| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
our data highlight that early life stress-induced glutamatergic plasticity in lhb may dampen the positive reinforcing and motivational properties of both natural rewards and opioids, and may contribute to the development of anhedonia and dysphoric states associated with opioids. |
2021-11-26 |
2023-08-13 |
rat |
| b' Marc Fakhoury, Giovanni Hernandez, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area. Behavioural brain research. vol 393. 2021-10-25. PMID:32593543.' |
the rostromedial tegmental nucleus also referred to as the tail of the ventral tegmental area (tvta) contains a cluster of gamma-aminobutyric acid (gaba)ergic neurons that receive dense glutamatergic afferents from the lateral habenula (lhb), and project to dopamine (da) neurons of the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2021-10-25 |
2023-08-13 |
Not clear |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
interestingly, majority of neurons in lhb were aversion-activated and reward-inhibited neurons, consisting mainly of glutamatergic neurons, while most neurons in vta were reward-activated and aversion-inhibited neurons, which inhibited by glutamatergic neurons in the lhb. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
furthermore, optogenetic activation or inhibition of glutamatergic neurons in lhb and their terminals in vta could induce aversive or reward behaviors. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
the aversion behaviors induced by activating lhb glutamatergic neurons may be due to its inhibition on reward-activated neurons in vta. |
2021-09-21 |
2023-08-13 |
mouse |
| Shiyi Zhao, Rui Li, Huiming Li, Sa Wang, Xinxin Zhang, Dan Wang, Juan Guo, Huihui Li, Ao Li, Tingting Tong, Haixing Zhong, Qianzi Yang, Hailong Don. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice. Neuroscience bulletin. vol 37. issue 7. 2021-08-18. PMID:33847915. |
photostimulation of lha glutamatergic projections to the lateral habenula (lhb) also facilitated the emergence from anesthesia and the transition of anesthesia depth to a lighter level. |
2021-08-18 |
2023-08-13 |
mouse |
| Shiyi Zhao, Rui Li, Huiming Li, Sa Wang, Xinxin Zhang, Dan Wang, Juan Guo, Huihui Li, Ao Li, Tingting Tong, Haixing Zhong, Qianzi Yang, Hailong Don. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice. Neuroscience bulletin. vol 37. issue 7. 2021-08-18. PMID:33847915. |
collectively, lha glutamatergic neurons and their projections to the lhb regulate anesthetic potency and eeg features. |
2021-08-18 |
2023-08-13 |
mouse |
| Alvaro Nuno-Perez, Massimo Trusel, Arnaud L Lalive, Mauro Congiu, Denise Gastaldo, Anna Tchenio, Salvatore Lecca, Mariano Soiza-Reilly, Claudia Bagni, Manuel Mamel. Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula. Neuron. vol 109. issue 6. 2021-03-26. PMID:33535028. |
accordingly, stressful experiences increased error choices while decreasing glutamatergic neurotransmission onto lhb neurons. |
2021-03-26 |
2023-08-13 |
mouse |
| Dan Wang, Ao Li, Keyi Dong, Huihui Li, Yongxin Guo, Xinxin Zhang, Min Cai, Huiming Li, Guangchao Zhao, Qianzi Yan. Lateral hypothalamus orexinergic inputs to lateral habenula modulate maladaptation after social defeat stress. Neurobiology of stress. vol 14. 2021-02-12. PMID:33569507. |
when mice were defeated during social interaction, both orexinergic neurons in the lha and glutamatergic neurons in the lhb were strongly activated, as indicated by the fostrap strategy. |
2021-02-12 |
2023-08-13 |
mouse |
| Wen-Qiang Cui, Wen-Wen Zhang, Teng Chen, Qian Li, Fei Xu, Qi-Liang Mao-Ying, Wen-Li Mi, Yan-Qing Wang, Yu-Xia Ch. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32264959. |
adeno-associated virus (aav)-mediated expression of hm4d(gi) in glutamatergic neurons of the unilateral lhb followed by clozapine-n-oxide application relieved pt-ion-induced anxiety-like behaviors but not allodynia. |
2021-01-15 |
2023-08-13 |
mouse |
| Wen-Qiang Cui, Wen-Wen Zhang, Teng Chen, Qian Li, Fei Xu, Qi-Liang Mao-Ying, Wen-Li Mi, Yan-Qing Wang, Yu-Xia Ch. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32264959. |
whole-cell patch clamp recording showed that tacr3 overexpression suppressed nerve injury-induced hyperexcitation of lhb neurons, and western blotting showed that the pt-ion-induced upregulation of p-camkii was reversed by aav-mediated tacr3 overexpression or chemicogenetic inhibition of glutamatergic neurons in the lhb. |
2021-01-15 |
2023-08-13 |
mouse |
| Rao Fu, Qinghua Mei, Wanhong Zuo, Jing Li, Danielle Gregor, Alex Bekker, Jianghong Y. Low-dose ethanol excites lateral habenula neurons projecting to VTA, RMTg, and raphe. International journal of physiology, pathophysiology and pharmacology. vol 9. issue 6. 2020-09-30. PMID:29348799. |
most of the ethanol-activated cfos-ir lhb neurons expressed vglut2 (vesicular glutamate transporters 2, a marker of a glutamatergic phenotype). |
2020-09-30 |
2023-08-13 |
rat |
| Iakovos Lazaridis, Ourania Tzortzi, Moritz Weglage, Antje Märtin, Yang Xuan, Marc Parent, Yvonne Johansson, Janos Fuzik, Daniel Fürth, Lief E Fenno, Charu Ramakrishnan, Gilad Silberberg, Karl Deisseroth, Marie Carlén, Konstantinos Meleti. A hypothalamus-habenula circuit controls aversion. Molecular psychiatry. vol 24. issue 9. 2020-04-27. PMID:30755721. |
we have defined the identity and function of glutamatergic (vglut2) control of the lhb, comparing the role of inputs originating in the globus pallidus internal segment (gpi), and lateral hypothalamic area (lha), respectively. |
2020-04-27 |
2023-08-13 |
Not clear |
| Guang-Wei Zhang, Li Shen, Wen Zhong, Ying Xiong, Li I Zhang, Huizhong W Ta. Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway. Neuron. vol 99. issue 5. 2019-08-01. PMID:30122379. |
cell-type-specific screening reveals that glutamatergic ms projections to the lateral habenula (lhb) are responsible for the induction of aversion, which can be antagonized by gabaergic ms projections to lhb. |
2019-08-01 |
2023-08-13 |
Not clear |
| Yoshikage Muroi, Toshiaki Ishi. Glutamatergic Signals in the Dorsal Raphe Nucleus Regulate Maternal Aggression and Care in an Opposing Manner in Mice. Neuroscience. vol 400. 2019-06-21. PMID:30605702. |
we first examined neuronal activity in the medial prefrontal cortex (mpfc) and lateral habenula (lhb), which send glutamatergic input to the drn, in dams by injecting fluorogold, a retrograde tracer, into the drn. |
2019-06-21 |
2023-08-13 |
mouse |
| Yoshikage Muroi, Toshiaki Ishi. Glutamatergic Signals in the Dorsal Raphe Nucleus Regulate Maternal Aggression and Care in an Opposing Manner in Mice. Neuroscience. vol 400. 2019-06-21. PMID:30605702. |
these results suggest that glutamatergic signals in the drn, which may originate from the mpfc and/or lhb, regulate the preferential display of biting behavior over nurturing behavior in dams. |
2019-06-21 |
2023-08-13 |
mouse |
| Seungwoo Kang, Jing Li, Alex Bekker, Jiang-Hong Y. Rescue of glutamate transport in the lateral habenula alleviates depression- and anxiety-like behaviors in ethanol-withdrawn rats. Neuropharmacology. vol 129. 2018-07-27. PMID:29128307. |
here we show that dihydrokainic acid (dhk), a glt-1 blocker, potentiated glutamatergic transmission to lhb neurons in slices from ethanol naïve rats; this potentiation, though, was not observed in slices from rats withdrawn from repeated in vivo ethanol administration, suggesting reduced glt-1 function. |
2018-07-27 |
2023-08-13 |
human |
| Avi Shah, Wanhong Zuo, Seungwoo Kang, Jing Li, Rao Fu, Haifeng Zhang, Alex Bekker, Jiang-Hong Y. The lateral habenula and alcohol: Role of glutamate and M-type potassium channels. Pharmacology, biochemistry, and behavior. vol 162. 2018-06-18. PMID:28624587. |
multidisciplinary work in animals collectively suggests that lhb function and activity, including m-type potassium channels and glutamatergic transmission are altered by acute and repeated chronic alcohol exposure. |
2018-06-18 |
2023-08-13 |
Not clear |
| Jing Li, Seungwoo Kang, Rao Fu, Liangzhi Wu, Wei Wu, Hongwei Liu, Danielle Gregor, Wanhong Zuo, Alex Bekker, Jiang-Hong Y. Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats. Neuropharmacology. vol 126. 2018-06-12. PMID:28865912. |
glutamatergic synapses in lhb neurons largely express glua1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (ampar) that can be modulated by ca |
2018-06-12 |
2023-08-13 |
rat |
| Salvatore Lecca, Frank Julius Meye, Massimo Trusel, Anna Tchenio, Julia Harris, Martin Karl Schwarz, Denis Burdakov, Francois Georges, Manuel Mamel. Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior. eLife. vol 6. 2018-05-14. PMID:28871962. |
the foot-shock-driven excitation within the lhb requires glutamatergic signaling from the lh, but not from the midbrain. |
2018-05-14 |
2023-08-13 |
mouse |