| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Joaquín Merino, Vilma Muñetón-Gómez, María-Isabel Alvárez, Adolfo Toledano-Día. Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD? Current Alzheimer research. vol 13. issue 4. 2016-12-15. PMID:26567742. |
in mouse models, inflammatory activation of microglia accelerates tau pathology. |
2016-12-15 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
direct evidence of internalization of tau by microglia in vitro and in vivo. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
here we demonstrate that microglia take up tau in vitro and in vivo. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
in this regard, microglia from primary cultures internalized soluble (human recombinant tau42) and insoluble (homogenates derived from human ad brain) tau in vitro. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
furthermore, using stereotaxic injection of tau in mice in vivo, we show that murine microglia internalize human tau. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
in addition, we demonstrate, for the first time, that microglia colocalize with various forms of tau in postmortem brain tissue of patients with alzheimer's disease and non-demented control subjects. |
2016-10-07 |
2023-08-13 |
mouse |
| Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. |
our data reveal a potential role of microglia in the internalization of tau that might be relevant for the design of strategies to enhance the clearance of extracellular tau in neurodegenerative diseases characterized by the accumulation of this protein. |
2016-10-07 |
2023-08-13 |
mouse |
| Andrea F N Rosenberger, Tjado H J Morrema, Wouter H Gerritsen, Elise S van Haastert, Hripsime Snkhchyan, Riet Hilhorst, Annemieke J M Rozemuller, Philip Scheltens, Saskia M van der Vies, Jeroen J M Hoozeman. Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology. Journal of neuroinflammation. vol 13. 2016-10-06. PMID:26732432. |
in addition to the occurrence of amyloid deposits and widespread tau pathology, ad is associated with a neuroinflammatory response characterized by the activation of microglia and astrocytes. |
2016-10-06 |
2023-08-13 |
Not clear |
| Robert Siman, Ryan Cocca, Yina Don. The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy. PloS one. vol 10. issue 11. 2016-06-14. PMID:26540269. |
focal expression of human tau carrying a p301l mutation but not egfp as a control in layer ii of the lateral entorhinal cortex triggered rapid degeneration of these neurons, loss of lateral perforant pathway synapses in the dentate gyrus outer molecular layer, and activation of neuroinflammatory microglia and astroglia in the two locations. |
2016-06-14 |
2023-08-13 |
mouse |
| Michael M Zeineh, Yuanxin Chen, Hagen H Kitzler, Robert Hammond, Hannes Vogel, Brian K Rut. Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26190634. |
to explore iron-associated neuroinflammatory ad pathology, we studied ad and control human brain specimens by (1) performing ultra-high resolution ex vivo 7 tesla mri, (2) coregistering the mri with successive histologic staining for iron, microglia, amyloid beta, and tau, and (3) quantifying the relationship between magnetic resonance signal intensity and histological staining. |
2016-04-25 |
2023-08-13 |
human |
| Michael M Zeineh, Yuanxin Chen, Hagen H Kitzler, Robert Hammond, Hannes Vogel, Brian K Rut. Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26190634. |
in ad, we identified numerous small mr hypointensities primarily within the subiculum that were best explained by the combination of microscopic iron and activated microglia (p = 0.025), in contradistinction to the relatively lesser contribution of tau or amyloid. |
2016-04-25 |
2023-08-13 |
human |
| Wenjie Luo, Wencheng Liu, Xiaoyan Hu, Mary Hanna, April Caravaca, Steven M Pau. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific reports. vol 5. 2016-04-12. PMID:26057852. |
however, it is not known whether microglia play a similar role in the clearance of tau, the major component of neurofibrillary tangles (nfts). |
2016-04-12 |
2023-08-13 |
mouse |
| Wenjie Luo, Wencheng Liu, Xiaoyan Hu, Mary Hanna, April Caravaca, Steven M Pau. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific reports. vol 5. 2016-04-12. PMID:26057852. |
we now report that murine microglia rapidly internalize and degrade hyperphosphorylated pathological tau isolated from ad brain tissue in a time-dependent manner in vitro. |
2016-04-12 |
2023-08-13 |
mouse |
| Wenjie Luo, Wencheng Liu, Xiaoyan Hu, Mary Hanna, April Caravaca, Steven M Pau. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific reports. vol 5. 2016-04-12. PMID:26057852. |
we further demonstrate that microglia readily degrade human tau species released from ad brain sections and eliminate nfts from brain sections of p301s tauopathy mice. |
2016-04-12 |
2023-08-13 |
mouse |
| Wenjie Luo, Wencheng Liu, Xiaoyan Hu, Mary Hanna, April Caravaca, Steven M Pau. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific reports. vol 5. 2016-04-12. PMID:26057852. |
our data identify a potential role for microglia in the degradation and clearance of pathological tau species in brain and provide a mechanism explaining the potential therapeutic actions of passively administered anti-tau monoclonal antibodies. |
2016-04-12 |
2023-08-13 |
mouse |
| Mario M Dorostkar, Chengyu Zou, Lidia Blazquez-Llorca, Jochen Herm. Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities. Acta neuropathologica. vol 130. issue 1. 2016-03-22. PMID:26063233. |
furthermore, tau hyperphosphorylation and microglia activation, which are thought to be consequences of amyloidosis in alzheimer's disease, may also contribute to spine loss. |
2016-03-22 |
2023-08-13 |
mouse |
| Arlan Richardson, Veronica Galvan, Ai-Ling Lin, Salvatore Odd. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Experimental gerontology. vol 68. 2016-02-22. PMID:25481271. |
rapamycin has been shown to prevent (and possibly restore in some cases) the deficit in memory observed in the mouse model of alzheimer's disease (ad-tg) as well as reduce aβ and tau aggregation, restore cerebral blood flow and vascularization, and reduce microglia activation. |
2016-02-22 |
2023-08-13 |
mouse |
| Fiona Car. Microglia: Tau distributors. Nature reviews. Neuroscience. vol 16. issue 12. 2016-02-22. PMID:26507296. |
microglia: tau distributors. |
2016-02-22 |
2023-08-13 |
Not clear |
| Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler, Tsuneya Ikez. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature neuroscience. vol 18. issue 11. 2016-02-09. PMID:26436904. |
depletion of microglia and inhibition of exosome synthesis halt tau propagation. |
2016-02-09 |
2023-08-13 |
mouse |
| Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler, Tsuneya Ikez. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature neuroscience. vol 18. issue 11. 2016-02-09. PMID:26436904. |
microglia, the primary phagocytes in the brain, are positively correlated with tau pathology, but their involvement in tau propagation is unknown. |
2016-02-09 |
2023-08-13 |
mouse |