| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karen K Szumlinski, Daria L Thompson, Rachel M Renton, Alexis W Ary, Kevin D Lomina. Enduring dysregulation of nucleus accumbens catecholamine and glutamate transmission by developmental exposure to phenylpropanolamine. Brain research. vol 1748. 2021-10-25. PMID:32896521. |
these data confirm that juvenile exposure to ppa produces protracted perturbations in the regulation of extracellular catecholamine and glutamate levels within the nac and further the hypothesis that early exposure to sympathomimetic drugs found in cough, cold and allergy medicines, have long-lasting effects upon neurotransmission within brain regions gating motivation. |
2021-10-25 |
2023-08-13 |
mouse |
| Steven R Laviolett. Molecular and neuronal mechanisms underlying the effects of adolescent nicotine exposure on anxiety and mood disorders. Neuropharmacology. vol 184. 2021-10-22. PMID:33245960. |
nicotine can potently regulate the transmission of various neurochemicals, including dopamine (da), γ-amino-butyric acid (gaba) and glutamate, within various mesocorticolimbic structures, such as the ventral tegmental area (vta), nucleus accumbens (nac) and prefrontal cortex (pfc), all of which show pathologies in these disorders. |
2021-10-22 |
2023-08-13 |
Not clear |
| Olga Skiteva, Ning Yao, Karima Chergu. Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34650029. |
ketamine-induced metaplasticity was independent of group i metabotropic glutamate receptors (mglurs) because an agonist of these receptors had similar effects on glutamatergic transmission in mice treated with saline and in mice treated with ketamine in both vta da neurons and in the nac. |
2021-10-21 |
2023-08-13 |
mouse |
| Xiaotao Xu, Kaixuan Wu, Xiaqing Ma, Wenying Wang, Haiyan Wang, Min Huang, Limin Luo, Chen Su, Tifei Yuan, Haibo Shi, Ji Han, Aizhong Wang, Tao X. mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34227060. |
we hypothesized that metabotropic glutamate receptor 5 (mglur5) expressed in the nucleus accumbens (nac) normalizes the depressive-like behaviors and pain following csds. |
2021-10-08 |
2023-08-13 |
mouse |
| Claudia Rangel-Barajas, Israel Coronel, Yanping Zhang, Maribel Hernández, Stephen L Boehm I. Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression. Neuropharmacology. vol 181. 2021-09-23. PMID:33010299. |
because pb exposure is associated with increased glutamatergic tone, we also studied the effects on the expression of synaptic and non-synaptic glutamate transporters in brain regions associated with drug addiction such as the nucleus accumbens (nac), dorsomedial striatum (dms), dorsolateral striatum (dls), and medial prefrontal cortex (mpfc). |
2021-09-23 |
2023-08-13 |
mouse |
| William C Griffin, Harold L Haun, Vorani S Ramachandra, Lori A Knackstedt, Patrick J Mulholland, Howard C Becke. Effects of ceftriaxone on ethanol drinking and GLT-1 expression in ethanol dependence and relapse drinking. Alcohol (Fayetteville, N.Y.). vol 92. 2021-09-23. PMID:33465464. |
previous reports from our laboratory show that cie increases extracellular glutamate in the nucleus accumbens (nac) and that manipulating accumbal glutamate concentrations will alter ethanol drinking, indicating that glutamate homeostasis plays a crucial role in ethanol drinking in this model. |
2021-09-23 |
2023-08-13 |
mouse |
| Mieke H J Schulte, Anna E Goudriaan, Wouter J Boendermaker, Wim van den Brink, Reinout W Wier. The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - A randomized proof of concept study. Neuroscience letters. vol 762. 2021-09-14. PMID:34332028. |
to this end, the combined effects of n-acetylcysteine (nac) and working memory (wm) training on glutamate concentrations in the dorsal and rostral acc were investigated in a randomized, double-blind placebo-controlled design. |
2021-09-14 |
2023-08-13 |
Not clear |
| Sumin Sohn, Sunghyun Kim, Ju Hwan Yang, Eun Sang Cho. Linking of NMDA receptors and mGluR5 in the nucleus accumbens core to repeated cocaine-induced 50-kHz ultrasonic vocalization in rats. Addiction biology. 2021-08-25. PMID:34378829. |
this study demonstrated the linking of glutamate receptors in the nucleus accumbens (nac) to vocal expression of 50-khz usv calls after repeated cocaine administration in freely moving rats. |
2021-08-25 |
2023-08-13 |
rat |
| Price Ward, Hunter G Moss, Truman R Brown, Peter Kalivas, Dorothea D Jenkin. N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats. Pediatric research. vol 88. issue 1. 2021-08-24. PMID:31935745. |
we hypothesized that n-acetylcysteine (nac) administered during acute opioid withdrawal in neonatal rats would decrease withdrawal behaviors and normalize cns glutathione and glutamate. |
2021-08-24 |
2023-08-13 |
rat |
| Javier Novoa, Carlos J Rivero, Enrique U Pérez-Cardona, Jaime A Freire-Arvelo, Juan Zegers, Héctor E Yarur, Iván G Santiago-Marerro, José L Agosto-Rivera, Jorge L González-Pérez, Katia Gysling, Annabell C Segarr. Social isolation of adolescent male rats increases anxiety and K The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:34097788. |
this study investigated the effects of social isolation after weaning on anxiety, body weight and locomotion, and on extracellular dopamine (da) and glutamate (glu) in the nucleus accumbens (nac) and their modulation by corticotropin releasing factor receptor 1. |
2021-08-20 |
2023-08-13 |
rat |
| Constanza Garcia-Keller, Cora Smiley, Cara Monforton, Samantha Melton, Peter W Kalivas, Justin Gas. N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31282090. |
n-acetylcysteine (nac) restores drug and stress-induced reductions in glial glutamate transporter-1 and has proven effective at reducing cue-induced reinstatement of drug seeking. |
2021-08-11 |
2023-08-13 |
rat |
| Hui Shen, Kai Chen, Rosa Anna M Marino, Ross A McDevitt, Zheng-Xiong X. Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33444596. |
to test this hypothesis, we used cre-loxp techniques to selectively delete vglut2 from midbrain da neurons, and then examined nucleus accumbens (nac) da and glutamate responses to meth using in vivo brain microdialysis between da-vglut2-ko mice and their vglut2-het littermates. |
2021-08-10 |
2023-08-13 |
mouse |
| Hui Shen, Kai Chen, Rosa Anna M Marino, Ross A McDevitt, Zheng-Xiong X. Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice. Pharmacology, biochemistry, and behavior. vol 202. 2021-08-10. PMID:33444596. |
glutamate corelease from da neurons may in part contributes to meth-induced increase in nac glutamate release. |
2021-08-10 |
2023-08-13 |
mouse |
| Sudie E Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L Jones, Amber M Jarnecke, Jane E Joseph, James Prisciandaro, Therese Killeen, Delisa G Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C Flanagan, Peter W Kaliva. N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial. Contemporary clinical trials. vol 91. 2021-08-04. PMID:32087337. |
animal studies and prior clinical research suggest a role for nac in the treatment of substance use disorders and ptsd via glutamate modulation. |
2021-08-04 |
2023-08-13 |
Not clear |
| Sudie E Back, Kevin Gray, Elizabeth Santa Ana, Jennifer L Jones, Amber M Jarnecke, Jane E Joseph, James Prisciandaro, Therese Killeen, Delisa G Brown, Linda Taimina, Ebele Compean, Robert Malcolm, Julianne C Flanagan, Peter W Kaliva. N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial. Contemporary clinical trials. vol 91. 2021-08-04. PMID:32087337. |
nac is a cysteine pro-drug that stimulates the cystine-glutamate exchanger, normalizes glial glutamate transporters, and restores glutamatergic tone on presynaptic receptors in reward regions of the brain. |
2021-08-04 |
2023-08-13 |
Not clear |
| Rebecca McKetin, Olivia M Dean, Alyna Turner, Peter J Kelly, Brendan Quinn, Dan I Lubman, Paul Dietze, Gregory Carter, Peter Higgs, Barbara Sinclair, David Reid, Amanda L Baker, Victoria Manning, Nina Te Pas, Tamsin Thomas, Ramez Bathish, Dayle K Raftery, Anna Wrobel, Lucy Saunders, Shalini Arunogiri, Frank Cordaro, Harry Hill, Scott Hall, Philip J Clare, Mohammadreza Mohebbi, Michael Ber. N-acetylcysteine (NAC) for methamphetamine dependence: A randomised controlled trial. EClinicalMedicine. vol 38. 2021-07-27. PMID:34308314. |
the cysteine prodrug, n-acetylcysteine (nac), has been found to ameliorate glutamate dysregulation in addiction, and to reduce craving for methamphetamine and other drugs. |
2021-07-27 |
2023-08-13 |
Not clear |
| Andre U Deutschmann, Julia M Kirkland, Lisa A Brian. Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling. Addiction biology. 2021-07-19. PMID:34278652. |
we show that social isolation rearing alters presynaptic plasticity in the nac by decreasing the paired-pulse ratio and the size of the readily releasable pool of glutamate. |
2021-07-19 |
2023-08-13 |
mouse |
| Nada A Elsayed, Theresa M Boyer, Irina Bur. Fetal Neuroprotective Strategies: Therapeutic Agents and Their Underlying Synaptic Pathways. Frontiers in synaptic neuroscience. vol 13. 2021-07-13. PMID:34248595. |
while nac acts as an antioxidant and a precursor to glutathione, it also modulates the glutamate system. |
2021-07-13 |
2023-08-13 |
Not clear |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
altered glutamate transmission within the nucleus accumbens (nac) has been proposed as a central mechanism underlying behavioural sensitisation associated with repeated cocaine exposure. |
2021-06-28 |
2023-08-13 |
mouse |
| Bethania Mongi-Bragato, María Paula Avalos, Andrea S Guzmán, Constanza García-Keller, Flavia A Bollati, Liliana M Cancel. Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. The European journal of neuroscience. vol 53. issue 5. 2021-06-28. PMID:33159343. |
however, the influence of enkephalin on long-term changes in glutamate transmission within the nac associated with cocaine-induced sensitisation has not been described. |
2021-06-28 |
2023-08-13 |
mouse |