iba1. |
2021-12-25 |
2023-08-13 |
mouse |
| Xiaoting Zhou, Jiachen Lu, Kehong Wei, Jing Wei, Puyuan Tian, Mengyun Yue, Yun Wang, Daojun Hong, Fangjun Li, Bo Wang, Tingtao Chen, Xin Fan. Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota. Oxidative medicine and cellular longevity. vol 2021. 2021-12-23. PMID:34938384. |
ceftriaxone alleviated the behavioural and neuropathological changes induced by mptp, downregulated the expression of glial fibrillary acidic protein (gfap) and ionised calcium-binding adapter molecule 1 (iba1) as markers of astroglia and microglia, respectively, and reduced the expression of neuroinflammation-related toll-like receptor 4 (tlr4), myeloid differentiation primary response 88 (myd88), and phosphorylated nuclear factor kappa-b (p-nf- |
2021-12-23 |
2023-08-13 |
mouse |
| Bang-Xu Nie, Gang Zhao, Xiao-Feng Yuan, Lin-Xin Yu, Jin Zhang, Yong Yuan, Yao Liu, Jun Hu, En Song, Yu-Cheng Zhou, Jun Sh. Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo. Journal of chemical neuroanatomy. vol 119. 2021-12-11. PMID:34839004. |
the expression levels of glial fibrillary acidic protein (gfap), ionized calcium-binding adaptor (iba) and choline acetyltransferase (chat) in the anterior horn were determined using immunohistochemistry assays to investigate astrocytes, microglia and motor neurons, respectively, in the anterior horn. |
2021-12-11 |
2023-08-13 |
rat |
| Yu Zhou, Wei-Jiang Zhao, Wei Quan, Chen-Meng Qiao, Chun Cui, Hui Hong, Yun Shi, Gu-Yu Niu, Li-Ping Zhao, Yan-Qin She. Dynamic changes of activated AHR in microglia and astrocytes in the substantia nigra-striatum system in an MPTP-induced Parkinson's disease mouse model. Brain research bulletin. vol 176. 2021-12-10. PMID:34478811. |
to determine exactly the ahr activation in relation to changes of glial cell reactivity, double if labeling was performed for either iba1 (microglia marker) and p-ahr, or gfap (astrocyte marker) and p-ahr. |
2021-12-10 |
2023-08-13 |
mouse |
| Alexander Kirschner, Ana N Strat, John Yablonski, Hannah Yoo, Tyler Bagué, Haiyan Li, Jing Zhao, Kathryn E Bollinger, Samuel Herberg, Preethi S Ganapath. Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes. Experimental eye research. vol 212. 2021-12-08. PMID:34656548. |
primary optic nerve head astrocytes were positive for the astrocyte marker gfap and negative for markers for microglia (f4/80) and oligodendrocytes (osp1). |
2021-12-08 |
2023-08-13 |
mouse |
| Keigo Takahashi, Steven Q Le, Shih-Hsin Kan, Matthew J Jansen, Patricia I Dickson, Jonathan D Coope. Neuropathology of murine Sanfilippo D syndrome. Molecular genetics and metabolism. 2021-11-30. PMID:34844863. |
we found significantly increased immunostaining for glial fibrillary associated protein (gfap), cd68 (a marker of activated microglia), and lysosomal-associated membrane protein-1 (lamp-1) in sanfilippo d mice compared to controls at 12 weeks of age in all brain regions. |
2021-11-30 |
2023-08-13 |
mouse |
| D P Ferrari, M Bortolanza, E A Del Be. Interferon-γ Involvement in the Neuroinflammation Associated with Parkinson's Disease and L-DOPA-Induced Dyskinesia. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33687725. |
in conclusion, ifn-γ/ko mice presented an intensification of the inflammatory reaction accompanying l-dopa treatment and suggest that inos and gfap increase, and the activation of astrocytes and microglia induced afterward l-dopa treatment was ifn-γ independent events. |
2021-11-29 |
2023-08-13 |
mouse |
| A V Morgun, E D Osipova, E B Boitsova, A N Shuvaev, N A Malinovskaya, A I Mosiagina, A B Salmin. Neurogenic Potential of Implanted Neurospheres Is Regulated by Optogenetic Stimulation of Hippocampal Astrocytes Ex Vivo. Bulletin of experimental biology and medicine. vol 170. issue 6. 2021-11-26. PMID:33893948. |
the electrophysiological characteristics of the hippocampus and expression of molecules involved in the mechanisms of activation of astrocytes and microglia (gfap, cd38, c3/c3b, cx43, cd11b, and cd18) were evaluated. |
2021-11-26 |
2023-08-13 |
mouse |
| Jinhan Yang, Tong Wang, Xiaoxia Jin, Gaoyang Wang, Fenghong Zhao, Yaping Ji. Roles of Crosstalk between Astrocytes and Microglia in Triggering Neuroinflammation and Brain Edema Formation in 1,2-Dichloroethane-Intoxicated Mice. Cells. vol 10. issue 10. 2021-11-25. PMID:34685627. |
the present research revealed, for the first time, that subacute intoxication with 1,2-dce might provoke the proinflammatory polarization of microglia, and pretreatment with minocycline, a specific inhibitor of microglial activation, may attenuate the enhanced protein levels of ionized calcium-binding adapter molecule1 (iba-1), cluster of differentiation 11b (cd11b), glial fibrillary acidic protein (gfap), soluble calcium-binding protein 100b (s100b), tumor necrosis factor α (tnf-α), interleukin 6 (il-6), inducible nitric oxide synthase (inos), vascular cell adhesion molecule-1 (vcam-1), intercellular adhesion molecule-1 (icam-1), matrix metalloproteinase-9 (mmp-9), toll-like receptor 4 (tlr4), myd88, and p-p65, and ameliorate the suppressed protein expression levels of occludin and claudin 5; we also observed changes in water content and made pathological observations on edema in the brains of 1,2-dce-intoxicated mice. |
2021-11-25 |
2023-08-13 |
mouse |
| Bailey Balouch, Jessica L Funnell, Alexis M Ziemba, Devan L Puhl, Kathy Lin, Manoj K Gottipati, Ryan J Gilber. Conventional immunomarkers stain a fraction of astrocytes in vitro: A comparison of rat cortical and spinal cord astrocytes in naïve and stimulated cultures. Journal of neuroscience research. vol 99. issue 3. 2021-11-23. PMID:33295039. |
however, glast, glt-1, gs, and sox9 are also produced by microglia and oligodendrocytes and gfap, glast, glt-1, and gs production levels are affected by astrocyte phenotypic changes associated with reactive astrogliosis. |
2021-11-23 |
2023-08-13 |
rat |
| Nahanna Zimmermann Menezes Carvalho, Gabriela Bortolança Chiarotto, Danielle Bernardes, Paula Regina Gelinski Kempe, Alexandre Leite Rodrigues Oliveir. Neuroprotection by dimethyl fumarate following ventral root crush in C57BL/6J mice. Brain research bulletin. vol 164. 2021-10-29. PMID:32866558. |
glial reactions were evaluated with anti-iba1 (microglia) and gfap (astrocytes). |
2021-10-29 |
2023-08-13 |
mouse |
| Giedre Milinkeviciute, Sima M Chokr, Emily M Castro, Karina S Crame. CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem. The Journal of comparative neurology. vol 529. issue 11. 2021-10-29. PMID:33797066. |
microglia depletion also led to a decrease in glial fibrillary acidic protein (gfap), a marker for mature astrocytes. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yan Cheng, Woong-Ki Kim, Laurie L Wellman, Larry D Sanford, Ming-Lei Gu. Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner. Life (Basel, Switzerland). vol 11. issue 10. 2021-10-26. PMID:34685469. |
for the status of microglia and astrocytes, we determined the levels of iba1 and gfap in these brain regions. |
2021-10-26 |
2023-08-13 |
mouse |
| R L Moretti, E N Dias, S G Kiel, M C M Augusto, P S Rodrigues, A C S Sampaio, L S Medeiros, M F M Martins, I B Suffredini, C V Cardoso, E F Bonda. Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment. Research in veterinary science. vol 140. 2021-10-15. PMID:34536813. |
brains were collected and analyzed by hematoxylin-eosin and luxol fast blue staining techniques and by immunohistochemistry for gfap (glial fibrillary acidic protein) expression in astrocytes and iba1 (ionized calcium-binding adaptor molecule 1) expression in microglia. |
2021-10-15 |
2023-08-13 |
rat |
| R L Moretti, E N Dias, S G Kiel, M C M Augusto, P S Rodrigues, A C S Sampaio, L S Medeiros, M F M Martins, I B Suffredini, C V Cardoso, E F Bonda. Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment. Research in veterinary science. vol 140. 2021-10-15. PMID:34536813. |
dox-injected rats presented short-term and long-term memory impairments as seen in the nort at 3 and 24 h after habituation and increased gfap and iba1 expression, respectively, in astrocytes and microglia of the frontal cortex, hypothalamus and hippocampus. |
2021-10-15 |
2023-08-13 |
rat |
| Jin Wang, Yushu Hou, Lixia Zhang, Min Liu, Jianshuai Zhao, Zhen Zhang, Yulong Ma, Wugang Ho. Estrogen Attenuates Traumatic Brain Injury by Inhibiting the Activation of Microglia and Astrocyte-Mediated Neuroinflammatory Responses. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33085047. |
we found that e2 treatment significantly alleviated tbi-induced neurological deficits, neuronal injuries, and brain edema and significantly inhibited iba1 and gfap expression, which are markers of microglia and astrocyte activation, respectively. |
2021-10-13 |
2023-08-13 |
mouse |