| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler, Tsuneya Ikez. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature neuroscience. vol 18. issue 11. 2016-02-09. PMID:26436904. |
we found that depleting microglia dramatically suppressed the propagation of tau and reduced excitability in the dentate gyrus in this mouse model. |
2016-02-09 |
2023-08-13 |
mouse |
| Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler, Tsuneya Ikez. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature neuroscience. vol 18. issue 11. 2016-02-09. PMID:26436904. |
moreover, we demonstrate that microglia spread tau via exosome secretion, and inhibiting exosome synthesis significantly reduced tau propagation in vitro and in vivo. |
2016-02-09 |
2023-08-13 |
mouse |
| Kristen E Funk, Hilda Mirbaha, Hong Jiang, David M Holtzman, Marc I Diamon. Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. The Journal of biological chemistry. vol 290. issue 35. 2015-11-20. PMID:26126828. |
two therapeutic antibodies (hj8.5 and hj9.4) promoted uptake of full-length tau fibrils into microglia via fc receptors. |
2015-11-20 |
2023-08-13 |
mouse |
| Moonhee Lee, Edith McGeer, Patrick L McGee. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25169677. |
activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for alzheimer's disease pathogenesis. |
2015-09-21 |
2023-08-13 |
human |
| Moonhee Lee, Edith McGeer, Patrick L McGee. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25169677. |
pretreatment of lps/ifnγ-stimulated human microglia cells with the nonsteroidal anti-inflammatory drugs ibuprofen and aspirin, the antioxidant gsh, the h₂s donor nash, and the anti-inflammatory cytokine il-10, resulted in a cm with diminished ability to stimulate tau expression. |
2015-09-21 |
2023-08-13 |
human |
| Moonhee Lee, Edith McGeer, Patrick L McGee. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25169677. |
our data indicate that reactive microglia play an important role in governing the expression of aβ and tau, and therefore the progression of ad. |
2015-09-21 |
2023-08-13 |
human |
| Peter Filipcik, Martin Cente, Norbert Zilka, Tomas Smolek, Jozef Hanes, Juraj Kucerak, Alena Opattova, Branislav Kovacech, Michal Nova. Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25772164. |
the topological dissociation of neuronally expressed pathological tau and the induction of astrocytic hsp27, gfap, and vimentin along with up-regulation of microglia specific markers such as cd18, cd68 and c3 point to cooperation of astrocytes, microglia and neurons in response to intra-neuronal accumulation of insoluble tau. |
2015-08-27 |
2023-08-13 |
rat |
| Petra Majerova, Monika Zilkova, Zuzana Kazmerova, Andrej Kovac, Kristina Paholikova, Branislav Kovacech, Norbert Zilka, Michal Nova. Microglia display modest phagocytic capacity for extracellular tau oligomers. Journal of neuroinflammation. vol 11. 2015-08-07. PMID:25217135. |
microglia display modest phagocytic capacity for extracellular tau oligomers. |
2015-08-07 |
2023-08-13 |
Not clear |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25833819. |
reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. |
2015-08-07 |
2023-08-13 |
mouse |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25833819. |
here, we show that microglia drive tau pathology in a cell-autonomous manner. |
2015-08-07 |
2023-08-13 |
mouse |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25833819. |
third, adoptive transfer of purified microglia derived from htaucx3cr1(-/-) mice induces tau hyperphosphorylation within the brains of non-transgenic recipient mice. |
2015-08-07 |
2023-08-13 |
mouse |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25833819. |
together, our results suggest that reactive microglia are sufficient to drive tau pathology and correlate with the spread of pathological tau in the brain. |
2015-08-07 |
2023-08-13 |
mouse |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Astrid E Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Loss of tau rescues inflammation-mediated neurodegeneration. Frontiers in neuroscience. vol 9. 2015-06-19. PMID:26089772. |
activated microglia spatially coexist with microtubule-associated protein tau (mapt or tau)-burdened neurons in the brains of human ad and non-ad tauopathies. |
2015-06-19 |
2023-08-13 |
mouse |
| Brandon Peter Lucke-Wold, Ryan Coddington Turner, Aric Flint Logsdon, Julian Edwin Bailes, Jason Delwyn Huber, Charles Lee Rose. Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development. Journal of neurotrauma. vol 31. issue 13. 2015-02-23. PMID:24499307. |
cte is a progressive disease distinguished by characteristic tau neurofibrillary tangles (nfts) and, occasionally, transactive response dna binding protein 43 (tdp43) oligomers, both of which have a predilection for perivascular and subcortical areas near reactive astrocytes and microglia. |
2015-02-23 |
2023-08-12 |
Not clear |
| Karlijn J Doorn, Andrea Goudriaan, Carla Blits-Huizinga, John G J M Bol, Annemieke J Rozemuller, Piet V J M Hoogland, Paul J Lucassen, Benjamin Drukarch, Wilma D J van de Berg, Anne-Marie van Da. Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients. Brain pathology (Zurich, Switzerland). vol 24. issue 2. 2015-02-21. PMID:24033473. |
these amoeboid microglia cells were in close apposition to β-amyloid, hyperphosphorylated tau or α-synuclein deposits, but no uptake of pathological proteins by microglia could be visualized. |
2015-02-21 |
2023-08-12 |
Not clear |
| Karlijn J Doorn, Andrea Goudriaan, Carla Blits-Huizinga, John G J M Bol, Annemieke J Rozemuller, Piet V J M Hoogland, Paul J Lucassen, Benjamin Drukarch, Wilma D J van de Berg, Anne-Marie van Da. Increased amoeboid microglial density in the olfactory bulb of Parkinson's and Alzheimer's patients. Brain pathology (Zurich, Switzerland). vol 24. issue 2. 2015-02-21. PMID:24033473. |
subsequent analysis showed (i) no correlation between microglia and α-synuclein (pd), (ii) a positive correlation with β-amyloid (ad), and (iii) a negative correlation with hyperphosphorylated tau (ad). |
2015-02-21 |
2023-08-12 |
Not clear |
| Melissa E Murray, Scott A Przybelski, Timothy G Lesnick, Amanda M Liesinger, Anthony Spychalla, Bing Zhang, Jeffrey L Gunter, Joseph E Parisi, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack, Dennis W Dickson, Kejal Kantarc. Early Alzheimer's disease neuropathology detected by proton MR spectroscopy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 49. 2015-02-19. PMID:25471565. |
immunohistochemical evaluation was performed on the posterior cingulate gyrus using antibodies to synaptic vesicles, hyperphosphorylated tau (ptau), neurofibrillary tangle conformational-epitope (cnft), amyloid-β, astrocytes, and microglia. |
2015-02-19 |
2023-08-13 |
human |
| Sungho Lee, Guixiang Xu, Taylor R Jay, Sabina Bhatta, Ki-Wook Kim, Steffen Jung, Gary E Landreth, Richard M Ransohoff, Bruce T Lam. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 37. 2015-01-07. PMID:25209291. |
however, the mechanisms by which microglia regulate the pathological hallmarks of ad--extracellular deposition of β-amyloid (aβ) and intraneuronal hyperphosphorylation of microtubule-associated protein tau (mapt)--remain to be established. |
2015-01-07 |
2023-08-13 |
mouse |
| Xin Yan, Fan Yang, Jan Lukas, Martin Witt, Andreas Wree, Arndt Rolfs, Jiankai Lu. Hyperactive glial cells contribute to axonal pathologies in the spinal cord of Npc1 mutant mice. Glia. vol 62. issue 7. 2015-01-02. PMID:24644136. |
however, activities of astrocytes and microglia in the npc1 mutant spinal cord were progressively increased earlier from p10 onwards, accompanied by increased expression of interleukin-1β and apolipoprotein e, as well as up-regulated p38-mapk activity and enhanced phosphorylated tau protein, but not cyclin-dependent kinase 5/p35 complex and glycogen synthase kinase-3β. |
2015-01-02 |
2023-08-12 |
mouse |
| Lu Wang, Qian Jiang, Jiang Chu, Li Lin, Xiao-Guang Li, Gao-Shang Chai, Qun Wang, Jian-Zhi Wang, Qing Tia. Expression of Tau40 induces activation of cultured rat microglial cells. PloS one. vol 8. issue 10. 2014-07-24. PMID:24146816. |
tau was observed in microglia, but its role is not illustrated. |
2014-07-24 |
2023-08-12 |
human |