| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masashi Kitazawa, Salvatore Oddo, Tritia R Yamasaki, Kim N Green, Frank M LaFerl. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 39. 2006-02-21. PMID:16192374. |
we find that microglia became activated in a progressive and age-dependent manner, and this activation correlated with the onset of fibrillar amyloidbeta-peptide plaque accumulation and tau hyperphosphorylation. |
2006-02-21 |
2023-08-12 |
mouse |
| Kuo-Sheng Hung, Shiuh-Lin Hwang, Chung-Ling Liang, Yann-Jang Chen, Tsung-Hsing Lee, Jong-Kang Liu, Shen-Long Howng, Cheng-Haung Wan. Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats. Journal of neuropathology and experimental neurology. vol 64. issue 1. 2005-03-03. PMID:15715081. |
we examined the cell-permeable calpain inhibitor mdl28170 in the pathophysiological processes after spinal cord injury (sci) including p35-p25- cyclin-dependent kinase-5 (cdk5) activation, tau hyperphosphorylation, neuron cell death, calpain i activation, astrogliosis, and microglia activation. |
2005-03-03 |
2023-08-12 |
rat |
| Alexander Gerhard, Justin Watts, Iris Trender-Gerhard, Federico Turkheimer, Richard B Banati, Kailash Bhatia, David J Brook. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration. Movement disorders : official journal of the Movement Disorder Society. vol 19. issue 10. 2005-02-14. PMID:15390000. |
in cbd, activated microglia have been shown to be associated closely with the extensive tau pathology found in the affected basal ganglia, brainstem nuclei, and cortical regions. |
2005-02-14 |
2023-08-12 |
Not clear |
| Othman Ghribi, Mary M Herman, Patcharin Pramoonjago, Natalie K Spaulding, John Savor. GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases. Neurobiology of disease. vol 16. issue 2. 2004-08-13. PMID:15193298. |
these effects correlate with the activation of jnk and erk as well as of microglia and with the phosphorylation of tau protein. |
2004-08-13 |
2023-08-12 |
rabbit |
| Yong Zhang, Angela Hayes, Antonia Pritchard, Uma Thaker, M Sayeed Haque, Helen Lemmon, Judith Harris, Alistair Cumming, Jean-Charles Lambert, Marie-Christine Chartier-Harlin, David St Clair, Takeshi Iwatsubo, David M Mann, Corinne L Lendo. Interleukin-6 promoter polymorphism: risk and pathology of Alzheimer's disease. Neuroscience letters. vol 362. issue 2. 2004-07-23. PMID:15193763. |
we extended the study to genotype/phenotype correlations but found no correlation with age of onset (n = 338), brain amyloid load (n = 126) or tau load (n = 101), brain microglial cell load (n = 65) or brain reactive astrocytes (n = 127). |
2004-07-23 |
2023-08-12 |
Not clear |
| Toshiki Uchihara, Ayako Nakamura, Tetsuaki Arai, Kenji Ikeda, Kuniaki Tsuchiy. Microglial tau undergoes phosphorylation-independent modification after ischemia. Glia. vol 45. issue 2. 2004-04-30. PMID:14730711. |
tau2-immunoreactive bands, exclusively retrieved in tris-soluble fraction of brain homogenates from ischemic foci, normal human and bovine brains, were of similar electrophoretic mobility, indicating that tau2 ir in these microglia is unrelated to hyperphosphorylation of tau. |
2004-04-30 |
2023-08-12 |
human |
| Toshiki Uchihara, Ayako Nakamura, Tetsuaki Arai, Kenji Ikeda, Kuniaki Tsuchiy. Microglial tau undergoes phosphorylation-independent modification after ischemia. Glia. vol 45. issue 2. 2004-04-30. PMID:14730711. |
because conformation at ser101 of bovine tau is crucial for its affinity to tau2, this ser-like conformation mimicked by its human counterpart pro may represent pathological modification of tau shared by microglia around ischemic foci and nfts. |
2004-04-30 |
2023-08-12 |
human |
| J-C Lambert, E Luedecking-Zimmer, S Merrot, A Hayes, U Thaker, P Desai, A Houzet, X Hermant, D Cottel, A Pritchard, T Iwatsubo, F Pasquier, B Frigard, P M Conneally, M-C Chartier-Harlin, S T DeKosky, C Lendon, D Mann, M I Kamboh, P Amouye. Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease. Journal of medical genetics. vol 40. issue 6. 2003-07-07. PMID:12807963. |
however, abeta(40), abeta(42), abeta total, and tau loads or the level of microglial cell activation were not modulated by the 3'-utr olr1 polymorphisms. |
2003-07-07 |
2023-08-12 |
Not clear |
| Anne K Vehmas, Claudia H Kawas, Walter F Stewart, Juan C Troncos. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiology of aging. vol 24. issue 2. 2003-03-26. PMID:12498966. |
we examined the associations of postmortem neocortical immunoreactivities for microglia, astrocytes, abeta and tau with cognitive changes in clinically characterized subjects with pathological diagnoses (cerad classification) of definite ad (9), possible ad (15) and age-matched controls (11). |
2003-03-26 |
2023-08-12 |
human |
| Yuekui Li, Ling Liu, Steven W Barger, W Sue T Griffi. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 5. 2003-03-24. PMID:12629164. |
interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-mapk pathway. |
2003-03-24 |
2023-08-12 |
Not clear |
| Yuekui Li, Ling Liu, Steven W Barger, W Sue T Griffi. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 5. 2003-03-24. PMID:12629164. |
when such activated microglia were placed in coculture with primary neocortical neurons, a significant increase in the phosphorylation of neuronal tau was accompanied by a decline in synaptophysin levels. |
2003-03-24 |
2023-08-12 |
Not clear |
| Yuekui Li, Ling Liu, Steven W Barger, W Sue T Griffi. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 5. 2003-03-24. PMID:12629164. |
il-1 receptor antagonist (il-1ra) as well as anti-il-1beta antibody attenuated the influence of activated microglia on neuronal tau and synaptophysin, but anti-tnfalpha antibody was ineffective. |
2003-03-24 |
2023-08-12 |
Not clear |
| Yuekui Li, Ling Liu, Steven W Barger, W Sue T Griffi. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 5. 2003-03-24. PMID:12629164. |
some effects of microglial activation on neurons appear to be mediated by activation of p38 mitogen-activated protein kinase (p38-mapk), because activated microglia stimulated p38-mapk phosphorylation in neurons, and an inhibitor of p38-mapk reversed the influence of il-1beta on tau phosphorylation and synaptophysin levels. |
2003-03-24 |
2023-08-12 |
Not clear |
| A Hayes, U Thaker, T Iwatsubo, S M Pickering-Brown, D M A Man. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience letters. vol 331. issue 3. 2002-11-29. PMID:12383924. |
pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with alzheimer's disease. |
2002-11-29 |
2023-08-12 |
Not clear |
| A Hayes, U Thaker, T Iwatsubo, S M Pickering-Brown, D M A Man. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience letters. vol 331. issue 3. 2002-11-29. PMID:12383924. |
the extent of microglial cell activation (microglial cell load) was estimated by image analysis of ferritin-immunostained sections of frontal cortex from 72 patients with pathologically confirmed alzheimer's disease (ad), and correlated with the amount of pathological tau and amyloid beta protein (abeta), as both abeta(40) and abeta(42) load, in adjacent sections of the same cases. |
2002-11-29 |
2023-08-12 |
Not clear |
| A Hayes, U Thaker, T Iwatsubo, S M Pickering-Brown, D M A Man. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience letters. vol 331. issue 3. 2002-11-29. PMID:12383924. |
microglial cell load did not correlate with either abeta(40) or abeta(42) load but was significantly correlated with pathological tau load. |
2002-11-29 |
2023-08-12 |
Not clear |
| J G Sheng, R A Jones, X Q Zhou, J M McGinness, L J Van Eldik, R E Mrak, W S Griffi. Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578769. |
we found frequent colocalization of hyperphosphorylated tau protein (at8 antibody) and activated mapk-p38 in neurons and in dystrophic neurites in alzheimer brain, and frequent association of these structures with activated microglia overexpressing il-1. |
2001-12-28 |
2023-08-12 |
rat |
| A J Rozemuller, P Eikelenboom, J W Theeuwes, E N Jansen Steur, R A de Vo. Activated microglial cells and complement factors are unrelated to cortical Lewy bodies. Acta neuropathologica. vol 100. issue 6. 2001-03-01. PMID:11078223. |
microglia clustering was seen around congophilic plaques with or without tau pathology. |
2001-03-01 |
2023-08-12 |
Not clear |
| W J Lukiw, N G Baza. Neuroinflammatory signaling upregulation in Alzheimer's disease. Neurochemical research. vol 25. issue 9-10. 2001-02-15. PMID:11059791. |
these three seemingly disperse attributes of ad etiopathogenesis are linked by the fact that proinflammatory microglia, reactive astrocytes and their associated cytokines and chemokines are associated with the biology of the microtubule associated protein tau, betaa speciation and aggregation. |
2001-02-15 |
2023-08-12 |
human |
| J G Sheng, R E Mrak, W S Griffi. Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution. Neuropathology and applied neurobiology. vol 21. issue 4. 1996-01-11. PMID:7494597. |
there were positive correlations between the regional patterns of distribution of activated il-1 alpha+ microglia and tau 2+ neuritic plaques as well as between activated il-1 alpha+ microglia and activated astrocytes. |
1996-01-11 |
2023-08-12 |
Not clear |