| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Min Mao, Nirav Mathur, John Q Wan. Downregulation of surface AMPA receptor expression in the striatum following prolonged social isolation, a role of mGlu5 receptors. IBRO neuroscience reports. vol 13. 2022-06-17. PMID:35711245. |
noticeably, chronic treatment with the metabotropic glutamate (mglu) receptor 5 antagonist mtep reversed the reduction of ampa receptors in the nac and cpu. |
2022-06-17 |
2023-08-14 |
rat |
| Viktor A Stratilov, Oleg V Vetrovoy, Ekaterina I Tyulkov. Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. Molecular neurobiology. 2022-05-17. PMID:35581520. |
psh rats also demonstrated an increased level of phosphorylated darpp-32 protein (known as the relay for dopamine and glutamate signaling) at 34 threonine (pthr34darpp-32) in relation to its total amount in the nucleus accumbens of the striatum (nac). |
2022-05-17 |
2023-08-13 |
rat |
| Yan Li, Zhi Chen, Jianting Zhao, Heming Yu, Xiangyu Chen, Yong He, Yu Tian, Yue Wang, Chong Chen, Ke Cheng, Peng Xi. Neurotransmitter and Related Metabolic Profiling in the Nucleus Accumbens of Chronic Unpredictable Mild Stress-Induced Anhedonia-Like Rats. Frontiers in behavioral neuroscience. vol 16. 2022-05-16. PMID:35571281. |
anhedonia, as a core symptom, was closely associated with altered levels of 5-hydroxytryptamine (5-ht), dopamine (da), and diverse types of glutamate (glu) receptors in the nucleus accumbens (nac). |
2022-05-16 |
2023-08-13 |
rat |
| Alexander D Maitland, Carrie R Ferrari. Effect of rate of intravenous cocaine infusion on psychomotor sensitization and striatal AMPAR expression in female rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554015. |
furthermore, increases in cell-surface expression of ampa-type glutamate receptors within the nucleus accumbens (nac) are associated with psychomotor sensitization and enhanced cocaine-seeking, but potential effects of roi on nac glutamate plasticity had not been examined. |
2022-05-13 |
2023-08-13 |
rat |
| Chelsea Brown, Jackie Beltran, Elissa Fultz, Tori Tran, Brooke Barger, Nyssa Williams, Waylon Yen, Asher Park, Tod Kippin, Karen Szumlinsk. Investigating the Role of Corticostriatal Glutamate Signaling in Methamphetamine Reward and Reinforcement. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554032. |
while the majority of addiction research has implicated the dopamine system, the long-term neuroplasticity that maintains ma use disorder also involves drug-induced changes in glutamate signaling in reward regions of the brain like the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2022-05-13 |
2023-08-13 |
Not clear |
| Chelsea Brown, Jackie Beltran, Elissa Fultz, Tori Tran, Brooke Barger, Nyssa Williams, Waylon Yen, Asher Park, Tod Kippin, Karen Szumlinsk. Investigating the Role of Corticostriatal Glutamate Signaling in Methamphetamine Reward and Reinforcement. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554032. |
in order to further characterize the role of glutamate in ma reward and reinforcement, glutamate receptor scaffolding protein homer2 expression in the nac and activity in the glutamatergic projection pfc-nac were manipulated prior to place- and operant-conditioning procedures. |
2022-05-13 |
2023-08-13 |
Not clear |
| Richard C J Bradlow, Michael Berk, Peter W Kalivas, Sudie E Back, Richard A Kanaa. The Potential of N-Acet³yl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders. CNS drugs. 2022-03-22. PMID:35316513. |
primarily through its antioxidant, anti-inflammatory, and glutamate modulation activity, nac has been investigated in the treatment of neurodevelopmental disorders, schizophrenia spectrum disorders, bipolar-related disorders, depressive disorders, anxiety disorders, obsessive compulsive-related disorders, substance-use disorders, neurocognitive disorders, and chronic pain. |
2022-03-22 |
2023-08-13 |
Not clear |
| Katsuya Kami, Fumihiro Tajima, Emiko Senb. Brain Mechanisms of Exercise-Induced Hypoalgesia: To Find a Way Out from "Fear-Avoidance Belief". International journal of molecular sciences. vol 23. issue 5. 2022-03-10. PMID:35270027. |
we found that voluntary exercise (ve) activated glutamate (glu) neurons in the medial basal amyg projecting to the nucleus accumbens (nac) lateral shell, while it almost completely suppressed npp-induced activation of gaba neurons in the central nucleus of the amyg (cea). |
2022-03-10 |
2023-08-13 |
mouse |
| Nicholas K Smith, Jared M Plotkin, Brad A Gruete. Hunger dampens a nucleus accumbens circuit to drive persistent food seeking. Current biology : CB. 2022-03-08. PMID:35259342. |
biglen, a hunger-driven neuropeptide, acts through its receptor gpr171 to inhibit glutamate transmission onto nac shell drd1+ lh-projecting medium spiny neurons by suppressing cholinergic signaling. |
2022-03-08 |
2023-08-13 |
Not clear |
| Rusty W Nall, Lauren N Beloate, Michael E Meyerink, Tiffany Penaloza, Jade Doolittle, Brett Froeliger, Peter W Kalivas, Constanza Garcia-Kelle. Assessing combined effects of varenicline and N-acetylcysteine on reducing nicotine seeking in rats. Addiction biology. vol 27. issue 2. 2022-03-01. PMID:35229943. |
n-acetylcysteine (nac) normalizes glutamate transmission and prolongs cocaine abstinence. |
2022-03-01 |
2023-08-13 |
rat |
| Martina Tallarico, Antonio Leo, Lorenza Guarnieri, Maria Caterina Zito, Carmen De Caro, Ferdinando Nicoletti, Emilio Russo, Andrew Constanti, Giovambattista De Sarro, Rita Citrar. N-acetylcysteine aggravates seizures while improving depressive-like and cognitive impairment comorbidities in the WAG/Rij rat model of absence epilepsy. Molecular neurobiology. 2022-02-15. PMID:35167014. |
furthermore, the mechanism of action of nac was evaluated by analysing brain expression levels of some possible key targets: the excitatory amino acid transporter 2, cystine-glutamate antiporter, metabotropic glutamate receptor 2, the mechanistic target of rapamycin and p70s6k as well as levels of total glutathione. |
2022-02-15 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
these findings, for the first time, indicate that glutamate in the nac negatively regulates cocaine's rewarding effects, while an excess of glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior. |
2022-01-29 |
2023-08-13 |
rat |
| Ganesh Raghu, Michael Berk, Peter A Campochiaro, Hartmut Jaeschke, Giancarlo Marenzi, Luca Richeldi, Fu-Qiang Wen, Ferdinando Nicoletti, Peter M A Calverle. The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress. Current neuropharmacology. vol 19. issue 8. 2021-11-05. PMID:33380301. |
in particular, the discovery that nac can modulate the homeostasis of glutamate has prompted studies of nac in neuropsychiatric diseases characterized by impaired glutamate homeostasis. |
2021-11-05 |
2023-08-13 |
Not clear |
| Fei Zeng, Qiaosheng Zhang, Yaling Liu, Guanghao Sun, Anna Li, Robert S Talay, Jing Wan. AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain. Molecular brain. vol 14. issue 1. 2021-11-04. PMID:33653395. |
previous studies have shown that enhancement of glutamate signaling through the nac by ampakines, a class of agents that specifically potentiate the function of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors, reduces acute and persistent pain. |
2021-11-04 |
2023-08-13 |
rat |
| Ai T M Nguyen, Tran V B Quach, Peddanna Kotha, Szu-Yu Chien, Iona J MacDonald, Hsien-Yuan Lane, Cheng-Hao Tu, Jaung-Geng Lin, Yi-Hung Che. Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34211013. |
this experimental study compared the effects of electroacupuncture (ea) at acupoints li4 and li11 with those of another potentially beneficial intervention, gabapentin (gbp), alone or in combination, on reinstatement of cocaine-induced conditioned place preference (cpp) and levels of Δfosb and glutamate receptor subunit 2 (glur2) expression in the nucleus accumbens (nac). |
2021-11-03 |
2023-08-13 |
Not clear |
| Erik J Garcia, Mary E Cai. Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations. The European journal of neuroscience. vol 54. issue 7. 2021-11-01. PMID:34481424. |
preclinical models have determined that glutamate receptor plasticity within the nucleus accumbens (nac) drives amplified cue-evoked drug seeking after prolonged abstinence (>40 days). |
2021-11-01 |
2023-08-13 |
rat |
| Tomaz Martini, Jürgen A Ripperger, Jimmy Stalin, Andrej Kores, Michael Stumpe, Urs Albrech. Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice. Scientific reports. vol 11. issue 1. 2021-10-27. PMID:34112905. |
this is paralleled by an increase of the gaba transporter 2 (gat2/slc6a13) and dopamine receptor d3 (drd3) mrna, and a reduction of glutamate levels in the nucleus accumbens (nac). |
2021-10-27 |
2023-08-13 |
mouse |
| Karen K Szumlinski, Daria L Thompson, Rachel M Renton, Alexis W Ary, Kevin D Lomina. Enduring dysregulation of nucleus accumbens catecholamine and glutamate transmission by developmental exposure to phenylpropanolamine. Brain research. vol 1748. 2021-10-25. PMID:32896521. |
the present study employed a combination of in vivo microdialysis and immunoblotting approaches to better understand how juvenile ppa exposure impacts catecholamine and glutamate function within the nac. |
2021-10-25 |
2023-08-13 |
mouse |
| Karen K Szumlinski, Daria L Thompson, Rachel M Renton, Alexis W Ary, Kevin D Lomina. Enduring dysregulation of nucleus accumbens catecholamine and glutamate transmission by developmental exposure to phenylpropanolamine. Brain research. vol 1748. 2021-10-25. PMID:32896521. |
juvenile ppa pretreatment facilitated the rise in nac glutamate elicited by dopamine, norepinephrine and glutamate transporter inhibitors and blunted mglu2/3 inhibition of glutamate release in this region. |
2021-10-25 |
2023-08-13 |
mouse |