| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miguel Skirzewski, Oren Princz-Lebel, Liliana German-Castelan, Alycia M Crooks, Gerard Kyungwook Kim, Sophie Henke Tarnow, Amy Reichelt, Sara Memar, Daniel Palmer, Yulong Li, R Jane Rylett, Lisa M Saksida, Vania F Prado, Marco A M Prado, Timothy J Busse. Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues. Nature communications. vol 13. issue 1. 2022-12-23. PMID:36564387. |
nac output activity mediated by spiny projecting neurons (spns) is regulated by dopamine, but also by cholinergic interneurons (cins), which can release acetylcholine and glutamate via the activity of the vesicular acetylcholine transporter (vacht) or the vesicular glutamate transporter (vglut3), respectively. |
2022-12-23 |
2023-08-14 |
mouse |
| Alaa M Hammad, Asma'a Naser, Haneen Amawi, F Scott Hall, Amit K Tiwari, Bahaa Al-Tra. Effect of Amoxicillin/Clavulanic acid in attenuating Pregabalin-induced Condition Place Preference. Behavioural brain research. 2022-12-05. PMID:36470419. |
moreover, like other drugs of abuse, pregabalin also produced alterations in glutamate homeostasis, reducing the mrna expression of slc1a2 and slc7a11 in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2022-12-05 |
2023-08-14 |
Not clear |
| Fateme Padoei, Peyman Mamsharifi, Pooya Hazegh, Homa Boroumand, Fatemeh Ostadmohammady, Samira Abbaszadeh-Mashkani, Hamid Reza Banafshe, Amir Hassan Matini, Amir Ghaderi, Somayeh Ghadami Dehkohne. The therapeutic effect of N-acetylcysteine as an add-on to methadone maintenance therapy medication in outpatients with substance use disorders: A randomized, double-blind, placebo-controlled clinical trial. Brain and behavior. 2022-11-30. PMID:36448959. |
n-acetylcysteine (nac) enhances extracellular glutamate, and is effective in the treatment of neuropsychiatric disorders. |
2022-11-30 |
2023-08-14 |
Not clear |
| He Chen, Limei Chen, Zhirong Yuan, Jiajie Yuan, Yitong Li, Yuesi Xu, Jieyi Wu, Lu Zhang, Guohua Wang, Juan L. Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity. Frontiers in cellular neuroscience. vol 16. 2022-11-21. PMID:36406750. |
glutamate receptor-interacting protein 1 (grip1) is known to be associated with cocaine addiction, but the role of grip1 in d1-msns and d2-msns of the nac in cocaine acquisition and reinstatement remains unknown. |
2022-11-21 |
2023-08-14 |
Not clear |
| Hasan Alhaddad, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Edward Melenski, Richard L Bell, Youssef Sar. Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats. The Journal of pharmacology and experimental therapeutics. vol 383. issue 3. 2022-11-17. PMID:36153003. |
our laboratory has shown that chronic exposure to ethanol reduced the expression of glutamate transporter 1 (glt-1) and cystine/glutamate exchanger (xct) and, as a result, increased extracellular glutamate concentrations in the nac of alcohol-preferring (p) rats. |
2022-11-17 |
2023-11-20 |
rat |
| Peter J Vollbrecht, Kathryn M Nesbitt, Victoria M Addis, Keenan M Boulnemour, Daniel A Micheli, Kendall B Smith, Darleen A Sandoval, Robert T Kennedy, Carrie R Ferrari. Differential Regulation of Nucleus Accumbens Glutamate and GABA in Obesity-Prone and Obesity-Resistant Rats. Journal of neurochemistry. 2022-11-06. PMID:36336816. |
for example, there are basal enhancements in excitability of nac gabaergic medium spiny neurons (msn) and reductions in basal expression of ampa-type glutamate receptors in obesity-prone vs obesity-resistant rats. |
2022-11-06 |
2023-08-14 |
rat |
| Peter J Vollbrecht, Kathryn M Nesbitt, Victoria M Addis, Keenan M Boulnemour, Daniel A Micheli, Kendall B Smith, Darleen A Sandoval, Robert T Kennedy, Carrie R Ferrari. Differential Regulation of Nucleus Accumbens Glutamate and GABA in Obesity-Prone and Obesity-Resistant Rats. Journal of neurochemistry. 2022-11-06. PMID:36336816. |
however, very little is known about the regulation of extracellular glutamate and gaba within the nac of these models. |
2022-11-06 |
2023-08-14 |
rat |
| William C Griffin, Marcelo F Lopez, John J Woodward, Howard C Becke. Alcohol Dependence and the Ventral Hippocampal Influence on Alcohol Drinking in Male Mice. Alcohol (Fayetteville, N.Y.). 2022-11-03. PMID:36328184. |
lastly, activating the vhc-nac pathway increased cfos expression and evoked significant glutamate release from the vhc terminals in the nac. |
2022-11-03 |
2023-08-14 |
mouse |
| Daozhong Jin, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. α2δ-1 Protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry. 2022-10-12. PMID:36222452. |
glutamate nmda receptors (nmdars) in the nucleus accumbens (nac) are critically involved in drug dependence and reward. |
2022-10-12 |
2023-08-14 |
mouse |
| Peifang Yang, Xiang Chen, Xingzhou Tian, Zhinan Zhou, Yan Zhang, Wen Tang, Kaibin Fu, Jiafu Zhao, Yong Rua. A Proteomic Study of the Effect of N-acetylcysteine on the Regulation of Early Pregnancy in Goats. Animals : an open access journal from MDPI. vol 12. issue 18. 2022-09-23. PMID:36139298. |
moreover, nac supplementation increased the levels of the reproductive hormones follicle-stimulating hormone (fsh), luteinizing hormone (lh), oestradiol (e2), progesterone (p4), superoxide dismutase (sod), glutamate peroxidase (gsh-px) and nitric oxide (no) in the serum of does. |
2022-09-23 |
2023-08-14 |
Not clear |
| Juan Zegers-Delgado, Alejandro Aguilera-Soza, Florencia Calderón, Harley Davidson, Daniel Verbel-Vergara, Hector E Yarur, Javier Novoa, Camila Blanlot, Cristian P Bastias, María Estela Andrés, Katia Gyslin. Type 1 Corticotropin-Releasing Factor Receptor Differentially Modulates Neurotransmitter Levels in the Nucleus Accumbens of Juvenile versus Adult Rats. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142716. |
our previous data showed that infusion of a crf-r1 antagonist into the nac of juvenile rats increased da levels in response to a depolarizing stimulus and decreased basal glutamate levels. |
2022-09-23 |
2023-08-14 |
rat |
| Carlos Morgan, Patricio Sáez-Briones, Rafael Barra, Andrea Reyes, Katherine Zepeda-Morales, Luis Constandil, Miguel Ríos, Paulina Ramírez, Héctor Burgos, Alejandro Hernánde. Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077493. |
a loss of neuroplastic control on nucleus accumbens (nac) neuronal activity exerted by the medial prefrontal cortex (mpfc) through long-term depression (ltd) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite synapses of the nucleus accumbens (nac) core. |
2022-09-09 |
2023-08-14 |
mouse |
| Ida Fredriksson, Nitya Jayaram-Lindström, Peter W Kalivas, Philippe A Melas, Pia Steenslan. N-acetylcysteine improves impulse control and attenuates relapse-like alcohol intake in long-term drinking rats. Behavioural brain research. 2022-09-05. PMID:36063970. |
n-acetylcysteine (nac) is a cystine prodrug that has been found to promote glutamate homeostasis and drug abstinence. |
2022-09-05 |
2023-08-14 |
rat |
| Austin W Blum, Jon E Gran. N-acetylcysteine in the treatment of compulsive sexual behavior disorder: A case series. Journal of psychiatric research. vol 154. 2022-08-11. PMID:35952519. |
n-acetylcysteine (nac), an amino acid that seems to restore extracellular levels of glutamate in the nucleus accumbens, has previously demonstrated efficacy in treating multiple psychiatric disorders, including substance use disorders and putative behavioral addictions. |
2022-08-11 |
2023-08-14 |
Not clear |
| Alex B Kawa, Eun-Kyung Hwang, Jonathan R Funke, Hongyi Zhou, Mauro Costa-Mattioli, Marina E Wol. Positive Allosteric Modulation of mGlu Biological psychiatry. 2022-07-23. PMID:35871097. |
after incubation has occurred, stimulation of nac metabotropic glutamate 1 (mglu |
2022-07-23 |
2023-08-14 |
Not clear |
| Yvonne S Yang, Richard J Maddock, Huailin Zhang, Junghee Lee, Gerhard Hellemann, Stephen R Marder, Michael F Gree. N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study. Psychiatry research. Neuroimaging. vol 325. 2022-07-15. PMID:35839558. |
in this double-blind, randomized, placebo-controlled preliminary study, 40 patients with schizophrenia or schizoaffective disorder were randomized to receive 2400 mg nac daily or placebo over eight weeks to examine the effects of nac on prefrontal magnetic resonance spectroscopy levels of glutathione and glutamate. |
2022-07-15 |
2023-08-14 |
Not clear |
| Yvonne S Yang, Richard J Maddock, Huailin Zhang, Junghee Lee, Gerhard Hellemann, Stephen R Marder, Michael F Gree. N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study. Psychiatry research. Neuroimaging. vol 325. 2022-07-15. PMID:35839558. |
we found that nac treatment was associated with increased glutathione (statistically significant) and decreased glutamate (trend-level) compared with placebo in medial prefrontal cortex but not dorsolateral prefrontal cortex. |
2022-07-15 |
2023-08-14 |
Not clear |
| Sujan C Das, Yusuf S Althobaiti, Alaa M Hammad, Fawaz Alasmari, Youssef Sar. Role of suppressing GLT-1 and xCT in ceftriaxone-induced attenuation of relapse-like alcohol drinking in alcohol-preferring rats. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754102. |
within nac, altered glutamate homeostasis is one of the neuroadaptive changes caused by alcohol dependence. |
2022-06-27 |
2023-08-14 |
rat |
| Sujan C Das, Yusuf S Althobaiti, Alaa M Hammad, Fawaz Alasmari, Youssef Sar. Role of suppressing GLT-1 and xCT in ceftriaxone-induced attenuation of relapse-like alcohol drinking in alcohol-preferring rats. Addiction biology. vol 27. issue 4. 2022-06-27. PMID:35754102. |
here, we used alcohol-preferring (p) rats in relapse-like ethanol drinking paradigm to (a) determine the effect of relapse-like ethanol drinking on gene and protein expression of glt-1 and xct in nac, measured by quantitative polymerase chain reaction (qpcr) and western blot, respectively; (b) examine if glutamate uptake is affected by relapse-like ethanol drinking in nac, measured by radioactive glutamate uptake assay; (c) elucidate if upregulation of either/both glt-1 or/and xct through ceftriaxone is/are required to attenuate relapse-like ethanol drinking. |
2022-06-27 |
2023-08-14 |
rat |
| Julie E Finnell, Carrie R Ferrari. Intra-NAc insulin reduces the motivation for food and food intake without altering cue-triggered food-seeking. Physiology & behavior. 2022-06-26. PMID:35753434. |
furthermore, insulin receptor activation alters dopamine and glutamate transmission within mesolimbic regions that influence food-seeking and feeding including the nucleus accumbens (nac). |
2022-06-26 |
2023-08-14 |
rat |