| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Karolina Santana Nunes, Catarina Rapôso, Sura Wanessa Santos Rocha, Karla Patrícia de Sousa Barbosa, Rayana Leal de Almeida Luna, Maria Alice da Cruz-Höfling, Christina Alves Peixot. Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model. Brain research. vol 1627. 2016-08-17. PMID:26404052. |
cpz induced an increase in the expression of gfap, il-1β tnf-α, total nfkb and inactive ampk, and prompt microglia activation. |
2016-08-17 |
2023-08-13 |
mouse |
| Cyrill Bussy, Khuloud T Al-Jamal, Jorge Boczkowski, Sophie Lanone, Maurizio Prato, Alberto Bianco, Kostas Kostarelo. Microglia Determine Brain Region-Specific Neurotoxic Responses to Chemically Functionalized Carbon Nanotubes. ACS nano. vol 9. issue 8. 2016-07-11. PMID:26043308. |
after exposure to mwnts, cnt were uptaken more effectively by cd11b/c positive cells (microglia), compared to gfap positive cells (astrocytes). |
2016-07-11 |
2023-08-13 |
rat |
| Alberto Serrano-Pozo, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American journal of pathology. vol 186. issue 2. 2016-06-14. PMID:26687817. |
we performed an unbiased plaque-centered quantification of smi312(+) dystrophic neurites, gfap(+) reactive astrocytes, and iba1(+) and cd68(+) activated microglia in randomly selected dense-core (thioflavin-s(+)) plaques from the temporal neocortex of 40 ad subjects with a symptom duration ranging from 4 to 20 years, and nine nondemented control subjects with dense-core plaques. |
2016-06-14 |
2023-08-13 |
human |
| Irena Baranowska-Bosiacka, Joanna Listos, Izabela Gutowska, Anna Machoy-Mokrzyńska, Agnieszka Kolasa-Wołosiuk, Maciej Tarnowski, Kamila Puchałowicz, Adam Prokopowicz, Sylwia Talarek, Piotr Listos, Agnieszka Wąsik, Dariusz Chlube. Effects of perinatal exposure to lead (Pb) on purine receptor expression in the brain and gliosis in rats tolerant to morphine analgesia. Toxicology. vol 339. 2016-05-23. PMID:26478469. |
the aim of the present study was to investigate the molecular effects of perinatal exposure to lead (pb) on protein and mrna expression of purine receptors: p2x4, p2x7, adenosine receptor a1; and astrocytes (gfap mrna expression) and on microglia activation (iba1 mrna expression) in several structures of the mesolimbic system (striatum, hippocampus, prefrontal cortex) in rats expressing tolerance to the antinociceptive effect of morphine. |
2016-05-23 |
2023-08-13 |
rat |
| Jia Bak, Hee Jung Kim, Seong Yun Kim, Yun-Sik Cho. Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 20. issue 3. 2016-05-10. PMID:27162482. |
furthermore, immunohistochemical data showed that immunoreactivity to glial fibrillary acidic protein (gfap) and cd45, markers for astrocyte and microglia activation, respectively, were strikingly reduced. |
2016-05-10 |
2023-08-13 |
mouse |
| Yoon-Jung Choy, Sung-Young Hong, Sang-Jin Pack, Ran-Sook Woo, Tai-Kyoung Baik, Dae-Yong Son. Changes of gene expression of Gal3, Hsp27, Lcn2, and Timp1 in rat substantia nigra following medial forebrain bundle transection using a candidate gene microarray. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25858852. |
in a double immunofluorescence assay, galectin 3 almost completely co-localized with ox6-positive activated microglia, and heat shock protein 27 mainly co-localized with glial fibrillary acidic protein (gfap) positive astrocytes. |
2016-05-05 |
2023-08-13 |
rat |
| M Silva, D Martins, I Tavares, C Morgad. Inhibition of spinal 5-HT3R reverted diabetes-induced mechanical hypersensitivity in a GABAAR-mediated neurotransmission-dependent manner. Neuroscience. vol 304. 2016-05-03. PMID:26210577. |
the spinal activation of extracellular signal-regulated kinases (erks) pathway and the expression of 5-ht3r, glial fibrillary acidic protein (gfap; marker of astroglia activation) and ionized calcium binding adaptor molecule 1 (iba-1; marker of microglia activation) were evaluated at the peak maximum effect of y25130. |
2016-05-03 |
2023-08-13 |
rat |
| Nian Liu, Kai-Kai Zang, Yu-Qiu Zhan. [Activation of microglia and astrocytes in different spinal segments after peripheral nerve injury in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 67. issue 6. 2016-05-03. PMID:26701632. |
iba-1 and gfap immunofluorescence staining in wt mice showed the same result of microglia and astrocyte activation on day 14 after cci. |
2016-05-03 |
2023-08-13 |
mouse |
| Mariko Saito, Gusheng Wu, Maria Hui, Kurt Masiello, Kostantin Dobrenis, Robert W Ledeen, Mitsuo Sait. Ganglioside accumulation in activated glia in the developing brain: comparison between WT and GalNAcT KO mice. Journal of lipid research. vol 56. issue 8. 2016-04-26. PMID:26063460. |
immunohistochemical studies indicated that ethanol-induced acute neurodegeneration in postnatal day 7 (p7) wt mice was associated with gm2 accumulation in the late endosomes/lysosomes of both phagocytic microglia and increased glial fibrillary acidic protein (gfap)-positive astrocytes. |
2016-04-26 |
2023-08-13 |
mouse |
| Bin Zhang, Song-xian Sun, Yi-chen Chen, Chun-xiang Zho. [Effect of Zhixin Formula on Gliocyte Protein Expressions, TLRs and NF-κB in Bone Cancer Pain Model Rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 35. issue 6. 2016-04-26. PMID:26242124. |
to explore the analgesic effect of zhixin formula (zf) and its effects on spinal glial fibrillary acidic protein (glial fibillary acidic protein, gfap, a marker of astrocyte) , cd11b (a maker of microglia), toll like receptors (tlr2 and tlr4) and nuclear factor κb (nf-κb) in bone cancer pain model rats. |
2016-04-26 |
2023-08-13 |
rat |
| Min Joung Kim, Jun Hwi Cho, Jeong-Hwi Cho, Joon Ha Park, Ji Hyeon Ahn, Hyun-Jin Tae, Geum-Sil Cho, Bing Chun Yan, In Koo Hwang, Choong Hyun Lee, Eun Joo Bae, Moo-Ho Won, Jae-Chul Le. Impact of hyperthermia before and during ischemia-reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia. Journal of the neurological sciences. vol 348. issue 1-2. 2016-04-04. PMID:25434714. |
in addition, we examined activations of astrocytes and microglia using immunohistochemistry for anti-glial fibrillary acidic protein (gfap) and anti-ionized calcium-binding adapter molecule 1 (iba-1). |
2016-04-04 |
2023-08-13 |
Not clear |
| Felipe V Gomes, Ricardo Llorente, Elaine A Del Bel, Maria-Paz Viveros, Meritxell López-Gallardo, Francisco S Guimarãe. Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol. Schizophrenia research. vol 164. issue 1-3. 2016-03-28. PMID:25680767. |
we also evaluated changes in neun (a neuronal marker), iba-1 (a microglia marker) and gfap (an astrocyte marker) expression in the medial prefrontal cortex (mpfc), dorsal striatum, nucleus accumbens core and shell, and dorsal hippocampus by immunohistochemistry. |
2016-03-28 |
2023-08-13 |
Not clear |
| Daniela Impellizzeri, Akbar Ahmad, Rosanna Di Paola, Michela Campolo, Michele Navarra, Emanuela Esposito, Salvatore Cuzzocre. Role of Toll like receptor 4 signaling pathway in the secondary damage induced by experimental spinal cord injury. Immunobiology. vol 220. issue 9. 2016-03-24. PMID:25990044. |
sci tlr4 ko mice developed severer hind limb motor dysfunction and neuronal death by histological evaluation, myeloid differentiation primary response 88 (myd88) expression as well as an increase in nuclear factor nf-κb activity, tumor necrosis factor (tnf)-α and interleukin (il)-1β levels, glial fibrillary acidic protein (gfap), microglia marker (cd11β), inducible nitric oxide synthases (inos), poly-adp-ribose polymerase (parp) and nitrotyrosine expression compared to wt mice. |
2016-03-24 |
2023-08-13 |
mouse |
| Monika J Brzozowski, Peter Jenner, Sarah Ros. Inhibition of i-NOS but not n-NOS protects rat primary cell cultures against MPP(+)-induced neuronal toxicity. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 6. 2016-02-22. PMID:25503828. |
mpp(+) induced a loss of th-positive neurones accompanied by an increase in immunoreactivity for gfap and ox-6 as markers of astrocytes and activated microglia, respectively, and induced i-nos immunoreactivity. |
2016-02-22 |
2023-08-13 |
rat |
| Michiko Mandai, Kohei Homma, Satoshi Okamoto, Chikako Yamada, Akane Nomori, Masayo Takahash. Adequate Time Window and Environmental Factors Supporting Retinal Graft Cell Survival in rd Mice. Cell medicine. vol 4. issue 1. 2016-02-09. PMID:26858854. |
we first studied the background features of the mice with phosphodiesterase 6b (pde6b) gene mutation (rd; c3h/hej) and found that the infiltration of microglia and glial fibrillary acidic protein (gfap) expression once increased at the peak of rod death (∼2-3 weeks of age) but then reduced for a following period until gliosis began to take place with enhanced gfap expression (∼8 weeks of age). |
2016-02-09 |
2023-08-13 |
mouse |
| Willem Kamphuis, Lieneke Kooijman, Marie Orre, Oscar Stassen, Milos Pekny, Elly M Ho. GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Glia. vol 63. issue 6. 2016-01-08. PMID:25731615. |
gfap and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for alzheimer's disease. |
2016-01-08 |
2023-08-13 |
mouse |
| Willem Kamphuis, Lieneke Kooijman, Marie Orre, Oscar Stassen, Milos Pekny, Elly M Ho. GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Glia. vol 63. issue 6. 2016-01-08. PMID:25731615. |
to identify molecular pathways coupled to if regulation in reactive astrocytes, and to study the interaction with microglia, we examined wt and appswe/ps1de9 (ad) mice lacking either gfap, or both vim and gfap, and determined the transcriptome of cortical astrocytes and microglia from 15- to 18-month-old mice. |
2016-01-08 |
2023-08-13 |
mouse |
| J L Hawkins, J E Denson, D R Miley, P L Durha. Nicotine stimulates expression of proteins implicated in peripheral and central sensitization. Neuroscience. vol 290. 2015-12-15. PMID:25637801. |
nicotine also promoted elevations in the expression of glial fibrillary acidic protein (gfap), a biomarker of activated astrocytes, and the microglia biomarker ionized calcium-binding adapter molecule 1 (iba1). |
2015-12-15 |
2023-08-13 |
rat |
| Judith M van der Harg, Leslie Eggels, Silvie R Ruigrok, Jeroen J M Hoozemans, Susanne E la Fleur, Wiep Schepe. Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation. Frontiers in neuroscience. vol 9. 2015-11-30. PMID:26617484. |
remarkably, neither of the diabetic animal models showed reactive microglia or increased gfap and cox-2 levels in the cortex or hippocampus. |
2015-11-30 |
2023-08-13 |
rat |
| Frederika Maria Byrne, Sharon Cheetham, Steven Vickers, Victoria Chapma. Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. Journal of diabetes research. vol 2015. 2015-10-29. PMID:25759824. |
hfd/stz rats had significantly lower numbers of spinal iba-1 positive cells (morphologically identified as activated microglia) and spinal gfap immunofluorescence (a marker of astrogliosis) in the spinal cord at day 50, compared to time-matched controls. |
2015-10-29 |
2023-08-13 |
rat |