| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark D Namba, Qiaowei Xie, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. EcoHIV Infection Modulates the Effects of Cocaine Exposure Pattern and Abstinence on Cocaine Seeking and Neuroimmune Protein Expression in Male Mice. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659915. |
analysis of corticolimbic cx3cl1-cx3cr1 and glutamate receptor expression revealed alterations in medial prefrontal cortex (mpfc) cx3cl1 and nucleus accumbens (nac) glun2a receptors that correlated with cocaine seeking following daily cocaine exposure. |
2024-04-25 |
2024-04-28 |
mouse |
| Nazanin Kahvandi, Zahra Ebrahimi, Maryam Sharifi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Rasool Haddadi, Abdolrahman Sarih. S-3,4-DCPG, a potent orthosteric agonist for the mGlu8 receptor, facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Pharmacology, biochemistry, and behavior. 2024-04-23. PMID:38653345. |
the limbic system, particularly the nac, shows a high concentration of metabotropic glutamate receptors (mglurs). |
2024-04-23 |
2024-04-26 |
rat |
| Nazanin Kahvandi, Zahra Ebrahimi, Maryam Sharifi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Rasool Haddadi, Abdolrahman Sarih. S-3,4-DCPG, a potent orthosteric agonist for the mGlu8 receptor, facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Pharmacology, biochemistry, and behavior. 2024-04-23. PMID:38653345. |
this effect may be associated with the modulation of glutamate engagement within the nac and the plasticity of reward pathways at the synaptic level. |
2024-04-23 |
2024-04-26 |
rat |
| Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sar. Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol. Brain research bulletin. 2024-04-03. PMID:38570076. |
chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mpfc) and nucleus accumbens (nac), and consequently leading to oxidative stress and neuroinflammation. |
2024-04-03 |
2024-04-06 |
rat |
| Annisa D Harlivasari, Agus D Susanto, Feni F Taufik, Tribowo T Gintin. The Role of Twice-Daily N-acetylcysteine (NAC) 2400 mg in Smoking Cessation: A Randomized, Placebo-Controlled Trial in Indonesia. Cureus. vol 16. issue 2. 2024-03-19. PMID:38500894. |
this is a preclinical trial on glutamate modulator in n-acetylcysteine (nac) as a new potential treatment for smoking cessation. it is based on the administration of nac related to elevated levels of dopamine in the central nervous system to accomplish successful smoking cessation. |
2024-03-19 |
2024-03-21 |
Not clear |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. |
2024-02-20 |
2024-02-23 |
rat |
| Norman R Greenberg, Farzaneh Farhadi, Benjamin Kazer, Marc N Potenza, Gustavo A Angarit. The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review. Current addiction reports. vol 9. issue 4. 2024-02-16. PMID:38362235. |
n-acetylcysteine (nac), a well-tolerated cysteine pro-drug and antioxidant, may reduce addictive behaviors by restoring glutamate homeostasis. |
2024-02-16 |
2024-02-18 |
Not clear |
| Seyedeh-Najmeh Katebi, Anahita Torkaman-Boutorabi, Esmail Riahi, Abbas Haghparas. N-acetylcysteine attenuates accumbal core neuronal activity in response to morphine in the reinstatement of morphine CPP in morphine extinguished rats. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-12. PMID:38215930. |
these results suggest that modulating glutamate transmission through daily nac during extinction may effectively inhibit the morphine place preference following the excitatory effects of morphine on nacore neurons. |
2024-01-12 |
2024-01-15 |
rat |
| Murat Sırrı Akosman, Ruhi Türkmen, Hasan Hüseyin Demire. The protective effect of N-acetylcysteine against MK-801-induced neurodegeneration in mice. Molecular biology reports. 2023-11-16. PMID:37971568. |
this study aims to determine whether n-acetylcysteine (nac) is useful to treat brain degeneration caused by mk-801, an n-methyl-d-aspartate glutamate receptor antagonist. |
2023-11-16 |
2023-11-20 |
mouse |
| Woonyen Wong, Youssef Sar. Effects of Chronic Hydrocodone Exposure and Ceftriaxone on the Expression of Astrocytic Glutamate Transporters in Mesocorticolimbic Brain Regions of C57/BL Mice. Toxics. vol 11. issue 10. 2023-10-27. PMID:37888720. |
however, hydrocodone exposure increased the expression of g-protein-coupled metabotropic glutamate receptors (mglur5) in the nac, amy, and dmpfc. |
2023-10-27 |
2023-11-08 |
mouse |
| Benjamin M Siemsen, Adam R Denton, Jeffrey Parrila-Carrero, Kaylee N Hooker, Eilish A Carpenter, Meagan E Prescot, Ashley G Brock, Annaka M Westphal, Mary-Nan Leath, John A McFaddin, Thomas C Jhou, Jacqueline F McGinty, Michael D Scofiel. Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte-Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine. Cells. vol 12. issue 14. 2023-07-29. PMID:37508477. |
normalizing astrocyte glutamate homeostasis with drugs like the antioxidant n-acetylcysteine (nac) prevents cue-induced heroin seeking. |
2023-07-29 |
2023-08-14 |
rat |
| Lauren Faget, Lucie Oriol, Wen-Chun Lee, Cody Sargent, Dhakshin Ramanathan, Thomas S Hnask. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502884. |
however, vp glut neurons evoked da in reward-associated ventromedial nucleus accumbens (nac), but reduced da in aversion-associated dorsomedial nac. |
2023-07-28 |
2023-08-14 |
human |
| Amanda M Catalfio, Tracy L Fetterly, Allison M Nieto, Terry E Robinson, Carrie R Ferrari. Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex. Biology of sex differences. vol 14. issue 1. 2023-06-24. PMID:37355656. |
ampa-type glutamate receptors (ampars) provide the main source of excitatory drive to the nac and enhancements in transmission of calcium-permeable ampars (cp-ampars) mediate increased cue-triggered drug-seeking following prolonged withdrawal. |
2023-06-24 |
2023-08-14 |
Not clear |
| Adejoke Elizabeth Memud. The Efficacy of N-Acetyl-Cysteine (NAC) Supplementation in FST Model for Screening Antidepressants. Basic and clinical neuroscience. vol 13. issue 6. 2023-06-16. PMID:37323955. |
this study was aimed at potential antidepressant mechanism of n-acetyl cysteine (nac), a glutamate precursor on fst animal model for screening antidepressant drugs using fluoxetine, a selective serotonin reuptake inhibitors (ssris) as standard antidepressant drug. |
2023-06-16 |
2023-08-14 |
rat |
| Tracy L Fetterly, Amanda M Catalfio, Carrie R Ferrari. Effects of junk-food on food-motivated behavior and NAc glutamate plasticity; insights into the mechanism of NAc calcium-permeable AMPA receptor recruitment. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292760. |
effects of junk-food on food-motivated behavior and nac glutamate plasticity; insights into the mechanism of nac calcium-permeable ampa receptor recruitment. |
2023-06-09 |
2023-08-14 |
rat |
| Lorraine Madur, Christian Ineichen, Giorgio Bergamini, Alexandra Greter, Giulia Poggi, Nagiua Cuomo-Haymour, Hannes Sigrist, Yaroslav Sych, Jean-Charles Paterna, Klaus D Bornemann, Coralie Viollet, Francesc Fernandez-Albert, Gregorio Alanis-Lobato, Bastian Hengerer, Christopher R Pryc. Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice. Communications biology. vol 6. issue 1. 2023-04-15. PMID:37061616. |
glutamate neurons in basal amygdala (ba) project to various regions including nucleus accumbens (nac). |
2023-04-15 |
2023-08-14 |
mouse |
| Zahra Ebrahimi, Nazanin Kahvandi, Elahe Shahriari, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Maryam Sharifi, Abdolrahman Sarih. VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. Brain research bulletin. 2023-03-30. PMID:36997034. |
the findings suggested that the mglur4 in the nac facilitates the extinction and inhibits the reinstatement of the morphine-induced cpp, which could be mediated by an increase in the release of extracellular glutamate. |
2023-03-30 |
2023-08-14 |
rat |
| Adelaja Akinlolu, Victor Emejovwe, Raphael Uwejigho, Juliet Ilesanmi, Rokibat Owolabi, Abimbola Iganda. Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathology and dys-regulations of Dopamine and Glutamate in rat brain. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2023-02-28. PMID:36852734. |
this study examined neuro-protective potentials of n-acetyl-cysteine (nac) and zinc on expression levels of dopamine and glutamate in the cerebrum, hypothalami and pituitary glands in di(2-ethylhexyl)-phthalate (dehp)-induced neurotoxicity in rats. |
2023-02-28 |
2023-08-14 |
rat |
| Yifeng Shi, Mengqi Wang, Linglong Xiao, Luolan Gui, Wen Zheng, Lin Bai, Bo Su, Bin Li, Yangyang Xu, Wei Pan, Jie Zhang, Wei Wan. Potential therapeutic mechanism of deep brain stimulation of the nucleus accumbens in obsessive-compulsive disorder. Frontiers in cellular neuroscience. vol 16. 2023-01-23. PMID:36687525. |
furthermore, we found that the local levels of monoamines [dopamine (da) and serotonin (5-ht)] and amino acids [glutamate (glu) and gamma-aminobutyric acid (gaba)] in the nac were increased in ocd status, and that the expression of the two types of da receptors in the nac exhibited an opposite change. |
2023-01-23 |
2023-08-14 |
rat |
| Allison M Nieto, Amanda M Catalfio, Helena Papacostas Quintanilla, Yanaira Alonso-Caraballo, Carrie R Ferrari. Transient effects of junk food on NAc core MSN excitability and glutamatergic transmission in obesity-prone female rats. Obesity (Silver Spring, Md.). 2022-12-27. PMID:36575127. |
this study examines effects of junk food and junk food deprivation on nac core medium spiny neuron (msn) excitability and glutamate transmission in females. |
2022-12-27 |
2023-08-14 |
rat |