| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nian-Hong Chen, Jian-Jiang Zhon. p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 18. issue 8-9. 2011-10-14. PMID:21353507. |
furthermore, comparing the ratios of hct-116 p53(+/+) and p53(-/-) cells, p53 modified ga-t inhibition of migration and adhesion and ga-t promotion of cell aggregation, and p53 also modified ga-t inhibition of nf-κb nuclear translocation, iκbα degradation, and down-regulation of urokinase-type plaminogen activator (upa), matrix metalloproteinase-2/9 (mmp-2/9), inducible nitric oxide synthase (inos/nos2) protein expression and inducible nitric oxide (no) production. |
2011-10-14 |
2023-08-12 |
human |
| Wei-Hsuan Hsu, Bao-Hong Lee, Tzu-Ming Pa. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 6. 2011-08-30. PMID:21419818. |
the results demonstrated that rmde decreased nitric oxide (no), reactive oxygen species (ros), and prostaglandin e(2) (pge(2)) overexpression in hamster buccal pouches in the dmba treatment group and increased p53, serum tumor necrosis factor-α (tnf-α), and interleukin-1β (il-1β) to significantly stimulate caspase-8 and -3 activities, indicating that rmde reduced oxidative damage causing by dmba and induced apoptosis in oral cancer cells. |
2011-08-30 |
2023-08-12 |
Not clear |
| W Han, K N Yu, L J Wu, Y C Wu, H Z Wan. Mechanism of protection of bystander cells by exogenous carbon monoxide: impaired response to damage signal of radiation-induced bystander effect. Mutation research. vol 709-710. 2011-06-21. PMID:21376740. |
the results from medium transfer experiments showed that α-particle irradiated chinese hamster ovary (cho) cells would release nitric oxide (no), which was detected with specific no fluorescence probe, to induce p53 binding protein 1 (bp1) formation in the cell population receiving the medium, and the release peak was found to be at 1h post irradiation. |
2011-06-21 |
2023-08-12 |
Not clear |
| Ali Tebbi, Olivier Guittet, Marie-Hélène Cottet, Marie-Françoise Vesin, Michel Lepoivr. TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis. The Journal of biological chemistry. vol 286. issue 10. 2011-05-11. PMID:21212274. |
nitric oxide (no) is a potent activator of the p53 tumor suppressor protein, thereby inducing cell cycle arrest and apoptosis. |
2011-05-11 |
2023-08-12 |
mouse |
| H Sone, H Akanuma, T Fukud. Oxygenomics in environmental stress. Redox report : communications in free radical research. vol 15. issue 3. 2010-10-08. PMID:20594413. |
these pathways are classifiable into several categories: reactive oxygen species (ros) metabolism and antioxidant defenses, p53 pathway signaling, nitric oxide (no) signaling pathway, hypoxia signaling, transforming growth factor (tgf)-beta bone morphogenetic protein (bmp) signaling, tumor necrosis factor (tnf) ligand-receptor signaling, and mitochondrial function. |
2010-10-08 |
2023-08-12 |
human |
| Vasily A Yakovlev, Alexander S Bayden, Paul R Graves, Glen E Kellogg, Ross B Mikkelse. Nitration of the tumor suppressor protein p53 at tyrosine 327 promotes p53 oligomerization and activation. Biochemistry. vol 49. issue 25. 2010-07-21. PMID:20499882. |
previous studies demonstrate that nitric oxide (no) promotes p53 transcriptional activity by a classical dna damage responsive mechanism involving activation of atm/atr and phosphorylation of p53. |
2010-07-21 |
2023-08-12 |
Not clear |
| Daniel A Popowich, Ashley K Vavra, Christopher P Walsh, Hussein A Bhikhapurwala, Nicholas B Rossi, Qun Jiang, Oliver O Aalami, Melina R Kibb. Regulation of reactive oxygen species by p53: implications for nitric oxide-mediated apoptosis. American journal of physiology. Heart and circulatory physiology. vol 298. issue 6. 2010-06-23. PMID:20382856. |
nitric oxide (no) induces vascular smooth muscle cell (vsmc) apoptosis in part through activation of p53. |
2010-06-23 |
2023-08-12 |
Not clear |
| Jiangang Shen, Xingshen Qiu, Bo Jiang, Deliang Zhang, Wenjuan Xin, Peter C W Fung, Baolu Zha. Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes. Science in China. Series C, Life sciences. vol 46. issue 1. 2010-06-03. PMID:20213359. |
nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes. |
2010-06-03 |
2023-08-12 |
rat |
| Xiaoming Su, Akihisa Takahashi, Guozhen Guo, Eiichiro Mori, Noritomo Okamoto, Ken Ohnishi, Toshiyasu Iwasaki, Takeo Ohnish. Biphasic effects of nitric oxide radicals on radiation-induced lethality and chromosome aberrations in human lung cancer cells carrying different p53 gene status. International journal of radiation oncology, biology, physics. vol 77. issue 2. 2010-05-24. PMID:20381264. |
biphasic effects of nitric oxide radicals on radiation-induced lethality and chromosome aberrations in human lung cancer cells carrying different p53 gene status. |
2010-05-24 |
2023-08-12 |
human |
| Xiaoming Su, Akihisa Takahashi, Guozhen Guo, Eiichiro Mori, Noritomo Okamoto, Ken Ohnishi, Toshiyasu Iwasaki, Takeo Ohnish. Biphasic effects of nitric oxide radicals on radiation-induced lethality and chromosome aberrations in human lung cancer cells carrying different p53 gene status. International journal of radiation oncology, biology, physics. vol 77. issue 2. 2010-05-24. PMID:20381264. |
the aim of this study was to clarify the effects of nitric oxide (no) on radiation-induced cell killing and chromosome aberrations in two human lung cancer cell lines with a different p53 gene status. |
2010-05-24 |
2023-08-12 |
human |
| T A Rajewskaya, S A Goncharova, N P Konovalova, A A Terent'ev, M A Lapshin. Effect of nitric oxide donor, a modulator of tumor drug resistance, on cell death and p53 protein expression. Bulletin of experimental biology and medicine. vol 147. issue 4. 2009-12-28. PMID:19704938. |
effect of nitric oxide donor, a modulator of tumor drug resistance, on cell death and p53 protein expression. |
2009-12-28 |
2023-08-12 |
Not clear |
| Min Young Kim, Laura J Trudel, Gerald N Woga. Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer research. vol 29. issue 10. 2009-11-30. PMID:19846903. |
we examined the role of nitric oxide (no) and influence of p53 status during apoptosis induced by these agents in two isogenic hct116 human colon carcinomas, wild-type p53 (p53-wt) and complete knockout of p53 (p53-null) cells. |
2009-11-30 |
2023-08-12 |
human |
| Katherine J Hughes, Gordon P Meares, Kari T Chambers, John A Corbet. Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression. The Journal of biological chemistry. vol 284. issue 40. 2009-10-21. PMID:19648647. |
p53 is a logical target of jnk-dependent dna repair; however, nitric oxide does not stimulate p53 activation or accumulation in beta-cells. |
2009-10-21 |
2023-08-12 |
Not clear |
| Koichi Tan-No, Masakazu Shimoda, Kenya Watanabe, Osamu Nakagawasai, Fukie Niijima, Syu-Ichi Kanno, Masaaki Ishikawa, Georgy Bakalkin, Takeshi Tadan. Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine. Neuroscience letters. vol 450. issue 3. 2009-04-20. PMID:19084050. |
these results indicate that the increased expression and activation of p53, and the nitric oxide and caspase systems related to p53 may contribute to the development of antinociceptive tolerance to morphine in the mouse spinal cord. |
2009-04-20 |
2023-08-12 |
mouse |
| J Kitagaki, Y Yang, J E Saavedra, N H Colburn, L K Keefer, A O Peranton. Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53. Oncogene. vol 28. issue 4. 2009-02-17. PMID:18978812. |
nitric oxide prodrug js-k inhibits ubiquitin e1 and kills tumor cells retaining wild-type p53. |
2009-02-17 |
2023-08-12 |
Not clear |
| Chandrasekharan Guruvayoorappan, Girija Kutta. Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. Journal of experimental therapeutics & oncology. vol 7. issue 3. 2009-01-15. PMID:19066129. |
amentoflavone stimulates apoptosis in b16f-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in b16f-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. |
2009-01-15 |
2023-08-12 |
Not clear |
| Chandrasekharan Guruvayoorappan, Girija Kutta. Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. Journal of experimental therapeutics & oncology. vol 7. issue 3. 2009-01-15. PMID:19066129. |
in conclusion, the observed results suggests that, amentoflavone stimulates apoptosis by regulating bcl-2, caspase-3 and p53 genes in b16f-10 melanoma cells and regulates nitric oxide and proinflammatory cytokine production in b16f-10 cells, tams and peritoneal macrophages. |
2009-01-15 |
2023-08-12 |
Not clear |
| Cuk-Seong Kim, Saet-Byel Jung, Asma Naqvi, Timothy A Hoffman, Jeremy DeRicco, Tohru Yamamori, Marsha P Cole, Byeong-Hwa Jeon, Kaikobad Iran. p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc. Circulation research. vol 103. issue 12. 2009-01-09. PMID:18988897. |
in addition, we demonstrate that downregulation of p66shc expression, as well as inhibition of p53 function in mice, mitigates angiotensin ii-induced impairment of endothelium-dependent vasorelaxation, decrease in bioavailable nitric oxide, and hypertension. |
2009-01-09 |
2023-08-12 |
mouse |
| Seung-Il Jeong, Beng Zhou, Jin-Beom Bae, Nam-Seok Kim, Sun-Geun Kim, Jin Kwon, Dae-Keun Kim, Tae-Yong Shin, Hoon Jeon, Jong-Phil Lim, Hongjun Kim, Ho Kyoung Kim, Chan-Ho O. Apoptosis-inducing effect of akebia saponin D from the roots of Dipsacus asper Wall in U937 cells. Archives of pharmacal research. vol 31. issue 11. 2009-01-05. PMID:19023535. |
taken together, these results strongly indicate that asd may exert apoptosis-inducing activity via induction of apoptosis through activation chiefly via the nitric oxide and apoptosis-related p53 and bax gene expression. |
2009-01-05 |
2023-08-12 |
human |
| Aysegul Uysal, Gulperi Oktem, Ozlem Yilmaz, Serap Uslu, Huseyin Aktug, Mine Ertem Yurtseve. Quantitative immunohistochemical analysis of nitric oxide synthases and apoptosis regulator proteins in the fetal rat brain following maternal uterine artery ligation. The International journal of neuroscience. vol 118. issue 6. 2008-11-18. PMID:18465431. |
the purpose of this study was to determine the relation between nitric oxide synthases (calcium-independent inos and calcium-dependent enos) and apoptosis regulator proteins (anti-apoptotic bcl-2, pro-apoptotic p53) of fetal rat brain in experimental intrauterine growth retardation (iugr) model via quantitative immunohistochemistry. |
2008-11-18 |
2023-08-12 |
rat |