| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minati Singh, Janelle E Garrison, Kai Wang, Val C Sheffiel. Absence of BBSome function leads to astrocyte reactivity in the brain. Molecular brain. vol 12. issue 1. 2020-05-26. PMID:31072410. |
increased gfap expression is a hallmark of astrocyte reactivity that is associated with microglia activation and neuro-inflammation. |
2020-05-26 |
2023-08-13 |
mouse |
| Rita Machaalani, Melisande Thawley, Jessica Huang, Hui Che. Effects of prenatal cigarette smoke exposure on BDNF, PACAP, microglia and gliosis expression in the young male mouse brainstem. Neurotoxicology. vol 74. 2020-05-12. PMID:31121239. |
using a mouse model of pre- into post- natal cigarette smoke exposure (se), we aimed to determine the effects on brain derived neurotrophic factor (bdnf) and its receptor trkb, neuropeptide pituitary adenylate cyclase activating polypeptide (pacap) and its receptor pac1, and astrocyte (gfap) and microglia (iba-1) immunohistochemical expression, in seven nuclei of the medulla and the facial (fac) nucleus of the pons. |
2020-05-12 |
2023-08-13 |
mouse |
| Matthew C Valdez, Danielle Freeborn, Joseph M Valdez, Andrew F M Johnstone, Samantha J Snow, Alan H Tennant, Urmila P Kodavanti, Prasada Rao S Kodavant. Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets. International journal of molecular sciences. vol 20. issue 24. 2020-04-28. PMID:31847143. |
microglial morphology and gfap immunoreactivity were assessed across diet groups; results indicated that fish oil consistently decreased reactive microglia in the hypothalamus and hippocampus. |
2020-04-28 |
2023-08-13 |
rat |
| Mi Sun Sung, Hwan Heo, Gwang Hyeon Eom, So Young Kim, Helong Piao, Yue Guo, Sang Woo Par. HDAC2 Regulates Glial Cell Activation in Ischemic Mouse Retina. International journal of molecular sciences. vol 20. issue 20. 2020-04-13. PMID:31627491. |
expression of macroglial and microglial cell markers (gfap and iba1), hypoxia inducing factor (hif)-1α, and histone acetylation was analyzed after ir injury. |
2020-04-13 |
2023-08-13 |
mouse |
| Daniela Talhada, Isabel Gonçalves, João Carlos Gomes, Maria João Saraiva, Cecília Reis Santos, Karsten Rusche. Transthyretin expression in the postischemic brain. PloS one. vol 14. issue 9. 2020-03-16. PMID:31479465. |
no ttr immunoreactivity was found when stainings were performed with markers for neurons (neuronal nuclei, neun), reactive astrocytes (glial fibrillary acidic protein, gfap) or microglia (cluster of differentiation 68, cd68). |
2020-03-16 |
2023-08-13 |
mouse |
| Carlo Perego, Stefano Fumagalli, Kapka Miteva, Marinos Kallikourdis, Maria-Grazia De Simon. Combined Genetic Deletion of IL (Interleukin)-4, IL-5, IL-9, and IL-13 Does Not Affect Ischemic Brain Injury in Mice. Stroke. vol 50. issue 8. 2020-03-09. PMID:31272316. |
neuropathologic outcome was assessed at 24 hours (n=6), 7 days (n=6), and 5 weeks (n=6-7) by examination of the ischemic lesion, neuronal count, microglia and infiltrated macrophages markers, brain atrophy, collagen deposition, and gfap (glial fibrillary acidic protein) immunohistochemistry. |
2020-03-09 |
2023-08-13 |
mouse |
| Lihe Li, Baoyang Li. ROCK inhibitor Y‑27632 protects rats against cerebral ischemia/reperfusion‑induced behavioral deficits and hippocampal damage. Molecular medicine reports. vol 20. issue 4. 2020-02-04. PMID:31432130. |
finally, the expression of recombinant glial fibrillary acidic protein (gfap) and allograft inflammatory factor 1 (aif1) in the brain were measured to assess the activation of astrocytes and microglia, respectively. |
2020-02-04 |
2023-08-13 |
rat |
| Lihe Li, Baoyang Li. ROCK inhibitor Y‑27632 protects rats against cerebral ischemia/reperfusion‑induced behavioral deficits and hippocampal damage. Molecular medicine reports. vol 20. issue 4. 2020-02-04. PMID:31432130. |
the levels of gfap and aif1 were increased by mcao and further promoted by y‑27632, indicating the activation of astrocytes and microglia. |
2020-02-04 |
2023-08-13 |
rat |
| Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim, Phil-Ok Ko. Baicalin attenuates lipopolysaccharide-induced neuroinflammation in cerebral cortex of mice via inhibiting nuclear factor kappa B (NF-κB) activation. The Journal of veterinary medical science. vol 81. issue 9. 2020-01-31. PMID:31366818. |
ionized calcium binding adaptor molecule-1 (iba-1) and glial fibrillary acidic protein (gfap) are known as markers of activated microglia and astrocyte, respectively. |
2020-01-31 |
2023-08-13 |
mouse |
| Mengmeng Yu, Dianxu Yang, Mingliang Wang, Xiaoer Wei, Wenbin L. Early stage of diffusional kurtosis imaging and dynamic contrast-enhanced magnetic resonance imaging correlated with long-term neurocognitive function after experimental traumatic brain injury. Neuroscience letters. vol 705. 2019-12-23. PMID:31005651. |
immunohistochemistry (ihc) analysis of neuron [neun], astroglia [gfap], microglia [iba-1], and myelin [mbp] was performed after the mwm test. |
2019-12-23 |
2023-08-13 |
rat |
| A. Dietrich, Z.L. Fülöp, M. D. Chambers, R.S. Darrell, D.G. Stei. The effect of Ginkgo biloba extract (EGb 761) on gliotic reactions in the hippocampal formation after unilateral entorhinal cortex lesions. Restorative neurology and neuroscience. vol 16. issue 2. 2019-11-20. PMID:12671211. |
microglia and their precursors were visualized with a silver impregnation method, and astrocytes with gfap. |
2019-11-20 |
2023-08-12 |
rat |
| A. Dietrich, Z.L. Fülöp, M. D. Chambers, R.S. Darrell, D.G. Stei. The effect of Ginkgo biloba extract (EGb 761) on gliotic reactions in the hippocampal formation after unilateral entorhinal cortex lesions. Restorative neurology and neuroscience. vol 16. issue 2. 2019-11-20. PMID:12671211. |
reactive astrocytes were stained with gfap and were found to be more numerous than activated microglia, particularly in the ipsilateral corpus callo-sum. |
2019-11-20 |
2023-08-12 |
rat |
| Salil Sharma, Ines Khadimallah, Adam Williamson Corya, Yousuf Omar Ali, Xi Rao, Yunlong Liu, Hui-Chen L. Presymptomatic change in microRNAs modulates Tau pathology. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29915328. |
similar to what was observed in tau brains, overexpressing mir142 in wildtype cortical neurons augments mrna levels of glial fibrillary acidic protein (gfap) and colony stimulating factor 1 (csf1), accompanied by a significant increase in microglia and reactive astrocyte numbers. |
2019-10-09 |
2023-08-13 |
mouse |
| Ashley E Mohrman, Mahmoud Farrag, Rachel K Grimm, Nic D Leipzi. Evaluation of in situ gelling chitosan-PEG copolymer for use in the spinal cord. Journal of biomaterials applications. vol 33. issue 3. 2019-09-30. PMID:30111249. |
the saline and hydrogel-injected animals both showed a similar response from ed1+ microglia and gfap overexpression. |
2019-09-30 |
2023-08-13 |
rat |
| William M Pardridge, Ruben J Boado, Daniel J Patrick, Eric Ka-Wai Hui, Jeff Zhiqiang L. Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor. Molecular pharmaceutics. vol 15. issue 11. 2019-08-28. PMID:30226787. |
immunohistochemistry of terminal brain tissue showed microglia activation, based on enhanced iba1 immuno-staining, in conjunction with astrogliosis, based on increased gfap immuno-staining. |
2019-08-28 |
2023-08-13 |
human |
| Olena Y Glushakova, Andriy O Glushakov, Cesar V Borlongan, Alex B Valadka, Ronald L Hayes, Alexander V Glushako. Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats. Journal of neurotrauma. vol 35. issue 1. 2019-07-08. PMID:28637381. |
we studied astrocytes (glial fibrillary acidic protein [gfap]), microglia (ionized calcium-binding adapter molecule 1 [iba1]), bbb (endothelial barrier antigen [eba]), and activated microglia/macrophages (cluster of differentiation 68 [cd68]). |
2019-07-08 |
2023-08-13 |
rat |
| Louis Nerurkar, Alison McColl, Gerard Graham, Jonathan Cavanag. The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation. Scientific reports. vol 7. issue 1. 2019-07-03. PMID:29185473. |
indeed, the association of imiquimod with the brain correlated with increased iba1 and gfap staining, indicative of microglia and astrocyte reactivity. |
2019-07-03 |
2023-08-13 |
mouse |
| Si-Jia Zhang, Rong-Liang Wang, Hai-Ping Zhao, Zhen Tao, Jin-Cheng Li, Fei Ju, Zi-Ping Han, Qing-Feng Ma, Ping Liu, Shu-Bei Ma, Guo-Dong Cao, Yu-Min Lu. MEPO promotes neurogenesis and angiogenesis but suppresses gliogenesis in mice with acute ischemic stroke. European journal of pharmacology. vol 849. 2019-06-19. PMID:30716313. |
whereas, mepo treatment also reduced the numbers of newly generated astrocytes (gfap) and microglia (iba1) (p < 0.05). |
2019-06-19 |
2023-08-13 |
mouse |
| Wenqin Xu, Zhicha Hu, Yang Lv, Guorui Dou, Zifeng Zhang, Haiyan Wang, Yusheng Wan. Microglial density determines the appearance of pathological neovascular tufts in oxygen-induced retinopathy. Cell and tissue research. vol 374. issue 1. 2019-06-17. PMID:29767277. |
after checking the expression of iba1, a microglial marker and gfap, an astrocyte and müller cell marker, we found that minocycline and clodronate could inhibit the activation of microglia or decrease the density of microglia, while they had no significant effect on astrocytes and müller cells. |
2019-06-17 |
2023-08-13 |
mouse |
| Jiayin Zhou, Yuanyuan Deng, Fei Li, Caixia Yin, Jingshan Shi, Qihai Gon. Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30590319. |
as expected, lps injection exhibited neuronal morphological damage, and ionized calcium binding adapter molecule 1 (iba-1) of microglia and glial fibrillary acidic protein (gfap) of astrocyte were activated. |
2019-06-13 |
2023-08-13 |
rat |