| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sukanya G Gakare, Rajesh R Ugal. Pharmacological evaluation of lateral habenula and rostromedial tegmental nucleus in the expression of ethanol-induced place preference. Behavioural pharmacology. vol 34. issue 4. 2023-05-12. PMID:37171461. |
we found that activation of lhb glutamatergic system by intra-lhb administration of l-trans-2,4-pyrrolidine dicarboxylate (pdc) (glutamate transporter inhibitor) significantly decreased cpp score; on the contrary, lamotrigine (inhibits glutamate release) significantly increased cpp score and showed a rewarding effect in cpp. |
2023-05-12 |
2023-08-14 |
Not clear |
| Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. |
signaling in the lhb-vta pathway can be exacerbated during pain conditions by a hyperactivity of lhb glutamatergic neurons to inhibit local vta daergic cells. |
2023-03-29 |
2023-08-14 |
rat |
| Wen-Wen Zhang, Teng Chen, Shi-Yi Li, Xin-Yue Wang, Wen-Bo Liu, Yu-Quan Wang, Wen-Li Mi, Qi-Liang Mao-Ying, Yan-Qing Wang, Yu-Xia Ch. Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice. Frontiers in immunology. vol 14. 2023-02-09. PMID:36756128. |
chemicogenetic activation of bilateral lhb glutamatergic neurons in naive mice induced orofacial allodynia and anxiety-like behaviors, and pharmacological activation of nk3r in the lhb attenuated allodynia and anxiety-like behaviors induced by pt-ion. |
2023-02-09 |
2023-08-14 |
mouse |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711842. |
glutamatergic projection neurons of the lateral habenula (lhb) drive behavioral state modulation by regulating the activity of midbrain monoaminergic neurons. |
2023-01-30 |
2023-08-14 |
mouse |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711842. |
our data confirm that gad2+/vglut2+ neurons intrinsic to the lhb co-express markers of both glutamatergic and gabaergic transmission and that they are transcriptionally distinct from either gabaergic interneurons or habenular glutamatergic neurons. |
2023-01-30 |
2023-08-14 |
mouse |
| Lucas Lecourtier, Laura Durieux, Victor Mathi. Alteration of LHb function prevents the proper exploration of a novel environment. Neuroscience. 2023-01-30. PMID:36716915. |
in the present study, we used two pharmacological approaches altering lhb activity, intra-lhb infusion of either the gaba-a receptor agonist, muscimol, or the glutamatergic ampa receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx) and exposed rats to three consecutive open field (of) sessions. |
2023-01-30 |
2023-08-14 |
rat |
| Fang Wang, Juen Zhang, Yuan Yuan, Ming Chen, Zilong Gao, Shulu Zhan, Chengyu Fan, Wenzhi Sun, Ji H. Salience processing by glutamatergic neurons in the ventral pallidum. Science bulletin. vol 65. issue 5. 2023-01-20. PMID:36659230. |
besides, vp glutamatergic neurons project to both the lateral habenula (lhb) and the ventral tegmental area (vta). |
2023-01-20 |
2023-08-14 |
Not clear |
| Jessica L Swanson, Joshua Ortiz-Guzman, Snigdha Srivastava, Pey-Shyuan Chin, Sean W Dooling, Elizabeth Hanson Moss, Mikhail Y Kochukov, Patrick J Hunt, Jay M Patel, Brandon T Pekarek, Qingchun Tong, Benjamin R Arenkie. Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior. Scientific reports. vol 12. issue 1. 2022-12-21. PMID:36543829. |
using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the bf that project to the lhb, which responds to diverse sensory cues, including aversive and food-related odors. |
2022-12-21 |
2023-08-14 |
Not clear |
| Jack F Webster, Sanne Beerens, Christian Wozn. Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-11-13. PMID:36371544. |
however, while we find the lhb to be less active at rest, we report that the neurons reside in a sensitised state where they are more responsive to re-exposure to stress in adulthood in the form of acute restraint, thus priming them to respond to aversive events with an increase in neuronal activity mediated by changes in glutamatergic transmission. |
2022-11-13 |
2023-08-14 |
mouse |
| William J Flerlage, Ludovic D Langlois, Milan Rusnak, Sarah C Simmons, Shawn Gouty, Regina C Armstrong, Brian M Cox, Aviva Symes, Mumeko C Tsuda, Fereshteh Nugen. Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits. Journal of neurotrauma. 2022-08-16. PMID:35972745. |
additionally, mtbi diminished spontaneous glutamatergic and gabaergic synaptic activity onto lhb neurons, while synaptic excitation and inhibition (e/i) balance was shifted toward excitation through a greater suppression of gabaergic transmission. |
2022-08-16 |
2023-08-14 |
Not clear |
| William J Flerlage, Ludovic D Langlois, Milan Rusnak, Sarah C Simmons, Shawn Gouty, Regina C Armstrong, Brian M Cox, Aviva Symes, Mumeko C Tsuda, Fereshteh Nugen. Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits. Journal of neurotrauma. 2022-08-16. PMID:35972745. |
we found that chemogenetic inhibition of lhb glutamatergic neurons was sufficient to reverse mtbi-induced delays in grooming behavior. |
2022-08-16 |
2023-08-14 |
Not clear |
| Aki Takahashi, Romain Durand-de Cuttoli, Meghan E Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D Blitzer, Michael Lazarus, Kenji F Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J Russ. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nature communications. vol 13. issue 1. 2022-07-21. PMID:35864121. |
here, we found that glutamatergic projections from the lateral habenula (lhb) to the drn were activated in male mice that experienced pre-exposure to a rival male mouse ("social instigation") resulting in heightened intermale aggression. |
2022-07-21 |
2023-08-14 |
mouse |
| Aki Takahashi, Romain Durand-de Cuttoli, Meghan E Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D Blitzer, Michael Lazarus, Kenji F Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J Russ. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nature communications. vol 13. issue 1. 2022-07-21. PMID:35864121. |
our results demonstrate that the lhb glutamatergic inputs to the drn promote aggressive arousal induced by social instigation, which contributes to aggressive behavior by activating vta-projecting non-serotonergic drn neurons as one of its potential targets. |
2022-07-21 |
2023-08-14 |
mouse |
| Jian Xu, Andrew Jo, Raina P DeVries, Sercan Deniz, Suraj Cherian, Idris Sunmola, Xingqi Song, John J Marshall, Katherine A Gruner, Tanya L Daigle, Anis Contractor, Talia N Lerner, Hongkui Zeng, Yongling Zh. Intersectional mapping of multi-transmitter neurons and other cell types in the brain. Cell reports. vol 40. issue 1. 2022-07-06. PMID:35793636. |
focusing on the lateral habenula (lhb) as a target, we identified glutamatergic, gabaergic, or co-glutamatergic/gabaergic innervations from ∼40 brain regions. |
2022-07-06 |
2023-08-14 |
mouse |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
in this study, we used viral tracing combined with in situ hybridization targeting vesicular glutamate transporter 2 (vglut2) and glutamic acid decarboxylase 2 (gad2) to generate a comprehensive whole-brain atlas of inputs to glutamatergic and γ-aminobutyric acid (gaba)ergic neurons in the lhb. |
2022-06-01 |
2023-08-13 |
mouse |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
our results reveal a comprehensive connectivity atlas of glutamatergic and gabaergic inputs to the lhb in both sexes, which may facilitate a better understanding of sexual dimorphism in physiological and pathological brain functions. |
2022-06-01 |
2023-08-13 |
mouse |
| Marjorie R Levinstein, David J Bergkamp, Zoë K Lewis, Alex Tsobanoudis, Koichi Hashikawa, Garret D Stuber, John F Neumaie. PACAP-expressing neurons in the lateral habenula diminish negative emotional valence. Genes, brain, and behavior. 2022-03-19. PMID:35304804. |
while primarily glutamatergic, lhb neurons express genes coding for many neuropeptides, such as adcyap1 the gene encoding pituitary adenylate cyclase-activating polypeptide (pacap), which itself has been associated with anxiety and stress disorders. |
2022-03-19 |
2023-08-13 |
Not clear |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
md-induced potentiation of glutamatergic synaptic transmission onto lhb neurons shifts the coordination of excitation/inhibition (e/i) balance towards excitation, resulting in an increase in the overall spontaneous neuronal activity with elevation in bursting and tonic firing, and in the intrinsic excitability of lhb neurons in early adolescent male rats. |
2021-11-26 |
2023-08-13 |
rat |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
here, we explored how md affects intravenous morphine self-administration (msa) acquisition and sucrose preference as well as glutamatergic synaptic function in lhb neurons of adult male rats self-administering morphine. |
2021-11-26 |
2023-08-13 |
rat |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
we found that md-induced increases in lhb neuronal and glutamatergic synaptic activity and e/i ratio persisted into adulthood. |
2021-11-26 |
2023-08-13 |
rat |