| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Brockhaus, B Brün. p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome c release in response to nitric oxide. Oncogene. vol 18. issue 47. 2000-01-04. PMID:10597241. |
p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome c release in response to nitric oxide. |
2000-01-04 |
2023-08-12 |
Not clear |
| A D Ormerod, P Copeland, I Hay, A Husain, S W Ewe. The inflammatory and cytotoxic effects of a nitric oxide releasing cream on normal skin. The Journal of investigative dermatology. vol 113. issue 3. 1999-09-30. PMID:10469339. |
nitric oxide treated skin showed significant increases in cells expressing cd3, cd4, cd8, cd68, neutrophil elastase, icam-1, vcam-1, nitrosotyrosine, p53, and apoptotic cells compared with skin treated with ascorbic acid alone. |
1999-09-30 |
2023-08-12 |
human |
| A D Ormerod, P Copeland, I Hay, A Husain, S W Ewe. The inflammatory and cytotoxic effects of a nitric oxide releasing cream on normal skin. The Journal of investigative dermatology. vol 113. issue 3. 1999-09-30. PMID:10469339. |
apoptosis, cytotoxicity, and p53 staining were relatively greater after 48 h exposure than after 24 h. these results suggest that nitric oxide is pro-inflammatory and is toxic to dna, leading to the accumulation of p53 and subsequent apoptosis. |
1999-09-30 |
2023-08-12 |
human |
| S Glockzin, A von Knethen, M Scheffner, B Brün. Activation of the cell death program by nitric oxide involves inhibition of the proteasome. The Journal of biological chemistry. vol 274. issue 28. 1999-08-05. PMID:10391892. |
accumulation of p53 and induction of apoptosis in raw 264.7 macrophages in response to nitric oxide are well established. |
1999-08-05 |
2023-08-12 |
Not clear |
| S Glockzin, A von Knethen, M Scheffner, B Brün. Activation of the cell death program by nitric oxide involves inhibition of the proteasome. The Journal of biological chemistry. vol 274. issue 28. 1999-08-05. PMID:10391892. |
here we show that, similar to nitric oxide, treatment of macrophages with specific proteasome inhibitors, including clastolactacystin-beta-lactone, induces p53 accumulation and apoptosis, suggesting that nitric oxide may affect the activity of the proteasome. |
1999-08-05 |
2023-08-12 |
Not clear |
| S Glockzin, A von Knethen, M Scheffner, B Brün. Activation of the cell death program by nitric oxide involves inhibition of the proteasome. The Journal of biological chemistry. vol 274. issue 28. 1999-08-05. PMID:10391892. |
moreover, chemically diverse nitric oxide donors interfere with proteasome-mediated degradation of polyubiquitinated p53 in vitro. |
1999-08-05 |
2023-08-12 |
Not clear |
| H Matsumoto, S Hayashi, M Hatashita, K Ohnishi, T Ohtsubo, R Kitai, H Shioura, T Ohnishi, E Kan. Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma. Cancer research. vol 59. issue 13. 1999-07-28. PMID:10397271. |
nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma. |
1999-07-28 |
2023-08-12 |
human |
| H Matsumoto, S Hayashi, M Hatashita, K Ohnishi, T Ohtsubo, R Kitai, H Shioura, T Ohnishi, E Kan. Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma. Cancer research. vol 59. issue 13. 1999-07-28. PMID:10397271. |
to verify this hypothesis, we examined the effect of nitric oxide produced endogenously by heat-shocked cells on nonstressed cells using a human glioblastoma cell line, a-172, and its mutant p53 (mp53) transfectant (a-172/mp53). |
1999-07-28 |
2023-08-12 |
human |
| H Matsumoto, S Hayashi, M Hatashita, K Ohnishi, T Ohtsubo, R Kitai, H Shioura, T Ohnishi, E Kan. Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma. Cancer research. vol 59. issue 13. 1999-07-28. PMID:10397271. |
our finding of the accumulation of hsp72 and p53 in nitric oxide-recipient cells cocultivated with heated nitric oxide-donor cells provides the first evidence for an intercellular signal transduction pathway via nitric oxide as intermediate without cell-to-cell interactions such as gap junctions. |
1999-07-28 |
2023-08-12 |
human |
| D Borderie, P Hilliquin, A Hernvann, H Lemarechal, C J Menkes, O G Ekindjia. Apoptosis induced by nitric oxide is associated with nuclear p53 protein expression in cultured osteoarthritic synoviocytes. Osteoarthritis and cartilage. vol 7. issue 2. 1999-06-15. PMID:10222219. |
apoptosis induced by nitric oxide is associated with nuclear p53 protein expression in cultured osteoarthritic synoviocytes. |
1999-06-15 |
2023-08-12 |
Not clear |
| Q Shi, S Huang, W Jiang, L S Kutach, H N Ananthaswamy, K Xi. Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53. Cancer research. vol 59. issue 9. 1999-05-20. PMID:10232590. |
our data indicate that a low to moderate level of nos ii expression directly correlates with metastatic ability of uv-2237 fibrosarcoma cells carrying mutant p53 and that a high level of nitric oxide production suppresses tumor growth and metastasis. |
1999-05-20 |
2023-08-12 |
mouse |
| D Callsen, B Brün. Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis. Biochemistry. vol 38. issue 8. 1999-03-16. PMID:10029520. |
the inflammatory mediator nitric oxide (no*) promotes apoptotic cell death based on morphological evidence, accumulation of the tumor suppressor p53, caspase-3 activation, and dna fragmentation in raw 264.7 macrophages. |
1999-03-16 |
2023-08-12 |
Not clear |
| S Ambs, W G Merriam, M O Ogunfusika, W P Bennett, N Ishibe, S P Hussain, E E Tzeng, D A Geller, T R Billiar, C C Harri. p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells. Nature medicine. vol 4. issue 12. 1998-12-23. PMID:9846573. |
our data indicate that tumor-associated nitric oxide production may promote cancer progression by providing a selective growth advantage to tumor cells with mutant p53, and that inhibitors of inducible nitric oxide synthase may have therapeutic activity in these tumors. |
1998-12-23 |
2023-08-12 |
mouse |
| B S Taylor, L H Alarcon, T R Billia. Inducible nitric oxide synthase in the liver: regulation and function. Biochemistry. Biokhimiia. vol 63. issue 7. 1998-12-01. PMID:9721329. |
inos expression requires the transcription factor nf-kappab and is down-regulated by steroids, tgf-beta, the heat shock response, p53, and nitric oxide (no) itself. |
1998-12-01 |
2023-08-12 |
human |
| J J Mei, S D Hursting, S N Perkins, J M Phan. p53-independent inhibition of nitric oxide generation by cancer preventive interventions in ex vivo mouse peritoneal macrophages. Cancer letters. vol 129. issue 2. 1998-09-08. PMID:9719461. |
in the present study, 4 weeks of calorie restriction or the dietary administration of chemopreventive steroids dehydroepiandrosterone and 16alpha-fluoro-5-androsten-17-one significantly reduced the inducible generation of nitric oxide (no) in ex vivo peritoneal macrophages from male p53 wild-type and p53-/- mice relative to the respective ad libitum-fed controls; expression of inducible nitric oxide synthase ii (nos2) protein was also markedly decreased compared with respective controls. |
1998-09-08 |
2023-08-12 |
mouse |
| Y Kitamura, W Kamoshima, S Shimohama, Y Nomura, T Taniguch. Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells. Neurochemistry international. vol 32. issue 1. 1998-03-06. PMID:9460707. |
in human neuroblastoma sh-sy5y cells, s-nitroso-n-acetylpenicillamine (snap), a nitric oxide (no)-donor, caused cell death accompanying p53 expression, nucleosomal dna fragmentation and cell death. |
1998-03-06 |
2023-08-12 |
human |
| J S Wang, H H Tseng, D F Shih, H S Jou, L P Ge. Expression of inducible nitric oxide synthase and apoptosis in human lupus nephritis. Nephron. vol 77. issue 4. 1998-02-12. PMID:9434061. |
this study suggests that induction of inos, and thus nitric oxide production, plays a role in the occurrence of apoptosis in the glomeruli of lupus nephritis; and the occurrence of apoptosis might in part be modulated by p53 and bcl-2-related pathways. |
1998-02-12 |
2023-08-12 |
human |
| J Murata, M Tada, R D Iggo, Y Sawamura, Y Shinohe, H Ab. Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide. Mutation research. vol 379. issue 2. 1997-12-01. PMID:9357550. |
nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide. |
1997-12-01 |
2023-08-12 |
Not clear |
| J Murata, M Tada, R D Iggo, Y Sawamura, Y Shinohe, H Ab. Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide. Mutation research. vol 379. issue 2. 1997-12-01. PMID:9357550. |
we have used a yeast p53 functional assay to study induction of mutations in the p53 tumor suppressor gene by nitric oxide and cytosine methylation. |
1997-12-01 |
2023-08-12 |
Not clear |
| J Murata, M Tada, R D Iggo, Y Sawamura, Y Shinohe, H Ab. Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide. Mutation research. vol 379. issue 2. 1997-12-01. PMID:9357550. |
p53 cdna was treated with the nitric oxide donor sydnonimine, pcr-amplified and transfected into yeast. |
1997-12-01 |
2023-08-12 |
Not clear |