| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U S Kayyali, W Zhang, A G Yee, J G Seidman, H Potte. Cytoskeletal changes in the brains of mice lacking calcineurin A alpha. Journal of neurochemistry. vol 68. issue 4. 1997-04-28. PMID:9084440. |
the increase in phosphorylated tau content occurred primarily in the mossy fibers of the cna alpha -/- hippocampus, which contained the highest level of calcineurin in brains of wild-type mice. |
1997-04-28 |
2023-08-12 |
mouse |
| C Duyckaerts, M Bennecib, Y Grignon, F Piette, J J Hau. [Is the topography of Alzheimer's disease lesions a clue to their pathogenesis?]. Bulletin de l'Academie nationale de medecine. vol 180. issue 7. 1997-04-11. PMID:9102152. |
tau positive neurofibrillary changes were present in the hippocampus and in the parahippocampal gyrus even in intellectually normal cases. |
1997-04-11 |
2023-08-12 |
Not clear |
| M Hoshi, A Takashima, M Murayama, K Yasutake, N Yoshida, K Ishiguro, T Hoshino, K Imahor. Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease. The Journal of biological chemistry. vol 272. issue 4. 1997-02-21. PMID:8999897. |
non-aged abeta1-42 impaired pyruvate dehydrogenase (pdh) activity by activating mitochondrial tau protein kinase i/glycogen synthase kinase-3beta, as we have already shown in hippocampal neurons (hoshi, m., takashima, a., noguchi, k., murayama, m., sato, m., kondo, s., saitoh, y., ishiguro, k., hoshino, t., and imahori, k. (1996) proc. |
1997-02-21 |
2023-08-12 |
Not clear |
| T Kimura, T Ono, J Takamatsu, H Yamamoto, K Ikegami, A Kondo, M Hasegawa, Y Ihara, E Miyamoto, T Miyakaw. Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. Dementia (Basel, Switzerland). vol 7. issue 4. 1997-01-30. PMID:8835879. |
we investigated the phosphorylation of tau in the hippocampus of nondemented patients and alzheimer's disease patients by immunostaining with five site-specific antibodies against phosphorylated tau. |
1997-01-30 |
2023-08-12 |
human |
| K T Wong, I V Allen, S McQuaid, R McConnel. An immunohistochemical study of neurofibrillary tangle formation in post-encephalitic Parkinsonism. Clinical neuropathology. vol 15. issue 1. 1997-01-17. PMID:8998852. |
staining patterns for tau protein, ubiquitin and beta/a4 amyloid protein were studied in frontal lobe, hippocampus, and midbrain in 2 classical cases of pep, 2 cases of ad and 2 controls matched for age and sex. |
1997-01-17 |
2023-08-12 |
Not clear |
| b' C M Kondratick, D D Vandr\\xc3\\xa. Alzheimer\'s disease neurofibrillary tangles contain mitosis-specific phosphoepitopes. Journal of neurochemistry. vol 67. issue 6. 1996-12-23. PMID:8931473.' |
to determine if similar mitosis-associated phosphoepitopes appeared in ad, sections of hippocampal tissue were stained for immunoreactivity with antibodies recognizing both tau and mitotic phosphoepitopes. |
1996-12-23 |
2023-08-12 |
human |
| H Geerts, R Nuydens, M De Jong, F Cornelissen, R Nuyens, L Wouter. Sabeluzole stabilizes the neuronal cytoskeleton. Neurobiology of aging. vol 17. issue 4. 1996-12-20. PMID:8832632. |
previous studies have shown that in human tr14 neuroblastoma cells and in rat hippocampal neurons a hyperstimulating medium of kinase activators leads to induction of aberrant tau phosphorylation followed by neurotoxicity. |
1996-12-20 |
2023-08-12 |
mouse |
| M Kempf, A Clement, A Faissner, G Lee, R Brand. Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 18. 1996-12-11. PMID:8795614. |
here we report that tau is extracted differentially in cultured hippocampal neurons yielding an axon-specific localization under conditions that keep the integrity of the plasma membrane. |
1996-12-11 |
2023-08-12 |
Not clear |
| J W Mandell, G A Banke. A spatial gradient of tau protein phosphorylation in nascent axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 18. 1996-12-11. PMID:8795628. |
to test this hypothesis, we mapped relative levels of tau phosphorylation within developing cultured hippocampal neurons. |
1996-12-11 |
2023-08-12 |
Not clear |
| L Buée, J Pérez-Tur, B Leveugle, V Buée-Scherrer, E J Mufson, A J Loerzel, M C Chartier-Harlin, D P Perl, A Delacourte, P R Ho. Apolipoprotein E in Guamanian amyotrophic lateral sclerosis/parkinsonism-dementia complex: genotype analysis and relationships to neuropathological changes. Acta neuropathologica. vol 91. issue 3. 1996-12-10. PMID:8834536. |
compared to tau protein immunoreactivity, there were generally fewer apo e-immunoreactive neurofibrillary tangles, particularly in the deep layers of the neocortex and in the hippocampus. |
1996-12-10 |
2023-08-12 |
Not clear |
| L Ferhat, N Chevassus au Louis, I Jorquera, J Niquet, M Khrestchatisky, Y Ben-Ari, A Repres. Transient increase of tenascin-C in immature hippocampus: astroglial and neuronal expression. Journal of neurocytology. vol 25. issue 1. 1996-12-06. PMID:8852938. |
double labelling experiments performed with a tenascin-c antibody or tenascin-c probes combined with specific markers of astrocytes (gfap) or neurons (map2 and tau) allowed us to demonstrate that tenascin-c is expressed by both immature astrocytes and neurons in immature hippocampus. |
1996-12-06 |
2023-08-12 |
rat |
| K Niizato, K Iked. Long-term antipsychotic medication of schizophrenics does not promote the development of Alzheimer's disease brain pathology. Journal of the neurological sciences. vol 138. issue 1-2. 1996-12-03. PMID:8791256. |
immunohistological staining of the hippocampal region with anti-human tau antibody was used to examine the degree of ad pathology in seven schizophrenic patients who had received long-term antipsychotic medication and in seven controls. |
1996-12-03 |
2023-08-12 |
Not clear |
| E B Mukaetova-Ladinska, C R Harrington, M Roth, C M Wischi. Alterations in tau protein metabolism during normal aging. Dementia (Basel, Switzerland). vol 7. issue 2. 1996-12-03. PMID:8866683. |
we have examined phf-bound and normal tau fractions in frontal, temporal, parietal and occipital neocortex, cerebellum, hippocampus and entorhinal cortex in 15 cognitively unimpaired individuals aged 19-88 years at death. |
1996-12-03 |
2023-08-12 |
Not clear |
| E B Mukaetova-Ladinska, C R Harrington, M Roth, C M Wischi. Alterations in tau protein metabolism during normal aging. Dementia (Basel, Switzerland). vol 7. issue 2. 1996-12-03. PMID:8866683. |
frontal grey matter and hippocampus were most vulnerable to age-related tau loss, decreasing by as much as 90% in the older subgroup. |
1996-12-03 |
2023-08-12 |
Not clear |
| E Bednarski, G Lync. Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L. Journal of neurochemistry. vol 67. issue 5. 1996-12-02. PMID:8863489. |
cytosolic proteolysis of tau by cathepsin d in hippocampus following suppression of cathepsins b and l. incubation of cultured hippocampal slices with an inhibitor [n-cbz-l-phenylalanyl-l-alanine-diazomethyl ketone (zpad)] of cathepsins b and l resulted in the degradation of high molecular weight isoforms of tau protein and the production of a 29-kda tau fragment (tau 29). |
1996-12-02 |
2023-08-12 |
Not clear |
| P Vermersch, N Sergeant, M M Ruchoux, H Hofmann-Radvanyi, A Wattez, H Petit, P Dwailly, A Delacourt. Specific tau variants in the brains of patients with myotonic dystrophy. Neurology. vol 47. issue 3. 1996-11-22. PMID:8797469. |
as in ad brain homogenates, pathologic tau proteins, named tau 55, 64, and 69, were exclusively immunodetected in the dm cases in the hippocampus, the entorhinal cortex, and in most of the temporal areas. |
1996-11-22 |
2023-08-12 |
Not clear |
| J A Ogeng'o, D L Cohen, J G Sayi, W B Matuja, H M Chande, J N Kitinya, J K Kimani, R P Friedland, H Mori, R N Kalari. Cerebral amyloid beta protein deposits and other Alzheimer lesions in non-demented elderly east Africans. Brain pathology (Zurich, Switzerland). vol 6. issue 2. 1996-11-08. PMID:8737923. |
tau protein reactive neurofibrillary tangles (nft) were also evident in the hippocampus of 4 subjects. |
1996-11-08 |
2023-08-12 |
human |
| K E Roertgen, J E Parisi, H B Clark, D L Barnes, T D O'Brien, K H Johnso. A beta-associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo). Neurobiology of aging. vol 17. issue 2. 1996-10-24. PMID:8744405. |
argyrophilic intracellular neurofibrillary tangles containing abnormally phosphorylated (ser 202) tau protein were present within cortical and hippocampal neurons. |
1996-10-24 |
2023-08-12 |
Not clear |
| R Layfield, J Fergusson, A Aitken, J Lowe, M Landon, R J Maye. Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins. Neuroscience letters. vol 209. issue 1. 1996-10-04. PMID:8734909. |
the localisation of 14-3-3 proteins compared to that of tau and ubiquitin-protein conjugates in sections of hippocampus from alzheimer's disease (ad) brains was examined by immunohistochemistry. |
1996-10-04 |
2023-08-12 |
Not clear |
| A Takashima, K Noguchi, G Michel, M Mercken, M Hoshi, K Ishiguro, K Imahor. Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neuroscience letters. vol 203. issue 1. 1996-09-26. PMID:8742040. |
exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase i/glycogen synthase kinase-3 beta. |
1996-09-26 |
2023-08-12 |
rat |