| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fu-Jen Huang, Yan-Der Hsuuw, Wen-Hsiung Cha. Characterization of apoptosis induced by emodin and related regulatory mechanisms in human neuroblastoma cells. International journal of molecular sciences. vol 14. issue 10. 2014-04-24. PMID:24113589. |
pretreatment with nitric oxide (no) scavengers suppressed the apoptotic biochemical changes induced by 20 μm emodin, and attenuated emodin-induced p53 and p21 expression involved in apoptotic signaling. |
2014-04-24 |
2023-08-12 |
human |
| Ming-Shu Hsieh, Wen-Hsiung Cha. Impact of methylglyoxal and high glucose co-treatment on human mononuclear cells. International journal of molecular sciences. vol 10. issue 4. 2014-01-15. PMID:19468318. |
pretreatment with nitric oxide (no) scavengers inhibited apoptotic biochemical changes induced by 5 microm mg/15 mm glucose, and increased the gene expression levels of p53 and p21 involved in apoptotic signaling. |
2014-01-15 |
2023-08-12 |
human |
| Judit Bátor, Judit Varga, József Szeberény. The effect of sodium nitroprusside on survival and stress signaling in PC12 rat phaeochromocytoma cells expressing a dominant negative RasH mutant protein. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 91. issue 4. 2013-12-31. PMID:23859017. |
cytotoxic concentrations of the nitric oxide donor sodium nitroprusside activated several proapoptotic mechanisms, including stimulation of the stress kinase pathways mediated by c-jun n-terminal kinase (jnk) and p38 mitogen-activated protein kinase (mapk), inhibition of the translation initiation factor eif2α, induction and phosphorylation of the p53 protein, and inhibited akt-mediated antiapoptotic signaling, independent of ras function. |
2013-12-31 |
2023-08-12 |
rat |
| Adilsaikhan Mendjargal, Erdenezaya Odkhuu, Naoki Koide, Hiroshi Nagata, Tsuyoshi Kurokawa, Toshiaki Nonami, Takashi Yokoch. Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway. International immunopharmacology. vol 15. issue 4. 2013-10-24. PMID:23454130. |
pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the myd88-independent pathway. |
2013-10-24 |
2023-08-12 |
mouse |
| Adilsaikhan Mendjargal, Erdenezaya Odkhuu, Naoki Koide, Hiroshi Nagata, Tsuyoshi Kurokawa, Toshiaki Nonami, Takashi Yokoch. Pifithrin-α, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway. International immunopharmacology. vol 15. issue 4. 2013-10-24. PMID:23454130. |
the effect of pifithrin (pft)-α, a pharmacological inhibitor of p53, on lipopolysaccharide (lps)-induced nitric oxide (no) production in raw 264.7 macrophage-like cells was examined. |
2013-10-24 |
2023-08-12 |
mouse |
| Shahana Safdar, Courtney A Payne, Nam H Tu, Lakeshia J Tait. Targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O(6) -methylguanine-DNA methyltransferase activity. Biotechnology and bioengineering. vol 110. issue 4. 2013-08-05. PMID:23125026. |
targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and o(6) -methylguanine-dna methyltransferase activity. |
2013-08-05 |
2023-08-12 |
human |
| Zan Wan, Wen Yu, Yun Chen, Yu-Tian Da. [Deacetylase SIRT1 and vascular endothelial function]. Zhonghua nan ke xue = National journal of andrology. vol 18. issue 9. 2013-06-24. PMID:23193674. |
recent studies show that through adjusting the activity of endothelial nitric oxide syntheses (enos), p53, forkhead box class o (foxo) and nuclear factor kappa b (nf-kappab), sirt1 can protect the functions of vascular endothelia and nerves in a variety of pathological conditions. |
2013-06-24 |
2023-08-12 |
Not clear |
| Vanessa B Sequeira, Mark S Rybchyn, Clare Gordon-Thomson, Wannit Tongkao-On, Mathew T Mizwicki, Anthony W Norman, Vivienne E Reeve, Gary M Halliday, Rebecca S Maso. Opening of chloride channels by 1α,25-dihydroxyvitamin D3 contributes to photoprotection against UVR-induced thymine dimers in keratinocytes. The Journal of investigative dermatology. vol 133. issue 3. 2013-06-20. PMID:23014341. |
as dna repair is inhibited by nitric oxide (no) products but facilitated by p53, we examined whether 1,25(oh)(2)d(3) altered the expression of nitrotyrosine, a product of no, or p53 after uvr in human keratinocytes. |
2013-06-20 |
2023-08-12 |
human |
| Ajay Kumar, Shiva Kant, Sukh Mahendra Sing. α-Cyano-4-hydroxycinnamate induces apoptosis in Dalton's lymphoma cells: role of altered cell survival-regulatory mechanisms. Anti-cancer drugs. vol 24. issue 2. 2013-05-23. PMID:22932131. |
in-vitro treatment of the dl cells with αchc resulted in the modulation of the biophysical parameters of the tumor cell culture medium with respect to ph, nitric oxide, glucose, and lactate, accompanied by an alteration in the expression of cytokines (il-10, il-6, and ifn-γ) and cell survival-regulatory proteins such as bcl2, p53, caspase-3, caspase-activated dnase, hsp70, and il2r. |
2013-05-23 |
2023-08-12 |
Not clear |
| Sona Krizkova, Marketa Ryvolova, Jan Hrabeta, Vojtech Adam, Marie Stiborova, Tomas Eckschlager, Rene Kize. Metallothioneins and zinc in cancer diagnosis and therapy. Drug metabolism reviews. vol 44. issue 4. 2013-05-09. PMID:23050852. |
antiapoptic effects of mts and their interactions with proteins nuclear factor kappa b, protein kinase c, esophageal cancer-related gene, and p53 as well as the role of mts in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. |
2013-05-09 |
2023-08-12 |
Not clear |
| Gordon P Meares, Dominique Fontanilla, Katarzyna A Broniowska, Teresa Andreone, Jack R Lancaster, John A Corbet. Differential responses of pancreatic β-cells to ROS and RNS. American journal of physiology. Endocrinology and metabolism. vol 304. issue 6. 2013-05-09. PMID:23321474. |
nitric oxide activates the unfolded protein and heat shock responses and mapk kinase signaling, whereas h₂o₂ stimulates p53 stabilization and poly(adp-ribose) polymerase (parp) activation but fails to induce the unfolded protein or heat shock responses or mapk activation. |
2013-05-09 |
2023-08-12 |
Not clear |
| b' J Zlatkovi\\xc4\\x87, D Filipovi\\xc4\\x8. Bax and B-cell-lymphoma 2 mediate proapoptotic signaling following chronic isolation stress in rat brain. Neuroscience. vol 223. 2013-05-01. PMID:22885231.' |
we tested this hypothesis by examining the effects of 2h of acute stress immobilization (im) or cold (c), 21days of social isolation as chronic stress and combined stress (chronic stress followed by acute stress) on cytosolic/mitochondrial levels and ratios of bax and bcl-2 proteins in relation to cytosolic nitric oxide (no) metabolites (nitrates and nitrites) and p53 protein redistribution between cytosolic and mitochondrial compartments in the prefrontal cortex (pfc) and hippocampus (hipp) of male wistar rats. |
2013-05-01 |
2023-08-12 |
rat |
| Martin Wiesinger, Bernd Mayer, Paul Jennings, Arno Luka. Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 6. 2013-01-04. PMID:22515967. |
among this large set of relevant molecular features four genes were found in common to all tissues and experimental conditions analyzed, namely heme oxygenase-1, nitric oxide synthetase 2, nfκb1 and p53. |
2013-01-04 |
2023-08-12 |
human |
| Ewy Mathé, Giang H Nguyen, Naotake Funamizu, Peijun He, Matthew Moake, Carlo M Croce, S Perwez Hussai. Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. International journal of cancer. vol 131. issue 3. 2012-07-30. PMID:22042537. |
inflammation regulates microrna expression in cooperation with p53 and nitric oxide. |
2012-07-30 |
2023-08-12 |
mouse |
| Ewy Mathé, Giang H Nguyen, Naotake Funamizu, Peijun He, Matthew Moake, Carlo M Croce, S Perwez Hussai. Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. International journal of cancer. vol 131. issue 3. 2012-07-30. PMID:22042537. |
inflammation and nitric oxide modulates the development of lymphomas in p53 knockout mice and there exists a negative feedback loop between p53 and nos2. |
2012-07-30 |
2023-08-12 |
mouse |
| Anjani Kumar, Alok Chandra Bharti, Sukh Mahendra Sing. Effect of aspirin administration on reversal of tumor-induced suppression of myelopoiesis in T-cell lymphoma bearing host. Blood cells, molecules & diseases. vol 48. issue 4. 2012-07-17. PMID:22421408. |
aspirin-exposed bmc also showed an altered expression of survival and cell cycle regulatory proteins p53, bcl2, caspase-activated deoxyribonuclease (cad), cyclin b1 and cyclin d. moreover, the bmc of aspirin-administered tumor-bearing mice showed an augmented colony-forming ability and differentiation in the macrophage lineage with an activated phenotype of bone marrow-derived macrophages (bmdm) with respect to macrophage-mediated tumoricidal activity and production of nitric oxide, il-1β, tnfα and vegf. |
2012-07-17 |
2023-08-12 |
mouse |
| Ayse Basak Engi. Dual function of nitric oxide in carcinogenesis, reappraisal. Current drug metabolism. vol 12. issue 9. 2012-06-29. PMID:21838704. |
the local concentration of the nitric oxide defines its anti- or protumorigenic function by interacting with dna or dna repair enzymes and tumor suppressor gene, p53, as well. |
2012-06-29 |
2023-08-12 |
human |
| Silvia Caggia, Massimo Libra, Grazia Malaponte, Venera Cardil. Modulation of YY1 and p53 expression by transforming growth factor-β3 in prostate cell lines. Cytokine. vol 56. issue 2. 2012-01-30. PMID:21807531. |
the expression of yy1, p53, pi3k, akt, pakt, pten, bcl-2, bax, and inos was evaluated through western blot analysis on bph-1, lncap, and du-145 cultures treated with 10 and 50 ng/ml of tgf-β3 for 24 h. the production of nitric oxide (no) was determined by griess reagent and cell viability through mtt assay. |
2012-01-30 |
2023-08-12 |
human |
| Xiaoming Su, Akihisa Takahashi, Natsuko Kondo, Yosuke Nakagawa, Toshiyasu Iwasaki, Guozhen Guo, Takeo Ohnish. Nitric oxide radical-induced radioadaptation and radiosensitization are G2/M phase-dependent. Journal of radiation research. vol 52. issue 5. 2012-01-26. PMID:21757848. |
the aim of this study was to examine biological effects of nitric oxide (no) on radiosensitivity and chromosome aberrations in different phases of the cell cycle in human cancer cells with a wild-type p53 (wtp53) genotype. |
2012-01-26 |
2023-08-12 |
human |
| E Chernigovskaya, D Atochin, L Yamova, P Huang, M Glazov. Immunohistochemical expression of Bcl-2, p53 and caspase-9 in hypothalamus magnocellular centers of nNOS knockout mice following water deprivation. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 86. issue 5. 2011-12-29. PMID:20662604. |
we studied the interactions between apoptosis regulator proteins (bcl-2, p53 and caspase-9) and neuronal nitric oxide in vasopressinergic magnocellular centers of the hypothalamus using neuronal nitric oxide synthase (nnos) gene knockout mice. |
2011-12-29 |
2023-08-12 |
mouse |