| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongren Huang, Xue Liu, Liping Wang, Feng Wan. Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes. Biology of sex differences. vol 15. issue 1. 2024-04-23. PMID:38654275. |
the cells in the lhb are predominantly glutamatergic and have heterogeneous functions in response to different stimuli. |
2024-04-23 |
2024-04-26 |
mouse |
| Hongren Huang, Xue Liu, Liping Wang, Feng Wan. Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes. Biology of sex differences. vol 15. issue 1. 2024-04-23. PMID:38654275. |
the circuitry connections of the lhb glutamatergic neurons play a crucial role in integrating a wide range of events. |
2024-04-23 |
2024-04-26 |
mouse |
| Hongren Huang, Xue Liu, Liping Wang, Feng Wan. Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes. Biology of sex differences. vol 15. issue 1. 2024-04-23. PMID:38654275. |
however, the circuitry connections of lhb glutamatergic neurons in both sexes have not been thoroughly investigated. |
2024-04-23 |
2024-04-26 |
mouse |
| Kang Zhou, Lin-Chen Zhang, He Zhu, Bei Wen, Jia-Li Tang, Ping-Chuan Yuan, A-Fang Zhu, Yu-Guang Huan. A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543149. |
recent studies have revealed that the glutamatergic neurons of the lateral habenula (lhb) play a crucial role in modulating the loc induced by propofol and sevoflurane. |
2024-03-28 |
2024-03-30 |
mouse |
| Sarah C Simmons, William J Flerlage, Ludovic D Langlois, Ryan D Shepard, Christopher Bouslog, Emily H Thomas, Kaitlyn M Gouty, Jennifer L Sanderson, Shawn Gouty, Brian M Cox, Mark L Dell'Acqua, Fereshteh S Nugen. AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula. Communications biology. vol 7. issue 1. 2024-03-21. PMID:38509283. |
using whole cell patch clamp recordings in lhb of male wildtype and Δpka knockin mice (with deficiency in akap-anchoring of pka), here we show that the genetic disruption of pka anchoring to akap150 significantly reduces ampa receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in lhb neurons. |
2024-03-21 |
2024-03-23 |
mouse |
| Xiaowei Chen, Xiaofeng Liu, Shuxin Luan, Xuxin Wang, Ying Zhang, Yulei Hao, Qiang Zhang, Jiaming Zhang, Hua Zha. Optogenetic activation of the lateral habenula European archives of psychiatry and clinical neuroscience. 2024-01-18. PMID:38236282. |
optogenetic activation of the lateral habenula a number of different receptors are distributed in glutamatergic neurons of the lateral habenula (lhb). |
2024-01-18 |
2024-01-20 |
Not clear |
| Xiaowei Chen, Xiaofeng Liu, Shuxin Luan, Xuxin Wang, Ying Zhang, Yulei Hao, Qiang Zhang, Jiaming Zhang, Hua Zha. Optogenetic activation of the lateral habenula European archives of psychiatry and clinical neuroscience. 2024-01-18. PMID:38236282. |
these glutamatergic neurons are involved in different neural pathways, which may identify how the lhb regulates various physiological functions. |
2024-01-18 |
2024-01-20 |
Not clear |
| S C Simmons, W J Flerlage, L D Langlois, R D Shepard, C Bouslog, E H Thomas, K M Gouty, J L Sanderson, S Gouty, B M Cox, M L Dell'Acqua, F S Nugen. AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula. bioRxiv : the preprint server for biology. 2023-12-18. PMID:38106086. |
using whole cell patch clamp recordings in lhb of male wildtype (wt) and Δpka knockin mice (with deficiency in akap-anchoring of pka), we found that the genetic disruption of pka anchoring to akap150 significantly reduced ampa receptor (ampar)-mediated glutamatergic transmission and prevented the induction of presynaptic endocannabinoid (ecb)-mediated long-term depression (ltd) in lhb neurons. |
2023-12-18 |
2023-12-21 |
mouse |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
in vivo extracellular recording found that the lh sent a glutamatergic projection to the lhb. |
2023-11-30 |
2023-12-07 |
Not clear |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
these findings suggest that the lh glutamatergic projection to the lhb plays an active role in the modulation of cocaine-induced psychomotor responses. |
2023-11-30 |
2023-12-07 |
Not clear |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
in vivo extracellular recording found that the lh sent a glutamatergic projection to the lhb. |
2023-11-29 |
2023-12-07 |
Not clear |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
these findings suggest that the lh glutamatergic projection to the lhb plays an active role in the modulation of cocaine-induced psychomotor responses. |
2023-11-29 |
2023-12-07 |
Not clear |
| Lei Zhang, Yuan Guo, Jian Liu, Libo Li, Yixuan Wang, Xiang Wu, Yihua Bai, Jing Li, Qiaojun Zhang, Yanping Hu. Transcranial direct current stimulation of the prefrontal cortex improves depression-like behaviors in rats with Parkinson's disease. Brain research. 2023-11-03. PMID:37923003. |
meanwhile, tdcs decreased the expression of c-fos protein (n = 8-11 rats/group) and the excitation of glutamatergic neurons (n = 6-8 rats/group) in the prl and lhb of pd model rats. |
2023-11-03 |
2023-11-08 |
rat |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-Nucleus Transcriptional Profiling of GAD2-Positive Neurons From Mouse Lateral Habenula Reveals Distinct Expression of Neurotransmission- and Depression-Related Genes. Biological psychiatry global open science. vol 3. issue 4. 2023-10-26. PMID:37881543. |
glutamatergic projection neurons of the lateral habenula (lhb) drive behavioral state modulation by regulating the activity of midbrain monoaminergic neurons. |
2023-10-26 |
2023-11-08 |
mouse |
| Jamie C Moffa, India N Bland, Jessica R Tooley, Vani Kalyanaraman, Monique Heitmeier, Meaghan C Creed, Bryan A Copit. Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systems. bioRxiv : the preprint server for biology. 2023-10-24. PMID:37873336. |
we tested these tools in multiple brain regions and cell types, including gabaergic neurons in the nucleus accumbens (nac), glutamatergic neurons projecting from the ventral pallidum (vp) to the lateral habenula (lhb), dopaminergic neurons in the ventral tegmental area (vta), and parvalbumin (pv)-positive proprioceptive neurons in the periphery. |
2023-10-24 |
2023-11-08 |
mouse |
| Chun-Kui Zhang, Pan Wang, Yuan-Yuan Ji, Jian-Shuai Zhao, Jun-Xiang Gu, Xian-Xia Yan, Hong-Wei Fan, Ming-Ming Zhang, Yu Qiao, Xiao-Die Liu, Bao-Juan Li, Ming-Hui Wang, Hai-Long Dong, Hao-Hong Li, Peng-Cheng Huang, Yun-Qing Li, Wu-Gang Hou, Jin-Lian Li, Tao Che. Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain. Science China. Life sciences. 2023-10-20. PMID:37864083. |
we determined that the spike discharges of the ventral tegmental area (vta)-projecting lateral habenula (lhb) glutamatergic (glu) neurons were sequentially increased in sham, resilient and susceptible mice, which consequently inhibited vta dopaminergic (da) neurons through a lhb |
2023-10-20 |
2023-11-08 |
mouse |
| Suchan Chang, Hyung Kyu Kim, Yeonhee Ryu, Han Byeol Jang, DanBi Ahn, Bong Hyo Lee, Dong-Ho Youn, Bae Hwan Lee, Hee Young Ki. Mediation of mPFC-LHb pathway in acupuncture inhibition of cocaine psychomotor activity. Addiction biology. vol 28. issue 10. 2023-09-27. PMID:37753567. |
optopatch experiment proved glutamatergic projections from mpfc to lhb. |
2023-09-27 |
2023-10-07 |
rat |
| Xingyun Xu, Hang Zhou, Hainan Wu, Zhigang Miao, Bo Wan, Haigang Ren, Wei Ge, Guanghui Wang, Xingshun X. Tet2 acts in the lateral habenula to regulate social preference in mice. Cell reports. vol 42. issue 7. 2023-07-04. PMID:37402169. |
further, tet2 knockdown in the glutamatergic neurons of lhb causes impaired social behaviors, but the inhibition of glutamatergic excitability restores social preference. |
2023-07-04 |
2023-08-14 |
mouse |
| Saida Oubraim, Roh-Yu Shen, Samir Haj-Dahman. Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. iScience. vol 26. issue 5. 2023-05-30. PMID:37250336. |
neuronal mapping demonstrates that oxt preferentially potentiates glutamate synapses of 5-ht neurons projecting to medial prefrontal cortex (mpfc) and depresses glutamatergic inputs to 5-ht neurons projecting to lateral habenula (lhb) and central amygdala (cea). |
2023-05-30 |
2023-08-14 |
Not clear |
| Han-Wen Gu, Guang-Fen Zhang, Pan-Miao Liu, Wei-Tong Pan, Yuan-Xiang Tao, Zhi-Qiang Zhou, Jian-Jun Yan. Contribution of activating lateral hypothalamus-lateral habenula circuit to nerve trauma-induced neuropathic pain in mice. Neurobiology of disease. 2023-05-14. PMID:37182721. |
here, we report that a projection from the lateral hypothalamus (lh) glutamatergic neurons to the lateral habenula (lhb), an excitatory lh-lhb neuronal circuit, participates in nerve injury-induced nociceptive hypersensitivity. |
2023-05-14 |
2023-08-14 |
mouse |