| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Torack, J W Mille. Denervation induced abnormal phosphorylation in hippocampal neurons. Brain research. vol 669. issue 1. 1995-05-12. PMID:7712157. |
this study demonstrates that combined dopaminergic and cholinergic denervation of the hippocampus results in the appearance of morphologically altered, tau reactive, apical dendrites of granule cells in the rat dentate gyrus. |
1995-05-12 |
2023-08-12 |
rat |
| T Horn, L Bauce, R Landgraf, Q J Pittma. Microdialysis with high NaCl causes central release of amino acids and dopamine. Journal of neurochemistry. vol 64. issue 4. 1995-04-18. PMID:7891091. |
in the dialysates of all perfusion areas, including the son, pvn, hippocampus, and striatum, concentrations of asp, glu, ser, gln, gly, taurine (tau), and gamma-aminobutyric acid (gaba) were significantly increased during perfusion with high-nacl medium. |
1995-04-18 |
2023-08-12 |
rat |
| T D Garver, K A Harris, R A Lehman, V M Lee, J Q Trojanowski, M L Billingsle. Tau phosphorylation in human, primate, and rat brain: evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro. Journal of neurochemistry. vol 63. issue 6. 1994-12-23. PMID:7964748. |
tau was rapidly isolated from human temporal neocortex and hippocampus, rhesus monkey temporal neocortex, and rat temporal neocortex and hippocampus under conditions that minimized dephosphorylation. |
1994-12-23 |
2023-08-12 |
human |
| C Schwab, V Bondada, D L Sparks, L D Cahan, J W Gedde. Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus. Hippocampus. vol 4. issue 2. 1994-12-20. PMID:7951696. |
postmortem changes in the levels and localization of microtubule-associated proteins (tau, map2 and map1b) in the rat and human hippocampus. |
1994-12-20 |
2023-08-12 |
human |
| C Schwab, V Bondada, D L Sparks, L D Cahan, J W Gedde. Postmortem changes in the levels and localization of microtubule-associated proteins (tau, MAP2 and MAP1B) in the rat and human hippocampus. Hippocampus. vol 4. issue 2. 1994-12-20. PMID:7951696. |
immunohistochemistry and immunoblots were used to examine the microtubule-associated proteins tau, map2, and map1b in the rat hippocampus at various times after death. |
1994-12-20 |
2023-08-12 |
human |
| R W Shin, V M Lee, J Q Trojanowsk. Aluminum modifies the properties of Alzheimer's disease PHF tau proteins in vivo and in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 2. 1994-12-02. PMID:7525898. |
to determine if aluminum salts interact directly and specifically with phf tau in situ, we pretreated sections of ad hippocampus with 10 mm alcl3 and then probed these sections by immunohistochemistry with antibodies to phf tau as well as to a number of other plaque and tangle components. |
1994-12-02 |
2023-08-12 |
human |
| H Braak, E Braak, M Strothjohan. Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neuroscience letters. vol 171. issue 1-2. 1994-10-10. PMID:7521944. |
frontal sections including temporal isocortex, entorhinal region and hippocampus from aged domestic animals (dog, cat, horse, sheep and goat) were studied for alzheimer-related changes using immunostaining with the at8 antibody for abnormally phosphorylated tau protein and selective silver techniques for a4 amyloid and neurofibrillary changes of the alzheimer type. |
1994-10-10 |
2023-08-12 |
human |
| Q Lu, R Kanumury, J G Woo. Abnormal phosphorylation of tau proteins associated with bovine brain microtubules: activation by excess ATP and tyrosine dephosphorylation. Journal of neuroscience research. vol 37. issue 6. 1994-08-31. PMID:8046776. |
the profound effect of tyrosine kinase inhibitors on tau phosphorylation was also demonstrated in living cells following microinjection of cultured hippocampal neurons. |
1994-08-31 |
2023-08-12 |
cattle |
| J W Geddes, C Schwab, S Craddock, J L Wilson, L C Pettigre. Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 14. issue 4. 1994-07-27. PMID:7516935. |
alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia. |
1994-07-27 |
2023-08-12 |
rat |
| L A Wong, M L Mayer, D E Jane, J C Watkin. Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 6. 1994-07-11. PMID:7515954. |
consistent with equilibrium potency measurements, in drg neurons the kinetics of deactivation for willardiines, recorded following a return to agonist-free solution, were rapid for 5-fluoro (tau off = 43 msec) but slow for 5-iodo (tau off = 4.2 sec), while the opposite sequence was observed for hippocampal neurons, slow for 5-fluoro (tau off = 2.1 sec) and rapid for 5-iodo (tau off = 188 msec). |
1994-07-11 |
2023-08-12 |
Not clear |
| J Q Trojanowski, M Mawal-Dewan, M L Schmidt, J Martin, V M Le. Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites. Brain research. vol 618. issue 2. 1993-10-21. PMID:8374766. |
since erk2 was detected in neurofibrillary tangles and senile plaque neurites in the ad hippocampus, erk2 is positioned to phosphorylate normal tau and could play a role in the generation of phfs in ad. |
1993-10-21 |
2023-08-12 |
Not clear |
| Q Lu, J P Soria, J G Woo. p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons. Journal of neuroscience research. vol 35. issue 4. 1993-09-30. PMID:7689658. |
p44mpk map kinase induces alzheimer type alterations in tau function and in primary hippocampal neurons. |
1993-09-30 |
2023-08-12 |
Not clear |
| Q Lu, J P Soria, J G Woo. p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons. Journal of neuroscience research. vol 35. issue 4. 1993-09-30. PMID:7689658. |
we show here that tau can be phosphorylated in cultured hippocampal neurons by the map kinase p44mpk, and phosphorylation of tau compromises its functional ability to assemble microtubules. |
1993-09-30 |
2023-08-12 |
Not clear |
| R W Shin, G T Bramblett, V M Lee, J Q Trojanowsk. Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 14. 1993-08-30. PMID:8393578. |
to probe the biological properties of a68 in vivo, and to assess interactions of a68 with endogenous proteins in the rodent brain, we injected a68, dephosphorylated a68 (dep-a68), and normal adult human tau protein into the hippocampus and neocortex of rats. |
1993-08-30 |
2023-08-12 |
human |
| E M Elliott, M P Mattson, P Vanderklish, G Lynch, I Chang, R M Sapolsk. Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8515288. |
corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo. |
1993-07-22 |
2023-08-12 |
rat |
| L W Duchen, M Poulter, A E Hardin. Dementia associated with a 216 base pair insertion in the prion protein gene. Clinical and neuropathological features. Brain : a journal of neurology. vol 116 ( Pt 3). 1993-07-21. PMID:8513392. |
in some places plaques bore a resemblance to senile neuritic plaques and in the hippocampus there were abundant typical neuritic plaques giving positive staining reactions for beta-amyloid protein and tau protein, but not prp. |
1993-07-21 |
2023-08-12 |
Not clear |
| M C Schiess, E K Asprodini, D G Rainnie, P Shinnick-Gallaghe. The central nucleus of the rat amygdala: in vitro intracellular recordings. Brain research. vol 604. issue 1-2. 1993-04-26. PMID:8457856. |
the s-ahp was defined by a slow decay time constant with a mean tau ahp = 1.7 s. the s-ahp was similar to the ahp mediated by iahp, a long duration calcium-dependent, noradrenaline-sensitive current present in hippocampal neurons. |
1993-04-26 |
2023-08-12 |
rat |
| M P Mattson, M A Lovell, W D Ehmann, W R Markesber. Comparison of the effects of elevated intracellular aluminum and calcium levels on neuronal survival and tau immunoreactivity. Brain research. vol 602. issue 1. 1993-04-12. PMID:8448655. |
we examined the effects of experimentally elevated intraneuronal levels of aluminum ([al]i) and/or calcium ([ca2+]i) on neuronal degeneration and antigenic alterations in the microtubule-associated protein tau in cell cultures of rat hippocampus and human cerebral cortex. |
1993-04-12 |
2023-08-12 |
human |
| N Taleghany, M M Oblinge. Regional distribution and biochemical characteristics of high molecular weight tau in the nervous system. Journal of neuroscience research. vol 33. issue 2. 1993-01-06. PMID:1453489. |
another tau isoform of slightly smaller size (90-100 kda), termed mid-molecular weight (mmw) tau, was present in abundant quantity in optic nerve samples and detectable in several other cns regions, including hippocampus and cerebellum. |
1993-01-06 |
2023-08-11 |
Not clear |
| C F Lippa, T W Smit. The indusium griseum in Alzheimer's disease: an immunocytochemical study. Journal of the neurological sciences. vol 111. issue 1. 1992-11-12. PMID:1328542. |
the immunocytochemical features of the indusium griseum (ig) were compared with the corresponding hippocampus in 5 patients with alzheimer's disease (ad) and 5 age-matched nondemented individuals using antibodies against beta-amyloid, the a68 protein (alz-50 antibody), tau, ubiquitin and synapsin i. beta-amyloid-positive plaques were prominent in the ad hippocampus but were not present in the ig. |
1992-11-12 |
2023-08-11 |
Not clear |