| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srikant Rangaraju, Marla Gearing, Lee-Way Jin, Allan Leve. Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 44. issue 3. 2015-10-26. PMID:25362031. |
in immunofluorescence studies, kv1.3 channels co-localized primarily with iba1 but not with astrocyte marker gfap, confirming that elevated kv1.3 expression is limited to microglia. |
2015-10-26 |
2023-08-13 |
human |
| Francisco Bruno Teixeira, Luana Nazaré da Silva Santana, Fernando Romualdo Bezerra, Sabrina De Carvalho, Enéas Andrade Fontes-Júnior, Rui Daniel Prediger, Maria Elena Crespo-López, Cristiane Socorro Ferraz Maia, Rafael Rodrigues Lim. Chronic ethanol exposure during adolescence in rats induces motor impairments and cerebral cortex damage associated with oxidative stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967633. |
following completion of behavioral tests, half of animals were submitted to immunohistochemical evaluation of neun (marker of neuronal bodies), gfap (a marker of astrocytes) and iba1 (microglia marker) in the cerebral cortex while the other half of the animals were subjected to analysis of oxidative stress markers by biochemical assays. |
2015-10-07 |
2023-08-13 |
rat |
| Xiandong Meng, Feng Yang, Tangpeng Ouyang, Bing Liu, Chen Wu, Wen Jian. Specific gene expression in mouse cortical astrocytes is mediated by a 1740bp-GFAP promoter-driven combined adeno-associated virus 2/5/7/8/9. Neuroscience letters. vol 593. 2015-09-08. PMID:25778419. |
cell-type specific antibodies and subsequent immunofluorescence were used to identify astrocytes (gfap), neurons (neuronal nuclear antigen, neun), microglia (ionized calcium-binding adapter molecule 1, iba1), and oligodendrocytes (myelin basic protein, mbp), whereby, egfp expression was measured in each cell type at 1-4 weeks post-injection. |
2015-09-08 |
2023-08-13 |
mouse |
| José Christian Machado Ximenes, Kelly Rose Tavares Neves, Luzia Kalyne A M Leal, Marta Regina Santos do Carmo, Gerly Anne de Castro Brito, Maria da Graça Naffah-Mazzacoratti, Ésper Abrão Cavalheiro, Glauce Socorro de Barros Vian. Valproic Acid Neuroprotection in the 6-OHDA Model of Parkinson's Disease Is Possibly Related to Its Anti-Inflammatory and HDAC Inhibitory Properties. Journal of neurodegenerative diseases. vol 2015. 2015-08-28. PMID:26317011. |
this neurotoxin increased the ox-42 and gfap immunoreactivities in the mesencephalon, indicating increased microglia and astrocyte reactivities, respectively, which were reversed by va. |
2015-08-28 |
2023-08-13 |
rat |
| Peter Filipcik, Martin Cente, Norbert Zilka, Tomas Smolek, Jozef Hanes, Juraj Kucerak, Alena Opattova, Branislav Kovacech, Michal Nova. Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25772164. |
the topological dissociation of neuronally expressed pathological tau and the induction of astrocytic hsp27, gfap, and vimentin along with up-regulation of microglia specific markers such as cd18, cd68 and c3 point to cooperation of astrocytes, microglia and neurons in response to intra-neuronal accumulation of insoluble tau. |
2015-08-27 |
2023-08-13 |
rat |
| Jastrow Canlas, Phillip Holt, Alexander Carroll, Shane Rix, Paul Ryan, Lorena Davies, Dusan Matusica, Stuart M Pitson, Claire F Jessup, Ian L Gibbins, Rainer V Haberberge. Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in molecular neuroscience. vol 8. 2015-08-18. PMID:26283908. |
similarly, sphk2(-/-) mice showed in contrast to wild-type no cpi-dependent increase in areas of the dorsal horn immunoreactive for the microglia marker iba-1 and the astrocyte marker glial fibrillary acidic protein (gfap). |
2015-08-18 |
2023-08-13 |
mouse |
| Adriano Zager, Jean Pierre Peron, Gregory Mennecier, Sandra C Rodrigues, Thiago P Aloia, João Palermo-Net. Maternal immune activation in late gestation increases neuroinflammation and aggravates experimental autoimmune encephalomyelitis in the offspring. Brain, behavior, and immunity. vol 43. 2015-08-07. PMID:25108214. |
prenatal exposure to lps worsened eae disease severity in adult offspring, and this worsening was linked to increased cns-infiltrating macrophages, th1 cells and th17 cells at the peak of eae severity; additionally, exacerbated gliosis was evidenced in microglia (mhc ii) and astrocytes (gfap protein level and immunoreactivity). |
2015-08-07 |
2023-08-13 |
mouse |
| Yu-Wen Hung, Shao-Wen Hung, Yi-Chen Wu, Lin-King Wong, Ming-Tsong Lai, Yang-Hsin Shih, Tzong-Shyuan Lee, Yung-Yang Li. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. Brain, behavior, and immunity. vol 43. 2015-08-07. PMID:25135858. |
in the hippocampus of wt mice, seh was mainly expressed in astrocytes (gfap(+)), neurons (neun(+)) and scattered microglia (iba-1(+)) in the regions of ca1, ca3 and dentate gyrus. |
2015-08-07 |
2023-08-13 |
mouse |
| Moyra B Lemus, Jacqueline A Bayliss, Sarah H Lockie, Vanessa V Santos, Alex Reichenbach, Romana Stark, Zane B Andrew. A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice. Endocrinology. vol 156. issue 5. 2015-06-25. PMID:25742051. |
a stereological analysis of npy, pomc, orexin, gfap astrocyte, and iba1 microglia cell number and volume in diet-induced obese male mice. |
2015-06-25 |
2023-08-13 |
mouse |
| Ishani De, Maria Nikodemova, Megan D Steffen, Emily Sokn, Vilena I Maklakova, Jyoti J Watters, Lara S Collie. CSF1 overexpression has pleiotropic effects on microglia in vivo. Glia. vol 62. issue 12. 2015-06-19. PMID:25042473. |
to examine the effects of csf1 overexpression on microglia, transgenic mice that overexpress csf1 in the glial fibrillary acidic protein (gfap) compartment were generated. |
2015-06-19 |
2023-08-13 |
mouse |
| Yonghui Lu, Mindi He, Yang Zhang, Shangcheng Xu, Lei Zhang, Yue He, Chunhai Chen, Chuan Liu, Huifeng Pi, Zhengping Yu, Zhou Zho. Differential pro-inflammatory responses of astrocytes and microglia involve STAT3 activation in response to 1800 MHz radiofrequency fields. PloS one. vol 9. issue 9. 2015-06-10. PMID:25275372. |
microglia and astrocytes were activated by rf exposure indicated by up-regulated cd11b and glial fibrillary acidic protein (gfap). |
2015-06-10 |
2023-08-13 |
Not clear |
| Zhi Ruan, Hong Min Wang, Xiao Tian Huang, Yan Fu, Jian Wu, Chun Yan Ye, Jin Long Li, Lei Wu, Qi Gong, Wei Min Zhao, Hai Yan Zhan. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects. Journal of neurochemistry. vol 133. issue 1. 2015-05-27. PMID:25626516. |
protective b-ca effects correlated with decreased inflammatory responses as indicated by inhibition of microglia and astrocyte activation [stained with ionized calcium-binding adapter molecule 1 (iba-1) and glial fibrillary acidic protein (gfap) antibody, respectively], as well as suppression of tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 overproduction in the ipsilateral cortex of ischemic rat. |
2015-05-27 |
2023-08-13 |
rat |
| Selva Rivas-Arancibia, Luis Fernando Hernández Zimbrón, Erika Rodríguez-Martínez, Perla D Maldonado, Gabino Borgonio Pérez, María Sepúlveda-Parad. Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat. Frontiers in aging neuroscience. vol 7. 2015-05-22. PMID:25999851. |
each group underwent (1) spectrophotometric analysis for protein oxidation; (2) western blot testing for microglia reactivity and nuclear factor kappa b expression levels; and (3) immunohistochemistry for cytochrome c, gfap, iba-1, nfkb, and cox-2. |
2015-05-22 |
2023-08-13 |
rat |
| Patricia Rivera, Laura Bindila, Antoni Pastor, Margarita Pérez-Martín, Francisco J Pavón, Antonia Serrano, Rafael de la Torre, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Frontiers in cellular neuroscience. vol 9. 2015-04-14. PMID:25870539. |
cell proliferation (phospho-h3(+) or brdu(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (gfap(+)), and microglia (iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with urb597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). |
2015-04-14 |
2023-08-13 |
rat |
| Pablo Granados-Durán, María D López-Ávalos, Jesús M Grondona, María Del Carmen Gómez-Roldán, Manuel Cifuentes, Margarita Pérez-Martín, Martina Alvarez, Fernando Rodríguez de Fonseca, Pedro Fernández-Llebre. Neuroinflammation induced by intracerebroventricular injection of microbial neuraminidase. Frontiers in medicine. vol 2. 2015-04-08. PMID:25853134. |
the expression of icam1 in the endothelial cells of the periventricular vessels, iba1 in microglia, and gfap in astrocytes notably increased in the regions reached by the injected neuraminidase. |
2015-04-08 |
2023-08-13 |
rat |
| Olena Y Glushakova, Danny Johnson, Ronald L Haye. Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood-brain barrier disruption, and progressive white matter damage. Journal of neurotrauma. vol 31. issue 13. 2015-02-23. PMID:24564198. |
ihc revealed tbi-induced focal abnormalities including blood-brain barrier (bbb) damage (igg), endothelial damage (intercellular adhesion molecule 1 [icam-1]), activation of reactive microglia (ionized calcium binding adaptor molecule 1 [iba1]), gliosis (glial fibrillary acidic protein [gfap]) and macrophage-mediated inflammation (cluster of differentiation 68 [cd68]), all showing different temporal profiles. |
2015-02-23 |
2023-08-12 |
rat |
| Stephen T Vito, Adam T Austin, Christopher N Banks, Bora Inceoglu, Donald A Bruun, Dorota Zolkowska, Daniel J Tancredi, Michael A Rogawski, Bruce D Hammock, Pamela J Lei. Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. Toxicology and applied pharmacology. vol 281. issue 2. 2015-02-06. PMID:25448683. |
however, this treatment did not prevent persistent reactive astrogliosis and microglial activation, as determined by gfap and iba-1 immunoreactivity and microglial cell morphology. |
2015-02-06 |
2023-08-13 |
mouse |
| Vikas Singh, Sumonto Mitra, Anuj Kumar Sharma, Ruchi Gera, Debabrata Ghos. Isolation and characterization of microglia from adult mouse brain: selected applications for ex vivo evaluation of immunotoxicological alterations following in vivo xenobiotic exposure. Chemical research in toxicology. vol 27. issue 5. 2015-01-05. PMID:24754514. |
purity of the isolated microglia was checked by immunostaining of microglial (cd11b and cd68) and nonmicroglial (gfap) markers. |
2015-01-05 |
2023-08-13 |
mouse |
| Maria Meyer, Maria Claudia Gonzalez Deniselle, Hazel Hunt, E Ronald de Kloet, Alejandro F De Nicol. The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice. The Journal of steroid biochemistry and molecular biology. vol 143. 2014-12-29. PMID:24565565. |
we compared the response of doublecortin (dcx)+ neuroblasts in the subgranular layer of the dentate gyrus (dg), neun+ cells in the hilus of the dg, glial fibrillary acidic protein (gfap)+ astrocytes and the phenotype of iba1+ microglia in cort108297-treated and vehicle-treated wobblers. |
2014-12-29 |
2023-08-12 |
mouse |
| Catarina Rapôso, Rayana Leal de Almeida Luna, Ana Karolina Santana Nunes, Rodolfo Thomé, Christina Alves Peixot. Role of iNOS-NO-cGMP signaling in modulation of inflammatory and myelination processes. Brain research bulletin. vol 104. 2014-12-28. PMID:24727400. |
vcam and icam (adhesion proteins), gfap and iba-1 (astrocyte and microglia markers, respectively), pkg (cgmp-dependent protein kinase), sgc, enos (constitutive endothelial no sinthase) and gstpi (a marker of mature oligodendrocytes) were evaluated in the cerebellum using immunohistochemistry or western blotting. |
2014-12-28 |
2023-08-13 |
mouse |