| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S K Shankar, R Yanagihara, R M Garruto, I Grundke-Iqbal, K S Kosik, D C Gajduse. Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Annals of neurology. vol 25. issue 2. 1989-04-03. PMID:2493213. |
cryostat-cut sections of formalin-fixed and unfixed hippocampus from 23 guamanian chamorros with clinically and neuropathologically verified amyotrophic lateral sclerosis (als) (8 cases) and parkinsonism-dementia (pd) (15 cases) and from 12 neurologically normal guamanians (5 with and 7 without neurofibrillary degeneration) were evaluated by the immunoperoxidase technique, using monoclonal antibodies against phosphorylated neurofilament, human fetal microtubule-associated protein tau, and paired helical filaments. |
1989-04-03 |
2023-08-11 |
human |
| J Q Trojanowski, T Schuck, M L Schmidt, V M Le. Distribution of tau proteins in the normal human central and peripheral nervous system. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 37. issue 2. 1989-02-16. PMID:2492045. |
in neocortex, hippocampus, and cerebellum, immunoreactive tau was widely expressed but segregated into the axon-neuropil domain of neurons. |
1989-02-16 |
2023-08-11 |
human |
| M L Schmidt, V M Lee, H Hurtig, J Q Trojanowsk. Properties of antigenic determinants that distinguish neurofibrillary tangles in progressive supranuclear palsy and Alzheimer's disease. Laboratory investigation; a journal of technical methods and pathology. vol 59. issue 4. 1988-11-21. PMID:2459498. |
all mabs raised to tau (three) and paired helical filaments (two) recognized brain stem psp nfts and ad nfts in brain stem and hippocampus. |
1988-11-21 |
2023-08-11 |
Not clear |
| J Busciglio, A Ferreira, O Steward, A Cácere. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:3119145. |
an immunocytochemical and biochemical study of the microtubule-associated protein tau during post-lesion afferent reorganization in the hippocampus of adult rats. |
1988-01-11 |
2023-08-11 |
rat |
| J Busciglio, A Ferreira, O Steward, A Cácere. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:3119145. |
a monoclonal antibody against the microtubule-associated protein (map) tau was used to examine the fate of this molecule during post-lesion afferent reorganization in the hippocampus of adult rats. |
1988-01-11 |
2023-08-11 |
rat |
| J Busciglio, A Ferreira, O Steward, A Cácere. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:3119145. |
in the non-denervated hippocampus, tau immunoreactivity was detected in parallel axons and mossy fibers; no staining was present in neuronal cell bodies and dendrites. |
1988-01-11 |
2023-08-11 |
rat |
| J Busciglio, A Ferreira, O Steward, A Cácere. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:3119145. |
the modifications in tau immunoreactivity in the denervated hippocampus were also accompanied by changes in the polypeptide composition of this heterogeneous group of maps, as revealed by immunoblot analysis of hippocampal extracts obtained at different post-lesion intervals; these changes involved a rapid and significant increase in low molecular weight migrating tau-immunoreactive polypeptides. |
1988-01-11 |
2023-08-11 |
rat |
| J Busciglio, A Ferreira, O Steward, A Cácere. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain research. vol 419. issue 1-2. 1988-01-11. PMID:3119145. |
the present observations indicate that important modifications in tau proteins occur in the deafferented hippocampus, a phenomenon that may well be related with the regulation of microtubule polymerization during post-lesion axonal growth. |
1988-01-11 |
2023-08-11 |
rat |
| C G Dotti, G A Banker, L I Binde. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience. vol 23. issue 1. 1988-01-11. PMID:3120034. |
the expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. |
1988-01-11 |
2023-08-11 |
rat |
| C G Dotti, G A Banker, L I Binde. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience. vol 23. issue 1. 1988-01-11. PMID:3120034. |
in hippocampal cultures ranging from 12 h to 4 weeks in vitro tau was present in neurons but not in glial cells, as it is in situ. |
1988-01-11 |
2023-08-11 |
rat |
| C G Dotti, G A Banker, L I Binde. The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience. vol 23. issue 1. 1988-01-11. PMID:3120034. |
despite the non-restricted distribution of tau in hippocampal neurons in culture, and despite the presence of only the immature isoform which has a lessened stimulatory effect on microtubule polymerization, axons and dendrites appear to grow normally and to exhibit appropriate functional properties. |
1988-01-11 |
2023-08-11 |
rat |
| W E Wilson, P M Hudson, T Kanamatsu, T J Walsh, H A Tilson, J S Hong, R R Marenpot, M Thompso. Trimethyltin-induced alterations in brain amino acids, amines and amine metabolites: relationship to hyperammonemia. Neurotoxicology. vol 7. issue 3. 1987-04-20. PMID:2434891. |
decreased levels of taurine (tau) occurred on day 7 in both hippocampus and frontal cortex; hippocampal tau remained below control levels through post-dosing day 28. |
1987-04-20 |
2023-08-11 |
rat |