| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Wang, Jia Xia, Mengjun Shen, Yifan Zhou, Zhe Wu, Yuhuan Shi, Jianrong Xu, Lina Hou, Rui Zhang, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang, Hao Wan. Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of β-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30723404. |
additionally, the immunohistochemistry and elisa results revealed that microglia (ionized calcium-binding adapter molecule 1, iba1) and astrocyte (glial fibrillary acidic protein, gfap) activation and the secretion of relevant inflammatory factors (tnfα and il-6) induced by aβ were decreased by the bis-mep treatment. |
2020-10-01 |
2023-08-13 |
mouse |
| Jessika M Hutchinson, Lori G Isaacso. Elimination of microglia in mouse spinal cord alters the retrograde CNS plasticity observed following peripheral axon injury. Brain research. vol 1721. 2020-10-01. PMID:31295468. |
though baseline astrocyte activation and gfap protein expression were unaffected, microglia elimination led to increased activation and gfap protein post injury when compared with mice fed the control diet. |
2020-10-01 |
2023-08-13 |
mouse |
| Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim, Phil-Ok Ko. Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice. Laboratory animal research. vol 36. 2020-10-01. PMID:32983956. |
ionized calcium binding adaptor molecule-1 (iba-1) and glial fibrillary acidic protein (gfap) are widely used as microglia and astrocyte markers, respectively. |
2020-10-01 |
2023-08-13 |
mouse |
| Peng-Fei Wang, Zhen-Guang Li, Yong Zhang, Xiao-Hua Ju, Xin-Wu Liu, Ai-Ming Zhou, Jing Che. NLRP6 Inflammasome Ameliorates Brain Injury after Intracerebral Hemorrhage. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28798666. |
moreover, immunofluorescence staining showed that nlrp6 inflammasome was mainly colocalized in glial fibrillary acidic protein (gfap)-positive astrocytes, while with little colocalized expression in neun-positive neurons and without expression in cd11b-positive microglia and cd31-positive endothelial cell in the perihematomal brain tissue of mice after ich. |
2020-09-30 |
2023-08-13 |
mouse |
| L E Toader, G C Rosu, B Catalin, V Tudorica, I Pirici, O Taisescu, D F Muresan. Clinical and Histopathological Assessment on an Animal Model with Experimental Autoimmune Encephalomyelitis. Current health sciences journal. vol 44. issue 3. 2020-09-30. PMID:30647949. |
we utilized histochemistry, immunohistochemistry, and densitometric image analysis methods to assess myelin loss [luxol fast blue, immunohistochemistry for the presence of microglia (iba1) and reactive astrocytes (gfap)]. |
2020-09-30 |
2023-08-13 |
mouse |
| Raul Chavez-Valdez, Amin Mottahedin, Linnea Stridh, Tracylyn R Yellowhair, Lauren L Jantzie, Frances J Northington, Carina Mallar. Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study. Frontiers in physiology. vol 10. 2020-09-30. PMID:30971945. |
a second group of pups were killed at 24 h (p9) or 7 days (p15) after poly i:c to assess astrocytic (gfap) and microglia (iba1) activation in the hippocampus, thalamus and cortex using immunohistochemistry, and gene and protein expression of cytokines/chemokines using real time rt-pcr and msd, respectively (4-6/group). |
2020-09-30 |
2023-08-13 |
mouse |
| Johnny Di Pierdomenico, Diego García-Ayuso, Isabel Pinilla, Nicolás Cuenca, Manuel Vidal-Sanz, Marta Agudo-Barriuso, María P Villegas-Pére. Early Events in Retinal Degeneration Caused by Rhodopsin Mutation or Pigment Epithelium Malfunction: Differences and Similarities. Frontiers in neuroanatomy. vol 11. 2020-09-29. PMID:28321183. |
in both models, microglial cell activation occurs simultaneously with the initiation of photoreceptor death while gfap over-expression starts later. |
2020-09-29 |
2023-08-13 |
rat |
| Erica Zamberletti, Marina Gabaglio, Marie Woolley-Roberts, Sharon Bingham, Tiziana Rubino, Daniela Parolar. Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31447649. |
prenatal vpa exposure increased cb1 receptor, faah and magl levels, enhanced gfap, cd11b, and tnfα levels and triggered microglia activation restricted to the hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Gholam-Reza Mahmoudiasl, Hojjat Allah Abbaszadeh, Mostafa Rezaei-Tavirani, Mohammad-Amin Abdollahifar, Yousef Sadeghi, Maryam Sadat Khoramgah, Somayeh Niknazar, Shahram Darab. Postmortem Study of Molecular and Histological Changes in the CA1 Hippocampal Region of Chronic Methamphetamine User. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 4. 2020-09-28. PMID:32184870. |
iba-1 (microglia) and glial fibrillary acidic protein, gfap (astrocytes) expression were assayed by western blotting and immunohistochemistry (ihc) methods. |
2020-09-28 |
2023-08-13 |
human |
| Ju-Bin Kang, Dong-Ju Park, Murad-Ali Shah, Myeong-Ok Kim, Phil-Ok Ko. Lipopolysaccharide induces neuroglia activation and NF-κB activation in cerebral cortex of adult mice. Laboratory animal research. vol 35. 2020-09-28. PMID:32257907. |
iba-1 and gfap are well accepted as markers of activated microglia and astrocytes, respectively. |
2020-09-28 |
2023-08-13 |
mouse |
| Swathi Beladakere Ramaswamy, Sachin M Bhagavan, Harleen Kaur, Gema E Giler, Duraisamy Kempuraj, Ramasamy Thangavel, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita Zaheer, Shankar S Iyer, Raghav Govindarajan, Asgar Zahee. Glia Maturation Factor in the Pathogenesis of Alzheimer's disease. Open access journal of neurology & neurosurgery. vol 12. issue 3. 2020-09-28. PMID:32775957. |
glial fibrillary acidic protein (gfap), reactive astrocytes, ionized calcium binding adaptor molecule-1 (iba-1) labelled activated microglia and gmf immunoreactive glial cells are increased in the entorhinal cortical layers especially at the sites of aps and tau containing nfts indicating a role for gmf. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ebtesam M Abd-El-Basset, Muddanna Sakkattu Rao, Ameerah Alsaqob. Interferon-Gamma and Interleukin-1Beta Enhance the Secretion of Brain-Derived Neurotrophic Factor and Promotes the Survival of Cortical Neurons in Brain Injury. Neuroscience insights. vol 15. 2020-09-28. PMID:32776009. |
immunostaining of frozen brain sections for astrocytes (gfap), microglia (iba-1) and fluoro-jade b staining for degenerating neurons were used. |
2020-09-28 |
2023-08-13 |
mouse |
| Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P Jesper Sjöström, Andrea C LeBlan. Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31843022. |
increased neuroinflammation, measured by ionized calcium binding adaptor molecule 1 (iba1)-positive microglia numbers and subtypes, and glial fibrillary acidic protein (gfap)-positive astrocytes, were decreased by methylene blue treatment. |
2020-09-25 |
2023-08-13 |
mouse |
| Fabio Gualtieri, Marta Nowakowska, Eva-Lotta von Rüden, Isabel Seiffert, Heidrun Potschk. Epileptogenesis-Associated Alterations of Heat Shock Protein 70 in a Rat Post-Status Epilepticus Model. Neuroscience. vol 415. 2020-09-23. PMID:31319099. |
no colocalization with the astrocytic marker gfap or the microglia marker iba1 was found. |
2020-09-23 |
2023-08-13 |
rat |
| GuoQing Wang, YanZhen Zhou, YanYing Wang, DaiDi Li, Jie Liu, Feng Zhan. Age-Associated Dopaminergic Neuron Loss and Midbrain Glia Cell Phenotypic Polarization. Neuroscience. vol 415. 2020-09-23. PMID:31325563. |
the expressions of astroglia markers (glial fibrillary acidic protein, gfap), microglia markers (ionized calcium binding adaptor molecule 1, iba-1), m1 markers (tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β), m2 markers (arginase 1 (arg1) and il-10), a1 markers (lipocalin-2 (lcn2) and complement c3 (c3), a2 markers (brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) were examined by real time rt-pcr and western blotting. |
2020-09-23 |
2023-08-13 |
rat |
| Marc Oria, Soner Duru, Rebeca L Figueira, Federico Scorletti, Lucas E Turner, Irati Fernandez-Alonso, Alejandra Fernandez-Martin, Mario Marotta, Lourenco Sbragia, Aimen F Shaaban, Jose L Peir. Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis. Cell death & disease. vol 10. issue 10. 2020-08-27. PMID:31558708. |
e17 fetuses had reduced expression of neun, gfap and oligodendrocytes in the brain with primed microglia. |
2020-08-27 |
2023-08-13 |
mouse |
| Wenwen Dong, Yingfu Sun, Hao Cheng, Bei Yang, Linlin Wang, Zhenfei Jiang, Bingxuan Li, Shuheng Wen, Xiangshen Guo, Dawei Guan, Rui Zha. Dynamic cell type-specific expression of Nrf2 after traumatic brain injury in mice. The European journal of neuroscience. vol 50. issue 2. 2020-08-20. PMID:30828870. |
neun, gfap, iba1 and ng2 were used as cell type-specific markers to neurons, astrocytes, microglia and ng2 glia, respectively. |
2020-08-20 |
2023-08-13 |
mouse |
| Malvindar K Singh-Bains, Vanessa Linke, Micah D R Austria, Adelie Y S Tan, Emma L Scotter, Nasim F Mehrabi, Richard L M Faull, Mike Draguno. Altered microglia and neurovasculature in the Alzheimer's disease cerebellum. Neurobiology of disease. vol 132. 2020-08-06. PMID:31454549. |
immunoreactivity was compared between control and ad groups for neuropathological hallmarks (amyloid-β, tau, ubiquitin), purkinje cells (calbindin), microglia (iba1, hla-dr), astrocytes (gfap) basement-membrane associated molecules (fibronectin, collagen iv), endothelial cells (cd31/pecam-1) and mural cells (pdgfrβ, αsma). |
2020-08-06 |
2023-08-13 |
human |
| Udaiyappan Janakiraman, Jie Yu, Aubin Moutal, Dhanalakshmi Chinnasamy, Lisa Boinon, Shelby N Batchelor, Annaduri Anandhan, Rajesh Khanna, Mark A Nelso. TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex. Neurobiology of disease. vol 132. 2020-07-27. PMID:31344492. |
we also observed a decreased in gfap positive astrocytes and an increase in iba1 positive microglia within the granular layer of the cerebellum in taf1-edited animals. |
2020-07-27 |
2023-08-13 |
mouse |
| Candela Zorzo, Sara G Higarza, Marta Méndez, Juan A Martínez, Alberto M Pernía, Jorge L Aria. High frequency repetitive transcranial magnetic stimulation improves neuronal activity without affecting astrocytes and microglia density. Brain research bulletin. vol 150. 2020-07-24. PMID:31082456. |
for this purpose, we performed histochemistry and immunohistochemistry procedures: the histochemistry of cytochrome oxidase (cox) to assess neuronal metabolic activity, and the immunohistochemistry of c-fos (marker of neuronal activity), gfap (marker of astrocytic reactivity), and iba1 (selective marker of reactive microglia). |
2020-07-24 |
2023-08-13 |
rat |