| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Wang, A Zalcenstein, M Ore. Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation. Cell death and differentiation. vol 10. issue 4. 2003-10-02. PMID:12719724. |
nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation. |
2003-10-02 |
2023-08-12 |
Not clear |
| X Wang, A Zalcenstein, M Ore. Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation. Cell death and differentiation. vol 10. issue 4. 2003-10-02. PMID:12719724. |
nitric oxide (no) is a potent activator of the p53 tumor suppressor protein. |
2003-10-02 |
2023-08-12 |
Not clear |
| Uwe Wenzel, Sabine Kuntz, Ulrike Jambor De Sousa, Hannelore Danie. Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions. International journal of cancer. vol 106. issue 5. 2003-09-16. PMID:12866025. |
in cells lacking a functional p53 tumor suppressor protein, the endogenous free radical nitric oxide (no) appears to inhibit apoptosis, and thereby promotes growth of cancer cells. |
2003-09-16 |
2023-08-12 |
human |
| Oreste Gallo, Nicola Schiavone, Laura Papucci, Iacopo Sardi, Lucia Magnelli, Alessandro Franchi, Emanuela Masini, Sergio Capacciol. Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. The American journal of pathology. vol 163. issue 2. 2003-09-10. PMID:12875991. |
down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. |
2003-09-10 |
2023-08-12 |
Not clear |
| Nicole Schneiderhan, Andreja Budde, Yanping Zhang, Bernhard Brün. Nitric oxide induces phosphorylation of p53 and impairs nuclear export. Oncogene. vol 22. issue 19. 2003-06-23. PMID:12771937. |
nitric oxide induces phosphorylation of p53 and impairs nuclear export. |
2003-06-23 |
2023-08-12 |
Not clear |
| Dominique Lamarque, Jeanne Tran Van Nhieu, Maxime Breba. [What are the gastric modifications induced by acute and chronic Helicobacter pylori infection?]. Gastroenterologie clinique et biologique. vol 27. issue 3 Pt 2. 2003-06-06. PMID:12700495. |
the development of atrophic gastritis towards cancer is supported by nitric oxide which has a mutagenic effect on dna and inhibits p53 protein and by the bacterium itself which decreases dna mismatch repairing activity. |
2003-06-06 |
2023-08-12 |
Not clear |
| S Perwez Hussain, Lorne J Hofseth, Curtis C Harri. Radical causes of cancer. Nature reviews. Cancer. vol 3. issue 4. 2003-05-07. PMID:12671666. |
in particular, we highlight the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis. |
2003-05-07 |
2023-08-12 |
Not clear |
| M R Müller, K H Wiesmüller, G Jung, T Loop, M Humar, S D C Pfannes, W G Bessler, K Mittenbühle. Lipopeptide adjuvants: monitoring and comparison of P3CSK4- and LPS-induced gene transcription. International immunopharmacology. vol 2. issue 8. 2003-03-18. PMID:12349944. |
p3csk4 activates the expression of tumor suppressor protein p53 (p53), c-rel, inhibitor of nuclear factor kappa b (nfkappab) alpha (ikappab alpha), type 2 (inducible) nitric oxide (no) synthase (inos), cd40-lr, intercellular adhesion molecule-1 (icam-1) and interleukin 1/6/15 (il-1/6/15). |
2003-03-18 |
2023-08-12 |
Not clear |
| Christopher M Schonhoff, Marie-Claire Daou, Stephen N Jones, Celia A Schiffer, Alonzo H Ros. Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry. vol 41. issue 46. 2002-12-19. PMID:12427017. |
we tested in vitro whether nitric oxide may indirectly control p53 by s-nitrosylation and inactivation of the p53 negative regulator, hdm2. |
2002-12-19 |
2023-08-12 |
zebrafish |
| Christopher M Schonhoff, Marie-Claire Daou, Stephen N Jones, Celia A Schiffer, Alonzo H Ros. Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry. vol 41. issue 46. 2002-12-19. PMID:12427017. |
treatment of hdm2 with a nitric oxide donor inhibits hdm2-p53 binding, a critical step in hdm2 regulation of p53. |
2002-12-19 |
2023-08-12 |
zebrafish |
| X L Chen, S S Huang, Y X Yao, W B Li, X L Wang, A M Zho. Promotion of pulmonary fibroblast proliferation and apoptosis by sodium nitroprusside. Sheng li xue bao : [Acta physiologica Sinica]. vol 53. issue 6. 2002-11-19. PMID:11930231. |
the effects of nitric oxide (no) donor sodium nitroprusside (snp) on the proliferation and apoptosis and on bcl-2, bax and p53 proteins of pulmonary fibroblasts were investigated by using mtt cleavage assay, agarose gel electrophoresis and flow cytometric analysis. |
2002-11-19 |
2023-08-12 |
Not clear |
| Alessandro Franchi, Marco Santucci, Emanuela Masini, Iacopo Sardi, Milena Paglierani, Oreste Gall. Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck. Cancer. vol 95. issue 9. 2002-11-15. PMID:12404284. |
in this study, the authors examined whether the expression of mmps in hnscc is correlated with other steps involved in tumor growth and metastasis, like angiogenesis, activation the nitric oxide (no) pathway, and alteration of the p53 tumor suppressor gene. |
2002-11-15 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Sang-Gu Hwang, Deug Y Shin, Shin-Sung Kang, Jang-Soo Chu. p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. The Journal of biological chemistry. vol 277. issue 36. 2002-10-29. PMID:12091386. |
nitric oxide (no) during primary culture of articular chondrocytes causes apoptosis via p38 mitogen-activated protein kinase in association with elevation of p53 protein level, caspase-3 activation, and differentiation status. |
2002-10-29 |
2023-08-12 |
Not clear |
| Akinori Sakai, Shinya Tanaka, Takeshi Sakata, Makoto Watanuki, Miyuki Zenke, Toshitaka Nakamur. [Regulation of bone mass for skeletal loading]. Journal of UOEH. vol 24. issue 3. 2002-10-28. PMID:12235958. |
our observations demonstrate that generation of nitric oxide through inducible nitric oxide synthase is essential for the stimulation of bone formation upon mechanical reloading, and that disruption of p53 gene in response to 1-week unloading does not result in reductions in bone volume and bone formation. |
2002-10-28 |
2023-08-12 |
Not clear |
| Tanya Das, Gaurisankar Sa, Sreya Chattopadhyay, Prasanta K Ra. Protein A-induced apoptosis of cancer cells is effected by soluble immune mediators. Cancer immunology, immunotherapy : CII. vol 51. issue 7. 2002-09-27. PMID:12192537. |
(1) activation of the immune system of the host to release different apoptogenic factors like tumor necrosis factor-alpha (tnf-alpha) and nitric oxide (no); and (2) induction of eac apoptosis by these soluble immune mediators through the up-regulation of pro-apoptotic factors (p53 and bax) and down-regulation of anti-apoptotic factor (bcl-2), resulting in the activation of caspase-3. |
2002-09-27 |
2023-08-12 |
mouse |
| Xinjiang Wang, Dan Michael, Gilbert de Murcia, Moshe Ore. p53 Activation by nitric oxide involves down-regulation of Mdm2. The Journal of biological chemistry. vol 277. issue 18. 2002-07-02. PMID:11867628. |
p53 activation by nitric oxide involves down-regulation of mdm2. |
2002-07-02 |
2023-08-12 |
mouse |
| Alexandra Heinloth, Bernhard Brüne, Barbara Fischer, Jan Gall. Nitric oxide prevents oxidised LDL-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation. Atherosclerosis. vol 162. issue 1. 2002-06-28. PMID:11947902. |
nitric oxide prevents oxidised ldl-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation. |
2002-06-28 |
2023-08-12 |
Not clear |
| Alexandra Heinloth, Bernhard Brüne, Barbara Fischer, Jan Gall. Nitric oxide prevents oxidised LDL-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation. Atherosclerosis. vol 162. issue 1. 2002-06-28. PMID:11947902. |
here we studied the impact of nitric oxide (no) on oxldl-induced cytochrome c release, apoptosis, and expression of the proapoptotic p53 in macrophages. |
2002-06-28 |
2023-08-12 |
Not clear |
| Y Chen, A Stanford, R L Simmons, H R Ford, R A Hoffma. Nitric oxide protects thymocytes from gamma-irradiation-induced apoptosis in correlation with inhibition of p53 upregulation and mitochondrial damage. Cellular immunology. vol 214. issue 1. 2002-04-30. PMID:11902831. |
nitric oxide protects thymocytes from gamma-irradiation-induced apoptosis in correlation with inhibition of p53 upregulation and mitochondrial damage. |
2002-04-30 |
2023-08-12 |
mouse |
| Melina R Kibbe, Jianrong Li, Suhua Nie, Byung Min Choi, Imre Kovesdi, Alena Lizonova, Timothy R Billiar, Edith Tzen. Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells. American journal of physiology. Cell physiology. vol 282. issue 3. 2002-03-21. PMID:11832348. |
the functional role of p53 in nitric oxide (no)-mediated vascular smooth muscle cell (vsmc) apoptosis remains unknown. |
2002-03-21 |
2023-08-12 |
Not clear |