| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Wang, Qian Jiang, Jiang Chu, Li Lin, Xiao-Guang Li, Gao-Shang Chai, Qun Wang, Jian-Zhi Wang, Qing Tia. Expression of Tau40 induces activation of cultured rat microglial cells. PloS one. vol 8. issue 10. 2014-07-24. PMID:24146816. |
by immunofluorescence staining and the fractal dimension value assay in the present study, we observed that microglia were activated in the brains of rats and mice during aging, simultaneously, the immunoreactivities of total tau and the phosphorylated tau were significantly enhanced in the activated microglia. |
2014-07-24 |
2023-08-12 |
human |
| Lu Wang, Qian Jiang, Jiang Chu, Li Lin, Xiao-Guang Li, Gao-Shang Chai, Qun Wang, Jian-Zhi Wang, Qing Tia. Expression of Tau40 induces activation of cultured rat microglial cells. PloS one. vol 8. issue 10. 2014-07-24. PMID:24146816. |
furtherly by transient transfection of tau40 (human 2n/4r tau) into the cultured rat microglia, we demonstrated that expression of tau40 increased the level of iba1, indicating activation of microglia. |
2014-07-24 |
2023-08-12 |
human |
| Lu Wang, Qian Jiang, Jiang Chu, Li Lin, Xiao-Guang Li, Gao-Shang Chai, Qun Wang, Jian-Zhi Wang, Qing Tia. Expression of Tau40 induces activation of cultured rat microglial cells. PloS one. vol 8. issue 10. 2014-07-24. PMID:24146816. |
moreover, expression of tau40 significantly enhanced the membranous localization of the phosphorylated tau at ser396 in microglia possibly by a mechanism involving protein phosphatase 2a, extracellular signal-regulated kinase and glycogen synthase kinase-3β. |
2014-07-24 |
2023-08-12 |
human |
| Seiko Ikezu, Tsuneya Ikez. Tau-tubulin kinase. Frontiers in molecular neuroscience. vol 7. 2014-06-24. PMID:24808823. |
our recent study shows that there is a striking switch in mononuclear phagocyte and activation phenotypes in the anterior horn of the spinal cord from alternatively activated (m2-skewed) microglia in p301l tau mutant mice to pro-inflammatory (m1-skewed) infiltrating peripheral monocytes by crossing the tau mice with ttbk1 transgenic mice. |
2014-06-24 |
2023-08-13 |
mouse |
| Ana M García-Cabrero, Rosa Guerrero-López, Beatriz G Giráldez, María Llorens-Martín, Jesús Avila, José M Serratosa, Marina P Sánche. Hyperexcitability and epileptic seizures in a model of frontotemporal dementia. Neurobiology of disease. vol 58. 2014-04-23. PMID:23774255. |
astrocytosis and activated microglia are prominent in the hippocampus and other brain regions of young ftdp-17 mice where the human mutant tau transgene is expressed, before the appearance of hyperphosphorylated tau aggregates in these structures. |
2014-04-23 |
2023-08-12 |
mouse |
| Shan Liu, Ariel Breitbart, Yanjie Sun, Pankaj D Mehta, Allal Boutajangout, Henrieta Scholtzova, Thomas Wisniewsk. Blocking the apolipoprotein E/amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology. Journal of neurochemistry. vol 128. issue 4. 2014-04-08. PMID:24117759. |
we show that treatment with aβ12-28p substantially reduces tau pathology both immunohistochemically and biochemically, as well as reducing the amyloid burden and suppressing the activation of astrocytes and microglia. |
2014-04-08 |
2023-08-12 |
mouse |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. |
here, we show that hippocampal ht22 cells expressing human tau(p301l) mutant protein produce fractalkine, which in microglia activates akt, inhibits glycogen synthase kinase-3β and upregulates the transcription factor nrf2/nfe2l2 and its target genes including heme oxygenase 1. |
2014-03-11 |
2023-08-12 |
mouse |
| Isabel Lastres-Becker, Nadia G Innamorato, Tomasz Jaworski, Alberto Rábano, Sebastian Kügler, Fred Van Leuven, Antonio Cuadrad. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24277722. |
nrf2- and fractalkine receptor-knockout mice did not express heme oxygenase 1 in microglia and exhibited increased microgliosis and astrogliosis in response to neuronal tau(p301l) expression, demonstrating a crucial role of the fractalkine/nrf2/heme oxygenase 1 pathway in attenuation of the pro-inflammatory phenotype. |
2014-03-11 |
2023-08-12 |
mouse |
| Ramasamy Thangavel, Duraisamy Kempuraj, Deirdre Stolmeier, Poojya Anantharam, Mohammad Khan, Asgar Zahee. Glia maturation factor expression in entorhinal cortex of Alzheimer's disease brain. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23715664. |
results showed that gmf immunoreactive glial cells, glial fibrillary acidic protein labeled reactive astrocytes and ionized calcium binding adaptor molecule-1 labeled activated microglia were increased in the entorhinal cortical layers especially at the sites of 6e10 labeled aps and tau containing nfts. |
2014-03-10 |
2023-08-12 |
Not clear |
| Kevin R Nash, Daniel C Lee, Jerry B Hunt, Josh M Morganti, Maj-Linda Selenica, Peter Moran, Patrick Reid, Milene Brownlow, Clement Guang-Yu Yang, Miloni Savalia, Carmelina Gemma, Paula C Bickford, Marcia N Gordon, David Morga. Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23332170. |
in mouse models, inflammatory activation of microglia accelerates tau pathology. |
2013-12-11 |
2023-08-12 |
mouse |
| Wei-Yi Ong, Kazuhiro Tanaka, Gavin S Dawe, Lars M Ittner, Akhlaq A Farooqu. Slow excitotoxicity in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23481689. |
this article reviews possible links between ad pathogenic factors such as aβpp/aβ and tau; novel risk genes including clusterin, phosphatidylinositol-binding clathrin assembly protein, complement receptor 1, bridging integrator 1, atp-binding cassette transporter 7, membrane-spanning 4-domains subfamily a, cd2-associated protein, sialic acid-binding immunoglobulin-like lectin, and ephrin receptor a1; metabolic changes including insulin resistance and hypercholesterolemia; lipid changes including alterations in brain phospholipids, cholesterol and ceramides; glial changes affecting microglia and astrocytes; alterations in brain iron metallome and oxidative stress; and slow excitotoxicity. |
2013-12-10 |
2023-08-12 |
human |
| Marco A Meraz-Ríos, Danira Toral-Rios, Diana Franco-Bocanegra, Juana Villeda-Hernández, Victoria Campos-Peñ. Inflammatory process in Alzheimer's Disease. Frontiers in integrative neuroscience. vol 7. 2013-08-21. PMID:23964211. |
nevertheless the chronic activation of the microglia has been related with an increase of aβ and possibly with tau phosphorylation. |
2013-08-21 |
2023-08-12 |
Not clear |
| D C Lee, J Rizer, J B Hunt, M-L B Selenica, M N Gordon, D Morga. Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology. Neuropathology and applied neurobiology. vol 39. issue 1. 2013-07-24. PMID:23171029. |
review: experimental manipulations of microglia in mouse models of alzheimer's pathology: activation reduces amyloid but hastens tau pathology. |
2013-07-24 |
2023-08-12 |
mouse |
| Gustavo Román, Belén Pascua. Contribution of neuroimaging to the diagnosis of Alzheimer's disease and vascular dementia. Archives of medical research. vol 43. issue 8. 2013-06-18. PMID:23142262. |
there are isotope markers for amyloid-beta ((11)o-pib, (18)f-florbetapir), tau ((18)fddnp) and activated microglia ((11)c-pk11195). |
2013-06-18 |
2023-08-12 |
Not clear |
| Xin Zhang, Lixi Li, Xiaojie Zhang, Wenjie Xie, Liang Li, Dehua Yang, Xin Heng, Yunlan Du, Rachelle S Doody, Weidong L. Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer's disease neuropathology in APPSwe/PS1A246E transgenic mice. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22795785. |
finally, we demonstrated striking neuropathologic changes in prenatal hypoxic ad mice, showing increased phosphorylation of tau, decreased hypoxia-induced factor, and enhanced activation of astrocytes and microglia. |
2013-05-24 |
2023-08-12 |
mouse |
| Simantini Ghosh, Michael D Wu, Solomon S Shaftel, Stephanos Kyrkanides, Frank M LaFerla, John A Olschowka, M Kerry O'Banio. Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486975. |
after 1 and 3 months of transgene expression, we found robust increases in tau phosphorylation despite an ∼70-80% reduction in amyloid load and fourfold to sixfold increase in plaque-associated microglia, as well as evidence of greater microglial activation at the site of inflammation. |
2013-05-06 |
2023-08-12 |
mouse |
| Bobby Tan, Rachel Huiyi Choi, Tammy Jing Yee Chin, Charanjit Kaur, Eng-Ang Lin. Manipulation of microglial activity as a therapy for Alzheimer's disease. Frontiers in bioscience (Scholar edition). vol 4. 2013-04-29. PMID:22652882. |
based on the amyloid cascade hypothesis, a beta-activated microglia can produce pro-inflammatory cytokines which may exacerbate the hyperphosporylation of tau proteins that forms nft in ad pathology. |
2013-04-29 |
2023-08-12 |
Not clear |
| Agneta Mewes, Heike Franke, David Singe. Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies. PloS one. vol 7. issue 9. 2013-03-05. PMID:22984603. |
ad is characterized by two protein alterations, namely tau hyperphosphorylation and excessive amyloid β deposition, both causing microglia and astrocyte activation. |
2013-03-05 |
2023-08-12 |
mouse |
| Aida Attar, Cristian Ripoli, Elisa Riccardi, Panchanan Maiti, Domenica D Li Puma, Tingyu Liu, Jane Hayes, Mychica R Jones, Kristin Lichti-Kaiser, Fusheng Yang, Greg D Gale, Chi-Hong Tseng, Miao Tan, Cui-Wei Xie, Jeffrey L Straudinger, Frank-Gerrit Klärner, Thomas Schrader, Sally A Frautschy, Claudio Grassi, Gal Bita. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain : a journal of neurology. vol 135. issue Pt 12. 2013-02-15. PMID:23183235. |
treatment of 15-month-old triple-transgenic mice for 1 month with clr01 resulted in a decrease in brain amyloid β protein aggregates, hyperphosphorylated tau and microglia load as observed by immunohistochemistry. |
2013-02-15 |
2023-08-12 |
mouse |
| Aaron Y Lai, Kamaldeep S Dhami, Comfort D Dibal, Kathryn G Tod. Neonatal rat microglia derived from different brain regions have distinct activation responses. Neuron glia biology. vol 7. issue 1. 2013-01-14. PMID:22857737. |
these region-specific responses could be altered by pre-conditioning the microglia in a different neurochemical milieu, with taurine (tau) being one of the key molecules involved. |
2013-01-14 |
2023-08-12 |
rat |