| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florence Le Calvez, Anush Mukeria, Jay D Hunt, Olaf Kelm, Rayjean J Hung, Philippe Tanière, Paul Brennan, Paolo Boffetta, David G Zaridze, Pierre Hainau. TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers. Cancer research. vol 65. issue 12. 2005-08-08. PMID:15958551. |
expression of p53, cyclooxygenase-2 (cox-2), and nitrotyrosine (n-tyr), a marker of protein damage by nitric oxide, were analyzed by immunohistochemistry. |
2005-08-08 |
2023-08-12 |
Not clear |
| Tian-Jye Hsieh, Tsan-Zon Liu, Chi-Liang Chern, Der-An Tsao, Fung-Jou Lu, Yu-Hua Syu, Pei-Ying Hsieh, Han-Shu Hu, Ting-Ting Chang, Ching-Hsein Che. Liriodenine inhibits the proliferation of human hepatoma cell lines by blocking cell cycle progression and nitric oxide-mediated activation of p53 expression. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 43. issue 7. 2005-07-14. PMID:15833387. |
this study was designed to assess cell cycle arrest, the production of nitric oxide (no) and p53 expression in liriodenine-treated human hepatoma cell lines, including wild-type p53 (hep g2 and sk-hep-1). |
2005-07-14 |
2023-08-12 |
human |
| Wageh M Awara, Alaa E El-Sisi, Magda E El-Sayad, Ahmed E God. The potential role of cyclooxygenase-2 inhibitors in the treatment of experimentally-induced mammary tumour: does celecoxib enhance the anti-tumour activity of doxorubicin? Pharmacological research. vol 50. issue 5. 2005-02-25. PMID:15458769. |
the anti-tumour activity of celecoxib (25 mg kg(-1)), diclofenac (12.5 mg kg(-1)) and doxorubicin (2 mg kg(-1)) either alone or in combination were investigated on sec in vivo through the assessment of tumour growth delay (tgd) and tumour volume (tv), changes in tumour dna content and nitric oxide (no) levels, immunohistochemical staining of the tumour suppressor gene product; p53 histopathological examination and determination of apoptotic index of sec. |
2005-02-25 |
2023-08-12 |
Not clear |
| Yong-Zhong Wang, You-Qing Cao, Jian-Nong Wu, Miao Chen, Xiao-Ying Ch. Expression of nitric oxide synthase in human gastric carcinoma and its relation to p53, PCNA. World journal of gastroenterology. vol 11. issue 1. 2005-02-10. PMID:15609395. |
to investigate the expression of nos in gastric carcinoma, and to explore the relationship between the expression of nitric oxide synthases (nos) and p53, pcna, pathological features and clinical staging of gastric cancer. |
2005-02-10 |
2023-08-12 |
human |
| John M Routes, Kristin Morris, Misoo C Ellison, Sharon Rya. Macrophages kill human papillomavirus type 16 E6-expressing tumor cells by tumor necrosis factor alpha- and nitric oxide-dependent mechanisms. Journal of virology. vol 79. issue 1. 2005-01-14. PMID:15596807. |
the lysis of cells that expressed e6 by macrophages was p53 independent but dependent on the production of tumor necrosis factor alpha (tnf-alpha) or nitric oxide (no) by macrophages. |
2005-01-14 |
2023-08-12 |
human |
| Tracy Cook, Zifa Wang, Sean Alber, Kaihong Liu, Simon C Watkins, Yoram Vodovotz, Timothy R Billiar, David Blumber. Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53. Cancer research. vol 64. issue 21. 2004-11-30. PMID:15520210. |
nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53. |
2004-11-30 |
2023-08-12 |
mouse |
| Shiro Mizuno, Maiko Kadowaki, Yoshiki Demura, Shingo Ameshima, Isamu Miyamori, Takeshi Ishizak. p42/44 Mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cells. American journal of respiratory cell and molecular biology. vol 31. issue 2. 2004-09-23. PMID:15016620. |
p42/44 mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cells. |
2004-09-23 |
2023-08-12 |
human |
| Julie E Goodman, Lorne J Hofseth, S Perwez Hussain, Curtis C Harri. Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. Environmental and molecular mutagenesis. vol 44. issue 1. 2004-09-16. PMID:15199542. |
nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. |
2004-09-16 |
2023-08-12 |
human |
| M L Tappa. Taurine biosynthetic enzymes and taurine transporter: molecular identification and regulations. Neurochemical research. vol 29. issue 1. 2004-08-17. PMID:14992266. |
other regulations of taurine transporter expression were more recently reported, which involve glucose, tumor suppressor protein p53, tumor necrosis factor-alpha, and nitric oxide. |
2004-08-17 |
2023-08-12 |
Not clear |
| Douglas D Thomas, Michael Graham Espey, Lisa A Ridnour, Lorne J Hofseth, Daniele Mancardi, Curtis C Harris, David A Win. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 24. 2004-08-05. PMID:15178764. |
hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. |
2004-08-05 |
2023-08-12 |
human |
| Chun-Qi Li, Ana I Robles, Christin L Hanigan, Lorne J Hofseth, Laura J Trudel, Curtis C Harris, Gerald N Woga. Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer research. vol 64. issue 9. 2004-06-23. PMID:15126337. |
apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. |
2004-06-23 |
2023-08-12 |
human |
| Hong Wa Yung, Anna K Bal-Price, Guy C Brown, Aviva M Tolkovsk. Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and Bax-dependent pathways. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140181. |
nitric oxide also elevates p53 expression, causing a concomitant increase in p53 serine 18 phosphorylation and p53 translocation from the cytoplasm to the nucleus. |
2004-06-04 |
2023-08-12 |
mouse |
| Peter K M Kim, Timothy R Billia. There's NO business like p53 business: nitric oxide regulates phosphorylation of p53 in chronic inflammatory disease. Cell cycle (Georgetown, Tex.). vol 2. issue 2. 2004-04-14. PMID:12695658. |
there's no business like p53 business: nitric oxide regulates phosphorylation of p53 in chronic inflammatory disease. |
2004-04-14 |
2023-08-12 |
Not clear |
| Huang Guo, Dong Liu, Harris Gelbard, Tong Cheng, Rae Insalaco, José A Fernández, John H Griffin, Berislav V Zlokovi. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. vol 41. issue 4. 2004-03-30. PMID:14980205. |
apc blocked several steps in nmda-induced apoptosis downstream to nitric oxide, i.e., caspase-3 activation, nuclear translocation of apoptosis-inducing factor (aif), and induction of p53, and prevented staurosporine-induced apoptosis by blocking caspase-8 activation upstream of caspase-3 activation and aif nuclear translocation. |
2004-03-30 |
2023-08-12 |
mouse |
| Chi-Hui Tang, Elizabeth A Grim. Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines. The Journal of biological chemistry. vol 279. issue 1. 2004-03-03. PMID:14576150. |
strikingly, we observed that the depletion of nitric oxide inhibits cisplatin-induced wild type p53 accumulation and p21(waf1/cip1/sdi1) expression in melanoma cells. |
2004-03-03 |
2023-08-12 |
Not clear |
| Chi-Hui Tang, Elizabeth A Grim. Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines. The Journal of biological chemistry. vol 279. issue 1. 2004-03-03. PMID:14576150. |
when cisplatin-induced p53 binding to the p21(waf1/cip1/sdi1) promoter was examined, it was found that nitric oxide depletion significantly reduced the presence of p53-dna complexes after cisplatin treatment. |
2004-03-03 |
2023-08-12 |
Not clear |
| Chi-Hui Tang, Elizabeth A Grim. Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines. The Journal of biological chemistry. vol 279. issue 1. 2004-03-03. PMID:14576150. |
together, these data strongly suggest that endogenously produced nitric oxide is required for cisplatin-induced p53 activation and p21(waf1/cip1/sdi1) expression, which can regulate melanoma sensitivity to cisplatin. |
2004-03-03 |
2023-08-12 |
Not clear |
| Y K Chen, S S Hsue, L M Li. Correlation between inducible nitric oxide synthase and p53 expression for DMBA-induced hamster buccal-pouch carcinomas. Oral diseases. vol 9. issue 5. 2003-12-16. PMID:14628889. |
it has been reported previously that there may be a negative feedback loop existing between nitric oxide (no) production and wild-type p53 tumor-suppressor gene, but the relationship has not previously been studied for oral experimental carcinogenesis. |
2003-12-16 |
2023-08-12 |
Not clear |
| Johan Saldeen, Linda Tillmar, Ella Karlsson, Nils Wels. Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis. Molecular and cellular biochemistry. vol 243. issue 1-2. 2003-11-18. PMID:12619896. |
here we report that nicotinamide-induced inhibition of poly(adp-ribosyl)ation and cytokine-induced nitric oxide production both result in a transient increase in p53 levels in pancreatic tumor rinm5f cells. |
2003-11-18 |
2023-08-12 |
mouse |
| Rika Fukunaga-Takenaka, Kaoru Fukunaga, Masayuki Tatemichi, Hiroshi Ohshim. Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis. Biochemical and biophysical research communications. vol 308. issue 4. 2003-10-14. PMID:12927814. |
nitric oxide prevents uv-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis. |
2003-10-14 |
2023-08-12 |
human |