| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ernest T Chivero, Susmita Sil, Seema Singh, Annadurai Thangaraj, Lila Gordon, Grace B Evah-Nzoughe, Natasha Ferguson, Shannon Callen, Shilpa Buc. Protective Role of Lactobacillus rhamnosus Probiotic in Reversing Cocaine-Induced Oxidative Stress, Glial Activation and Locomotion in Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-10-10. PMID:34628571. |
in cocaine administered mice, there was increased activation of both microglia and astrocytes in the striatum and cortex of the brain as shown by enhanced expression of cd11b and gfap, respectively. |
2021-10-10 |
2023-08-13 |
mouse |
| Tunahan Kirabali, Ruslan Rust, Serena Rigotti, Alessandro Siccoli, Roger M Nitsch, Luka Kuli. Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32866303. |
post-mortem human cortical and hippocampal samples derived from ad patients and non-demented elderly control individuals were immunostained using a panel of markers representing specific components of the nvu including collagen iv (basement membrane), pdgfr-β (pericytes), gfap (astrocytes), iba1 (microglia), mrc1 (perivascular macrophages) and lectin as an endothelial cell label. |
2021-10-06 |
2023-08-13 |
human |
| Tunahan Kirabali, Ruslan Rust, Serena Rigotti, Alessandro Siccoli, Roger M Nitsch, Luka Kuli. Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32866303. |
astrocytes (gfap) and microglia (iba1) were quantified both in the whole visual-field and specifically within the nvu, and the sample set was additionally analyzed using anti-tau (at8) and three different anti-aβ (clones g2-10, g2-11, 4g8) antibodies. |
2021-10-06 |
2023-08-13 |
human |
| Ronak Mousaviyan, Nahid Davoodian, Faezeh Alizadeh, Maryam Ghasemi-Kasman, Seyed Abdollah Mousavi, Fatemeh Shaerzadeh, Haniyeh Kazem. Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation. Biological trace element research. vol 199. issue 11. 2021-09-27. PMID:33400154. |
at postnatal day 60, the density of both microglia and astrocyte cells and the expression levels of il-6, il-1β, inos, tnf-α, nf-κb, and gfap were evaluated in the pfc of male pups. |
2021-09-27 |
2023-08-13 |
rat |
| MiaoJun Lv, GuoFang Xue, HuiFeng Cheng, PengFei Meng, Xia Lian, Christian Hölscher, DongFang L. The GLP-1/GIP dual-receptor agonist DA5-CH inhibits the NF-κB inflammatory pathway in the MPTP mouse model of Parkinson's disease more effectively than the GLP-1 single-receptor agonist NLY01. Brain and behavior. vol 11. issue 8. 2021-09-22. PMID:34125470. |
when measuring the levels of the inflammation markers toll-like receptor 4 (tlr4), specific markers of microglia activation (iba-1), the marker of astrocyte activation glial fibrillary acidic protein (gfap), nuclear factor-κb (nf-κb), tumor necrosis factor (tnf-α), and transforming growth factor β1 (tgf-β1), da5-ch was very effective in reducing the chronic inflammation response, while nly01 did not show significant effects. |
2021-09-22 |
2023-08-13 |
mouse |
| Andrea Lewen, Thuy-Truc Ta, Tiziana Cesetti, Jan-Oliver Hollnagel, Ismini E Papageorgiou, Bruno Chausse, Oliver Kan. Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. Journal of neuroscience research. vol 98. issue 10. 2021-09-17. PMID:32638411. |
chronic exposure of slice cultures to liposome-encapsulated clodronate reduced the microglial cell population by about 96%, whereas neuronal structures, astrocyte gfap expression, and basal levels of cytokines and no were unchanged. |
2021-09-17 |
2023-08-13 |
rat |
| Lifen Liu, Yutong Liu, Nana Li, Runzhi Huang, Ximing Zheng, Liang Huang, Shuangxin Hou, Qionglan Yua. Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice. Brain research bulletin. vol 156. 2021-08-20. PMID:31931120. |
confocal microscope analysis revealed that microglia not astrocytes began to phagocytose aβ in 6-month-old tgapp/ps1 mice, evidenced by the intracellular aβ in iba1 positive microglia not in gfap positive astrocytes. |
2021-08-20 |
2023-08-13 |
mouse |
| Agata Ciechanowska, Katarzyna Popiolek-Barczyk, Katarzyna Pawlik, Katarzyna Ciapała, Marco Oggioni, Domenico Mercurio, Maria-Grazia De Simoni, Joanna Mik. Changes in macrophage inflammatory protein-1 (MIP-1) family members expression induced by traumatic brain injury in mice. Immunobiology. vol 225. issue 3. 2021-08-06. PMID:32059938. |
we also observed the upregulation of neutrophil marker (mpo) at the early time points (24 h and 7 days) in the cortex, while the profound activation of microglia (iba-1) and astroglia (gfap) was observed mainly on day 7. |
2021-08-06 |
2023-08-13 |
mouse |
| Maike Michel, Bernd L Fiebich, Hanna Kuzior, Sophie Meixensberger, Benjamin Berger, Simon Maier, Kathrin Nickel, Kimon Runge, Dominik Denzel, Benjamin Pankratz, Miriam A Schiele, Katharina Domschke, Ludger Tebartz van Elst, Dominique Endre. Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34021122. |
in conclusion, higher gfap levels in patients with depression may be indicative of altered microglia activity, especially in astrocytes, in patients with unipolar depression. |
2021-07-14 |
2023-08-13 |
Not clear |
| E P G Vazi, F Holanda, N A Santos, C V Cardoso, M F M Martins, E F Bonda. Short-term systemic methotrexate administration in rats induces astrogliosis and microgliosis. Research in veterinary science. vol 138. 2021-07-08. PMID:34091228. |
on the 5th day, brain samples were collected for hematoxylin-eosin and luxol fast blue staining techniques, as well as for immunohistochemical staining for glial fibrillary acidic protein (gfap) expression in astrocytes and iba1 (ionized calcium binding adaptor molecule 1) for microglia in the frontal cortex, hippocampus, hypothalamus and molecular/granular layers of the cerebellum. |
2021-07-08 |
2023-08-13 |
rat |
| Chia-Li Chung, Chieh-Hsin Wu, Yu-Hua Huang, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwa. Blocking Hepatoma-Derived Growth Factor Attenuates Vasospasm and Neuron Cell Apoptosis in Rats Subjected to Subarachnoid Hemorrhage. Translational stroke research. 2021-07-06. PMID:34227049. |
immunofluorescence staining for iba-1, gfap, tunel, and neun was detected proliferation of microglia and astrocyte and apoptosis of neuron cells. |
2021-07-06 |
2023-08-13 |
rat |
| Antonio Garrido, Mariano De La Serna, Mónica De La Fuente, Eva María Marco, Meritxell López-Gallard. Neuronal and glial region dependent changes in female mice from a model of premature aging. Experimental gerontology. vol 146. 2021-06-02. PMID:33388380. |
through the application of immunohistochemical techniques we evaluated changes in the expression of neun (a neuronal marker), iba-1 (a microglia marker) and gfap (an astrocyte marker) in brain areas related to the behavioral alterations previously detected in both pam and chronologically old mice. |
2021-06-02 |
2023-08-13 |
mouse |
| Karen Bohmwald, Jorge A Soto, Catalina Andrade-Parra, Ayleen Fernández-Fierro, Janyra A Espinoza, Mariana Ríos, Eliseo A Eugenin, Pablo A González, María Cecilia Opazo, Claudia A Riedel, Alexis M Kalergi. Lung pathology due to hRSV infection impairs blood-brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:32979471. |
we identified the presence of hrsv in the brain cortex where it colocalizes with vwf, map-2, iba-1, and gfap, which are considered markers for endothelial cells, neurons, microglia, and astrocyte, respectively. |
2021-05-27 |
2023-08-13 |
mouse |
| Nagla A El-Sherbeeny, Afaf T Ibrahiem, Howaida S Ali, Noha E Farag, Eman A Toraih, Sawsan A Zaiton. Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia. Archives of pharmacal research. vol 43. issue 7. 2021-05-17. PMID:32676893. |
the spinal cords were evaluated for synaptic plasticity (growth associated protein-43, gap43), microglia cell expression (by cd11b) and astrocyte expression (glial fibrillary acidic protein, gfap). |
2021-05-17 |
2023-08-13 |
mouse |
| Kenta Sakai, Fuyuko Takata, Gaku Yamanaka, Miho Yasunaga, Kana Hashiguchi, Kazuki Tominaga, Kouichi Itoh, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohg. Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice. Journal of pharmacological sciences. vol 145. issue 1. 2021-05-13. PMID:33357774. |
the expression of iba1 and gfap, as markers of microglia and astrocytes, respectively, increased from 4 to 28 days after cci. |
2021-05-13 |
2023-08-13 |
mouse |
| Haixia Du, Yu He, Yuanjiang Pan, Mengdi Zhao, Zhiwei Li, Yu Wang, Jiehong Yang, Haitong Wa. Danhong Injection Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through the Suppression of the Neuroinflammation. Frontiers in pharmacology. vol 12. 2021-05-02. PMID:33927611. |
immunohistochemical staining results also revealed that dhi dose-dependently diminished the protein expressions of icam-1 and cox-2, and suppressed the activation of microglia (ionized calcium-binding adapter molecule 1, iba-1) and astrocyte (glial fibrillary acidic protein, gfap) in the cerebral cortex. |
2021-05-02 |
2023-08-13 |
rat |
| Hyunha Kim, Ji Seon Seo, Seo-Yeon Lee, Ki-Tae Ha, Byung Tae Choi, Yong-Il Shin, Young Ju Yun, Hwa Kyoung Shi. AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32201254. |
aim2 immunoreactivity of the psci group was primarily co-localized with iba-1 (microglial marker) and cd31 (endothelial cell marker) immunoreactivities but not neun (neuronal marker) and gfap (astrocyte marker) immunoreactivities, suggesting that microglia or endothelial cell-induced aim2 production mediated psci pathogenesis. |
2021-04-27 |
2023-08-13 |
mouse |
| Ning Zhang, Chunhong Liu, Ruiyan Zhang, Li Jin, Xiaohan Yin, Xuexing Zheng, Hans-Christian Siebert, Yubao Li, Zhengping Wang, Gabriele Loers, Athanasios K Petridi. Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet. Food & function. vol 11. issue 6. 2021-04-26. PMID:32539054. |
concomitant, the protein expressions of glial fibrillary acidic protein (gfap, an astrocyte marker), ionized calcium-binding adaptor molecule 1 (iba-1, a microglial marker), cd68 (an activated microglia marker) and cd16/32 (a m1 microglial marker) were down-regulated, while the expression of oligodendrocyte lineage transcription factor 2 (olig2, an oligodendrocyte precursor cells marker) was up-regulated by the kd treatment. |
2021-04-26 |
2023-08-13 |
mouse |
| Mafalda Campeão, Luciana Fernandes, Inês R Pita, Cristina Lemos, Syed F Ali, Félix Carvalho, Paulo Rodrigues-Santos, Carlos A Fontes-Ribeiro, Edna Soares, Sofia D Viana, Frederico C Pereir. Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature. Pharmaceuticals (Basel, Switzerland). vol 14. issue 3. 2021-04-13. PMID:33809599. |
additionally, striatal th (meth neurotoxicity hallmark), iba-1 (microglia), gfap (astrocyte), rage, and tlr2/4/7 (immune modulators) protein densities remained unchanged after mdpv-exposure. |
2021-04-13 |
2023-08-13 |
mouse |
| Xiaoling Hu, Yiming Liu, Junting Wu, Yu Liu, Wenjie Liu, Ji Chen, Fengrui Yan. Inhibition of P2X7R in the amygdala ameliorates symptoms of neuropathic pain after spared nerve injury in rats. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32311494. |
a-438079 administration significantly attenuated the elevated immunoreactivities of iba-1 and gfap in microglia and astrocytes after sni. |
2021-04-06 |
2023-08-13 |
rat |